ATE472523T1 - Verbessertes verfahren zur herstellung von rivastigmin - Google Patents
Verbessertes verfahren zur herstellung von rivastigminInfo
- Publication number
- ATE472523T1 ATE472523T1 AT06847312T AT06847312T ATE472523T1 AT E472523 T1 ATE472523 T1 AT E472523T1 AT 06847312 T AT06847312 T AT 06847312T AT 06847312 T AT06847312 T AT 06847312T AT E472523 T1 ATE472523 T1 AT E472523T1
- Authority
- AT
- Austria
- Prior art keywords
- improved method
- formula
- rivastigmine
- producing
- producing rivastigmine
- Prior art date
Links
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 title abstract 2
- 229960004136 rivastigmine Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229930040373 Paraformaldehyde Natural products 0.000 abstract 1
- 239000007868 Raney catalyst Substances 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- 239000002253 acid Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 229920002866 paraformaldehyde Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1290MU2006 | 2006-08-17 | ||
| PCT/IN2006/000404 WO2008020452A1 (en) | 2006-08-17 | 2006-10-06 | Improved process for the preparation of rivastigmine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE472523T1 true ATE472523T1 (de) | 2010-07-15 |
Family
ID=38173597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06847312T ATE472523T1 (de) | 2006-08-17 | 2006-10-06 | Verbessertes verfahren zur herstellung von rivastigmin |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7683205B2 (de) |
| EP (1) | EP2054373B1 (de) |
| AT (1) | ATE472523T1 (de) |
| CA (1) | CA2661009A1 (de) |
| DE (1) | DE602006015241D1 (de) |
| WO (1) | WO2008020452A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010023535A1 (en) * | 2008-08-25 | 2010-03-04 | Jubilant Organosys Limited | A process for producing (s)-3-[(1-dimethylamino)ethyl] phenyl-n-ethyl-n-methyl-carbamate via novel intermediates |
| KR101085170B1 (ko) * | 2009-08-19 | 2011-11-18 | 주식회사 셀트리온화학연구소 | (ｓ)-리바스티그민의 제조방법 |
| HUE038434T2 (hu) | 2010-06-17 | 2018-10-29 | Codexis Inc | Biokatalizátorok és módszerek (S)-3(1-aminoetil)-fenol szintéziséhez |
| CN104151176B (zh) * | 2014-08-29 | 2016-08-24 | 大连韦德生化科技有限公司 | 一种卡巴拉汀手性中间体及其制备方法 |
| KR20200035359A (ko) * | 2018-09-26 | 2020-04-03 | 캐딜라 파마슈티클즈 리미티드 | 리바스티그민 제조용 중간체의 합성 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL74497A (en) * | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
| NL195004C (nl) * | 1987-03-04 | 2003-11-04 | Novartis Ag | Fenylcarbamaat bevattend farmaceutisch preparaat. |
| AU2003263574A1 (en) * | 2002-05-31 | 2003-12-19 | Patel, Hetalkumar, Virendrabhai | A process for the preparation of phenylcarbamates |
| CZ293014B6 (cs) * | 2002-10-24 | 2004-01-14 | Léčiva, A.S. | Způsob výroby (-)-(S)-3-[1-(dimethylamino)ethyl]fenyl-N-ethyl-N-methylkarbamátu |
| JP4954886B2 (ja) * | 2004-11-08 | 2012-06-20 | エムキュア ファーマシューティカルズ リミテッド | （ｓ）−３−［（１−ジメチルアミノ）エチル］−フェニル−ｎ−エチル−ｎ−メチル−カルバミン酸の効率的製造方法 |
| KR20060072326A (ko) * | 2004-12-23 | 2006-06-28 | 동국제약 주식회사 | 페닐카바메이트 유도체의 새로운 합성 방법 |
-
2006
- 2006-10-06 WO PCT/IN2006/000404 patent/WO2008020452A1/en not_active Ceased
- 2006-10-06 EP EP06847312A patent/EP2054373B1/de not_active Not-in-force
- 2006-10-06 CA CA002661009A patent/CA2661009A1/en not_active Abandoned
- 2006-10-06 AT AT06847312T patent/ATE472523T1/de not_active IP Right Cessation
- 2006-10-06 DE DE602006015241T patent/DE602006015241D1/de active Active
- 2006-10-31 US US11/590,566 patent/US7683205B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2054373B1 (de) | 2010-06-30 |
| EP2054373A1 (de) | 2009-05-06 |
| US20080045743A1 (en) | 2008-02-21 |
| DE602006015241D1 (de) | 2010-08-12 |
| CA2661009A1 (en) | 2008-02-21 |
| WO2008020452A1 (en) | 2008-02-21 |
| US7683205B2 (en) | 2010-03-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |