ATE472549T1 - Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel - Google Patents

Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel

Info

Publication number
ATE472549T1
ATE472549T1 AT07803370T AT07803370T ATE472549T1 AT E472549 T1 ATE472549 T1 AT E472549T1 AT 07803370 T AT07803370 T AT 07803370T AT 07803370 T AT07803370 T AT 07803370T AT E472549 T1 ATE472549 T1 AT E472549T1
Authority
AT
Austria
Prior art keywords
cupyrrol
derivatives
antiviral agents
antiviral
agents
Prior art date
Application number
AT07803370T
Other languages
English (en)
Inventor
Remy Lemoine
Chris Richard Melville
David Mark Rotstein
Jutta Wanner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38787632&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE472549(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE472549T1 publication Critical patent/ATE472549T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT07803370T 2006-09-18 2007-09-10 Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel ATE472549T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84533406P 2006-09-18 2006-09-18
PCT/EP2007/059453 WO2008034731A1 (en) 2006-09-18 2007-09-10 Octahydropyrrolo [3, 4-c] pyrrole derivatives an their use as antiviral agents

Publications (1)

Publication Number Publication Date
ATE472549T1 true ATE472549T1 (de) 2010-07-15

Family

ID=38787632

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07803370T ATE472549T1 (de) 2006-09-18 2007-09-10 Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel

Country Status (13)

Country Link
US (1) US7625905B2 (de)
EP (1) EP2066674B1 (de)
JP (1) JP2010503714A (de)
CN (1) CN101516884A (de)
AR (1) AR062798A1 (de)
AT (1) ATE472549T1 (de)
CA (1) CA2662835A1 (de)
CL (1) CL2007002671A1 (de)
DE (1) DE602007007497D1 (de)
ES (1) ES2345130T3 (de)
PE (1) PE20081375A1 (de)
TW (1) TW200821311A (de)
WO (1) WO2008034731A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2585806T3 (es) 2009-10-23 2016-10-10 Janssen Pharmaceutica N.V. Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina
WO2011050202A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
EP2491034B1 (de) 2009-10-23 2013-12-18 Janssen Pharmaceutica, N.V. Kondensierte heterocyclische verbindungen als orexinrezeptormodulatoren
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
AU2012273125B2 (en) 2011-06-19 2017-05-25 New York University Leukotoxin E/D as a new anti-inflammatory agent and microbicide
MA39792B1 (fr) 2014-03-26 2019-12-31 Hoffmann La Roche Composés bicycliques en tant qu'inhibiteurs de production d'autotaxine (atx) et d'acide lysophosphatidique (lpa)
EA201790185A1 (ru) 2014-07-15 2017-07-31 Грюненталь Гмбх Замещенные азаспиро(4.5)декановые производные
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
MX387736B (es) 2015-09-04 2025-03-18 Hoffmann La Roche Derivados de fenoximetilo.
HRP20220642T1 (hr) 2016-03-10 2022-06-24 Janssen Pharmaceutica Nv Postupci za liječenje depresije uporabom antagonista receptora oreksina 2
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03008109A (es) * 2001-03-07 2003-12-12 Pfizer Prod Inc Moduladores de la actividad de receptores de quimiocinas.
US7271172B2 (en) * 2002-12-13 2007-09-18 Smithkline Beecham Corporation Pyrrolidine and azetidine compounds as CCR5 antagonists
RU2005118407A (ru) * 2002-12-13 2006-03-10 СмитКлайн Бичем Корпорейшн (US) Производные пиперидина в качестве антагонистов ccr5
CA2573951A1 (en) * 2003-07-18 2005-01-27 Virochem Pharma Inc. Spiro compounds and methods for the modulation of chemokine receptor activity
ES2285485T3 (es) 2003-07-31 2007-11-16 Astrazeneca Ab Derivados de piperidina como moduladores del receptor ccr5.
TW200610761A (en) * 2004-04-23 2006-04-01 Astrazeneca Ab Chemical compounds
DK1761542T3 (da) 2004-06-09 2008-04-28 Hoffmann La Roche Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler
SE0401657D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab Chemical compounds
SE0403106D0 (sv) 2004-12-20 2004-12-20 Astrazeneca Ab Chemical compounds
EP1987035A1 (de) 2006-02-15 2008-11-05 F.Hoffmann-La Roche Ag Heterocyclische antivirale verbindungen
CA2641389A1 (en) 2006-02-15 2007-08-23 F. Hoffmann-La Roche Ag Hetero-bycyclic antiviral compounds

Also Published As

Publication number Publication date
AR062798A1 (es) 2008-12-03
EP2066674B1 (de) 2010-06-30
JP2010503714A (ja) 2010-02-04
ES2345130T3 (es) 2010-09-15
TW200821311A (en) 2008-05-16
DE602007007497D1 (de) 2010-08-12
CA2662835A1 (en) 2008-03-27
CL2007002671A1 (es) 2008-04-18
PE20081375A1 (es) 2008-10-17
EP2066674A1 (de) 2009-06-10
US20080103125A1 (en) 2008-05-01
WO2008034731A1 (en) 2008-03-27
CN101516884A (zh) 2009-08-26
US7625905B2 (en) 2009-12-01

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