ATE472549T1 - Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel - Google Patents

Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel

Info

Publication number
ATE472549T1
ATE472549T1 AT07803370T AT07803370T ATE472549T1 AT E472549 T1 ATE472549 T1 AT E472549T1 AT 07803370 T AT07803370 T AT 07803370T AT 07803370 T AT07803370 T AT 07803370T AT E472549 T1 ATE472549 T1 AT E472549T1
Authority
AT
Austria
Prior art keywords
cupyrrol
derivatives
antiviral agents
antiviral
agents
Prior art date
Application number
AT07803370T
Other languages
English (en)
Inventor
Remy Lemoine
Chris Richard Melville
David Mark Rotstein
Jutta Wanner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38787632&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE472549(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE472549T1 publication Critical patent/ATE472549T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT07803370T 2006-09-18 2007-09-10 Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel ATE472549T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84533406P 2006-09-18 2006-09-18
PCT/EP2007/059453 WO2008034731A1 (en) 2006-09-18 2007-09-10 Octahydropyrrolo [3, 4-c] pyrrole derivatives an their use as antiviral agents

Publications (1)

Publication Number Publication Date
ATE472549T1 true ATE472549T1 (de) 2010-07-15

Family

ID=38787632

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07803370T ATE472549T1 (de) 2006-09-18 2007-09-10 Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel

Country Status (13)

Country Link
US (1) US7625905B2 (de)
EP (1) EP2066674B1 (de)
JP (1) JP2010503714A (de)
CN (1) CN101516884A (de)
AR (1) AR062798A1 (de)
AT (1) ATE472549T1 (de)
CA (1) CA2662835A1 (de)
CL (1) CL2007002671A1 (de)
DE (1) DE602007007497D1 (de)
ES (1) ES2345130T3 (de)
PE (1) PE20081375A1 (de)
TW (1) TW200821311A (de)
WO (1) WO2008034731A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011050200A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
WO2011050202A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
ES2585806T3 (es) 2009-10-23 2016-10-10 Janssen Pharmaceutica N.V. Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
AU2012273125B2 (en) 2011-06-19 2017-05-25 New York University Leukotoxin E/D as a new anti-inflammatory agent and microbicide
CN106103446B (zh) * 2014-03-26 2019-07-30 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物
BR112017000762A2 (pt) 2014-07-15 2017-11-21 Gruenenthal Gmbh derivados de azaspiro(4.5)decano substituído.
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
CA2992889A1 (en) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Phenoxymethyl derivatives
US10828302B2 (en) 2016-03-10 2020-11-10 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2440803A1 (en) * 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
AU2003296992A1 (en) * 2002-12-13 2004-07-09 Smithkline Beecham Corporation Pyrrolidine and azetidine compounds as ccr5 antagonists
BR0317230A (pt) * 2002-12-13 2005-10-25 Smithkline Beecham Corp Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto
EP1776362A1 (de) * 2003-07-18 2007-04-25 Virochem Pharma Inc. Spiroverbindungen und verfahren zur modulation der aktivität des chemokinrezeptors
ATE361911T1 (de) 2003-07-31 2007-06-15 Astrazeneca Ab Piperidinderivate als ccr5-rezeptormodulatoren
TW200610761A (en) * 2004-04-23 2006-04-01 Astrazeneca Ab Chemical compounds
RU2006146608A (ru) 2004-06-09 2008-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) ОКТАГИДРОПИРРОЛО[3,4-с]-ПРОИЗВОДНЫЕ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПРОТИВОВИРУСНЫХ АГЕНТОВ
SE0401657D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab Chemical compounds
SE0403106D0 (sv) 2004-12-20 2004-12-20 Astrazeneca Ab Chemical compounds
RU2008136756A (ru) 2006-02-15 2010-03-20 Ф.Хоффманн-Ля Рош Аг (Ch) Гетеробициклические противовирусные соединения
CA2641382A1 (en) 2006-02-15 2007-08-23 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds

Also Published As

Publication number Publication date
US20080103125A1 (en) 2008-05-01
DE602007007497D1 (de) 2010-08-12
ES2345130T3 (es) 2010-09-15
AR062798A1 (es) 2008-12-03
PE20081375A1 (es) 2008-10-17
CA2662835A1 (en) 2008-03-27
CN101516884A (zh) 2009-08-26
EP2066674B1 (de) 2010-06-30
CL2007002671A1 (es) 2008-04-18
US7625905B2 (en) 2009-12-01
TW200821311A (en) 2008-05-16
JP2010503714A (ja) 2010-02-04
EP2066674A1 (de) 2009-06-10
WO2008034731A1 (en) 2008-03-27

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