ATE473009T1 - Hemmung der neurodegeneration - Google Patents

Hemmung der neurodegeneration

Info

Publication number
ATE473009T1
ATE473009T1 AT02739383T AT02739383T ATE473009T1 AT E473009 T1 ATE473009 T1 AT E473009T1 AT 02739383 T AT02739383 T AT 02739383T AT 02739383 T AT02739383 T AT 02739383T AT E473009 T1 ATE473009 T1 AT E473009T1
Authority
AT
Austria
Prior art keywords
disease
inhibiting neurodegeneration
alzheimer
inhibiting
neurodegeneration
Prior art date
Application number
AT02739383T
Other languages
English (en)
Inventor
Jack Wands
La Monte Suzanne De
Original Assignee
Rhode Island Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhode Island Hospital filed Critical Rhode Island Hospital
Application granted granted Critical
Publication of ATE473009T1 publication Critical patent/ATE473009T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AT02739383T 2001-06-01 2002-05-28 Hemmung der neurodegeneration ATE473009T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/872,968 US6770797B2 (en) 2001-06-01 2001-06-01 Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid
PCT/US2002/016429 WO2002099036A2 (en) 2001-06-01 2002-05-28 Inhibition of neurodegeneration

Publications (1)

Publication Number Publication Date
ATE473009T1 true ATE473009T1 (de) 2010-07-15

Family

ID=25360708

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02739383T ATE473009T1 (de) 2001-06-01 2002-05-28 Hemmung der neurodegeneration

Country Status (8)

Country Link
US (2) US6770797B2 (de)
EP (1) EP1414478B1 (de)
JP (1) JP2005516886A (de)
AT (1) ATE473009T1 (de)
AU (1) AU2002312033B2 (de)
CA (1) CA2448863C (de)
DE (1) DE60236939D1 (de)
WO (1) WO2002099036A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002089841A2 (en) * 2001-05-04 2002-11-14 Nymox Corporation Method of preventing cell death using antibodies to neural thread proteins
AU2003233120B2 (en) * 2002-04-26 2008-08-21 Ferguson, Ian Andrew Non-invasive delivery of polypeptides through the blood-brain barrier, and in vivo selection of endocytotic ligands
EP1503801A4 (de) * 2002-04-26 2006-02-08 Ian A Ferguson Nichtinvasive abgabe von polypeptiden durch die blut-hirn-schranke und in-vivo-auswahl von endozytotischen liganden
US7544771B2 (en) * 2005-02-23 2009-06-09 Nymox Corporation Protein and its use in diagnosing Alzheimer's disease
JP2012513477A (ja) * 2008-12-23 2012-06-14 ソーク インスティチュート フォー バイオロジカル スタディーズ 神経変性疾患の治療方法
JP5819851B2 (ja) * 2010-01-08 2015-11-24 オンコヘルス コーポレーション Ｈｐｖ関連の癌の治療及びスクリーニングのための細胞に基づいた高処理能力ｈｐｖ免疫アッセイ

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948634A (en) * 1988-12-21 1999-09-07 The General Hospital Coporation Neural thread protein gene expression and detection of alzheimer's disease
CA2109955A1 (en) * 1991-05-24 1992-11-26 Toru Hayakawa Equipment for intracerebral administration of preparations
DK0697893T3 (da) 1993-04-20 2006-02-20 Gen Hospital Corp Nervetrådproteingenekspression og detektion af Alzheimers sygdom
US5744335A (en) * 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US5863898A (en) * 1996-10-29 1999-01-26 Incyte Pharmaceuticals, Inc. Human lim proteins
JP3758792B2 (ja) * 1997-02-25 2006-03-22 三菱重工業株式会社 ガスタービン動翼のプラットフォーム冷却機構
CA2282729A1 (en) 1997-02-26 1998-09-03 The General Hospital Corporation Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of alzheimer's disease
EP1006794B1 (de) 1997-03-12 2007-11-28 Robert W. Esmond Verfahren zur behandlung oder prävention der alzheimerischen krankheit

Also Published As

Publication number Publication date
EP1414478A2 (de) 2004-05-06
WO2002099036A2 (en) 2002-12-12
EP1414478A4 (de) 2007-03-21
CA2448863C (en) 2010-05-04
US6770797B2 (en) 2004-08-03
WO2002099036A3 (en) 2004-01-08
US20050090441A1 (en) 2005-04-28
US20030050262A1 (en) 2003-03-13
AU2002312033B2 (en) 2007-10-18
CA2448863A1 (en) 2002-12-12
DE60236939D1 (de) 2010-08-19
JP2005516886A (ja) 2005-06-09
EP1414478B1 (de) 2010-07-07
US7319094B2 (en) 2008-01-15

Similar Documents

Publication Publication Date Title
EP1319408A4 (de) Arzneimittel für herzversagen
MXPA04004714A (es) Derivados de aril 1,4-pirazina sustituidos.
EP1697308A4 (de) Phenylamid- und pyridylamid-beta-sekretase-inhibitoren zur behandlung von alzheimer-krankheit
AP2004003026A0 (en) Methods for treating ocular neovascular diseases.
WO2005004814A3 (en) Sirt1 and genetic disorders
EA200300027A1 (ru) Способ лечения сердечно-сосудистых заболеваний
MX2007016136A (es) Metodo para diagnosticar la enfermedad de alzheimer.
IT1319834B1 (it) Procedimento per la produzione di getti in lega leggera.
ATE473009T1 (de) Hemmung der neurodegeneration
WO2004006856A3 (en) Iron sequestration or elimination to reduce neurodegeneration or parkinsons disease progression
DE60133466D1 (de) Metallischer einsatzkörper, verfahren zur herstellung desselben und metallisches gussteil
DE60323034D1 (de) Form zur Herstellung von Modell und Modell zum Feingiessen
AU2001262726A1 (en) Transgenic non-human mammal and method of constructing the same, animal disease model and method of clarifying gene function
EP1743036A4 (de) Mit dem alter bei erstauftreten von alzheimer im zusammenhang stehende apoe-genmarker
TW200503717A (en) Substituted 1,4-pyrazine derivatives
WO2002082043A3 (en) Transgenic zebrafish models for neurodegenerative diseases
SI1292187T1 (sl) Transgenski zivalski model nevrodegenerativnih motenj
EP1678328A4 (de) Mit dem alter beim ausbruch von morbus alzheimer assoziierte genetische ntrk1-marker
WO2004064768A3 (en) Animal model for alzheimer's disease
DK1670309T3 (da) Transgenetiske dyr med større lidelser i forbindelse med Alzheimers sygdom
DE60133563D1 (de) Külen
WO2005072241A3 (en) Inhibition of bright function as a treatment for excessive immunoglobulin production
WO2006017386A3 (en) Signaling intermediates in an in vitro model of alzheimer’s disease
WO2003103593A3 (en) SECRETASES ASSOCIATED WITH ALZHEIMER'S DISEASE
IT1314446B1 (it) Mezzi per l'aggancio di elementi in microfusione nella produzione dimonili in metallo prezioso o simili.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties