ATE473009T1 - Hemmung der neurodegeneration - Google Patents

Hemmung der neurodegeneration

Info

Publication number
ATE473009T1
ATE473009T1 AT02739383T AT02739383T ATE473009T1 AT E473009 T1 ATE473009 T1 AT E473009T1 AT 02739383 T AT02739383 T AT 02739383T AT 02739383 T AT02739383 T AT 02739383T AT E473009 T1 ATE473009 T1 AT E473009T1
Authority
AT
Austria
Prior art keywords
disease
inhibiting neurodegeneration
alzheimer
inhibiting
neurodegeneration
Prior art date
Application number
AT02739383T
Other languages
English (en)
Inventor
Jack Wands
La Monte Suzanne De
Original Assignee
Rhode Island Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhode Island Hospital filed Critical Rhode Island Hospital
Application granted granted Critical
Publication of ATE473009T1 publication Critical patent/ATE473009T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AT02739383T 2001-06-01 2002-05-28 Hemmung der neurodegeneration ATE473009T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/872,968 US6770797B2 (en) 2001-06-01 2001-06-01 Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid
PCT/US2002/016429 WO2002099036A2 (en) 2001-06-01 2002-05-28 Inhibition of neurodegeneration

Publications (1)

Publication Number Publication Date
ATE473009T1 true ATE473009T1 (de) 2010-07-15

Family

ID=25360708

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02739383T ATE473009T1 (de) 2001-06-01 2002-05-28 Hemmung der neurodegeneration

Country Status (8)

Country Link
US (2) US6770797B2 (de)
EP (1) EP1414478B1 (de)
JP (1) JP2005516886A (de)
AT (1) ATE473009T1 (de)
AU (1) AU2002312033B2 (de)
CA (1) CA2448863C (de)
DE (1) DE60236939D1 (de)
WO (1) WO2002099036A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE378069T1 (de) * 2001-05-04 2007-11-15 Nymox Corp Verfahren zur vorbeugung von zelltod unter verwendung von antikörpern gegen neural thread proteine
JP2005535580A (ja) * 2002-04-26 2005-11-24 イアン， エイ． ファーガソン， 血液脳関門を通したポリペプチドの非侵襲的な送達およびエンドサイトーシスリガンドの生体内選択
AU2003233120B2 (en) * 2002-04-26 2008-08-21 Ferguson, Ian Andrew Non-invasive delivery of polypeptides through the blood-brain barrier, and in vivo selection of endocytotic ligands
US7544771B2 (en) * 2005-02-23 2009-06-09 Nymox Corporation Protein and its use in diagnosing Alzheimer's disease
CA2748119A1 (en) * 2008-12-23 2010-07-01 Salk Institute For Biological Studies Method of treating neurodegenerative disease
JP5819851B2 (ja) * 2010-01-08 2015-11-24 オンコヘルス コーポレーション Ｈｐｖ関連の癌の治療及びスクリーニングのための細胞に基づいた高処理能力ｈｐｖ免疫アッセイ

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948634A (en) 1988-12-21 1999-09-07 The General Hospital Coporation Neural thread protein gene expression and detection of alzheimer's disease
EP0586700A4 (de) * 1991-05-24 1994-10-19 Sumitomo Pharma Instrument zum applizieren eines arzneimittels ins innere des gehirns.
DK1564293T3 (da) 1993-04-20 2009-01-12 Gen Hospital Corp Nervetrådproteingenekspression og detektion af Alzheimers sygdom
US5744335A (en) * 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US5863898A (en) * 1996-10-29 1999-01-26 Incyte Pharmaceuticals, Inc. Human lim proteins
JP3758792B2 (ja) * 1997-02-25 2006-03-22 三菱重工業株式会社 ガスタービン動翼のプラットフォーム冷却機構
NZ337445A (en) 1997-02-26 2000-12-22 Gen Hospital Corp Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of alzheimer's disease
EP1006794B1 (de) 1997-03-12 2007-11-28 Robert W. Esmond Verfahren zur behandlung oder prävention der alzheimerischen krankheit

Also Published As

Publication number Publication date
DE60236939D1 (de) 2010-08-19
EP1414478A2 (de) 2004-05-06
US6770797B2 (en) 2004-08-03
EP1414478A4 (de) 2007-03-21
US20030050262A1 (en) 2003-03-13
US7319094B2 (en) 2008-01-15
WO2002099036A3 (en) 2004-01-08
US20050090441A1 (en) 2005-04-28
AU2002312033B2 (en) 2007-10-18
CA2448863C (en) 2010-05-04
WO2002099036A2 (en) 2002-12-12
CA2448863A1 (en) 2002-12-12
JP2005516886A (ja) 2005-06-09
EP1414478B1 (de) 2010-07-07

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