ATE473222T1 - Neues verfahren zur synthese von protonenpumpenhemmern - Google Patents
Neues verfahren zur synthese von protonenpumpenhemmernInfo
- Publication number
- ATE473222T1 ATE473222T1 AT06766252T AT06766252T ATE473222T1 AT E473222 T1 ATE473222 T1 AT E473222T1 AT 06766252 T AT06766252 T AT 06766252T AT 06766252 T AT06766252 T AT 06766252T AT E473222 T1 ATE473222 T1 AT E473222T1
- Authority
- AT
- Austria
- Prior art keywords
- synthesis
- new method
- proton pump
- pump inhibitors
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229940126409 proton pump inhibitor Drugs 0.000 title 1
- 239000000612 proton pump inhibitor Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 2
- 229960004157 rabeprazole Drugs 0.000 abstract 2
- YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 abstract 2
- ZGDLVKWIZHHWIR-UHFFFAOYSA-N 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]morpholine Chemical compound O1C(C)(C)C(C)(C)OB1C1=CC=C(N2CCOCC2)N=C1 ZGDLVKWIZHHWIR-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229960001778 rabeprazole sodium Drugs 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN190MU2005 | 2005-02-21 | ||
| PCT/IN2006/000077 WO2006117802A2 (en) | 2005-02-21 | 2006-02-21 | New process for synthesis of proton pump inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE473222T1 true ATE473222T1 (de) | 2010-07-15 |
Family
ID=37025098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06766252T ATE473222T1 (de) | 2005-02-21 | 2006-02-21 | Neues verfahren zur synthese von protonenpumpenhemmern |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7638633B2 (de) |
| EP (1) | EP1851212B1 (de) |
| KR (1) | KR101228823B1 (de) |
| AT (1) | ATE473222T1 (de) |
| AU (1) | AU2006242782B2 (de) |
| CA (1) | CA2606799C (de) |
| DE (1) | DE602006015287D1 (de) |
| NZ (1) | NZ561008A (de) |
| WO (1) | WO2006117802A2 (de) |
| ZA (1) | ZA200708388B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8247568B2 (en) | 2007-06-21 | 2012-08-21 | Matrix Laboratories Ltd | Process for the preparation of pure rabeprazole |
| WO2009066321A2 (en) * | 2007-10-03 | 2009-05-28 | Ipca Laboratories Limited | Process for optically active sulfoxide compounds |
| ES2326401B1 (es) * | 2007-12-28 | 2010-06-24 | Laboratorios Viñas | Procedimiento para fabricar 2-(((3-metil-4-(3-metoxipropoxi)-2-piridil)metil)sulfinil)-1h-benzimidazol. |
| WO2010146428A1 (en) * | 2009-06-15 | 2010-12-23 | Orchid Chemicals And Pharmaceuticals Ltd. | An improved process for the preparation of rabeprazole |
| ITMI20131859A1 (it) * | 2013-11-08 | 2015-05-09 | Dipharma Francis Srl | Procedimento per la preparazione di un composto benzimidazolico in forma amorfa |
| KR20160145264A (ko) | 2015-06-10 | 2016-12-20 | 정석훈 | 식물의 감정을 표시해주는 화분 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI90544C (fi) * | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
| ES2166269B1 (es) * | 1999-07-14 | 2003-04-01 | Sint Quimica Sa | Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol. |
| US7439367B2 (en) | 2003-01-15 | 2008-10-21 | Cipla Limited | Pharmaceutical process and compounds prepared thereby |
-
2006
- 2006-02-21 US US11/816,604 patent/US7638633B2/en not_active Expired - Fee Related
- 2006-02-21 CA CA2606799A patent/CA2606799C/en not_active Expired - Fee Related
- 2006-02-21 AT AT06766252T patent/ATE473222T1/de not_active IP Right Cessation
- 2006-02-21 NZ NZ561008A patent/NZ561008A/en not_active IP Right Cessation
- 2006-02-21 WO PCT/IN2006/000077 patent/WO2006117802A2/en not_active Ceased
- 2006-02-21 DE DE602006015287T patent/DE602006015287D1/de not_active Expired - Lifetime
- 2006-02-21 EP EP06766252A patent/EP1851212B1/de not_active Expired - Lifetime
- 2006-02-21 KR KR1020077021717A patent/KR101228823B1/ko not_active Expired - Fee Related
- 2006-02-21 AU AU2006242782A patent/AU2006242782B2/en not_active Ceased
-
2007
- 2007-01-01 ZA ZA200708388A patent/ZA200708388B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200708388B (en) | 2009-06-24 |
| CA2606799C (en) | 2015-04-28 |
| AU2006242782A1 (en) | 2006-11-09 |
| KR20080004471A (ko) | 2008-01-09 |
| AU2006242782B2 (en) | 2010-11-04 |
| EP1851212A2 (de) | 2007-11-07 |
| EP1851212B1 (de) | 2010-07-07 |
| DE602006015287D1 (de) | 2010-08-19 |
| NZ561008A (en) | 2009-09-25 |
| CA2606799A1 (en) | 2006-11-09 |
| US20080161579A1 (en) | 2008-07-03 |
| US7638633B2 (en) | 2009-12-29 |
| KR101228823B1 (ko) | 2013-02-15 |
| WO2006117802A3 (en) | 2006-12-21 |
| WO2006117802A2 (en) | 2006-11-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |