ATE473441T1 - Zellarrays und ihren verwendungen - Google Patents

Zellarrays und ihren verwendungen

Info

Publication number
ATE473441T1
ATE473441T1 AT00984413T AT00984413T ATE473441T1 AT E473441 T1 ATE473441 T1 AT E473441T1 AT 00984413 T AT00984413 T AT 00984413T AT 00984413 T AT00984413 T AT 00984413T AT E473441 T1 ATE473441 T1 AT E473441T1
Authority
AT
Austria
Prior art keywords
arrays
cell
conducting
based analyses
subject
Prior art date
Application number
AT00984413T
Other languages
English (en)
Inventor
Ronghao Li
Jennie Mather
Original Assignee
Raven Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Raven Biotechnologies Inc filed Critical Raven Biotechnologies Inc
Application granted granted Critical
Publication of ATE473441T1 publication Critical patent/ATE473441T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/0052—Essentially linear supports in the shape of elongated tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00673—Slice arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Luminescent Compositions (AREA)
AT00984413T 1999-12-17 2000-12-15 Zellarrays und ihren verwendungen ATE473441T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/466,011 US6406840B1 (en) 1999-12-17 1999-12-17 Cell arrays and the uses thereof
PCT/US2000/034010 WO2001043869A2 (en) 1999-12-17 2000-12-15 Cell arrays and the uses thereof

Publications (1)

Publication Number Publication Date
ATE473441T1 true ATE473441T1 (de) 2010-07-15

Family

ID=23850082

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00984413T ATE473441T1 (de) 1999-12-17 2000-12-15 Zellarrays und ihren verwendungen

Country Status (10)

Country Link
US (1) US6406840B1 (de)
EP (1) EP1239950B1 (de)
JP (1) JP4862146B2 (de)
AT (1) ATE473441T1 (de)
AU (1) AU783725B2 (de)
CA (1) CA2394821C (de)
DE (1) DE60044648D1 (de)
DK (1) DK1239950T3 (de)
HK (1) HK1045958B (de)
WO (1) WO2001043869A2 (de)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040434A1 (en) 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6780582B1 (en) 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6897073B2 (en) * 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US20040018485A1 (en) * 1999-04-15 2004-01-29 Ilya Ravkin Multiplexed analysis of cells
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US20010055764A1 (en) * 1999-05-07 2001-12-27 Empedocles Stephen A. Microarray methods utilizing semiconductor nanocrystals
US20020197656A1 (en) * 1999-12-17 2002-12-26 Ronghao Li Cell arrays and the uses thereof
DE10020704B4 (de) * 2000-04-27 2006-09-28 Bioref Gmbh Biochip zur Archivierung und labormedizinischen Analyse von biologischem Probenmaterial, Verfahren zu dessen Herstellung sowie dessen Verwendung in diagnostischen Verfahren
CA2414062A1 (en) * 2000-06-22 2001-12-27 Clinomics Laboratories, Inc. Frozen tissue microarrays and methods for using the same
US20020137053A1 (en) * 2000-07-19 2002-09-26 Dana Ault-Riche Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening
JP2004537712A (ja) * 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
EP1344057A2 (de) * 2000-11-10 2003-09-17 Children's Medical Center Corporation Organ system microarrays
WO2003050509A1 (en) * 2000-11-30 2003-06-19 Instrumedics Inc. A method for creating a frozen tissue array
US6534307B1 (en) * 2001-02-08 2003-03-18 Clinomics Biosciences, Inc. Frozen tissue microarrayer
US20020192717A1 (en) * 2001-03-23 2002-12-19 Kantor Aaron B. Cell-based assays for the simultaneous and discrete analysis of multiple analytes
US20020197729A1 (en) * 2001-06-21 2002-12-26 Fuji Photo Film Co., Ltd. Biochemical analysis unit and method for manufacturing the same
US20030143612A1 (en) * 2001-07-18 2003-07-31 Pointilliste, Inc. Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening
WO2003076892A2 (en) * 2001-08-06 2003-09-18 Vanderbilt University Device and methods for measuring the response of at least one cell to a medium
AU2003209272A1 (en) * 2002-01-16 2003-09-02 Zyomyx, Inc. Engineered binding proteins
WO2003062402A2 (en) * 2002-01-24 2003-07-31 Pointilliste, Inc. Use of collections of binding sites for sample profiling and other applications
WO2003076897A2 (en) * 2002-03-05 2003-09-18 Vitra Bioscience, Inc. Multiplexed analysis of cellular responses using endogenous reporter genes
DE10209609A1 (de) * 2002-03-05 2003-10-02 Europ Lab Molekularbiolog Verfahren und Vorrichtung zur Parallelanalyse von Bio-Molekülen
CA2479730A1 (en) 2002-03-21 2003-10-02 Sagres Discovery, Inc. Novel compositions and methods in cancer
US7272252B2 (en) * 2002-06-12 2007-09-18 Clarient, Inc. Automated system for combining bright field and fluorescent microscopy
US20050037406A1 (en) * 2002-06-12 2005-02-17 De La Torre-Bueno Jose Methods and apparatus for analysis of a biological specimen
AU2003243749B2 (en) 2002-06-19 2010-03-11 Macrogenics West, Inc. Novel RAAG10 cell surface target and a family of antibodies recognizing that target
AU2003249227A1 (en) * 2002-07-12 2004-02-02 University Of Washington Methods and systems for extended in vitro culture of neuronal cells
DE60332948D1 (de) * 2002-07-19 2010-07-22 Althea Technologies Inc Strategien zur genexpressionsanalyse
WO2004042019A2 (en) * 2002-10-30 2004-05-21 Pointilliste, Inc. Systems for capture and analysis of biological particles and methods using the systems
CA2505633A1 (en) * 2002-11-13 2004-05-27 Raven Biotechnologies, Inc. Antigen pipa and antibodies that bind thereto
US20040241748A1 (en) * 2003-02-10 2004-12-02 Dana Ault-Riche Self-assembling arrays and uses thereof
US20070149449A1 (en) 2003-02-14 2007-06-28 Morris David W Therapeutic targets in cancer
GB0304515D0 (en) * 2003-02-27 2003-04-02 Dakocytomation Denmark As Standard
WO2004099384A2 (en) * 2003-05-02 2004-11-18 Sigma-Aldrich Co. Solid phase cell lysis and capture platform
AU2004286201B2 (en) * 2003-09-10 2010-09-09 Altheadx, Inc. Expression profiling using microarrays
US20050060100A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company Computer software and algorithms for systems biologically linked to cellular phenotype
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
EP1676133A4 (de) * 2003-09-15 2008-05-21 Millipore Corp Tests mit primärzellen
US20050059083A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company High throughput method to identify ligands for cell attachment
WO2005028498A2 (en) 2003-09-18 2005-03-31 Raven Biotechnologies, Inc. Kid3 and kid3 antibodies that bind thereto
US20050095648A1 (en) * 2003-10-30 2005-05-05 Mario Geysen Method for designing linear epitopes and algorithm therefor and polypeptide epitopes
AU2004289316B2 (en) 2003-11-10 2011-03-31 Altor Bioscience Corporation Soluble TCR molecules and methods of use
US20060018911A1 (en) * 2004-01-12 2006-01-26 Dana Ault-Riche Design of therapeutics and therapeutics
JP2007523647A (ja) * 2004-02-05 2007-08-23 マサチューセッツ インスティテュート オブ テクノロジー 細胞ディスプレイライブラリー
US7572895B2 (en) 2004-06-07 2009-08-11 Raven Biotechnologies, Inc. Transferrin receptor antibodies
CA2579790A1 (en) * 2004-07-30 2006-02-09 Mount Sinai School Of Medicine Of New York University Npc1l1 and npc1l1 inhibitors and methods of use thereof
WO2006026248A1 (en) * 2004-08-25 2006-03-09 Sigma-Aldrich Co. Compositions and methods employing zwitterionic detergent combinations
US20060051348A1 (en) 2004-09-09 2006-03-09 Jorn Gorlach Method of producing a plurality of isolated antibodies to a plurality of cognate antigens
US20060121597A1 (en) * 2004-11-24 2006-06-08 Rongshan Li Cytoblock preparation system and methods of use
JP2008526256A (ja) 2005-01-12 2008-07-24 レイベン バイオテクノロジーズ，インコーポレイティド Ｋｉｄ３１およびｋｉｄ３１に結合する抗体
US7847070B2 (en) 2005-01-31 2010-12-07 Raven Biotechnologies, Inc. LUCA2 and antibodies that bind thereto
MX2007009222A (es) 2005-02-02 2008-01-16 Raven Biotechnologies Inc Moduladores de adam-9.
US7572896B2 (en) 2005-02-03 2009-08-11 Raven Biotechnologies, Inc. Antibodies to oncostatin M receptor
KR101363252B1 (ko) 2005-02-04 2014-02-13 레이븐 바이오테크놀로지스, 인코퍼레이티드 Ｅｐｈａ2에 결합하는 항체 및 그것의 사용방법
US7405056B2 (en) * 2005-03-02 2008-07-29 Edward Lam Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation
US7618809B2 (en) 2005-03-23 2009-11-17 Gebing Ronald A Microarrayer with coaxial multiple punches
EP1865981A2 (de) 2005-04-07 2007-12-19 Chiron Corporation Cacna1e in der diagnose und nachweis von sowie als therapeutisches mittel gegen krebs
AU2006235258A1 (en) 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. Cancer-related genes
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
CN101460604B (zh) * 2006-03-20 2012-12-19 李荣山 细胞块的制备装置
SI2059535T1 (sl) 2006-08-18 2014-03-31 Novartis Ag Za prlr specifiäśno protitelo in njegove uporabe
EP2094307A4 (de) 2006-11-08 2015-08-26 Macrogenics West Inc Tes7 und daran bindende antikörper
GB0706820D0 (en) * 2007-04-10 2007-05-16 Common Services Agency Blood grouop antibody screening
EP2076124A4 (de) 2007-04-20 2011-08-03 Acucela Inc Styrenylderivatverbindungen für die behandlung von ophthalmologischen krankheiten und leiden
JP2008301758A (ja) * 2007-06-07 2008-12-18 Univ Nihon 細胞培養装置
US8299307B2 (en) 2007-06-29 2012-10-30 Acucela Inc. Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders
JP5002750B2 (ja) * 2007-08-22 2012-08-15 株式会社日清製粉グループ本社 薄切する試料を収容・保持するためのセル
MX337100B (es) 2007-10-05 2016-02-11 Acucela Inc Compuestos alcoxi para el tratamiento de enfermedades.
EP2255188B1 (de) * 2008-02-29 2016-08-24 Imec Biosensor zum nachweis von neurotransmittern
LT2542256T (lt) 2010-03-04 2019-10-25 Macrogenics Inc Su b7-h3 reaguojantys antikūnai, jų imunologiškai aktyvūs fragmentai ir jų naudojimas
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
WO2012013204A1 (en) * 2010-07-28 2012-02-02 Canvax Biotech Sl Novel ultrasensitive cell based sensors and uses thereof
JP2012032238A (ja) * 2010-07-29 2012-02-16 Sakura Seiki Kk 組織アレイの作製方法
US20130183710A1 (en) 2010-08-17 2013-07-18 Siemens Healthcare Diagnostics Inc. Reference sample for quality control in molecular diagnosis
JP5629939B2 (ja) * 2010-09-09 2014-11-26 株式会社パソロジー研究所 パイルアップ組織アレイ
JP5660468B2 (ja) * 2011-03-15 2015-01-28 三菱レイヨン株式会社 生体関連物質検出用ゲルマイクロアレイの製造方法
EP2804605A4 (de) 2012-01-20 2015-07-08 Acucela Inc Substituierte heterocyclische verbindungen zur behandlung von krankheiten
JP2013185920A (ja) * 2012-03-07 2013-09-19 Pathology Institute 組織アレイシートの製造方法およびその製造装置
CN102943027B (zh) * 2012-11-22 2014-11-26 清华大学 一种正压型高通量单细胞图形化装置
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
WO2014164905A1 (en) 2013-03-12 2014-10-09 Acucela Inc. Substituted 3-phenylpropylamine derivatives for the treatment of ophthalmic diseases and disorders
US20150048085A1 (en) 2013-08-16 2015-02-19 Corning Incorporated Vessels and methods for cryopreservation
EP4159036A1 (de) 2015-11-16 2023-04-05 Corning Incorporated Kryogene phiolenanordnungen
US10638748B2 (en) 2015-12-22 2020-05-05 Corning Incorporated Break away/tear away cryopreservation vial and methods for manufacturing and using same
PE20190353A1 (es) 2016-04-15 2019-03-07 Macrogenics Inc Moleculas de union b7-h3 novedosas, conjugados anticuerpo-farmaco de los mismos y metodos de uso de los mismos
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
EP3617689B1 (de) * 2017-04-28 2023-03-01 Nihon University Verfahren zur auswahl von gewebeschnitten
CN115629059A (zh) * 2022-10-17 2023-01-20 重庆精准生物技术有限公司 细胞的应用、试剂盒、提高化学发光检测灵敏度的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
US5079600A (en) 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5478722A (en) * 1991-02-17 1995-12-26 The Curators Of The University Of Missouri Preserved cell preparations for flow cytometry and immunology
SE9404166D0 (sv) * 1994-11-30 1994-11-30 Pharmacia Biotech Ab Multifunctional surfaces
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
DE69738996D1 (de) 1996-05-30 2008-10-30 Cellomics Inc Miniaturisierte zellenanordnung und verfahren und vorrichtung zum screening mittels zellen
DE69824174T2 (de) 1997-02-27 2005-07-14 Cellomics, Inc. Ein system zur zellbasierten reihenuntersuchung
EP1207383B1 (de) 1997-09-11 2006-03-08 BioVentures, Inc., Verfahren zur Herstellung von Arrays hoher Dichte
CA2306970A1 (en) 1997-10-16 1999-04-22 Larry S. Millstein Method for producing arrays and devices relating thereto
DE69934222T2 (de) 1998-02-25 2007-10-25 The United States Government As Represented By The Department Human Services Zellulare anordnungen für schnelle molekulare profilidentifizierung
EP1068528B1 (de) 1998-02-25 2006-08-02 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Verfahren und vorrichtung zur erstellung eines arrays für schnelle molekulare profilidentifizierungen
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
EP0955084B1 (de) 1998-04-27 2006-07-26 Corning Incorporated Verfahren zur Ablage von biologischen Proben mit hilfe eines nachgezogenen Kapillar-speichers
AU4194899A (en) * 1998-05-21 1999-12-06 Hyseq, Inc. Linear arrays of immobilized compounds and methods of using same
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture

Also Published As

Publication number Publication date
CA2394821C (en) 2007-07-10
DK1239950T3 (da) 2010-11-01
HK1045958B (en) 2010-10-08
DE60044648D1 (de) 2010-08-19
EP1239950A2 (de) 2002-09-18
JP2003516747A (ja) 2003-05-20
JP4862146B2 (ja) 2012-01-25
EP1239950B1 (de) 2010-07-07
WO2001043869A3 (en) 2001-11-29
US6406840B1 (en) 2002-06-18
AU2103501A (en) 2001-06-25
WO2001043869A2 (en) 2001-06-21
HK1045958A1 (en) 2002-12-20
CA2394821A1 (en) 2001-06-21
AU783725B2 (en) 2005-12-01

Similar Documents

Publication Publication Date Title
ATE473441T1 (de) Zellarrays und ihren verwendungen
Evrony et al. Applications of single-cell DNA sequencing
Swanson et al. Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq
Sutandy et al. Overview of protein microarrays
de Rond et al. High throughput screening of enzyme activity with mass spectrometry imaging
Khandurina et al. Microchip-based high-throughput screening analysis of combinatorial libraries
CA2348132A1 (en) A system for cell-based screening
Ye et al. Studying hematopoiesis using single-cell technologies
DE60023905D1 (de) Optisches system analyse für zellen
DE60002562D1 (de) Ein system für zellbasierte reihenuntersuchungen
WO2000017643A8 (en) A system for cell-based screening
WO2001005935A3 (en) Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays
CA2310684A1 (en) Continuous format high throughput screening
CA2282658A1 (en) A system for cell-based screening
WO2001011341A3 (en) A system for cell-based screening
WO2001035072A3 (en) A system for cell-based screening
HUP0003261A2 (hu) Több funkció- vagy mátrixelemen belül, továbbá ezek alkalmazásai
Sharma et al. Using single cell analysis for translational studies in immune mediated diseases: opportunities and challenges
Kaur et al. Single-cell genomics: Technology and applications
THIEL‐EGENTER et al. Concordant genetic breaks, identified by combining clustering and tessellation methods, in two co‐distributed alpine plant species
Krumbach et al. Metabolic analysis of a bacterial synthetic community from maize roots provides new mechanistic insights into microbiome stability
Tian et al. Beyond single cells: microfluidics empowering multiomics analysis
Enya et al. A comparative study of methods for detecting extraterrestrial life in exploration missions to mars and the solar system II: Targeted characteristics, detection techniques, and their combination for survey, detection, and analysis
WO2007047149A3 (en) Susceptibility-matched multi-well sample holders for high-throughput screening by magnetic analysis
Karlsson et al. Single-cell protein interactomes by the proximity network assay

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties