ATE473736T1 - Verwendung von treprostinil zur behandlung von ischämischen läsionen - Google Patents
Verwendung von treprostinil zur behandlung von ischämischen läsionenInfo
- Publication number
- ATE473736T1 ATE473736T1 AT04814462T AT04814462T ATE473736T1 AT E473736 T1 ATE473736 T1 AT E473736T1 AT 04814462 T AT04814462 T AT 04814462T AT 04814462 T AT04814462 T AT 04814462T AT E473736 T1 ATE473736 T1 AT E473736T1
- Authority
- AT
- Austria
- Prior art keywords
- treprostinil
- treatment
- ischemic lesions
- lesions
- raynaud
- Prior art date
Links
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 title abstract 3
- 229960005032 treprostinil Drugs 0.000 title abstract 3
- 230000003902 lesion Effects 0.000 title abstract 2
- 230000000302 ischemic effect Effects 0.000 title 1
- 208000012322 Raynaud phenomenon Diseases 0.000 abstract 2
- 230000007654 ischemic lesion Effects 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000003782 Raynaud disease Diseases 0.000 abstract 1
- 206010039710 Scleroderma Diseases 0.000 abstract 1
- 206010040943 Skin Ulcer Diseases 0.000 abstract 1
- 201000009594 Systemic Scleroderma Diseases 0.000 abstract 1
- 206010042953 Systemic sclerosis Diseases 0.000 abstract 1
- 206010043540 Thromboangiitis obliterans Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52962203P | 2003-12-16 | 2003-12-16 | |
| PCT/US2004/042283 WO2005058303A1 (en) | 2003-12-16 | 2004-12-16 | Use of treprostinil to treat and prevent ischemic lesions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE473736T1 true ATE473736T1 (de) | 2010-07-15 |
Family
ID=34700011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04814462T ATE473736T1 (de) | 2003-12-16 | 2004-12-16 | Verwendung von treprostinil zur behandlung von ischämischen läsionen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8765813B2 (de) |
| EP (1) | EP1696900B1 (de) |
| JP (2) | JP5190200B2 (de) |
| KR (1) | KR101161889B1 (de) |
| CN (2) | CN101647792B (de) |
| AT (1) | ATE473736T1 (de) |
| CA (1) | CA2549724C (de) |
| DE (1) | DE602004028155D1 (de) |
| ES (1) | ES2347254T3 (de) |
| WO (1) | WO2005058303A1 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2670872T3 (es) | 2003-05-22 | 2018-06-01 | United Therapeutics Corporation | Polimorfo de una sal de dietanolamina de treprostinil |
| JP4906514B2 (ja) * | 2003-12-16 | 2012-03-28 | ユナイテッド セラピューティクス コーポレイション | 腎臓機能改善のためのトレプロスチニルの用途 |
| US8765813B2 (en) * | 2003-12-16 | 2014-07-01 | United Therapeutics Corporation | Use of treprostinil to treat and prevent ischemic lesions |
| CA2562614C (en) * | 2004-04-12 | 2013-09-17 | United Therapeutics, Inc. | Use of treprostinil to treat neuropathic diabetic foot ulcers |
| US8747897B2 (en) | 2006-04-27 | 2014-06-10 | Supernus Pharmaceuticals, Inc. | Osmotic drug delivery system |
| JP5797376B2 (ja) | 2006-05-15 | 2015-10-21 | ユナイテッド セラピューティクス コーポレーション | 定量吸入器を用いたトレプロスチニル投与 |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| WO2009078965A1 (en) | 2007-12-17 | 2009-06-25 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin |
| KR20110010753A (ko) * | 2008-05-08 | 2011-02-07 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐 일수화물 |
| EP2427054A4 (de) * | 2009-05-07 | 2014-01-15 | United Therapeutics Corp | Feste formulierungen aus prostacyclin-analogen |
| JP5681276B2 (ja) | 2010-03-15 | 2015-03-04 | ユナイテッド セラピューティクス コーポレイション | 肺高血圧症のための治療 |
| US8481782B2 (en) | 2010-06-03 | 2013-07-09 | United Therapeutics Corporation | Treprostinil production |
| WO2011159693A2 (en) * | 2010-06-15 | 2011-12-22 | United Therapeutics Corporation | Oral treatment of digital ischemic lesions |
| KR101454571B1 (ko) | 2011-03-02 | 2014-10-23 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐 생산을 위한 중간체 합성 |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| IN2015DN00934A (de) | 2012-08-01 | 2015-06-12 | United Therapeutics Corp | |
| ES2869701T3 (es) | 2012-08-01 | 2021-10-25 | United Therapeutics Corp | Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina |
| AU2014205557B2 (en) | 2013-01-09 | 2017-08-10 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| ES2927844T3 (es) | 2013-01-11 | 2022-11-11 | Corsair Pharma Inc | Profármacos de treprostinil |
| CA3125504C (en) | 2013-03-14 | 2023-10-24 | United Therapeutics Corporation | Solid forms of treprostinil |
| KR20150128903A (ko) | 2013-03-15 | 2015-11-18 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐의 염 |
| WO2014160638A1 (en) | 2013-03-25 | 2014-10-02 | United Therapeutics Corporation | Process of making prostacyclin compounds with linker thiol and pegylated forms |
| FR3008320B1 (fr) * | 2013-07-15 | 2018-04-20 | Centre Hospitalier Univ Grenoble | Dispositif de prevention ou de traitement d'une ulceration cutanee |
| AU2014306759B2 (en) | 2013-08-12 | 2018-04-26 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| SI3060041T1 (sl) | 2013-10-25 | 2021-04-30 | Insmed Incorporated | Spojine prostaciklina |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| ES2908142T3 (es) | 2014-06-13 | 2022-04-27 | United Therapeutics Corp | Formulaciones de treprostinil |
| EP3169315B1 (de) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Missbrauchssichere flüssigkeitsfülldosierform mit unmittelbarer freisetzung |
| US9593061B2 (en) | 2014-10-20 | 2017-03-14 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
| US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
| EP3904326A1 (de) | 2014-11-18 | 2021-11-03 | Insmed Incorporated | Verfahren zur herstellung von treprostinil und treprostinilderivat-prodrugs |
| EP3226838A1 (de) | 2014-12-03 | 2017-10-11 | Steadymed Ltd. | Konservierungsmittelfreie treprostinilformulierungen sowie verfahren und vorrichtungen zur verwendung damit |
| US9394227B1 (en) * | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| JO3749B1 (ar) * | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| US10898494B2 (en) | 2016-05-05 | 2021-01-26 | Liquidia Technologies, Inc. | Dry powder treprostinil for the treatment of pulmonary hypertension |
| CA3038276A1 (en) | 2016-09-26 | 2018-03-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| US11571444B2 (en) | 2016-10-24 | 2023-02-07 | United Therapeutics Corporation | Enhancement of MSC immunomodulatory properties by treprostinil |
| EP3548010A1 (de) * | 2016-12-05 | 2019-10-09 | Corsair Pharma, Inc. | Dermale und transdermale verabreichung von treprostinil und salzen davon |
| US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
| EP3853200B1 (de) | 2018-09-18 | 2024-01-24 | Eli Lilly and Company | Erbumine salz von treprostinil |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| WO2021041320A1 (en) | 2019-08-23 | 2021-03-04 | United Therapeutics Corporation | Treprostinil prodrugs |
| IL296567A (en) | 2020-04-17 | 2022-11-01 | United Therapeutics Corp | Terfostinil for use in the treatment of interstitial lung disease |
| US11793780B2 (en) | 2020-06-09 | 2023-10-24 | United Therapeutics Corporation | Prodrugs of treprosiinil |
| KR20250133451A (ko) | 2020-12-14 | 2025-09-05 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드러그로 질환을 치료하는 방법 |
| AU2022229367A1 (en) | 2021-03-03 | 2023-09-14 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
| US20230263807A1 (en) | 2022-02-08 | 2023-08-24 | United Therapeutics Corporation | Treprostinil iloprost combination therapy |
| KR20250002687A (ko) | 2022-04-29 | 2025-01-07 | 자오커 파마슈티컬 (광저우) 컴퍼니., 리미티드 | 트레프로스티닐 소프트 미스트 흡입제 |
| EP4651879A1 (de) | 2023-01-18 | 2025-11-26 | United Therapeutics Corporation | Behandlung von pulmonaler arterieller hypertonie |
| AU2024208919A1 (en) | 2023-01-19 | 2025-07-17 | United Therapeutics Corporation | Treprostinil analogs |
| WO2025034784A1 (en) | 2023-08-08 | 2025-02-13 | United Therapeutics Corporation | A method of producing an oral osmotic pharmaceutical delivery system and a pharmaceutical batch produced using the same |
| US20250197338A1 (en) | 2023-11-09 | 2025-06-19 | United Therapeutics Corporation | Syntheses of compounds useful for producing treprostinil |
| US20260041656A1 (en) | 2024-08-06 | 2026-02-12 | United Therapeutics Corporation | Treating pulmonary hypertension based on novel biomarker |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4254145A (en) * | 1978-08-16 | 1981-03-03 | American Cyanamid Company | Topical application of prostaglandin hypotensive agents |
| DE2845770A1 (de) * | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
| US4281113A (en) * | 1979-07-31 | 1981-07-28 | The Upjohn Company | 2,5-Inter-o-phenylene-3,4-dinor-6,9α-epoxy-6.beta.-5-iodo-PGF1 compounds |
| US4338457A (en) * | 1980-02-28 | 1982-07-06 | The Upjohn Company | Composition and process |
| CA1201712A (en) | 1980-02-28 | 1986-03-11 | Paul A. Aristoff | Carbacyclin analogs |
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| US4306076A (en) * | 1980-04-23 | 1981-12-15 | The Upjohn Company | Inter-phenylene CBA compounds |
| DE3048906A1 (de) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4349689A (en) * | 1980-12-22 | 1982-09-14 | The Upjohn Company | Methano carbacyclin analogs |
| US4486598A (en) * | 1982-02-22 | 1984-12-04 | The Upjohn Company | Carbacyclin analogs |
| ZA851337B (en) | 1984-03-08 | 1985-10-30 | Upjohn Co | Interphenylene carbacyclin derivatives |
| CA1241324A (en) | 1984-03-08 | 1988-08-30 | Paul A. Aristoff | Interphenylene carbacyclin derivatives |
| US4683330A (en) * | 1984-03-08 | 1987-07-28 | The Upjohn Company | Interphenylene carbacyclin derivatives |
| US4668814A (en) * | 1984-03-08 | 1987-05-26 | The Upjohn Company | Interphenylene carbacyclin derivatives |
| EP0223831B1 (de) * | 1985-05-22 | 1992-07-15 | Liposome Technology, Inc. | Verfahren und system zum einatmen von liposomen |
| GB8814438D0 (en) * | 1988-06-17 | 1988-07-20 | Wellcome Found | Compounds for use in medicine |
| JPH0240325A (ja) | 1988-06-17 | 1990-02-09 | Wellcome Found Ltd:The | 医薬用化合物 |
| GB9011588D0 (en) | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
| US5190972A (en) * | 1992-01-27 | 1993-03-02 | The University Of Melbourne | Method of combatting cyclosporine organ toxicity with prostaglandin analogs |
| AU735975B2 (en) | 1995-02-27 | 2001-07-19 | Toray Industries, Inc. | Remedy for pulmonary heart |
| US6441245B1 (en) * | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| KR100638684B1 (ko) * | 1997-11-14 | 2006-10-27 | 유나이티드 세러퓨틱스 코오포레이션 | 말초 혈관 질환의 치료를 위한 9-데옥시-2',9-알파-메타노-3-옥사-4,5,6-트리노르-3,7-(1',3'-인터페닐렌)-13,14-디하이드로-프로스타글란딘 에프1의 용도 |
| US6521212B1 (en) * | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| EP1164846A1 (de) | 1999-03-31 | 2002-01-02 | United Therapeutics Corporation | Prostaglandinverbindungen, zusammensetzungen und verfahren zur behandlung von peripheren gefässkrankheiten und pulmonaler hypertonie |
| CA2375617A1 (en) * | 1999-06-07 | 2000-12-14 | Edwards Lifesciences Corporation | Targeted angiogenesis |
| AU2002339730A1 (en) | 2002-08-28 | 2004-03-19 | Universita "Campus Bio-Medico" Di Roma | Use of prostacyclin and analogs thereof for improving venous flow |
| US7550133B2 (en) * | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| ES2670872T3 (es) * | 2003-05-22 | 2018-06-01 | United Therapeutics Corporation | Polimorfo de una sal de dietanolamina de treprostinil |
| US20040265238A1 (en) * | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
| US8765813B2 (en) * | 2003-12-16 | 2014-07-01 | United Therapeutics Corporation | Use of treprostinil to treat and prevent ischemic lesions |
| CA2562614C (en) * | 2004-04-12 | 2013-09-17 | United Therapeutics, Inc. | Use of treprostinil to treat neuropathic diabetic foot ulcers |
-
2004
- 2004-12-16 US US11/012,723 patent/US8765813B2/en active Active
- 2004-12-16 DE DE602004028155T patent/DE602004028155D1/de not_active Expired - Lifetime
- 2004-12-16 JP JP2006545436A patent/JP5190200B2/ja not_active Expired - Fee Related
- 2004-12-16 WO PCT/US2004/042283 patent/WO2005058303A1/en not_active Ceased
- 2004-12-16 CN CN2009101645686A patent/CN101647792B/zh not_active Expired - Fee Related
- 2004-12-16 EP EP04814462A patent/EP1696900B1/de not_active Expired - Lifetime
- 2004-12-16 AT AT04814462T patent/ATE473736T1/de not_active IP Right Cessation
- 2004-12-16 CN CN2004800417809A patent/CN1917866B/zh not_active Expired - Fee Related
- 2004-12-16 ES ES04814462T patent/ES2347254T3/es not_active Expired - Lifetime
- 2004-12-16 KR KR1020067013988A patent/KR101161889B1/ko not_active Expired - Fee Related
- 2004-12-16 CA CA2549724A patent/CA2549724C/en not_active Expired - Fee Related
-
2012
- 2012-09-28 JP JP2012217695A patent/JP2013047235A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005058303A1 (en) | 2005-06-30 |
| EP1696900B1 (de) | 2010-07-14 |
| EP1696900A1 (de) | 2006-09-06 |
| CA2549724C (en) | 2014-02-11 |
| ES2347254T3 (es) | 2010-10-27 |
| CN1917866A (zh) | 2007-02-21 |
| JP2013047235A (ja) | 2013-03-07 |
| US8765813B2 (en) | 2014-07-01 |
| KR20060123483A (ko) | 2006-12-01 |
| CN101647792B (zh) | 2012-11-28 |
| JP5190200B2 (ja) | 2013-04-24 |
| CN101647792A (zh) | 2010-02-17 |
| DE602004028155D1 (de) | 2010-08-26 |
| JP2007514750A (ja) | 2007-06-07 |
| CA2549724A1 (en) | 2005-06-30 |
| KR101161889B1 (ko) | 2012-07-02 |
| US20050165111A1 (en) | 2005-07-28 |
| CN1917866B (zh) | 2010-12-15 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |