ATE473736T1 - Verwendung von treprostinil zur behandlung von ischämischen läsionen - Google Patents

Verwendung von treprostinil zur behandlung von ischämischen läsionen

Info

Publication number: ATE473736T1
Authority: AT; Austria
Prior art keywords: treprostinil; treatment; ischemic lesions; lesions; raynaud
Prior art date: 2003-12-16

Application number

AT04814462T

Other languages

English (en)

Inventor

Michael Wade

Roger A Jeffs

Robert Roscigno

Deborah Strootman

Kathryn Bronstein

Original Assignee

United Therapeutics Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-16

Filing date

2004-12-16

Publication date

2010-07-15

2004-12-16 Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp

2010-07-15 Application granted granted Critical

2010-07-15 Publication of ATE473736T1 publication Critical patent/ATE473736T1/de

Links

PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 title abstract 3
229960005032 treprostinil Drugs 0.000 title abstract 3
230000003902 lesion Effects 0.000 title abstract 2
230000000302 ischemic effect Effects 0.000 title 1
208000012322 Raynaud phenomenon Diseases 0.000 abstract 2
230000007654 ischemic lesion Effects 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
208000003782 Raynaud disease Diseases 0.000 abstract 1
206010039710 Scleroderma Diseases 0.000 abstract 1
206010040943 Skin Ulcer Diseases 0.000 abstract 1
201000009594 Systemic Scleroderma Diseases 0.000 abstract 1
206010042953 Systemic sclerosis Diseases 0.000 abstract 1
206010043540 Thromboangiitis obliterans Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Hematology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

AT04814462T 2003-12-16 2004-12-16 Verwendung von treprostinil zur behandlung von ischämischen läsionen ATE473736T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US52962203P	2003-12-16	2003-12-16
PCT/US2004/042283 WO2005058303A1 (en)	2003-12-16	2004-12-16	Use of treprostinil to treat and prevent ischemic lesions

Publications (1)

Publication Number	Publication Date
ATE473736T1 true ATE473736T1 (de)	2010-07-15

Family

ID=34700011

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04814462T ATE473736T1 (de)	2003-12-16	2004-12-16	Verwendung von treprostinil zur behandlung von ischämischen läsionen

Country Status (10)

Country	Link
US (1)	US8765813B2 (de)
EP (1)	EP1696900B1 (de)
JP (2)	JP5190200B2 (de)
KR (1)	KR101161889B1 (de)
CN (2)	CN101647792B (de)
AT (1)	ATE473736T1 (de)
CA (1)	CA2549724C (de)
DE (1)	DE602004028155D1 (de)
ES (1)	ES2347254T3 (de)
WO (1)	WO2005058303A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102697790A (zh)	2003-05-22	2012-10-03	联合治疗公司	化合物和释放前列环素类似物的方法
ES2331187T3 (es) *	2003-12-16	2009-12-23	United Therapeutics Corporation	Utilizacion de treprostinil para mejorar las funciones renales.
CN101647792B (zh) *	2003-12-16	2012-11-28	联合治疗公司	曲前列环素在制备治疗和预防缺血性损害的药物中的用途
WO2005099680A2 (en) *	2004-04-12	2005-10-27	United Therapeutics, Inc.	Use of treprostinil to treat neuropathic diabetic foot ulcers
US8747897B2 (en)	2006-04-27	2014-06-10	Supernus Pharmaceuticals, Inc.	Osmotic drug delivery system
KR101390579B1 (ko)	2006-05-15	2014-05-19	유나이티드 세러퓨틱스 코오포레이션	정량 흡입기를 사용한 트레프로스티닐 투여
DE102006026786A1 (de)	2006-06-07	2007-12-13	Joachim Kern	Dosierinhalator
EP2252570B1 (de)	2007-12-17	2017-04-05	United Therapeutics Corporation	Verbessertes verfahren zur herstellung von treprostinil, dem wirkstoff in remodulin
ES2575565T3 (es)	2008-05-08	2016-06-29	United Therapeutics Corporation	Procedimiento para la preparación de monohidrato de treprostinilo y su utilización para el almacenamiento y el envío
CN102421288B (zh) *	2009-05-07	2015-04-22	联合治疗公司	前列环素类似物的固体剂型
CN102883722B (zh)	2010-03-15	2014-11-05	联合治疗公司	用于肺动脉高血压的治疗
CA3029711A1 (en)	2010-06-03	2011-12-08	United Therapeutics Corporation	Treprostinil production
US20120004307A1 (en) *	2010-06-15	2012-01-05	United Therapeutics Corporation	Oral treatment of digital ischemic lesions
CN103476762B (zh)	2011-03-02	2015-04-22	联合治疗公司	用于生产曲前列环素的中间体的合成
CN103193626B (zh)	2012-01-10	2016-05-11	上海天伟生物制药有限公司	一种前列腺素类似物的晶型及其制备方法和用途
CN103193627B (zh)	2012-01-10	2016-04-20	上海天伟生物制药有限公司	一种前列腺素类似物的晶型及其制备方法和用途
CN104684561A (zh) *	2012-08-01	2015-06-03	联合治疗公司	利用间充质干细胞的肺动脉高血压的治疗
CA2880811C (en)	2012-08-01	2021-12-07	United Therapeutics Corporation	Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells
KR102466885B1 (ko)	2013-01-09	2022-11-11	유나이티드 세러퓨틱스 코오포레이션	프로스타시클린 및 중간엽 줄기 세포를 사용한 혈관병증의 치료
ES2927844T3 (es)	2013-01-11	2022-11-11	Corsair Pharma Inc	Profármacos de treprostinil
US9505737B2 (en)	2013-01-11	2016-11-29	Corsair Pharma, Inc.	Treprostinil derivative compounds and methods of using same
WO2014159050A1 (en)	2013-03-14	2014-10-02	United Therapeutics Corporation	Solid forms of treprostinil
CN109608326A (zh)	2013-03-15	2019-04-12	联合治疗公司	曲前列环素的盐
CA2908244C (en)	2013-03-25	2021-04-20	United Therapeutics Corporation	Process of making prostacyclin compounds with linker thiol and pegylated forms
FR3008320B1 (fr) *	2013-07-15	2018-04-20	Centre Hospitalier Univ Grenoble	Dispositif de prevention ou de traitement d'une ulceration cutanee
CA3042642A1 (en)	2013-08-12	2015-02-19	Pharmaceutical Manufacturing Research Services, Inc.	Extruded immediate release abuse deterrent pill
SI3060041T1 (sl)	2013-10-25	2021-04-30	Insmed Incorporated	Spojine prostaciklina
WO2015095391A1 (en)	2013-12-17	2015-06-25	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
US9492444B2 (en)	2013-12-17	2016-11-15	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
CA2952223C (en)	2014-06-13	2023-08-01	United Therapeutics Corporation	Treprostinil formulations
ES2809458T3 (es)	2014-07-17	2021-03-04	Pharmaceutical Manufacturing Res Services Inc	Forma de dosificación llena de líquido, disuasoria del abuso y de liberación inmediata
KR101890080B1 (ko)	2014-10-20	2018-09-20	유나이티드 쎄러퓨틱스 코포레이션	프로스타시클린 유도체 제조를 위한 중간체의 합성
EP3209282A4 (de)	2014-10-20	2018-05-23	Pharmaceutical Manufacturing Research Services, Inc.	Missbrauchssichere flüssigkeitsfülldosierform mit verlängerter freisetzung
AU2015349969B2 (en)	2014-11-18	2020-02-06	Insmed Incorporated	Methods of manufacturing treprostinil and treprostinil derivative prodrugs
WO2016088119A1 (en)	2014-12-03	2016-06-09	Steadymed Ltd	Preservative-free treprostinil formulations and methods and devices for use with same
US9643911B2 (en) *	2015-06-17	2017-05-09	Corsair Pharma, Inc.	Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en)	2015-06-17	2016-07-19	Corsair Pharma, Inc.	Treprostinil derivatives and compositions and uses thereof
JO3749B1 (ar) *	2015-08-27	2021-01-31	Lilly Co Eli	تركيبات إنسولين سريعة المفعول
US10898494B2 (en)	2016-05-05	2021-01-26	Liquidia Technologies, Inc.	Dry powder treprostinil for the treatment of pulmonary hypertension
CN110678174A (zh)	2016-09-26	2020-01-10	联合治疗学有限公司	曲前列环素的前药
AU2017350732B2 (en)	2016-10-24	2023-07-27	United Therapeutics Corporation	Enhancement of MSC immunomodulatory properties by treprostinil
CA3045917A1 (en) *	2016-12-05	2018-06-14	Corsair Pharma, Inc.	Dermal and transdermal administration of treprostinil and salts thereof
US10799653B2 (en)	2017-01-09	2020-10-13	United Therapeutics Corporation	Aerosol delivery device and method for manufacturing and operating the same
US12102610B2 (en)	2018-09-18	2024-10-01	Eli Lilly And Company	Treprostinil salt
CA3138530A1 (en)	2019-04-29	2020-11-05	Insmed Incorporated	Dry powder compositions of treprostinil prodrugs and methods of use thereof
WO2021041320A1 (en)	2019-08-23	2021-03-04	United Therapeutics Corporation	Treprostinil prodrugs
US11826327B2 (en)	2020-04-17	2023-11-28	United Therapeutics Corporation	Treatment for interstitial lung disease
JP7608480B2 (ja)	2020-06-09	2025-01-06	ユナイテッドセラピューティクスコーポレイション	トレプロスチニルのフマリルジケトピペリジンプロドラッグ
IL303668A (en)	2020-12-14	2023-08-01	United Therapeutics Corp	Stable treprostinil prodrugs and their uses for the treatment of diseases
CA3209987A1 (en)	2021-03-03	2022-09-09	Hitesh Batra	A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp)
CN118984697A (zh)	2022-02-08	2024-11-19	联合治疗公司	曲前列尼尔-伊洛前列素联合疗法
JP2025515512A (ja) *	2022-04-29	2025-05-15	兆科薬業（広州）有限公司	トレプロスチニルソフトミスト吸入剤
EP4651879A1 (de)	2023-01-18	2025-11-26	United Therapeutics Corporation	Behandlung von pulmonaler arterieller hypertonie
WO2024155752A1 (en)	2023-01-19	2024-07-25	United Therapeutics Corporation	Treprostinil analogs
AU2024319536A1 (en)	2023-08-08	2026-02-26	United Therapeutics Corporation	A method of producing an oral osmotic pharmaceutical delivery system and a pharmaceutical batch produced using the same
WO2025101824A1 (en)	2023-11-09	2025-05-15	United Therapeutics Corporation	Syntheses of compounds useful for producing treprostinil
WO2026035705A1 (en)	2024-08-06	2026-02-12	United Therapeutics Corporation	Treating pulmonary hypertension based on novel biomarker

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4254145A (en) *	1978-08-16	1981-03-03	American Cyanamid Company	Topical application of prostaglandin hypotensive agents
DE2845770A1 (de)	1978-10-19	1980-04-30	Schering Ag	Neue prostacyclin-derivate und verfahren zu ihrer herstellung
US4281113A (en)	1979-07-31	1981-07-28	The Upjohn Company	2,5-Inter-o-phenylene-3,4-dinor-6,9α-epoxy-6.beta.-5-iodo-PGF1 compounds
US4338457A (en) *	1980-02-28	1982-07-06	The Upjohn Company	Composition and process
CA1201712A (en)	1980-02-28	1986-03-11	Paul A. Aristoff	Carbacyclin analogs
US4306075A (en)	1980-03-28	1981-12-15	The Upjohn Company	Composition and process
US4306076A (en)	1980-04-23	1981-12-15	The Upjohn Company	Inter-phenylene CBA compounds
DE3048906A1 (de)	1980-12-19	1982-07-15	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4349689A (en)	1980-12-22	1982-09-14	The Upjohn Company	Methano carbacyclin analogs
US4486598A (en)	1982-02-22	1984-12-04	The Upjohn Company	Carbacyclin analogs
US4668814A (en)	1984-03-08	1987-05-26	The Upjohn Company	Interphenylene carbacyclin derivatives
CA1241324A (en)	1984-03-08	1988-08-30	Paul A. Aristoff	Interphenylene carbacyclin derivatives
US4683330A (en)	1984-03-08	1987-07-28	The Upjohn Company	Interphenylene carbacyclin derivatives
ZA851337B (en)	1984-03-08	1985-10-30	Upjohn Co	Interphenylene carbacyclin derivatives
EP0223831B1 (de)	1985-05-22	1992-07-15	Liposome Technology, Inc.	Verfahren und system zum einatmen von liposomen
GB8814438D0 (en)	1988-06-17	1988-07-20	Wellcome Found	Compounds for use in medicine
KR0158870B1 (ko)	1988-06-17	1998-12-01	마틴 에이. 로쓰블랫	폐순환 승압의 치료, 예방 또는 진단용 조성물
GB9011588D0 (en)	1990-05-24	1990-07-11	Wellcome Found	Prostaglandin analogues for use in medicine
US5190972A (en)	1992-01-27	1993-03-02	The University Of Melbourne	Method of combatting cyclosporine organ toxicity with prostaglandin analogs
AU735975B2 (en)	1995-02-27	2001-07-19	Toray Industries, Inc.	Remedy for pulmonary heart
US6441245B1 (en)	1997-10-24	2002-08-27	United Therapeutics Corporation	Process for stereoselective synthesis of prostacyclin derivatives
CA2312729C (en) *	1997-11-14	2006-05-23	United Therapeutics Corporation	Use of 9-deoxy-2', 9-.alpha.-methano-3- oxa-4,5,6- trinor-3, 7-(1',3'-interphenylene) -13,14-dihydro- prostaglandin f1 to treat peripheral vascular disease
US6521212B1 (en)	1999-03-18	2003-02-18	United Therapeutics Corporation	Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
JP2003523935A (ja)	1999-03-31	2003-08-12	ユナイテッドセラピューティクスコーポレイション	末梢血管疾患と肺高血圧症を治療するためのプロスタグランジン化合物、組成物および方法
CA2375617A1 (en) *	1999-06-07	2000-12-14	Edwards Lifesciences Corporation	Targeted angiogenesis
WO2004019952A1 (en) *	2002-08-28	2004-03-11	Università 'campus Bio-Medico' Di Roma	Use of prostacyclin and analogs thereof for improving venous flow
US7550133B2 (en)	2002-11-26	2009-06-23	Alexza Pharmaceuticals, Inc.	Respiratory drug condensation aerosols and methods of making and using them
CN102697790A (zh) *	2003-05-22	2012-10-03	联合治疗公司	化合物和释放前列环素类似物的方法
US20040265238A1 (en)	2003-06-27	2004-12-30	Imtiaz Chaudry	Inhalable formulations for treating pulmonary hypertension and methods of using same
CN101647792B (zh) *	2003-12-16	2012-11-28	联合治疗公司	曲前列环素在制备治疗和预防缺血性损害的药物中的用途
WO2005099680A2 (en) *	2004-04-12	2005-10-27	United Therapeutics, Inc.	Use of treprostinil to treat neuropathic diabetic foot ulcers

2004
- 2004-12-16 CN CN2009101645686A patent/CN101647792B/zh not_active Expired - Fee Related
- 2004-12-16 ES ES04814462T patent/ES2347254T3/es not_active Expired - Lifetime
- 2004-12-16 DE DE602004028155T patent/DE602004028155D1/de not_active Expired - Lifetime
- 2004-12-16 KR KR1020067013988A patent/KR101161889B1/ko not_active Expired - Fee Related
- 2004-12-16 AT AT04814462T patent/ATE473736T1/de not_active IP Right Cessation
- 2004-12-16 CN CN2004800417809A patent/CN1917866B/zh not_active Expired - Fee Related
- 2004-12-16 US US11/012,723 patent/US8765813B2/en active Active
- 2004-12-16 WO PCT/US2004/042283 patent/WO2005058303A1/en not_active Ceased
- 2004-12-16 JP JP2006545436A patent/JP5190200B2/ja not_active Expired - Fee Related
- 2004-12-16 EP EP04814462A patent/EP1696900B1/de not_active Expired - Lifetime
- 2004-12-16 CA CA2549724A patent/CA2549724C/en not_active Expired - Fee Related
2012
- 2012-09-28 JP JP2012217695A patent/JP2013047235A/ja active Pending

Also Published As

Publication number	Publication date
US20050165111A1 (en)	2005-07-28
CN101647792B (zh)	2012-11-28
DE602004028155D1 (de)	2010-08-26
EP1696900A1 (de)	2006-09-06
JP2007514750A (ja)	2007-06-07
ES2347254T3 (es)	2010-10-27
WO2005058303A1 (en)	2005-06-30
US8765813B2 (en)	2014-07-01
CA2549724C (en)	2014-02-11
CN101647792A (zh)	2010-02-17
JP5190200B2 (ja)	2013-04-24
CN1917866A (zh)	2007-02-21
JP2013047235A (ja)	2013-03-07
CA2549724A1 (en)	2005-06-30
KR20060123483A (ko)	2006-12-01
KR101161889B1 (ko)	2012-07-02
EP1696900B1 (de)	2010-07-14
CN1917866B (zh)	2010-12-15

Legal Events

Date	Code	Title	Description
2011-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE473736T1 (de)	2010-07-15	Verwendung von treprostinil zur behandlung von ischämischen läsionen
DE602005020269D1 (de)	2010-05-12	Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren
ATE336239T1 (de)	2006-09-15	Neue fettsäureanaloge zur behandlung des bluthochdrucks
AP2001002217A0 (en)	2001-09-30	Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids.
EA200300171A1 (ru)	2003-06-26	Циклопентаноиндолы, композиции, содержащие данные соединения, и способы лечения
DE69528273D1 (de)	2002-10-24	1,2-substituierte imidazolylverbindungen zur behandlung von entzündungen
EA200300293A1 (ru)	2003-08-28	Противовоспалительные конденсированные пирролокарбазолы
YU46097A (sh)	2000-10-30	Nova klasa estara i njihove farmaceutske smeše
EA200201214A1 (ru)	2003-06-26	Замещенные тиоацетамиды
WO2005012530A3 (en)	2005-05-12	Antagonists and agonists of ldcam and methods of use
TR199901905T2 (xx)	1999-10-21	2-(P�rin-9-il)-tetrahidrofuran-3,4-diol t�revleri.
EA200500169A1 (ru)	2005-06-30	Замещенные производные 1,3-дифенилпроп-2-ен-1-она, получение и применение
EA200300566A1 (ru)	2003-10-30	Применение cci-779 в качестве противоопухолевого средства
ATE409176T1 (de)	2008-10-15	1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
EA200401341A1 (ru)	2005-06-30	Применение остеопротегерина для лечения и/или профилактики фиброзного заболевания
ATE452884T1 (de)	2010-01-15	Arylmethylamin-derivate zur verwendung als inhibitoren von tryptase
DE60021381D1 (de)	2005-08-25	Chinonverbindungen zur behandlung von krankheiten
DE69720996D1 (de)	2003-05-22	Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer
CO5660287A2 (es)	2006-07-31	Derivados de tetrahidrocarbazol y su uso farmaceutico
DE60140960D1 (de)	2010-02-11	Verwendung von serp-1 in kombination mit einem immunosuppressor zur behandlung von arthritis
ATE271861T1 (de)	2004-08-15	Verwendung von nmda-antagonisten und/oder natriumkanalantagonisten zur behandlung von entzündlichen erkrankungen
EA200100297A1 (ru)	2001-08-27	Моногидрат гидробромида элетриптана
BR0109139B1 (pt)	2013-09-03	composiÇÕes farmacÊuticas incluindo alginatos
DE602004019541D1 (de)	2009-04-02	Cycloalkyläbü kondensierte indole
EA200600316A1 (ru)	2006-06-30	ПРОИЗВОДНЫЕ 3-НИТРОПИРАЗОЛО[1,5-a]ПИРИМИДИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИСПОЛЬЗУЕМЫЕ В НЕМ ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ЛЕКАРСТВЕННОЕ СРЕДСТВО (ВАРИАНТЫ) И СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С МОДУЛЯЦИЕЙ РЕЦЕПТОРА ГАМК(ВАРИАНТЫ)