ATE474584T1 - Verwendung von cis-rhenium (iii) diadamantat- verbindungen zur verstärkung der antitumoralen wirkung von platinkomplexen - Google Patents
Verwendung von cis-rhenium (iii) diadamantat- verbindungen zur verstärkung der antitumoralen wirkung von platinkomplexenInfo
- Publication number
- ATE474584T1 ATE474584T1 AT07729273T AT07729273T ATE474584T1 AT E474584 T1 ATE474584 T1 AT E474584T1 AT 07729273 T AT07729273 T AT 07729273T AT 07729273 T AT07729273 T AT 07729273T AT E474584 T1 ATE474584 T1 AT E474584T1
- Authority
- AT
- Austria
- Prior art keywords
- rhenium
- diadamantate
- cis
- enhance
- iii
- Prior art date
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical class [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 229910052702 rhenium Inorganic materials 0.000 title 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 231100000433 cytotoxic Toxicity 0.000 abstract 2
- 230000001472 cytotoxic effect Effects 0.000 abstract 2
- GNWBLLYJQXKPIP-ZOGIJGBBSA-N (1s,3as,3bs,5ar,9ar,9bs,11as)-n,n-diethyl-6,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1h-indeno[5,4-f]quinoline-1-carboxamide Chemical compound CN([C@@H]1CC2)C(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)N(CC)CC)[C@@]2(C)CC1 GNWBLLYJQXKPIP-ZOGIJGBBSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- JIMXXGFJRDUSRO-UHFFFAOYSA-N adamantane-1-carboxylic acid Chemical compound C1C(C2)CC3CC2CC1(C(=O)O)C3 JIMXXGFJRDUSRO-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 abstract 1
- 150000003057 platinum Chemical class 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003282 rhenium compounds Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06300497A EP1862169A1 (de) | 2006-05-19 | 2006-05-19 | Verwendung von cis-Rhenium(III)diadamantat-Verbindungen zur Potenzierung der antitumoralen Aktivität von Platinkomplexen |
| PCT/EP2007/054828 WO2007135095A1 (en) | 2006-05-19 | 2007-05-18 | Use of cis-rhenium (iii) diadamantate compounds for potentiating the antitumoral activity of platinium complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE474584T1 true ATE474584T1 (de) | 2010-08-15 |
Family
ID=37387389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07729273T ATE474584T1 (de) | 2006-05-19 | 2007-05-18 | Verwendung von cis-rhenium (iii) diadamantat- verbindungen zur verstärkung der antitumoralen wirkung von platinkomplexen |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP1862169A1 (de) |
| AT (1) | ATE474584T1 (de) |
| DE (1) | DE602007007970D1 (de) |
| WO (1) | WO2007135095A1 (de) |
-
2006
- 2006-05-19 EP EP06300497A patent/EP1862169A1/de not_active Withdrawn
-
2007
- 2007-05-18 AT AT07729273T patent/ATE474584T1/de not_active IP Right Cessation
- 2007-05-18 WO PCT/EP2007/054828 patent/WO2007135095A1/en not_active Ceased
- 2007-05-18 DE DE602007007970T patent/DE602007007970D1/de active Active
- 2007-05-18 EP EP07729273A patent/EP2068894B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| EP2068894B1 (de) | 2010-07-21 |
| WO2007135095A1 (en) | 2007-11-29 |
| DE602007007970D1 (de) | 2010-09-02 |
| EP2068894A1 (de) | 2009-06-17 |
| EP1862169A1 (de) | 2007-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |