ATE474855T1 - Polyklonaler-monoklonaler-elisa-assay zum nachweis von n-terminalem probnp - Google Patents
Polyklonaler-monoklonaler-elisa-assay zum nachweis von n-terminalem probnpInfo
- Publication number
- ATE474855T1 ATE474855T1 AT03811319T AT03811319T ATE474855T1 AT E474855 T1 ATE474855 T1 AT E474855T1 AT 03811319 T AT03811319 T AT 03811319T AT 03811319 T AT03811319 T AT 03811319T AT E474855 T1 ATE474855 T1 AT E474855T1
- Authority
- AT
- Austria
- Prior art keywords
- probnp
- human
- elisa assay
- purified
- specific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7019—Ischaemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/80—Antihypertensive peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/300,733 US20040096919A1 (en) | 2002-11-18 | 2002-11-18 | Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP |
| US10/359,051 US20040096920A1 (en) | 2002-11-18 | 2003-02-04 | Polyclonal-monoclonal elisa assay for detecting n-terminus proBNP |
| PCT/CA2003/001771 WO2004046194A2 (en) | 2002-11-18 | 2003-11-17 | Polyclonal-monoclonal elisa assay for detecting n-terminus probnp |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE474855T1 true ATE474855T1 (de) | 2010-08-15 |
Family
ID=32297956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03811319T ATE474855T1 (de) | 2002-11-18 | 2003-11-17 | Polyklonaler-monoklonaler-elisa-assay zum nachweis von n-terminalem probnp |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20040096919A1 (de) |
| EP (3) | EP2251356B1 (de) |
| AT (1) | ATE474855T1 (de) |
| DE (1) | DE60333471D1 (de) |
| ES (2) | ES2568894T3 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1562990B1 (de) | 2002-11-18 | 2010-07-21 | Syn X Pharma, Inc. | Polyklonaler-monoklonaler-elisa-assay zum nachweis von n-terminalem probnp |
| US7135329B2 (en) * | 2002-11-18 | 2006-11-14 | Princeton Biomeditech Corporation | Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients |
| US7109023B2 (en) * | 2002-11-18 | 2006-09-19 | Princeton Biomeditech Corporation | Immunossay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients |
| EP2256132B1 (de) * | 2003-05-12 | 2015-04-01 | Roche Diagnostics GmbH | Verfahren zum Nachweis von ProBNP mit einem monoklonalen Antikörper |
| DE10355731A1 (de) * | 2003-11-28 | 2005-06-30 | Roche Diagnostics Gmbh | Analytischer Sandwichtest zur Bestimmung von NT-proBNP |
| AT500800B1 (de) * | 2004-09-08 | 2008-07-15 | Biomedica Medizinprodukte Gmbh | Verfahren zur bestimmung von probnp |
| EP2047275B1 (de) * | 2006-08-04 | 2011-06-01 | Medizinische Hochschule Hannover | Verfahren zur risikobewertung von herzeingriffen auf gdf-15-basis |
| EP1884777A1 (de) * | 2006-08-04 | 2008-02-06 | Medizinische Hochschule Hannover | Mittel und Verfahren zur Risikobewertung von Herzeingriffen auf GDF-15-Basis |
| AT504942B1 (de) * | 2007-03-07 | 2009-08-15 | Biomedica Medizinprodukte Gmbh | Verfahren zur bestimmung von probnp |
| AU2011285694B2 (en) | 2010-08-04 | 2014-12-18 | Idexx Laboratories, Inc. | Detection of degradation products of canine NT-proBNP |
| EP2715353B1 (de) | 2011-05-31 | 2016-08-24 | IDEXX Laboratories, Inc. | Nachweis von abbauprodukten von felinem nt-probnp |
| CN102323418A (zh) * | 2011-08-31 | 2012-01-18 | 内蒙古科慧生物科技有限责任公司 | B型利钠肽原前体(proBNP)定量测定试剂盒及其检测方法 |
| CN102879589A (zh) * | 2012-09-26 | 2013-01-16 | 中国人民解放军总医院 | 一种能稳定保存的人NT-proBNP制剂及其制备方法 |
| WO2017033281A1 (ja) | 2015-08-25 | 2017-03-02 | 持田製薬株式会社 | 特異的に精製された抗プレセプシン抗体 |
| CN108613977B (zh) * | 2018-05-15 | 2021-02-26 | 绍兴圣康生物科技有限公司 | 一种n末端脑钠肽前体检测试剂盒 |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| JP7664226B2 (ja) | 2019-08-13 | 2025-04-17 | ゲンティアン アクティーゼルスカブ | Nt-プロbnpの定量のための高感度粒子増感アッセイ |
| CN111848775B (zh) * | 2020-08-05 | 2022-03-11 | 武汉生之源生物科技股份有限公司 | 一种NT-proBNP重组蛋白的保存液及其制备方法 |
| ES3022063T3 (en) | 2021-10-01 | 2025-05-28 | Gentian As | Novel method for determining a concentration of n-terminal pro-hormone bnp (nt-probnp) in a sample |
| US12493048B2 (en) * | 2021-10-25 | 2025-12-09 | Bionote, Inc. | Antibodies binding specifically to NT-proBNP and use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9211686D0 (en) * | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| US6117644A (en) * | 1998-06-04 | 2000-09-12 | Ottawa Heart Institute Research Corporation | Predicting and detecting cardiac allograft rejection |
| GB9827348D0 (en) | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
| PL204235B1 (pl) | 1999-01-29 | 2009-12-31 | Roche Diagnostics Gmbh | Sposób wykrywania natywnego N-końcowego proBNP, zastosowanie tego sposobu, zastosowanie zrekombinowanego N-końcowego proBNP, przeciwciała przeciw zrekombinowanemu N-końcowemu proBNP, linie komórkowe i sposoby wytwarzania przeciwciał poliklonalnych i monoklonalnych |
| US6960472B2 (en) * | 2002-11-18 | 2005-11-01 | Ottawa Heart Institute Research Corporation | Monoclonal antibodies against N-Terminus proBNP |
| EP1562990B1 (de) * | 2002-11-18 | 2010-07-21 | Syn X Pharma, Inc. | Polyklonaler-monoklonaler-elisa-assay zum nachweis von n-terminalem probnp |
-
2002
- 2002-11-18 US US10/300,733 patent/US20040096919A1/en not_active Abandoned
-
2003
- 2003-02-04 US US10/359,051 patent/US20040096920A1/en not_active Abandoned
- 2003-11-17 EP EP10169301.8A patent/EP2251356B1/de not_active Expired - Lifetime
- 2003-11-17 EP EP15203244.7A patent/EP3061769B1/de not_active Expired - Lifetime
- 2003-11-17 ES ES10169301.8T patent/ES2568894T3/es not_active Expired - Lifetime
- 2003-11-17 EP EP18186495.0A patent/EP3450457A1/de active Pending
- 2003-11-17 DE DE60333471T patent/DE60333471D1/de not_active Expired - Lifetime
- 2003-11-17 AT AT03811319T patent/ATE474855T1/de not_active IP Right Cessation
- 2003-11-17 ES ES15203244.7T patent/ES2688545T3/es not_active Expired - Lifetime
-
2021
- 2021-05-19 US US17/324,685 patent/US20220099687A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040096920A1 (en) | 2004-05-20 |
| EP2251356A3 (de) | 2011-08-31 |
| EP3061769B1 (de) | 2018-08-01 |
| EP2251356A2 (de) | 2010-11-17 |
| US20040096919A1 (en) | 2004-05-20 |
| DE60333471D1 (de) | 2010-09-02 |
| US20220099687A1 (en) | 2022-03-31 |
| EP3450457A1 (de) | 2019-03-06 |
| EP2251356B1 (de) | 2016-03-02 |
| HK1223947A1 (en) | 2017-08-11 |
| ES2568894T3 (es) | 2016-05-05 |
| EP3061769A1 (de) | 2016-08-31 |
| ES2688545T3 (es) | 2018-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |