ATE475438T1 - Lokale, vaskuläre verabreichung von etoposide in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungen - Google Patents

Lokale, vaskuläre verabreichung von etoposide in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungen

Info

Publication number: ATE475438T1
Authority: AT; Austria
Prior art keywords: devices; agents; compounds; medical device; utilized
Prior art date: 2004-03-22

Application number

AT05251710T

Other languages

English (en)

Inventor

Robert Falotico

Tom Jay Parry

Jonathon Z Zhao

Original Assignee

Cordis Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-22

Filing date

2005-03-21

Publication date

2010-08-15

2005-03-21 Application filed by Cordis Corp filed Critical Cordis Corp

2010-08-15 Application granted granted Critical

2010-08-15 Publication of ATE475438T1 publication Critical patent/ATE475438T1/de

Links

208000024248 Vascular System injury Diseases 0.000 title 1
208000012339 Vascular injury Diseases 0.000 title 1
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 title 1
229960005420 etoposide Drugs 0.000 title 1
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
208000037803 restenosis Diseases 0.000 title 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
229960002930 sirolimus Drugs 0.000 title 1
230000002792 vascular Effects 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 5
229940124597 therapeutic agent Drugs 0.000 abstract 4
229940126585 therapeutic drug Drugs 0.000 abstract 4
239000000560 biocompatible material Substances 0.000 abstract 2
208000007536 Thrombosis Diseases 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000011248 coating agent Substances 0.000 abstract 1
238000000576 coating method Methods 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000010828 elution Methods 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/43—Hormones, e.g. dexamethasone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Surgery (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
Dermatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Media Introduction/Drainage Providing Device (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Prostheses (AREA)

AT05251710T 2004-03-22 2005-03-21 Lokale, vaskuläre verabreichung von etoposide in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungen ATE475438T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/805,722 US7695731B2 (en)	2004-03-22	2004-03-22	Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury

Publications (1)

Publication Number	Publication Date
ATE475438T1 true ATE475438T1 (de)	2010-08-15

Family

ID=34862017

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05251710T ATE475438T1 (de)	2004-03-22	2005-03-21	Lokale, vaskuläre verabreichung von etoposide in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungen

Country Status (8)

Country	Link
US (1)	US7695731B2 (de)
EP (1)	EP1579877B1 (de)
JP (1)	JP5042460B2 (de)
CN (1)	CN1672745B (de)
AT (1)	ATE475438T1 (de)
CA (1)	CA2499220C (de)
DE (1)	DE602005022515D1 (de)
ES (1)	ES2347573T3 (de)

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US8747881B2 (en)	2003-12-19	2014-06-10	Cordis Corporation	Intraluminal medical devices in combination with therapeutic agents
US8652502B2 (en) *	2003-12-19	2014-02-18	Cordis Corporation	Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury
US20060281174A1 (en) *	2004-03-09	2006-12-14	Gang Xu	Methods for generating insulin-producing cells
EP1781264B1 (de)	2004-08-04	2013-07-24	Evonik Corporation	Verfahren zur herstellung von abgabevorrichtungen und damit erhaltene vorrichtungen
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US8784860B2 (en) *	2005-10-27	2014-07-22	Cordis Corporation	Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease
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US20080241215A1 (en) *	2007-03-28	2008-10-02	Robert Falotico	Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, aaa and stroke
US8216600B2 (en) *	2007-11-14	2012-07-10	Cordis Corporation	Polymeric materials for medical devices
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2004
- 2004-03-22 US US10/805,722 patent/US7695731B2/en active Active
2005
- 2005-03-03 CA CA2499220A patent/CA2499220C/en not_active Expired - Lifetime
- 2005-03-18 JP JP2005079873A patent/JP5042460B2/ja not_active Expired - Fee Related
- 2005-03-21 AT AT05251710T patent/ATE475438T1/de not_active IP Right Cessation
- 2005-03-21 ES ES05251710T patent/ES2347573T3/es not_active Expired - Lifetime
- 2005-03-21 DE DE602005022515T patent/DE602005022515D1/de not_active Expired - Lifetime
- 2005-03-21 EP EP05251710A patent/EP1579877B1/de not_active Expired - Lifetime
- 2005-03-22 CN CN2005100560273A patent/CN1672745B/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2499220C (en)	2013-12-10
US20050208092A1 (en)	2005-09-22
CA2499220A1 (en)	2005-09-22
EP1579877B1 (de)	2010-07-28
DE602005022515D1 (de)	2010-09-09
EP1579877A1 (de)	2005-09-28
JP5042460B2 (ja)	2012-10-03
US7695731B2 (en)	2010-04-13
ES2347573T3 (es)	2010-11-02
JP2005270657A (ja)	2005-10-06
CN1672745B (zh)	2010-08-11
CN1672745A (zh)	2005-09-28

Legal Events

Date	Code	Title	Description
2011-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE442169T1 (de)	2009-09-15	Lokale, vaskuläre verabreichung von cladribin in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungen
DE602005022378D1 (de)	2010-09-02	Lokale, vaskuläre Verabreichung von 2-methoxyestradiol in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen
EP2286848A3 (de)	2012-08-29	Lokale vaskuläre Abgabe von Mycophenolsäure in Kombination mit Rapamycin zur Verhinderung von Restenose
EP1582225A3 (de)	2008-06-04	Arzneimittelabgabevorrichtung
EP1568387A3 (de)	2006-01-25	Beschichtung mit strahlenschützender Verbindung für medizinische Geräte
CA2490170A1 (en)	2005-06-19	Local vascular delivery of trichostatin a alone or in combination with sirolimus to prevent restenosis following vascular injury
EP1591108A3 (de)	2007-08-29	Formulierungen von Sirolimus und seine Analoge in Lösungsform zur Behandlung von koronaren Herzkrankheit
EP1723976A3 (de)	2011-08-03	Therapeutische Mittel enthaltend intraluminale Instrumente
CA2467797A1 (en)	2004-11-20	Increased biocompatibility of implantable medical devices
EP1586337A3 (de)	2008-03-19	Lokale Verabreichung einer Kombination von Rapamycin und 17 beta-Estradiol zur Behandlung von vulnerabler Plaque
ATE475438T1 (de)	2010-08-15	Lokale, vaskuläre verabreichung von etoposide in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungen
EP1974758A3 (de)	2010-11-03	Lokale, vaskuläre Versorgung von Probucol allein oder in Kombination mit Sirolimus zur Behandlung der Restenose, empfindlichem Plaque, AAA und Schlaganfall
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MXPA03006825A (es)	2004-09-03	Dispositivos vasculares revestidos.
ATE339227T1 (de)	2006-10-15	Beschichtetes medizinsches implantat zur behandlung von gefässerkrankungen
US20040241211A9 (en)	2004-12-02	Devices and methods for reducing scar tissue formation
US20100119578A1 (en)	2010-05-13	Extracellular matrix modulating coatings for medical devices
MXPA03003869A (es)	2004-09-06	Dispositivos medicos revestidos.
MX2010007571A (es)	2011-01-25	Endoprotesis eluyente con receptaculo de rapamicina.
DE602005022645D1 (de)	2010-09-16	Implantierbare vaskuläre Vorrichtung zur Abgabe von Topotecan in Kombination mit Rapamycin
WO2006047378A3 (en)	2007-02-15	Biocompatible and hemocompatible amphiphilic coatings for drug deliver