ATE475648T1 - Piperidin- oder piperazin-substituierte tetrahydronaphthalin-1-carbonsäureverbindungen, die mtp inhibieren - Google Patents

Piperidin- oder piperazin-substituierte tetrahydronaphthalin-1-carbonsäureverbindungen, die mtp inhibieren

Info

Publication number: ATE475648T1
Authority: AT; Austria
Prior art keywords: tetrahydronaphthaline; piperazine; piperidine; substituted; carbonic acid
Prior art date: 2006-10-24

Application number

AT07821650T

Other languages

English (en)

Inventor

Lieven Meerpoel

Joannes Theodorus Maria Linders

Libuse Jaroskova

Marcel Viellevoye

Leo Jacobus Jozef Backx

Didier Jean-Claude Berthelot

Guuske Frederike Busscher

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-24

Filing date

2007-10-22

Publication date

2010-08-15

2007-10-22 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2010-08-15 Application granted granted Critical

2010-08-15 Publication of ATE475648T1 publication Critical patent/ATE475648T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

AT07821650T 2006-10-24 2007-10-22 Piperidin- oder piperazin-substituierte tetrahydronaphthalin-1-carbonsäureverbindungen, die mtp inhibieren ATE475648T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06122817		2006-10-24
PCT/EP2007/061286 WO2008049806A1 (en)	2006-10-24	2007-10-22	Piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid mtp inhibiting compounds

Publications (1)

Publication Number	Publication Date
ATE475648T1 true ATE475648T1 (de)	2010-08-15

Family

ID=37885794

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07821650T ATE475648T1 (de)	2006-10-24	2007-10-22	Piperidin- oder piperazin-substituierte tetrahydronaphthalin-1-carbonsäureverbindungen, die mtp inhibieren

Country Status (27)

Country	Link
US (1)	US8114880B2 (de)
EP (1)	EP2076494B1 (de)
JP (1)	JP5506085B2 (de)
KR (1)	KR101415536B1 (de)
CN (1)	CN101528695B (de)
AR (1)	AR063517A1 (de)
AT (1)	ATE475648T1 (de)
AU (1)	AU2007310925B2 (de)
BR (1)	BRPI0717357A2 (de)
CA (1)	CA2664141C (de)
CL (1)	CL2007003042A1 (de)
CY (1)	CY1111010T1 (de)
DE (1)	DE602007008124D1 (de)
DK (1)	DK2076494T3 (de)
EA (1)	EA016311B1 (de)
IL (1)	IL198332A (de)
JO (1)	JO2653B1 (de)
MX (1)	MX2009004386A (de)
NO (1)	NO20092005L (de)
NZ (1)	NZ575615A (de)
PL (1)	PL2076494T3 (de)
PT (1)	PT2076494E (de)
SI (1)	SI2076494T1 (de)
TW (1)	TWI396688B (de)
UA (1)	UA99109C2 (de)
WO (1)	WO2008049806A1 (de)
ZA (1)	ZA200902822B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0211230D0 (en)	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
JP5525261B2 (ja) *	2006-10-24	2014-06-18	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｍｔｐ阻害性テトラヒドロ−ナフタレン−１−カルボン酸誘導体
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
CN106167483B (zh)	2010-10-18	2019-02-15	塞伦尼斯医疗控股有限公司	可用于胆固醇动员的化合物、组合物和方法
HRP20191860T1 (hr)	2013-03-13	2019-12-27	Forma Therapeutics, Inc.	Derivati 2-hidroksi-1-{4-[(4-fenilfenil)karbonil]piperazin-1-il}etan-1-ona i srodni spojevi kao inhibitori sintaze masnih kiselina (fasn) za liječenje raka
ES2846833T3 (es)	2016-07-18	2021-07-29	Janssen Pharmaceutica Nv	Ligandos de obtención de imágenes de tau por PET
JP6960532B2 (ja) *	2018-05-15	2021-11-05	旭化成株式会社	アミノ酸アミノアルキルエステル又はその無機酸塩の製造方法
TWI767148B (zh)	2018-10-10	2022-06-11	美商弗瑪治療公司	抑制脂肪酸合成酶(fasn)
WO2020092395A1 (en)	2018-10-29	2020-05-07	Forma Therapeutics, Inc.	SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE
WO2024006701A1 (en) *	2022-06-28	2024-01-04	Stepan Company	Method for making dialkyl amino acid ester sulfonates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5595872A (en)	1992-03-06	1997-01-21	Bristol-Myers Squibb Company	Nucleic acids encoding microsomal trigyceride transfer protein
US5739135A (en)	1993-09-03	1998-04-14	Bristol-Myers Squibb Company	Inhibitors of microsomal triglyceride transfer protein and method
WO1996040640A1 (en) *	1995-06-07	1996-12-19	Pfizer Inc.	BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION
TR199901180T2 (xx)	1996-11-27	1999-08-23	Pfizer Inc.	Apo B-Salg�lama/MTP inhibit�r amidler.
GB9826412D0 (en)	1998-12-03	1999-01-27	Glaxo Group Ltd	Chemical compounds
DE19963235A1 (de) *	1999-12-27	2001-07-05	Boehringer Ingelheim Pharma	Substituierte Piperazinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
GB0013346D0 (en) *	2000-06-01	2000-07-26	Glaxo Group Ltd	Therapeutic benzamide derivatives
FR2816940A1 (fr)	2000-11-23	2002-05-24	Lipha	Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation
JP5525261B2 (ja)	2006-10-24	2014-06-18	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｍｔｐ阻害性テトラヒドロ−ナフタレン−１−カルボン酸誘導体

2007
- 2007-10-03 JO JO2007410A patent/JO2653B1/en active
- 2007-10-22 DE DE602007008124T patent/DE602007008124D1/de active Active
- 2007-10-22 SI SI200730371T patent/SI2076494T1/sl unknown
- 2007-10-22 US US12/446,580 patent/US8114880B2/en not_active Expired - Fee Related
- 2007-10-22 UA UAA200902359A patent/UA99109C2/ru unknown
- 2007-10-22 BR BRPI0717357-1A2A patent/BRPI0717357A2/pt not_active IP Right Cessation
- 2007-10-22 MX MX2009004386A patent/MX2009004386A/es active IP Right Grant
- 2007-10-22 NZ NZ575615A patent/NZ575615A/en not_active IP Right Cessation
- 2007-10-22 AU AU2007310925A patent/AU2007310925B2/en not_active Ceased
- 2007-10-22 PT PT07821650T patent/PT2076494E/pt unknown
- 2007-10-22 AT AT07821650T patent/ATE475648T1/de active
- 2007-10-22 PL PL07821650T patent/PL2076494T3/pl unknown
- 2007-10-22 CA CA2664141A patent/CA2664141C/en not_active Expired - Fee Related
- 2007-10-22 JP JP2009533800A patent/JP5506085B2/ja not_active Expired - Fee Related
- 2007-10-22 DK DK07821650.4T patent/DK2076494T3/da active
- 2007-10-22 KR KR1020097008396A patent/KR101415536B1/ko not_active Expired - Fee Related
- 2007-10-22 CN CN2007800393884A patent/CN101528695B/zh not_active Expired - Fee Related
- 2007-10-22 WO PCT/EP2007/061286 patent/WO2008049806A1/en not_active Ceased
- 2007-10-22 EA EA200970398A patent/EA016311B1/ru not_active IP Right Cessation
- 2007-10-22 EP EP07821650A patent/EP2076494B1/de active Active
- 2007-10-23 TW TW096139583A patent/TWI396688B/zh not_active IP Right Cessation
- 2007-10-23 CL CL200703042A patent/CL2007003042A1/es unknown
- 2007-10-23 AR ARP070104677A patent/AR063517A1/es not_active Application Discontinuation
2009
- 2009-04-23 ZA ZA200902822A patent/ZA200902822B/xx unknown
- 2009-04-23 IL IL198332A patent/IL198332A/en active IP Right Grant
- 2009-05-25 NO NO20092005A patent/NO20092005L/no not_active Application Discontinuation
2010
- 2010-10-27 CY CY20101100974T patent/CY1111010T1/el unknown

Also Published As

Publication number	Publication date
NO20092005L (no)	2009-06-04
EA016311B1 (ru)	2012-04-30
DE602007008124D1 (de)	2010-09-09
CA2664141A1 (en)	2008-05-02
SI2076494T1 (sl)	2010-11-30
EA200970398A1 (ru)	2009-08-28
JO2653B1 (en)	2012-06-17
TW200833680A (en)	2008-08-16
WO2008049806A1 (en)	2008-05-02
AU2007310925B2 (en)	2012-07-26
PL2076494T3 (pl)	2011-01-31
IL198332A (en)	2012-08-30
AU2007310925A1 (en)	2008-05-02
CN101528695A (zh)	2009-09-09
CN101528695B (zh)	2013-07-17
CL2007003042A1 (es)	2008-05-02
PT2076494E (pt)	2010-10-18
US20090325980A1 (en)	2009-12-31
JP5506085B2 (ja)	2014-05-28
HK1136823A1 (en)	2010-07-09
MX2009004386A (es)	2009-05-08
NZ575615A (en)	2011-01-28
US8114880B2 (en)	2012-02-14
UA99109C2 (ru)	2012-07-25
AR063517A1 (es)	2009-01-28
EP2076494B1 (de)	2010-07-28
JP2010507615A (ja)	2010-03-11
IL198332A0 (en)	2010-02-17
CY1111010T1 (el)	2015-06-11
EP2076494A1 (de)	2009-07-08
TWI396688B (zh)	2013-05-21
KR20090075832A (ko)	2009-07-09
DK2076494T3 (da)	2010-11-08
BRPI0717357A2 (pt)	2013-10-22
ZA200902822B (en)	2010-07-28
KR101415536B1 (ko)	2014-07-16
CA2664141C (en)	2015-04-28

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2011-02-15

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BRPI0918472A2 (pt)	2015-12-01	composto 2,4-diaminopirimidina
EP1985620A4 (de)	2012-08-15	10a-AZALIDVERBINDUNG
EP2036901A4 (de)	2009-11-18	C-phenyl-1-thioglucitverbindung
CR10353A (es)	2009-01-09	Nuevos compuestos.
DK1984502T3 (da)	2011-08-29	Nukleinsyre
EP1876179A4 (de)	2009-09-09	Thienopyrimidonverbindungen
DE602006021644D1 (de)	2011-06-09	Fungizidzusammensetzungen
BRPI0716197A2 (pt)	2013-11-12	Fungicidas
DK2016067T3 (da)	2012-10-22	Insecticidforbindelser
DE602006012221D1 (de)	2010-03-25	Pflanzenwachstumsregulierende zusammensetzungen
EP2124549A4 (de)	2010-01-20	Antihypercholesterinämische verbindungen
PL1999281T3 (pl)	2012-11-30	Ulepszona pionowa
ITMO20050173A1 (it)	2007-01-09	Manufatto per edilizia.
FI20051092L (fi)	2007-04-29	Hevosenkenkä
ITRM20060484A1 (it)	2008-03-14	Liquore di pinoli
FI20050482A0 (fi)	2005-05-06	Ohjauspuomi