ATE476417T1 - Verfahren zur herstellung von carvedilol - Google Patents

Verfahren zur herstellung von carvedilol

Info

Publication number
ATE476417T1
ATE476417T1 AT05744187T AT05744187T ATE476417T1 AT E476417 T1 ATE476417 T1 AT E476417T1 AT 05744187 T AT05744187 T AT 05744187T AT 05744187 T AT05744187 T AT 05744187T AT E476417 T1 ATE476417 T1 AT E476417T1
Authority
AT
Austria
Prior art keywords
formula
carvedilol
yield
enantiomeric
benzylamine
Prior art date
Application number
AT05744187T
Other languages
English (en)
Inventor
Rajendra Narayanrao Kankan
Dharmaraj Ramachandra Rao
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Application granted granted Critical
Publication of ATE476417T1 publication Critical patent/ATE476417T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT05744187T 2004-05-20 2005-05-19 Verfahren zur herstellung von carvedilol ATE476417T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0411273.6A GB0411273D0 (en) 2004-05-20 2004-05-20 Process and product
PCT/GB2005/001978 WO2005113502A1 (en) 2004-05-20 2005-05-19 Process for the preparation of carvedilol

Publications (1)

Publication Number Publication Date
ATE476417T1 true ATE476417T1 (de) 2010-08-15

Family

ID=32607663

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05744187T ATE476417T1 (de) 2004-05-20 2005-05-19 Verfahren zur herstellung von carvedilol

Country Status (12)

Country Link
US (1) US7705163B2 (de)
EP (1) EP1756057B1 (de)
JP (1) JP5118963B2 (de)
KR (1) KR101184920B1 (de)
AT (1) ATE476417T1 (de)
AU (1) AU2005245182B2 (de)
CA (1) CA2566197C (de)
DE (1) DE602005022707D1 (de)
GB (1) GB0411273D0 (de)
NZ (1) NZ551119A (de)
WO (1) WO2005113502A1 (de)
ZA (1) ZA200609206B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004501191A (ja) 2000-06-28 2004-01-15 テバ　ファーマシューティカル　インダストリーズ　リミティド カルベジロール
MXPA04006909A (es) 2002-01-15 2005-04-19 Teva Pharma Solidos cristalinos de carvedilol y procesos para su preparacion.
KR100746455B1 (ko) * 2006-02-23 2007-08-03 안국약품 주식회사 고광학순도의 키랄 카베딜롤의 제조방법
WO2008002683A2 (en) 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Polymorphous forms of carvedilol phosphate
WO2009116069A2 (en) * 2008-02-04 2009-09-24 Ipca Laboratories Limited Process for preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(2- methoxyphenoxy) ethyl] amino]-2-propanol
CN102190613B (zh) * 2010-03-14 2014-06-25 浙江华海药业股份有限公司 一种卡维地洛的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2928483C2 (de) * 1979-07-14 1980-12-11 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Herstellung von 4-Hydroxy-carbazol
DE3319027A1 (de) * 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten
HU227441B1 (en) * 1997-11-24 2011-06-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing carvedilol, enantiomers and salts thereof
MXPA02002283A (es) 1999-09-03 2002-07-30 Asahi Chemical Ind Proceso para preparar derivados triciclicos de amino alcoholes.
JP2004501191A (ja) * 2000-06-28 2004-01-15 テバ　ファーマシューティカル　インダストリーズ　リミティド カルベジロール
MXPA03006606A (es) 2001-01-25 2003-09-22 Hoffmann La Roche Proceso para preparacion de analogos de indeno heterociclico.
SK285547B6 (sk) * 2002-11-08 2007-03-01 Zentiva, A. S. Spôsob prípravy Carvedilolu
US7482471B2 (en) * 2003-06-20 2009-01-27 Sun Pharmaceutical Industries Limited Process for preparation of 1-[9H-carbazol-4-yloxy]-3-[{2-(2-(-methoxy)phenoxy)-ethyl}-amino]-propan-2-ol

Also Published As

Publication number Publication date
ZA200609206B (en) 2008-05-28
JP2007538061A (ja) 2007-12-27
CA2566197C (en) 2013-01-22
NZ551119A (en) 2010-04-30
WO2005113502A1 (en) 2005-12-01
JP5118963B2 (ja) 2013-01-16
CA2566197A1 (en) 2005-12-01
KR101184920B1 (ko) 2012-09-28
US7705163B2 (en) 2010-04-27
KR20070026607A (ko) 2007-03-08
DE602005022707D1 (de) 2010-09-16
US20080234492A1 (en) 2008-09-25
EP1756057B1 (de) 2010-08-04
AU2005245182A1 (en) 2005-12-01
EP1756057A1 (de) 2007-02-28
GB0411273D0 (en) 2004-06-23
AU2005245182B2 (en) 2011-08-04

Similar Documents

Publication Publication Date Title
US10308604B2 (en) Method for producing pyrrole derivative, and intermediate thereof
RU2008107336A (ru) Новые 1-арил-з-азабицикло{3.1.0.} гексаны: получение и применение для лечения психоневрологических расстройств
Nenajdenko et al. A new convenient approach to chiral β-aryl (heteroaryl) alkylamines
CN1037101C (zh) 4－取代的1,2,4－三唑衍生物、其制备方法及其用途
JPH10507464A (ja) レボブピバカインとその類似体の晶出
JP4015696B2 (ja) レボブピバカインと同類のピペリジンカルボキサニリド麻酔剤の製造に用いるラセミ化法
ATE476417T1 (de) Verfahren zur herstellung von carvedilol
CA2438854A1 (en) Method of preparing non-hydrated fexofenadine hydrochloride and novel crystalline form obtainable by this method
WO1998031669A1 (fr) Nouvelles arylpiperazines derivees de piperidine comme medicaments antidepresseurs
CA2297279C (fr) Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1873140B1 (de) Neue Naphtalinderivate, ihr Herstellungsverfahren und die pharmazeutischen Zusammensetzungen, die sie enthalten
CN1047167C (zh) 用于制备毒扁豆碱的中间体的对映选择性合成方法
CA2378628C (fr) Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2006058993A1 (fr) Derives d’arylpiperazine et leur utilisation comme ligands selectifs du recepteur d3 de la dopamine
WO2008000967A1 (fr) Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP3171260B2 (ja) 中間体としての置換３−アザビシクロ［３．２．０］ヘプタン−誘導体
EP2086933A2 (de) Neuartige indolderivate, herstellungsverfahren dafür und pharmazeutische zusammensetzungen damit
RU2006105711A (ru) Производные 2, 4-(гидроксиметилфениламино)пиперидин-1-ил-n-(9h-карбазол-3-ил) ацетамина и родственные им соединения в качестве лигандов нейропептида y 5 (npy5), предназначенные для лечения ожирения
EP1119564B1 (de) Aryl-4-fluoro-4-(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl-methanone derivate als 5-ht1-rezeptor-agonisten
FR2761069A1 (fr) Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments
FR2918369A1 (fr) Nouveaux derives naphtaleniques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2754261A1 (fr) Derives de quinuclidine, leur preparation et leur application en therapeutique
JPWO2004065368A1 (ja) トランドラプリル合成中間体の製造方法
KR20180073113A (ko) N-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 거울상 이성질체들의 라세미화 방법
CN1199398A (zh) 1－[2－(2,3－二氢－1h－茚－1－基)乙基]－4－(萘－1基)哌嗪衍生物,它们的制备方法及其在治疗中的应用

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties