ATE476506T1 - Modulatoren des cholesterinbiosynthesewegs und verwendungen davon - Google Patents

Modulatoren des cholesterinbiosynthesewegs und verwendungen davon

Info

Publication number: ATE476506T1
Authority: AT; Austria
Prior art keywords: cholesterol; fragment; variant; derivative; seq
Prior art date: 2003-06-05

Application number

AT04736173T

Other languages

English (en)

Inventor

Kandiah Jeyaseelan

Arunmozhiarasi Armugam

Siaw Ching Chai

Prabhakaran N Ramkishen

Ponnampalam Gopalakrishnakone

Kwong Huat Tan

Original Assignee

Univ Singapore

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-05

Filing date

2004-06-04

Publication date

2010-08-15

2004-06-04 Application filed by Univ Singapore filed Critical Univ Singapore

2010-08-15 Application granted granted Critical

2010-08-15 Publication of ATE476506T1 publication Critical patent/ATE476506T1/de

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 9
235000012000 cholesterol Nutrition 0.000 title abstract 4
230000006696 biosynthetic metabolic pathway Effects 0.000 title abstract 2
239000012634 fragment Substances 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 2
238000009825 accumulation Methods 0.000 abstract 2
125000003275 alpha amino acid group Chemical group 0.000 abstract 2
OKZYCXHTTZZYSK-ZCFIWIBFSA-N (R)-5-phosphomevalonic acid Chemical compound OC(=O)C[C@@](O)(C)CCOP(O)(O)=O OKZYCXHTTZZYSK-ZCFIWIBFSA-N 0.000 abstract 1
229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Insects & Arthropods (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Tropical Medicine & Parasitology (AREA)
Toxicology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Peptides Or Proteins (AREA)

AT04736173T 2003-06-05 2004-06-04 Modulatoren des cholesterinbiosynthesewegs und verwendungen davon ATE476506T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US47620803P	2003-06-05	2003-06-05
PCT/SG2004/000168 WO2004108928A1 (en)	2003-06-05	2004-06-04	Cholesterol biosynthesis pathway modulators and uses thereof

Publications (1)

Publication Number	Publication Date
ATE476506T1 true ATE476506T1 (de)	2010-08-15

Family

ID=33511764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04736173T ATE476506T1 (de)	2003-06-05	2004-06-04	Modulatoren des cholesterinbiosynthesewegs und verwendungen davon

Country Status (5)

Country	Link
US (1)	US20060222638A1 (de)
EP (1)	EP1636365B1 (de)
AT (1)	ATE476506T1 (de)
DE (1)	DE602004028469D1 (de)
WO (1)	WO2004108928A1 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5622985A (en) *	1990-06-11	1997-04-22	Bristol-Myers Squibb Company	Method for preventing a second heart attack employing an HMG CoA reductase inhibitor
US6369103B1 (en) *	1994-01-18	2002-04-09	Bristol-Myers Squibb Company	Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
US5902805A (en) *	1996-04-22	1999-05-11	L'oreal	Method for treatment of acne and/or the effects of ageing using HMG-coenzyme A-reductase inhibitor and compositions for performing the same

2004
- 2004-06-04 AT AT04736173T patent/ATE476506T1/de not_active IP Right Cessation
- 2004-06-04 EP EP04736173A patent/EP1636365B1/de not_active Expired - Lifetime
- 2004-06-04 US US10/559,649 patent/US20060222638A1/en not_active Abandoned
- 2004-06-04 WO PCT/SG2004/000168 patent/WO2004108928A1/en not_active Ceased
- 2004-06-04 DE DE602004028469T patent/DE602004028469D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1636365B1 (de)	2010-08-04
US20060222638A1 (en)	2006-10-05
DE602004028469D1 (de)	2010-09-16
WO2004108928A1 (en)	2004-12-16
EP1636365A1 (de)	2006-03-22

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Legal Events

Date	Code	Title	Description
2011-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties