ATE476751T1 - Piezoelektrisch geladene tröpfchenquelle - Google Patents
Piezoelektrisch geladene tröpfchenquelleInfo
- Publication number
- ATE476751T1 ATE476751T1 AT02725459T AT02725459T ATE476751T1 AT E476751 T1 ATE476751 T1 AT E476751T1 AT 02725459 T AT02725459 T AT 02725459T AT 02725459 T AT02725459 T AT 02725459T AT E476751 T1 ATE476751 T1 AT E476751T1
- Authority
- AT
- Austria
- Prior art keywords
- ion sources
- relates
- mass
- charged droplet
- sources
- Prior art date
Links
- 239000002245 particle Substances 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 230000037427 ion transport Effects 0.000 abstract 1
- 238000004949 mass spectrometry Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 238000010183 spectrum analysis Methods 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
- H01J49/0454—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for vaporising using mechanical energy, e.g. by ultrasonic vibrations
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
- H01J49/167—Capillaries and nozzles specially adapted therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
- Pyrane Compounds (AREA)
- Chair Legs, Seat Parts, And Backrests (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28063201P | 2001-03-29 | 2001-03-29 | |
| PCT/US2002/010182 WO2002080223A1 (en) | 2001-03-29 | 2002-03-29 | Piezoelectric charged droplet source |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE476751T1 true ATE476751T1 (de) | 2010-08-15 |
Family
ID=23073932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02725459T ATE476751T1 (de) | 2001-03-29 | 2002-03-29 | Piezoelektrisch geladene tröpfchenquelle |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6906322B2 (de) |
| EP (1) | EP1380045B1 (de) |
| AT (1) | ATE476751T1 (de) |
| CA (1) | CA2440833C (de) |
| DE (1) | DE60237196D1 (de) |
| WO (1) | WO2002080223A1 (de) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7470547B2 (en) * | 2003-07-31 | 2008-12-30 | Biodot, Inc. | Methods and systems for dispensing sub-microfluidic drops |
| EP1282910B1 (de) * | 2000-04-18 | 2017-04-05 | Waters Technologies Corporation | Verbesserte elektrospray- und andere lc-/ms-schnittstellen |
| NL1016030C1 (nl) | 2000-08-28 | 2002-03-01 | Aquamarijn Holding B V | Sproei inrichting met een nozzleplaat, een nozzleplaat, alsmede werkwijzen ter vervaardiging en voor toepassing van een dergelijke nozzleplaat. |
| US20020106308A1 (en) * | 2001-02-02 | 2002-08-08 | Zweifel Ronald A. | Microdrop dispensing apparatus |
| ATE476751T1 (de) | 2001-03-29 | 2010-08-15 | Wisconsin Alumni Res Found | Piezoelektrisch geladene tröpfchenquelle |
| US6777671B2 (en) * | 2001-04-10 | 2004-08-17 | Science & Engineering Services, Inc. | Time-of-flight/ion trap mass spectrometer, a method, and a computer program product to use the same |
| US20030209005A1 (en) * | 2002-05-13 | 2003-11-13 | Fenn John Bennett | Wick injection of liquids for colloidal propulsion |
| US6906319B2 (en) * | 2002-05-17 | 2005-06-14 | Micromass Uk Limited | Mass spectrometer |
| US7368728B2 (en) * | 2002-10-10 | 2008-05-06 | Universita' Degli Studi Di Milano | Ionization source for mass spectrometry analysis |
| US7078679B2 (en) | 2002-11-27 | 2006-07-18 | Wisconsin Alumni Research Foundation | Inductive detection for mass spectrometry |
| US6827287B2 (en) * | 2002-12-24 | 2004-12-07 | Palo Alto Research Center, Incorporated | High throughput method and apparatus for introducing biological samples into analytical instruments |
| US7208727B2 (en) * | 2003-01-14 | 2007-04-24 | Georgia Tech Research Corporation | Electrospray systems and methods |
| GB0308021D0 (en) | 2003-04-07 | 2003-05-14 | Aerstream Technology Ltd | Spray electrode |
| US7091477B2 (en) * | 2003-06-09 | 2006-08-15 | Ionica Mass Spectrometry Group, Inc. | Mass spectrometer interface |
| EP1654346B1 (de) * | 2003-06-12 | 2017-08-02 | Accupath Diagnostic Laboratories, Inc. | Verfahren und system zur analyse von proben von zellen mit hoher dichte |
| FR2857451B1 (fr) * | 2003-07-11 | 2005-09-30 | Commissariat Energie Atomique | Procede et dispositif pour l'analyse de milieux reactionnels vivants |
| US6943346B2 (en) * | 2003-08-13 | 2005-09-13 | Science & Engineering Services, Inc. | Method and apparatus for mass spectrometry analysis of aerosol particles at atmospheric pressure |
| US8212206B2 (en) * | 2003-09-04 | 2012-07-03 | Griffin Analytical Technologies, L.L.C. | Analysis methods, analysis device waveform generation methods, analysis devices, and articles of manufacture |
| DE10350614B4 (de) * | 2003-10-30 | 2007-11-29 | Bruker Daltonik Gmbh | Dispenser |
| KR100543176B1 (ko) * | 2003-11-06 | 2006-01-20 | 한국기계연구원 | 나노 패터닝용 프린팅헤드 장치 |
| DE10361903A1 (de) * | 2003-12-22 | 2005-07-28 | Carl Zeiss Jena Gmbh | Verfahren zur spektroskopischen Analyse einer biologischen oder chemischen Substanz |
| WO2005065307A2 (en) * | 2003-12-31 | 2005-07-21 | Ionwerks, Inc. | Maldi-im-ortho-tof mass spectrometry with simultaneaous positive and negative mode detection |
| US8003934B2 (en) * | 2004-02-23 | 2011-08-23 | Andreas Hieke | Methods and apparatus for ion sources, ion control and ion measurement for macromolecules |
| DE102004014618B3 (de) * | 2004-03-23 | 2005-11-10 | Eads Space Transportation Gmbh | Elektrothermisches Impuls-Triebwerk |
| JP4379473B2 (ja) * | 2004-04-23 | 2009-12-09 | パナソニック電工株式会社 | 静電霧化器を備えた加熱送風装置 |
| DE102004022950A1 (de) * | 2004-05-10 | 2005-12-08 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren und Vorrichtung zur Manipulation und Analyse tropfenförmiger Proben im Vakuum |
| US20070258861A1 (en) * | 2004-06-15 | 2007-11-08 | Barket Dennis Jr | Analytical Instruments, Assemblies, and Methods |
| US20060110833A1 (en) * | 2004-09-09 | 2006-05-25 | Agnes George R | Method and apparatus for coupling an analyte supply to an electrodynamic droplet processor |
| US7642511B2 (en) * | 2004-09-30 | 2010-01-05 | Ut-Battelle, Llc | Ultra high mass range mass spectrometer systems |
| US7388195B2 (en) * | 2004-09-30 | 2008-06-17 | Charles Stark Draper Laboratory, Inc. | Apparatus and systems for processing samples for analysis via ion mobility spectrometry |
| US6972408B1 (en) * | 2004-09-30 | 2005-12-06 | Ut-Battelle, Llc | Ultra high mass range mass spectrometer systems |
| GB0424426D0 (en) * | 2004-11-04 | 2004-12-08 | Micromass Ltd | Mass spectrometer |
| US7476851B2 (en) * | 2004-11-12 | 2009-01-13 | Regents Of The University Of Minnesota | Aerodynamic focusing of nanoparticle or cluster beams |
| US20060210443A1 (en) | 2005-03-14 | 2006-09-21 | Stearns Richard G | Avoidance of bouncing and splashing in droplet-based fluid transport |
| WO2006116564A2 (en) | 2005-04-25 | 2006-11-02 | Griffin Analytical Technologies, L.L.C. | Analytical instrumentation, appartuses, and methods |
| KR20080033259A (ko) * | 2005-06-17 | 2008-04-16 | 로렌스 리버모어 내쇼날 시큐리티, 엘엘시 | 에어로졸 포커싱 디바이스용 압력-플로우 감소기 |
| US20070001114A1 (en) * | 2005-06-29 | 2007-01-04 | Goodley Paul C | Apparatus and method for ion capture and production |
| US7645987B2 (en) * | 2005-09-22 | 2010-01-12 | Academia Sinica | Acoustic desorption mass spectrometry |
| US7518108B2 (en) * | 2005-11-10 | 2009-04-14 | Wisconsin Alumni Research Foundation | Electrospray ionization ion source with tunable charge reduction |
| JP5555428B2 (ja) * | 2006-02-08 | 2014-07-23 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 無線周波数イオンガイド |
| US7982070B2 (en) * | 2006-03-21 | 2011-07-19 | Wisconsin Alumni Research Foundation | Ionizable isotopic labeling reagents for relative quantification by mass spectrometry |
| KR100802139B1 (ko) * | 2006-08-08 | 2008-02-11 | 한국생명공학연구원 | 자성 나노입자를 함유하는 골드 나노케이지 |
| US7992424B1 (en) | 2006-09-14 | 2011-08-09 | Griffin Analytical Technologies, L.L.C. | Analytical instrumentation and sample analysis methods |
| JP2010504504A (ja) * | 2006-09-25 | 2010-02-12 | エムディーエス アナリティカル テクノロジーズ, ア ビジネス ユニット オブ エムディーエス インコーポレイテッド, ドゥーイング ビジネス スルー イッツ サイエックス ディビジョン | 質量分析計とともに使用するための複数の試料供給源、ならびにそのための装置、デバイスおよび方法 |
| CN101606220B (zh) * | 2006-11-07 | 2012-08-29 | 塞莫费雪科学(不来梅)有限公司 | 离子迁移装置 |
| US20090283674A1 (en) * | 2006-11-07 | 2009-11-19 | Reinhold Pesch | Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method |
| US7982183B2 (en) * | 2006-11-07 | 2011-07-19 | Thermo Fisher Scientific (Bremen) Gmbh | Ion transfer tube with spatially alternating DC fields |
| US7909897B2 (en) | 2006-11-28 | 2011-03-22 | Georgia Tech Research Corporation | Droplet impingement chemical reactors and methods of processing fuel |
| US20080227663A1 (en) | 2007-01-19 | 2008-09-18 | Biodot, Inc. | Systems and methods for high speed array printing and hybridization |
| US20090078064A1 (en) * | 2007-08-06 | 2009-03-26 | Abraham Oommen | Instrument for simultaneous analysis of multiple samples using multiple differential mobility analyzers |
| US8217345B2 (en) * | 2007-10-18 | 2012-07-10 | Dh Technologies Development Pte. Ltd. | Interface between differential mobility analyzer and mass spectrometer |
| DE102007052500A1 (de) * | 2007-11-02 | 2009-06-04 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Verfahren und Vorrichtung für den Nachweis von mindestens einer Zielsubstanz |
| US8502507B1 (en) | 2012-03-29 | 2013-08-06 | Accio Energy, Inc. | Electro-hydrodynamic system |
| DE102009007265B4 (de) * | 2009-02-03 | 2011-07-28 | Bruker Daltonik GmbH, 28359 | Tröpfchen- und Ionenführung in einer Elektrosprüh-Ionenquelle |
| US8592216B2 (en) * | 2009-04-15 | 2013-11-26 | Wisconsin Alumni Research Foundation | Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis |
| US20160368006A9 (en) * | 2009-04-29 | 2016-12-22 | Accio Energy, Inc. | Wave electro-hydrodynamic device |
| US8561486B2 (en) * | 2009-07-13 | 2013-10-22 | Enertechnix, Inc | Particle interrogation devices and methods |
| US8307723B2 (en) * | 2009-07-13 | 2012-11-13 | Enertechnix, Inc. | Particle interrogation devices and methods |
| US20110203931A1 (en) * | 2009-07-13 | 2011-08-25 | Enertechnix, Inc | Particle Interrogation Devices and Methods |
| DE102009037715B4 (de) * | 2009-08-17 | 2012-04-26 | Bruker Daltonik Gmbh | Führung von Sprühtröpfchen zur Einlasskapillare eines Massenspektrometers |
| US8399828B2 (en) * | 2009-12-31 | 2013-03-19 | Virgin Instruments Corporation | Merged ion beam tandem TOF-TOF mass spectrometer |
| US20110196657A1 (en) * | 2010-02-11 | 2011-08-11 | Jie Zhang | Solving a Solute Lubrication Equation for 3D Droplet Evaporation on a Complicated OLED Bank Structure |
| EP2561333B1 (de) | 2010-04-19 | 2015-11-25 | Battelle Memorial Institute | Elektrohydrodynamisches sprühen |
| EP2405463A1 (de) * | 2010-07-06 | 2012-01-11 | ETH Zurich | Ionenquelle für Laserablation mit Ionentrichter |
| US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
| EP2612344A2 (de) * | 2010-09-01 | 2013-07-10 | DH Technologies Development Pte. Ltd. | Ionenquelle für massenspektrometrie |
| WO2012100205A2 (en) | 2011-01-21 | 2012-07-26 | Biodot, Inc. | Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube |
| DE102012102875B4 (de) * | 2011-04-04 | 2024-04-18 | Wisconsin Alumni Research Foundation | Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben |
| JP5537487B2 (ja) * | 2011-04-12 | 2014-07-02 | 日本特殊陶業株式会社 | 微粒子検知システム |
| EP2776822B1 (de) * | 2011-10-26 | 2016-09-21 | DH Technologies Development Pte. Ltd. | Quantifizierung eines analyten im serum und anderen biologischen matrizen |
| GB201120143D0 (en) * | 2011-11-22 | 2012-01-04 | Micromass Ltd | Droplet manipulation using gas-phase standing-wave ultrasound fields in MS sources |
| US9279798B2 (en) | 2012-05-29 | 2016-03-08 | Biodesix, Inc. | Deep-MALDI TOF mass spectrometry of complex biological samples, e.g., serum, and uses thereof |
| CN104769410B (zh) | 2012-11-06 | 2018-07-27 | 拜奥-多特公司 | 用于核型分析的细胞样本的受控印刷 |
| FR3003083B1 (fr) * | 2013-03-11 | 2015-04-10 | Commissariat Energie Atomique | Dispositif de determination de la masse d'une particule en suspension ou en solution dans un fluide |
| JP6423878B2 (ja) * | 2013-08-07 | 2018-11-14 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 液体サンプルのための増大された噴霧形成 |
| WO2015127277A1 (en) * | 2014-02-20 | 2015-08-27 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Method for guiding cell spreading in automated cytogenetic assays |
| US11148164B2 (en) | 2014-07-25 | 2021-10-19 | Biodot, Inc. | Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube |
| CN113230021A (zh) * | 2015-01-12 | 2021-08-10 | 科达莱昂治疗公司 | 微滴递送设备和方法 |
| AU2016246060B2 (en) * | 2015-04-10 | 2020-10-22 | Bausch + Lomb Ireland Limited | Piezoelectric dispenser with replaceable ampoule |
| JP6335861B2 (ja) * | 2015-10-27 | 2018-05-30 | 日本特殊陶業株式会社 | 微粒子測定システム |
| US20180076014A1 (en) * | 2016-09-09 | 2018-03-15 | Science And Engineering Services, Llc | Sub-atmospheric pressure laser ionization source using an ion funnel |
| US10888454B2 (en) * | 2017-01-20 | 2021-01-12 | Kedalion Therapeutics, Inc. | Piezoelectric fluid dispenser |
| WO2018227079A1 (en) * | 2017-06-08 | 2018-12-13 | Board Of Regents, The University Of Texas System | Systems and methods for microarray droplet ionization analysis |
| KR102643190B1 (ko) | 2017-06-10 | 2024-03-04 | 아이노비아 인코포레이티드 | 유체를 취급하기 위한, 그리고 눈에 유체를 전달하기 위한 디바이스들 |
| CN111194475B (zh) * | 2017-10-27 | 2023-01-24 | 株式会社岛津制作所 | Esi喷雾器用管和esi喷雾器 |
| AU2018380433B2 (en) | 2017-12-08 | 2024-10-10 | Bausch + Lomb Ireland Limited | Fluid delivery alignment system |
| US20190314198A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| US12350194B1 (en) | 2018-04-12 | 2025-07-08 | Bausch + Lomb Ireland Limited | Topical ocular delivery of fluids with controlled mass dosing and wireless communication |
| US11798796B2 (en) * | 2018-06-15 | 2023-10-24 | University Of New Hampshire | Preconcentrating of environmental contaminant analytes for ambient ionization mass spectrometry |
| AU2019297326B2 (en) | 2018-07-03 | 2025-01-09 | Bausch + Lomb Ireland Limited | Topical ocular delivery devices and methods for using the same |
| US12280376B2 (en) * | 2019-02-07 | 2025-04-22 | University Of Washington | Devices and systems for droplet generation and methods for generating droplets |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
| US10763072B1 (en) * | 2019-03-15 | 2020-09-01 | Applied Materials, Inc. | Apparatus, system and techniques for mass analyzed ion beam |
| CN111403259A (zh) * | 2019-10-24 | 2020-07-10 | 宁波华仪宁创智能科技有限公司 | 液滴喷射方法 |
| US12496218B1 (en) | 2019-11-12 | 2025-12-16 | Bausch + Lomb Ireland Limited | Fractionated topical ocular drug delivery methods and devices for use in the same |
| CN115038414A (zh) | 2019-12-11 | 2022-09-09 | 艾诺维亚股份有限公司 | 用于向眼睛输送流体的系统和装置及使用方法 |
| BR112022020948A2 (pt) | 2020-04-17 | 2023-04-11 | Kedallion Therapeutics Inc | Sistema de distribuição livre de conservantes hidrodinamicamente atuado |
| WO2021212038A1 (en) | 2020-04-17 | 2021-10-21 | Kedalion Therapeutics, Inc. | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| US12290472B2 (en) | 2020-04-17 | 2025-05-06 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| US11651945B2 (en) | 2020-09-25 | 2023-05-16 | Ut-Battelle, Llc | Rapid droplet introduction interface (RDII) for mass spectrometry |
| CN113996354B (zh) * | 2021-10-25 | 2023-03-24 | 苏州缔因安生物科技有限公司 | 一种控制微液滴生成装置、生成方法及用途 |
| CN113996353A (zh) * | 2021-10-25 | 2022-02-01 | 苏州缔因安生物科技有限公司 | 一种微滴生成装置、生成方法及用途 |
| WO2023108163A1 (en) * | 2021-12-10 | 2023-06-15 | Ion Dx, Inc. | Apparatus and methods for depositing ions onto a surface |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US35494A (en) * | 1862-06-03 | Improvement in stoves | ||
| US125423A (en) * | 1872-04-09 | Improvement in machines for making horseshoe-nails | ||
| US158196A (en) * | 1874-12-29 | Improvement in derricks for hoisting cans containing fluids | ||
| US3298030A (en) * | 1965-07-12 | 1967-01-10 | Clevite Corp | Electrically operated character printer |
| US3683212A (en) | 1970-09-09 | 1972-08-08 | Clevite Corp | Pulsed droplet ejecting system |
| US3857049A (en) | 1972-06-05 | 1974-12-24 | Gould Inc | Pulsed droplet ejecting system |
| US4461155A (en) | 1979-09-10 | 1984-07-24 | Bertil Werjefelt | Aircraft cabin ventilation system |
| US4352570A (en) | 1980-05-27 | 1982-10-05 | Applied Plastics Co., Inc. | Vibratory treatment apparatus and method |
| US4383171A (en) * | 1980-11-17 | 1983-05-10 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Particle analyzing method and apparatus |
| US4492322A (en) | 1982-04-30 | 1985-01-08 | Indiana University Foundation | Device for the accurate dispensing of small volumes of liquid samples |
| JPS5935347A (ja) | 1982-08-20 | 1984-02-27 | Masahiko Tsuchiya | イオン生成装置 |
| DE3478202D1 (en) | 1983-01-06 | 1989-06-22 | Nat Res Dev | Electrostatic spray head |
| GB8305865D0 (en) * | 1983-03-03 | 1983-04-07 | British Res Agricult Eng | Electrostatic sprayers |
| US4924097A (en) | 1984-06-22 | 1990-05-08 | Georgia Tech Rss. Corp | Monodisperse aerosol generator for use with infrared spectrometry |
| US4762995A (en) * | 1984-06-22 | 1988-08-09 | Georgia Tech Research Corporation | Monodisperse aerosol generator |
| US5175433A (en) * | 1984-06-22 | 1992-12-29 | Georgia Tech Research Corporation | Monodisperse aerosol generator for use with infrared spectrometry |
| US4580148A (en) | 1985-02-19 | 1986-04-01 | Xerox Corporation | Thermal ink jet printer with droplet ejection by bubble collapse |
| US4667100A (en) * | 1985-04-17 | 1987-05-19 | Lagna William M | Methods and apparatus for mass spectrometric analysis of fluids |
| US4761545A (en) * | 1986-05-23 | 1988-08-02 | The Ohio State University Research Foundation | Tailored excitation for trapped ion mass spectrometry |
| US4935624A (en) * | 1987-09-30 | 1990-06-19 | Cornell Research Foundation, Inc. | Thermal-assisted electrospray interface (TAESI) for LC/MS |
| USRE34757E (en) * | 1988-04-05 | 1994-10-18 | Battelle Memorial Institute | Combined electrophoresis-electrospray interface and method |
| US4845512A (en) | 1988-10-12 | 1989-07-04 | Videojet Systems International, Inc. | Drop deflection device and method for drop marking systems |
| US4883958A (en) * | 1988-12-16 | 1989-11-28 | Vestec Corporation | Interface for coupling liquid chromatography to solid or gas phase detectors |
| US5073713A (en) | 1990-05-29 | 1991-12-17 | Battelle Memorial Institute | Detection method for dissociation of multiple-charged ions |
| US5076097A (en) | 1990-06-28 | 1991-12-31 | Tsi Incorporated | Method and apparatus for determining concentration of macromolecules and colloids in a liquid sample |
| AU2170392A (en) * | 1991-05-21 | 1992-12-30 | Analytica Of Branford, Inc. | Method and apparatus for improving electrospray ionization of solute species |
| US5247842A (en) * | 1991-09-30 | 1993-09-28 | Tsi Incorporated | Electrospray apparatus for producing uniform submicrometer droplets |
| US5192865A (en) | 1992-01-14 | 1993-03-09 | Cetac Technologies Inc. | Atmospheric pressure afterglow ionization system and method of use, for mass spectrometer sample analysis systems |
| US5270542A (en) * | 1992-12-31 | 1993-12-14 | Regents Of The University Of Minnesota | Apparatus and method for shaping and detecting a particle beam |
| US5359196A (en) * | 1993-05-24 | 1994-10-25 | Hewlett-Packard Company | Mass spectrometry with gas counterflow for particle beam |
| DE69430196T2 (de) | 1993-06-29 | 2002-10-31 | Ponwell Enterprises Ltd., Hongkong | Spender |
| US5448062A (en) * | 1993-08-30 | 1995-09-05 | Mims Technology Development Co. | Analyte separation process and apparatus |
| US5403617A (en) | 1993-09-15 | 1995-04-04 | Mobium Enterprises Corporation | Hybrid pulsed valve for thin film coating and method |
| US5504327A (en) | 1993-11-04 | 1996-04-02 | Hv Ops, Inc. (H-Nu) | Electrospray ionization source and method for mass spectrometric analysis |
| US5611846A (en) * | 1994-01-14 | 1997-03-18 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Portable gas chromatograph |
| US5608217A (en) * | 1994-03-10 | 1997-03-04 | Bruker-Franzen Analytik Gmbh | Electrospraying method for mass spectrometric analysis |
| US5750988A (en) | 1994-07-11 | 1998-05-12 | Hewlett-Packard Company | Orthogonal ion sampling for APCI mass spectrometry |
| US5560543A (en) * | 1994-09-19 | 1996-10-01 | Board Of Regents, The University Of Texas System | Heat-resistant broad-bandwidth liquid droplet generators |
| US6558633B1 (en) | 1994-09-21 | 2003-05-06 | Isis Pharmaceuticals, Inc. | Chemical reaction apparatus and methods |
| US5614711A (en) | 1995-05-04 | 1997-03-25 | Indiana University Foundation | Time-of-flight mass spectrometer |
| US5565677A (en) * | 1995-08-04 | 1996-10-15 | The University Of Delaware | Aerodynamic nozzle for aerosol particle beam formation into a vacuum |
| US6278111B1 (en) | 1995-08-21 | 2001-08-21 | Waters Investments Limited | Electrospray for chemical analysis |
| US5838002A (en) | 1996-08-21 | 1998-11-17 | Chem-Space Associates, Inc | Method and apparatus for improved electrospray analysis |
| US5922976A (en) | 1995-10-12 | 1999-07-13 | California Institute Of Technology | Method of measuring aerosol particles using automated mobility-classified aerosol detector |
| US5767512A (en) * | 1996-01-05 | 1998-06-16 | Battelle Memorial Institute | Method for reduction of selected ion intensities in confined ion beams |
| US5873523A (en) | 1996-02-29 | 1999-02-23 | Yale University | Electrospray employing corona-assisted cone-jet mode |
| US5958342A (en) | 1996-05-17 | 1999-09-28 | Incyte Pharmaceuticals, Inc. | Jet droplet device |
| US5945678A (en) | 1996-05-21 | 1999-08-31 | Hamamatsu Photonics K.K. | Ionizing analysis apparatus |
| US6469295B1 (en) * | 1997-05-30 | 2002-10-22 | Bruker Daltonics Inc. | Multiple reflection time-of-flight mass spectrometer |
| US6433154B1 (en) | 1997-06-12 | 2002-08-13 | Bristol-Myers Squibb Company | Functional receptor/kinase chimera in yeast cells |
| US6027699A (en) | 1997-07-28 | 2000-02-22 | Lockheed Martin Energy Research Corp. | Material forming apparatus using a directed droplet stream |
| US5965883A (en) | 1997-08-25 | 1999-10-12 | California Institute Of Technology | Capillary for electrospray ion source |
| CA2299439C (en) | 1997-09-12 | 2007-08-14 | Bruce A. Andrien | Multiple sample introduction mass spectrometry |
| US6051189A (en) | 1997-10-01 | 2000-04-18 | The United States Of America As Represented By The Secretary Of The Army | System and method for detection, identification and monitoring of submicron-sized particles |
| US5973904A (en) | 1997-10-10 | 1999-10-26 | Regents Of The University Of Minnesota | Particle charging apparatus and method of charging particles |
| US6331702B1 (en) | 1999-01-25 | 2001-12-18 | University Of Manitoba | Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use |
| US5992244A (en) | 1998-03-04 | 1999-11-30 | Regents Of The University Of Minnesota | Charged particle neutralizing apparatus and method of neutralizing charged particles |
| US6107628A (en) * | 1998-06-03 | 2000-08-22 | Battelle Memorial Institute | Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum |
| AU1704200A (en) | 1998-09-23 | 2000-04-10 | Wisconsin Alumni Research Foundation | Charge reduction in electrospray mass spectrometry |
| US6359275B1 (en) * | 1999-07-14 | 2002-03-19 | Agilent Technologies, Inc. | Dielectric conduit with end electrodes |
| US6815668B2 (en) | 1999-07-21 | 2004-11-09 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry |
| US6787764B2 (en) * | 2000-02-18 | 2004-09-07 | Bruker Daltonics, Inc. | Method and apparatus for automating a matrix-assisted laser desorption/ionization (MALDI) mass spectrometer |
| US6396057B1 (en) * | 2000-04-18 | 2002-05-28 | Waters Investments Limited | Electrospray and other LC/MS interfaces |
| US6593570B2 (en) * | 2000-05-24 | 2003-07-15 | Agilent Technologies, Inc. | Ion optic components for mass spectrometers |
| US6649907B2 (en) | 2001-03-08 | 2003-11-18 | Wisconsin Alumni Research Foundation | Charge reduction electrospray ionization ion source |
| ATE476751T1 (de) | 2001-03-29 | 2010-08-15 | Wisconsin Alumni Res Found | Piezoelektrisch geladene tröpfchenquelle |
-
2002
- 2002-03-29 AT AT02725459T patent/ATE476751T1/de not_active IP Right Cessation
- 2002-03-29 US US10/113,897 patent/US6906322B2/en not_active Expired - Lifetime
- 2002-03-29 US US10/113,956 patent/US6797945B2/en not_active Expired - Lifetime
- 2002-03-29 CA CA002440833A patent/CA2440833C/en not_active Expired - Fee Related
- 2002-03-29 DE DE60237196T patent/DE60237196D1/de not_active Expired - Lifetime
- 2002-03-29 WO PCT/US2002/010182 patent/WO2002080223A1/en not_active Ceased
- 2002-03-29 EP EP02725459A patent/EP1380045B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1380045A4 (de) | 2005-11-23 |
| US20020166961A1 (en) | 2002-11-14 |
| CA2440833C (en) | 2009-07-14 |
| US6797945B2 (en) | 2004-09-28 |
| CA2440833A1 (en) | 2002-10-10 |
| US6906322B2 (en) | 2005-06-14 |
| EP1380045B1 (de) | 2010-08-04 |
| EP1380045A1 (de) | 2004-01-14 |
| US20020158196A1 (en) | 2002-10-31 |
| WO2002080223A1 (en) | 2002-10-10 |
| DE60237196D1 (de) | 2010-09-16 |
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