ATE478845T1 - Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptor - Google Patents
Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptorInfo
- Publication number
- ATE478845T1 ATE478845T1 AT04740214T AT04740214T ATE478845T1 AT E478845 T1 ATE478845 T1 AT E478845T1 AT 04740214 T AT04740214 T AT 04740214T AT 04740214 T AT04740214 T AT 04740214T AT E478845 T1 ATE478845 T1 AT E478845T1
- Authority
- AT
- Austria
- Prior art keywords
- muscarine
- ligands
- receptor
- pyrrolidinium derivatives
- pyrrolidinium
- Prior art date
Links
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0314697A GB0314697D0 (en) | 2003-06-24 | 2003-06-24 | Organic compounds |
| GB0327526A GB0327526D0 (en) | 2003-11-26 | 2003-11-26 | Organic compounds |
| PCT/EP2004/006795 WO2005000815A2 (en) | 2003-06-24 | 2004-06-23 | Piperidinium and pyrrolidinium derivatives as ligands for the muscarinic m3 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478845T1 true ATE478845T1 (de) | 2010-09-15 |
Family
ID=33554160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04740214T ATE478845T1 (de) | 2003-06-24 | 2004-06-23 | Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptor |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7947730B2 (de) |
| EP (1) | EP1638940B1 (de) |
| JP (1) | JP2008529965A (de) |
| AR (1) | AR044851A1 (de) |
| AT (1) | ATE478845T1 (de) |
| AU (1) | AU2004251867B2 (de) |
| BR (1) | BRPI0411738A (de) |
| CA (1) | CA2526991C (de) |
| DE (1) | DE602004028821D1 (de) |
| MX (1) | MXPA05013823A (de) |
| PE (1) | PE20050231A1 (de) |
| PL (1) | PL1638940T3 (de) |
| PT (1) | PT1638940E (de) |
| TW (1) | TW200526573A (de) |
| WO (1) | WO2005000815A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0410712D0 (en) | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
| GB0428416D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0428418D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| ATE529399T1 (de) | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Sanfte anticholinerge ester |
| ATE529400T1 (de) | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Weiche anticholinerge zwitterionen |
| US20090182033A1 (en) * | 2005-12-16 | 2009-07-16 | Argenta Discovery Ltd. | Cyclic Amine Derivatives and Their Uses |
| EP2013172A4 (de) * | 2006-04-24 | 2010-08-04 | Astrazeneca Ab | Neue alkylester aus zyklischen aminoalkoholen mit muskarin-m3-rezeptorantagonostenaktivität zur behandlung von chronischer bronchienverstopfung, asthma oder überaktiver harnblase |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| JP2010513277A (ja) * | 2006-12-13 | 2010-04-30 | ギリード・サイエンシズ・インコーポレーテッド | ＣＯＰＤおよび慢性気管支炎の治療のためのムスカリン受容体アンタゴニストおよびβ−アゴニストの共通プロドラッグとしてのモノホスフェート |
| CA2675942C (en) * | 2007-02-23 | 2016-04-12 | Theravance, Inc. | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
| JP5656288B2 (ja) * | 2007-09-07 | 2015-01-21 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ムスカリン受容体アンタゴニストとして有用なグアジニン含有化合物 |
| US8017617B2 (en) * | 2007-12-14 | 2011-09-13 | Theravance, Inc. | Amidine-containing compounds useful as muscarinic receptor antagonists |
| EA017627B1 (ru) | 2008-05-13 | 2013-01-30 | Астразенека Аб | Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора |
| MX2011011446A (es) * | 2009-04-30 | 2011-11-18 | Teijin Pharma Ltd | Compuestos de sal de amonio cuaternario. |
| US9156833B2 (en) | 2012-07-16 | 2015-10-13 | Barry University, Inc. | Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof |
| PL3111978T3 (pl) | 2015-07-03 | 2022-01-24 | Novartis Ag | Inhalator przystosowany do odczytu informacji przechowywanych w środkach przechowywania danych pojemnika |
| AU2020235888A1 (en) | 2019-03-11 | 2021-09-30 | Nocion Therapeutics, Inc. | Charged ION channel blockers and methods for use |
| US10933055B1 (en) | 2019-11-06 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US12162851B2 (en) | 2020-03-11 | 2024-12-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| CN119118953A (zh) * | 2020-03-11 | 2024-12-13 | 诺西恩医疗公司 | 带电的离子通道阻滞剂及其使用方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3240784A (en) | 1966-03-15 | Esters of quaternary z-hydroxy methyl piperidinium compounds | ||
| US2746966A (en) | 1953-11-02 | 1956-05-22 | Lakeside Lab Inc | Esters of bis-(nu-substituted-3-hydroxypiperidinium) alkanes |
| GB833820A (en) * | 1957-10-17 | 1960-04-27 | Beecham Res Lab | Improvements in or relating to the preparation of pyrrolidyl esters and quaternary compounds thereof |
| JPS6018661B2 (ja) * | 1976-01-01 | 1985-05-11 | 太田製薬株式会社 | １−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体 |
| JPS5427570A (en) * | 1977-07-30 | 1979-03-01 | Ota Pharma | Stereoisomer of 44acyloxyy11 alkyll11*1*33dioxolanee44 ylmethyl* pideridinium salt derivative |
| JPS5679688A (en) * | 1979-12-04 | 1981-06-30 | Ota Seiyaku Kk | 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production |
| JPS5835177A (ja) * | 1981-08-26 | 1983-03-01 | Dainippon Pharmaceut Co Ltd | ２−環状アミノ−２−（１，２−ベンズイソキサゾ−ル−３−イル）酢酸エステル類並びにその酸付加塩類および第４級アンモニウム塩類 |
| JPS58208270A (ja) * | 1982-05-28 | 1983-12-03 | Dainippon Pharmaceut Co Ltd | α−環状アミノフエニル酢酸エステル類並びにその酸付加塩類及び第４級アンモニウム塩類 |
| GB9023023D0 (en) * | 1990-10-23 | 1990-12-05 | Barlow Richard B | Pharmaceutical compositions |
| US5750540A (en) * | 1995-04-28 | 1998-05-12 | Banyu Pharmaceutical Co., Ltd. | 1,4-di-substituted piperidine derivatives |
| CN100391942C (zh) | 1996-11-11 | 2008-06-04 | 索佛特克两合公司 | 对映异构纯的碱性芳基-环烷基-羟基羧酸酯,其制备方法及其在药品中的应用 |
| EP1302458A4 (de) * | 2000-07-11 | 2005-10-19 | Banyu Pharma Co Ltd | Esterderivate |
| ES2206021B1 (es) * | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| ATE529400T1 (de) * | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Weiche anticholinerge zwitterionen |
-
2004
- 2004-06-22 PE PE2004000611A patent/PE20050231A1/es not_active Application Discontinuation
- 2004-06-22 AR ARP040102162A patent/AR044851A1/es not_active Application Discontinuation
- 2004-06-23 DE DE602004028821T patent/DE602004028821D1/de not_active Expired - Lifetime
- 2004-06-23 CA CA2526991A patent/CA2526991C/en not_active Expired - Fee Related
- 2004-06-23 MX MXPA05013823A patent/MXPA05013823A/es active IP Right Grant
- 2004-06-23 PT PT04740214T patent/PT1638940E/pt unknown
- 2004-06-23 US US10/561,366 patent/US7947730B2/en not_active Expired - Fee Related
- 2004-06-23 AT AT04740214T patent/ATE478845T1/de active
- 2004-06-23 BR BRPI0411738-7A patent/BRPI0411738A/pt not_active Application Discontinuation
- 2004-06-23 EP EP04740214A patent/EP1638940B1/de not_active Expired - Lifetime
- 2004-06-23 JP JP2006516038A patent/JP2008529965A/ja active Pending
- 2004-06-23 TW TW093118142A patent/TW200526573A/zh unknown
- 2004-06-23 AU AU2004251867A patent/AU2004251867B2/en not_active Ceased
- 2004-06-23 WO PCT/EP2004/006795 patent/WO2005000815A2/en not_active Ceased
- 2004-06-23 PL PL04740214T patent/PL1638940T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004028821D1 (de) | 2010-10-07 |
| BRPI0411738A (pt) | 2006-08-08 |
| PT1638940E (pt) | 2010-11-08 |
| PE20050231A1 (es) | 2005-05-20 |
| EP1638940A2 (de) | 2006-03-29 |
| EP1638940B1 (de) | 2010-08-25 |
| MXPA05013823A (es) | 2006-02-28 |
| CA2526991C (en) | 2012-03-27 |
| WO2005000815A3 (en) | 2005-04-14 |
| US20060287362A1 (en) | 2006-12-21 |
| JP2008529965A (ja) | 2008-08-07 |
| AR044851A1 (es) | 2005-10-05 |
| CA2526991A1 (en) | 2005-01-06 |
| AU2004251867A1 (en) | 2005-01-06 |
| PL1638940T3 (pl) | 2011-02-28 |
| AU2004251867B2 (en) | 2008-08-07 |
| TW200526573A (en) | 2005-08-16 |
| WO2005000815A2 (en) | 2005-01-06 |
| US7947730B2 (en) | 2011-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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