ATE478850T1 - Herstellung von eslicarbazepin und verwandten verbindungen mittels asymmetrischer hydrierung - Google Patents

Herstellung von eslicarbazepin und verwandten verbindungen mittels asymmetrischer hydrierung

Info

Publication number
ATE478850T1
ATE478850T1 AT07747757T AT07747757T ATE478850T1 AT E478850 T1 ATE478850 T1 AT E478850T1 AT 07747757 T AT07747757 T AT 07747757T AT 07747757 T AT07747757 T AT 07747757T AT E478850 T1 ATE478850 T1 AT E478850T1
Authority
AT
Austria
Prior art keywords
eslicarbazepine
preparation
related compounds
asymmetric hydrogenation
hydrogenation
Prior art date
Application number
AT07747757T
Other languages
English (en)
Inventor
Bing Yu
Wenge Li
David Learmonth
Original Assignee
Bial Portela & Ca Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Portela & Ca Sa filed Critical Bial Portela & Ca Sa
Application granted granted Critical
Publication of ATE478850T1 publication Critical patent/ATE478850T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT07747757T 2006-04-11 2007-04-11 Herstellung von eslicarbazepin und verwandten verbindungen mittels asymmetrischer hydrierung ATE478850T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0607317A GB2437078A (en) 2006-04-11 2006-04-11 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives
PCT/PT2007/000017 WO2007117166A1 (en) 2006-04-11 2007-04-11 Preparation of eslicarbazepine and related compounds by asymmetric hydrogenation

Publications (1)

Publication Number Publication Date
ATE478850T1 true ATE478850T1 (de) 2010-09-15

Family

ID=36571661

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07747757T ATE478850T1 (de) 2006-04-11 2007-04-11 Herstellung von eslicarbazepin und verwandten verbindungen mittels asymmetrischer hydrierung

Country Status (21)

Country Link
US (1) US8367821B2 (de)
EP (1) EP2004610B1 (de)
JP (1) JP2009533424A (de)
KR (1) KR20080108352A (de)
CN (1) CN101421245A (de)
AR (1) AR060595A1 (de)
AT (1) ATE478850T1 (de)
AU (1) AU2007235756A1 (de)
BR (1) BRPI0709490A2 (de)
CA (1) CA2648916C (de)
CY (1) CY1111308T1 (de)
DE (1) DE602007008706D1 (de)
DK (1) DK2004610T3 (de)
ES (1) ES2350126T3 (de)
GB (1) GB2437078A (de)
MX (1) MX2008013022A (de)
PL (1) PL2004610T3 (de)
PT (1) PT2004610E (de)
RU (1) RU2008139061A (de)
SI (1) SI2004610T1 (de)
WO (1) WO2007117166A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2437078A (en) 2006-04-11 2007-10-17 Portela & Ca Sa 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
RU2012106827A (ru) 2009-07-27 2013-09-10 БИАЛ-ПОРТЕЛА энд КА., С.А. Применение производных 5н-дибенз/в, f/азепин-5-карбоксамида для лечения фибромиалгии
WO2011045648A2 (en) * 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs
WO2011117885A1 (en) * 2010-03-23 2011-09-29 Intas Pharmaceuticals Limited Process for preparation of enantiomers of licarbazepine
WO2011138795A2 (en) * 2010-05-03 2011-11-10 Msn Laboratories Limited Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide
CN102382033B (zh) * 2010-08-31 2013-04-03 凯瑞斯德生化(苏州)有限公司 一种光学活性米格列奈酯及米格列奈盐的制备方法
TR201008460A1 (tr) 2010-10-15 2012-05-21 Sanovel İlaç San.Ve Ti̇c.A.Ş. Eslikarbazepinin saşe formülasyonları.
CN102465159B (zh) * 2010-11-15 2014-11-26 浙江九洲药物科技有限公司 微生物法制备艾利西平的一种合成工艺
WO2012120356A2 (en) 2011-03-08 2012-09-13 Jubilant Life Sciences Limited Process for the preparation of (s)-(+)-or (r)-(-)-10 hydroxy dihydrodibenz[b,f]azepines by enantioselective reduction of 10, 11-dihydro-10-oxo-5h-dibenz[b,f]azepines and polymorphs thereof
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
US20150065704A1 (en) 2011-07-13 2015-03-05 Ketan Hirpara Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
IN2015DN02296A (de) 2012-09-26 2015-08-21 Ranbaxy Lab Ltd
WO2014152835A1 (en) * 2013-03-14 2014-09-25 Vistagen Therapeutics, Inc. Synthesis of chiral kynurenine compounds and intermediates
EP3064490A1 (de) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Verbessertes verfahren zur herstellung von eslicarbazepin und eslicarbazepinacetat
CN105198775B (zh) * 2015-10-10 2017-11-14 凯瑞斯德生化(苏州)有限公司 一种手性N‑Boc联苯丙氨醇的制备方法
CN106588773B (zh) * 2016-11-10 2019-09-27 北京现代药物代谢研究院 一种脑靶向艾司利卡西平酯类前药及其应用
CN108752276A (zh) * 2018-07-24 2018-11-06 天津安浩生物科技有限公司 不对称催化氢化反应的前体反应物的层析纯化工艺
CN108840825A (zh) * 2018-07-24 2018-11-20 天津安浩生物科技有限公司 不对称催化氢化反应的前体反应物的重结晶纯化工艺
CN109912508B (zh) * 2019-04-30 2022-08-12 上海天慈国际药业有限公司 一种右美托咪定及其盐酸盐的制备方法
CN114920696B (zh) * 2022-07-22 2022-10-11 北京丹大生物技术有限公司 奥卡西平代谢物的半抗原衍生物、人工抗原和单克隆抗体及其应用、杂交瘤细胞株

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
DE19706273A1 (de) * 1996-02-20 1997-07-03 Lonza Ag Verfahren zur Herstellung optisch aktiver gamma-Butyrolactame und -lactone
GB0111566D0 (en) * 2001-05-11 2001-07-04 Portela & Ca Sa Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide
JP3504254B2 (ja) 2001-10-31 2004-03-08 関東化学株式会社 光学活性アミノアルコールおよびその中間体の製造方法
WO2003106414A2 (en) * 2002-06-14 2003-12-24 Taro Pharmaceuticals U.S.A., Inc. Method of preparing a 5h-dibenz[b,f]azepine-5-carboxamide
JP2004075560A (ja) * 2002-08-12 2004-03-11 Kawaken Fine Chem Co Ltd ３−キヌクリジノンエノールエステルおよびそれを使用した光学活性３−キヌクリジノールエステルの製造方法
GB0223224D0 (en) 2002-10-07 2002-11-13 Novartis Ag Organic compounds
TW200502222A (en) * 2003-04-02 2005-01-16 Novartis Ag Use of 10-hydroxy-10,11-dihydrocarbamazepine derivatives for the treatment of affective disorders
GB2401605A (en) * 2003-05-12 2004-11-17 Portela & Ca Sa Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof
GB2416167A (en) * 2004-07-13 2006-01-18 Portela & Ca Sa Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides
GB2437078A (en) 2006-04-11 2007-10-17 Portela & Ca Sa 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives

Also Published As

Publication number Publication date
EP2004610B1 (de) 2010-08-25
GB2437078A (en) 2007-10-17
US8367821B2 (en) 2013-02-05
CN101421245A (zh) 2009-04-29
EP2004610A1 (de) 2008-12-24
CA2648916A1 (en) 2007-10-18
AR060595A1 (es) 2008-07-02
GB0607317D0 (en) 2006-05-24
PT2004610E (pt) 2010-11-12
WO2007117166A1 (en) 2007-10-18
KR20080108352A (ko) 2008-12-12
JP2009533424A (ja) 2009-09-17
AU2007235756A1 (en) 2007-10-18
US20100173893A1 (en) 2010-07-08
PL2004610T3 (pl) 2011-02-28
DE602007008706D1 (de) 2010-10-07
MX2008013022A (es) 2009-02-18
CA2648916C (en) 2015-11-17
BRPI0709490A2 (pt) 2011-07-19
CY1111308T1 (el) 2015-08-05
SI2004610T1 (sl) 2011-01-31
DK2004610T3 (da) 2010-11-22
ES2350126T3 (es) 2011-01-18
RU2008139061A (ru) 2010-05-20

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