ATE478885T1 - Pharmazeutische dopamin-glykokonjugat- zusammensetzungen und verfahren zu deren herstellung - Google Patents
Pharmazeutische dopamin-glykokonjugat- zusammensetzungen und verfahren zu deren herstellungInfo
- Publication number
- ATE478885T1 ATE478885T1 AT01924960T AT01924960T ATE478885T1 AT E478885 T1 ATE478885 T1 AT E478885T1 AT 01924960 T AT01924960 T AT 01924960T AT 01924960 T AT01924960 T AT 01924960T AT E478885 T1 ATE478885 T1 AT E478885T1
- Authority
- AT
- Austria
- Prior art keywords
- ring
- production
- substituents
- optional
- lower alkyl
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 229960003638 dopamine Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000003291 dopaminomimetic effect Effects 0.000 abstract 1
- 125000003147 glycosyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/547,506 US6548484B1 (en) | 2000-04-12 | 2000-04-12 | Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation |
| PCT/US2001/011914 WO2001079244A1 (en) | 2000-04-12 | 2001-04-12 | Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478885T1 true ATE478885T1 (de) | 2010-09-15 |
Family
ID=24184914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01924960T ATE478885T1 (de) | 2000-04-12 | 2001-04-12 | Pharmazeutische dopamin-glykokonjugat- zusammensetzungen und verfahren zu deren herstellung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6548484B1 (de) |
| EP (1) | EP1385857B1 (de) |
| JP (1) | JP2004523464A (de) |
| AT (1) | ATE478885T1 (de) |
| AU (2) | AU2001251565B2 (de) |
| CA (1) | CA2443774C (de) |
| DE (1) | DE60142934D1 (de) |
| IL (1) | IL158343A (de) |
| WO (1) | WO2001079244A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9302982B2 (en) | 2000-04-12 | 2016-04-05 | Glycon Llc | Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use |
| US20060189547A1 (en) * | 2000-04-12 | 2006-08-24 | Christian Samuel T | Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use |
| US7345031B2 (en) * | 2000-04-12 | 2008-03-18 | International Medical Innovations, Inc. | Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use |
| US7666445B2 (en) * | 2000-10-20 | 2010-02-23 | The Trustees Of The University Of Pennsylvania | Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use |
| GB0111191D0 (en) * | 2001-05-08 | 2001-06-27 | Merck Sharp & Dohme | Therapeutic agents |
| US7217696B2 (en) * | 2002-02-28 | 2007-05-15 | A & D Bioscience, Inc. | Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof |
| WO2003079980A2 (en) * | 2002-03-19 | 2003-10-02 | A & D Bioscience, Inc. | Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof |
| US7001888B2 (en) * | 2002-03-29 | 2006-02-21 | Threshold Pharmaceuticals, Inc. | Compositions and methods for treating cancer |
| US20050255038A1 (en) * | 2002-04-12 | 2005-11-17 | A And D Bioscience, Inc. | Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents and uses thereof |
| US20050153928A1 (en) * | 2002-05-07 | 2005-07-14 | Holick Michael F. | Conjugates comprising a central nervous system-active drug linked to glucuronic acid or glucosamine through an amide bond and uses thereof |
| US20050215487A1 (en) * | 2002-06-27 | 2005-09-29 | Holick Michael F | Conjugates comprising an nsaid and a sugar and uses thereof |
| US8133881B2 (en) | 2003-01-13 | 2012-03-13 | Shire Llc | Carbohydrate conjugates to prevent abuse of controlled substances |
| KR20050098246A (ko) * | 2003-01-13 | 2005-10-11 | 뉴 리버 파마슈티칼스, 인크. | 통제 물질의 남용 예방을 위한 탄수화물 접합체 |
| WO2004110255A2 (en) * | 2003-06-09 | 2004-12-23 | Gang Zheng | Antineoplastic agents targeted via glut transporters |
| US8420602B2 (en) * | 2004-09-14 | 2013-04-16 | Landon C. G. Miller | Endocannabinoid conjugate and a pharmaceutical composition for treatment of neuronal disorders |
| US7074775B2 (en) * | 2004-09-14 | 2006-07-11 | Miller Landon C G | Aminobutyramide conjugate and a pharmaceutical composition for treatment of neuronal disorders |
| US20080234385A1 (en) * | 2005-08-02 | 2008-09-25 | Caritas St. Elizabeth's Medical Center | Method For Inhibiting Tnf-Alpha |
| WO2008003604A2 (en) * | 2006-07-05 | 2008-01-10 | Ciba Holding Inc. | Coloured organic electrophoretic particles |
| JP2008187927A (ja) * | 2007-02-02 | 2008-08-21 | Chiba Univ | 新規なフェノール配糖化酵素 |
| DE102007035642A1 (de) * | 2007-07-30 | 2009-02-12 | Grietje Beck | Substanzen zur Protektion von Zellen und Geweben gegen Schädigung durch ungünstige Bedingungen |
| WO2012054528A2 (en) * | 2010-10-19 | 2012-04-26 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
| WO2014002039A1 (en) * | 2012-06-27 | 2014-01-03 | Shire Ag | Amphetamine prodrugs |
| DE102017008073A1 (de) * | 2017-08-28 | 2019-02-28 | Henkel Ag & Co. Kgaa | Neue anionische Tenside und Wasch- und Reinigungsmittel, welche diese enthalten |
| KR102482470B1 (ko) * | 2019-04-11 | 2022-12-28 | 연세대학교 산학협력단 | 혈관 신생 촉진용 조성물 및 이의 제조 방법 |
| CN115778930B (zh) * | 2022-12-08 | 2024-02-27 | 陕西中医药大学 | 一种具有血管舒张活性的二硫缩醛类化合物在制备具有血管舒张活性药物方面的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2595405A (en) | 1952-05-06 | Their production | ||
| US2427878A (en) | 1947-04-08 | 1947-09-23 | Parke Davis & Co | Dialkylaminopropyl ethers of benzhydrol |
| US2599000A (en) | 1950-09-02 | 1952-06-03 | Smith Kline French Lab | Nu, nu-disubstituted-beta-halo-alkylamines |
| US2682543A (en) | 1951-05-26 | 1954-06-29 | Burroughs Wellcome Co | Catalytic reduction of diphenyl alkanolamines and resulting products |
| US2789110A (en) | 1953-03-14 | 1957-04-16 | Knoll Ag | Amino alcohols substituted by bicycloalkyl residues and a process of making same |
| US2891890A (en) | 1954-02-19 | 1959-06-23 | Burroughs Wellcome Co | Method of treating parkinsonism |
| US3462536A (en) | 1960-07-22 | 1969-08-19 | Merck & Co Inc | Method of inhibiting decarboxylase |
| US3253023A (en) | 1963-09-27 | 1966-05-24 | Dow Chemical Co | Recovery of 3-(3, 4-dihydroxyphenyl)-l-alanine from velvet beans |
| US3405159A (en) | 1964-11-17 | 1968-10-08 | Merck & Co Inc | Process for resolving racemic mixtures of optically-active enantiomorphs |
| CH507249A (de) | 1968-05-31 | 1971-05-15 | Sandoz Ag | Verfahren zur Herstellung von 2-Brom-a-ergokryptin |
| US4016280A (en) | 1969-07-17 | 1977-04-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | 4,4-Diarylpiperidine compositions and use |
| US3962447A (en) | 1973-12-26 | 1976-06-08 | Interx Research Corporation | Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and method of using same |
| US3929813A (en) | 1973-12-26 | 1975-12-30 | Interx Research Corp | Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and process for preparing same |
| US4166182A (en) | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| US4540564A (en) | 1982-05-18 | 1985-09-10 | University Of Florida | Brain-specific drug delivery |
| JP2682713B2 (ja) * | 1988-12-27 | 1997-11-26 | 田辺製薬株式会社 | 光学活性テトラヒドロフランの製法 |
| IL92952A (en) | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
| US5180716A (en) | 1990-08-01 | 1993-01-19 | The Regents Of The University Of California | Cyclodextrin complexes for neuraxial administration of drugs |
| ZA923283B (en) | 1991-05-29 | 1993-01-27 | Akzo Nv | Phenoxyphenyl derivatives |
| US5639737A (en) * | 1991-11-04 | 1997-06-17 | Co Enzyme Technology Ltd. | Method and compositions for treating malignant tumors and inhibiting growth and metastases of malignant tumors |
| US6187754B1 (en) * | 1996-01-30 | 2001-02-13 | Glycotech Corp. | Sialyl-Lewisa and sialyl-Lewisx epitode analogues |
| JP5159274B2 (ja) | 2006-11-30 | 2013-03-06 | パナソニック株式会社 | 無線送信装置及び無線送信方法 |
| US8220897B2 (en) | 2009-12-23 | 2012-07-17 | Xerox Corporation | Computer based method and system for adjusting page placement on a continuous feed print engine |
-
2000
- 2000-04-12 US US09/547,506 patent/US6548484B1/en not_active Expired - Lifetime
-
2001
- 2001-04-12 EP EP01924960A patent/EP1385857B1/de not_active Expired - Lifetime
- 2001-04-12 CA CA002443774A patent/CA2443774C/en not_active Expired - Lifetime
- 2001-04-12 AT AT01924960T patent/ATE478885T1/de not_active IP Right Cessation
- 2001-04-12 AU AU2001251565A patent/AU2001251565B2/en not_active Ceased
- 2001-04-12 WO PCT/US2001/011914 patent/WO2001079244A1/en not_active Ceased
- 2001-04-12 IL IL158343A patent/IL158343A/en not_active IP Right Cessation
- 2001-04-12 AU AU5156501A patent/AU5156501A/xx active Pending
- 2001-04-12 DE DE60142934T patent/DE60142934D1/de not_active Expired - Lifetime
- 2001-04-12 JP JP2001576842A patent/JP2004523464A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1385857B1 (de) | 2010-08-25 |
| JP2004523464A (ja) | 2004-08-05 |
| AU5156501A (en) | 2001-10-30 |
| US6548484B1 (en) | 2003-04-15 |
| CA2443774C (en) | 2009-11-24 |
| IL158343A (en) | 2010-11-30 |
| EP1385857A1 (de) | 2004-02-04 |
| CA2443774A1 (en) | 2001-10-25 |
| IL158343A0 (en) | 2004-05-12 |
| EP1385857A4 (de) | 2006-09-06 |
| HK1063186A1 (en) | 2004-12-17 |
| DE60142934D1 (de) | 2010-10-07 |
| AU2001251565B2 (en) | 2006-09-28 |
| WO2001079244A1 (en) | 2001-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |