ATE479669T1 - Markierungsreagentien, markierte analyten, einschliesslich mischungen davon, und davon abgeleitete fragmentionen und verfahren zu deren analyse - Google Patents

Markierungsreagentien, markierte analyten, einschliesslich mischungen davon, und davon abgeleitete fragmentionen und verfahren zu deren analyse

Info

Publication number
ATE479669T1
ATE479669T1 AT05705033T AT05705033T ATE479669T1 AT E479669 T1 ATE479669 T1 AT E479669T1 AT 05705033 T AT05705033 T AT 05705033T AT 05705033 T AT05705033 T AT 05705033T AT E479669 T1 ATE479669 T1 AT E479669T1
Authority
AT
Austria
Prior art keywords
methods
labeling reagents
labeled analytes
including mixtures
analysis
Prior art date
Application number
AT05705033T
Other languages
English (en)
Inventor
Subhakar Dey
Darryl Pappin
Subhasish Purkayastha
Sasi Pillai
James Coull
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/751,353 external-priority patent/US20050147982A1/en
Priority claimed from US10/751,387 external-priority patent/US7355045B2/en
Priority claimed from US10/822,639 external-priority patent/US20050147985A1/en
Priority claimed from US10/852,730 external-priority patent/US20050148087A1/en
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Application granted granted Critical
Publication of ATE479669T1 publication Critical patent/ATE479669T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT05705033T 2004-01-05 2005-01-05 Markierungsreagentien, markierte analyten, einschliesslich mischungen davon, und davon abgeleitete fragmentionen und verfahren zu deren analyse ATE479669T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10/751,354 US20050148771A1 (en) 2004-01-05 2004-01-05 Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US10/751,353 US20050147982A1 (en) 2004-01-05 2004-01-05 Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US10/751,388 US7307169B2 (en) 2004-01-05 2004-01-05 Isotopically enriched N-substituted piperazines and methods for the preparation thereof
US10/751,387 US7355045B2 (en) 2004-01-05 2004-01-05 Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
US10/822,639 US20050147985A1 (en) 2004-01-05 2004-04-12 Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US10/852,730 US20050148087A1 (en) 2004-01-05 2004-05-24 Isobarically labeled analytes and fragment ions derived therefrom
PCT/US2005/000223 WO2005068446A1 (en) 2004-01-05 2005-01-05 Labeling reagents, labeled analytes, including mixtures thereof, and fragment ions derived therefrom and methods for the analysis thereof

Publications (1)

Publication Number Publication Date
ATE479669T1 true ATE479669T1 (de) 2010-09-15

Family

ID=34799954

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05705033T ATE479669T1 (de) 2004-01-05 2005-01-05 Markierungsreagentien, markierte analyten, einschliesslich mischungen davon, und davon abgeleitete fragmentionen und verfahren zu deren analyse

Country Status (7)

Country Link
US (4) US7307169B2 (de)
EP (2) EP1701945B1 (de)
AT (1) ATE479669T1 (de)
AU (1) AU2005205522A1 (de)
CA (1) CA2552304C (de)
DE (1) DE602005023260D1 (de)
WO (1) WO2005068446A1 (de)

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CA2542941C (en) * 2003-11-26 2013-02-12 Applera Corporation Analysis of mass spectral data in the quiet zones and label selection therefor
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US7307169B2 (en) 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
JP4613320B2 (ja) 2004-03-01 2011-01-19 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 結合特性に基づく分析物の特徴の決定
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US8809012B2 (en) 2010-08-23 2014-08-19 Postach Academy-Industry Foundation Labeling agent and methods for simultaneous sequencing and quantification of multiple peptides and proteins using the same
KR101229704B1 (ko) 2010-08-23 2013-02-05 포항공과대학교 산학협력단 동중체로 표지된 단백질 및 펩티드를 큰 질량의 ｙ－타입 이온을 이용하여 정량분석하는 방법
US8492163B2 (en) 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US20120329661A1 (en) * 2011-05-18 2012-12-27 Guo Zengkui Isotope Labeling-Assisted Quantification (iLAQ) of Biological Compounds
US10078091B2 (en) 2012-05-18 2018-09-18 Dh Technologies Development Pte. Ltd. Analysis of a panel of cerebrotendinous xanthomatosis biomarkers using site specific derivation and LC/MS/MS workflow
US9835629B2 (en) 2012-05-18 2017-12-05 Pierce Biotechnology, Inc. Methods and reagents for biomolecule labeling, enrichment and gentle elution
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CN113514531B (zh) * 2021-04-27 2022-10-25 清华大学 一种化合物的碎片离子预测方法及应用
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Also Published As

Publication number Publication date
DE602005023260D1 (de) 2010-10-14
CA2552304C (en) 2012-03-27
US7932388B2 (en) 2011-04-26
EP2251334A1 (de) 2010-11-17
US20050148773A1 (en) 2005-07-07
US20090227791A1 (en) 2009-09-10
CA2552304A1 (en) 2005-07-28
WO2005068446A1 (en) 2005-07-28
EP1701945A1 (de) 2006-09-20
US20080114169A1 (en) 2008-05-15
EP2251334B1 (de) 2013-08-14
US20050148771A1 (en) 2005-07-07
AU2005205522A1 (en) 2005-07-28
US7307169B2 (en) 2007-12-11
US8569304B2 (en) 2013-10-29
EP1701945B1 (de) 2010-09-01

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