ATE479678T1 - Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors - Google Patents

Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors

Info

Publication number: ATE479678T1
Authority: AT; Austria
Prior art keywords: pyridines; receptor; benzoimidazole; histamine; modulators
Prior art date: 2006-03-31

Application number

AT07754701T

Other languages

English (en)

Inventor

James Edwards

David Kindrachuk

Jennifer Venable

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-31

Filing date

2007-03-30

Publication date

2010-09-15

2007-03-30 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2010-09-15 Application granted granted Critical

2010-09-15 Publication of ATE479678T1 publication Critical patent/ATE479678T1/de

Links

RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
-1 BENZOIMIDAZOLE-2-YL Chemical class 0.000 title 1
102000004187 Histamine H4 receptors Human genes 0.000 title 1
108090000796 Histamine H4 receptors Proteins 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
YNFBMDWHEHETJW-UHFFFAOYSA-N 2-pyridin-2-yl-1h-benzimidazole Chemical class N1=CC=CC=C1C1=NC2=CC=CC=C2N1 YNFBMDWHEHETJW-UHFFFAOYSA-N 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
208000003251 Pruritus Diseases 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Hematology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Gastroenterology & Hepatology (AREA)
Neurosurgery (AREA)
Otolaryngology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)

AT07754701T 2006-03-31 2007-03-30 Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors ATE479678T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78818806P	2006-03-31	2006-03-31
PCT/US2007/008217 WO2007117400A2 (en)	2006-03-31	2007-03-30	Benzoimidazol-2-yl pyridines as modulators of the histamine h4 receptor

Publications (1)

Publication Number	Publication Date
ATE479678T1 true ATE479678T1 (de)	2010-09-15

Family

ID=38581555

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07754701T ATE479678T1 (de)	2006-03-31	2007-03-30	Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors

Country Status (9)

Country	Link
US (1)	US7589087B2 (de)
EP (1)	EP2004188B1 (de)
JP (1)	JP2009532367A (de)
CN (1)	CN101460168B (de)
AT (1)	ATE479678T1 (de)
AU (1)	AU2007235577B2 (de)
DE (1)	DE602007008859D1 (de)
ES (1)	ES2349237T3 (de)
WO (1)	WO2007117400A2 (de)

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JP5301999B2 (ja) †	2005-10-31	2013-09-25	メルク・シャープ・アンド・ドーム・コーポレーション	Ｃｅｔｐ阻害薬
PL2007752T3 (pl)	2006-03-31	2011-02-28	Janssen Pharmaceutica Nv	Benzoimidazol-2-ilopirymidyny i pirazyny jako modulatory receptora histaminowego H4
DE602007008859D1 (de)	2006-03-31	2010-10-14	Janssen Pharmaceutica Nv	Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors
WO2007120690A2 (en) *	2006-04-10	2007-10-25	Janssen Pharmaceutica N.V.	Combination histamine h1r and h4r antagonist therapy for treating pruritus
WO2008094437A2 (en)	2007-01-30	2008-08-07	Janssen Pharmaceutica N.V.	Chimeric peptide antagonist for gpcr135 or gpcr142
WO2009079001A1 (en) *	2007-12-18	2009-06-25	Janssen Pharmaceutica N.V.	Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine h4 receptor
MX2010013727A (es) *	2008-06-12	2011-01-14	Janssen Pharmaceutica Nv	Uso de un antagonista h4 de histamina para el tratamiento de adherencias postoperatorias.
TWI498326B (zh)	2008-06-30	2015-09-01	Janssen Pharmaceutica Nv	用於製備經取代之嘧啶衍生物之化合物
US20100029942A1 (en)	2008-06-30	2010-02-04	Sergio Cesco-Cancian	Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
US9371311B2 (en)	2008-06-30	2016-06-21	Janssen Pharmaceutica Nv	Benzoimidazol-2-yl pyrimidine derivatives
AU2013204436B2 (en) *	2008-06-30	2014-12-04	Janssen Pharmaceutica Nv	Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
CN102368905B (zh) *	2008-11-06	2015-04-01	南卡罗来纳医科大学研究发展基金会	酸性神经酰胺酶的向溶酶体抑制剂
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JP2013518085A (ja)	2010-02-01	2013-05-20	ノバルティスアーゲー	ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
AR080056A1 (es)	2010-02-01	2012-03-07	Novartis Ag	Derivados de ciclohexil-amida como antagonistas de los receptores de crf
JP5748777B2 (ja)	2010-02-02	2015-07-15	ノバルティスアーゲー	Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
SMT202000084T1 (it)	2013-03-06	2020-03-13	Janssen Pharmaceutica Nv	Modulatori benzoimidazol-2-il pirimidinici del recettore h4 dell'istamina

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JP5301999B2 (ja)	2005-10-31	2013-09-25	メルク・シャープ・アンド・ドーム・コーポレーション	Ｃｅｔｐ阻害薬
DE602007008859D1 (de)	2006-03-31	2010-10-14	Janssen Pharmaceutica Nv	Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors
PL2007752T3 (pl)	2006-03-31	2011-02-28	Janssen Pharmaceutica Nv	Benzoimidazol-2-ilopirymidyny i pirazyny jako modulatory receptora histaminowego H4
WO2007120690A2 (en)	2006-04-10	2007-10-25	Janssen Pharmaceutica N.V.	Combination histamine h1r and h4r antagonist therapy for treating pruritus

2007
- 2007-03-30 DE DE602007008859T patent/DE602007008859D1/de active Active
- 2007-03-30 EP EP07754701A patent/EP2004188B1/de active Active
- 2007-03-30 ES ES07754701T patent/ES2349237T3/es active Active
- 2007-03-30 WO PCT/US2007/008217 patent/WO2007117400A2/en not_active Ceased
- 2007-03-30 AU AU2007235577A patent/AU2007235577B2/en not_active Ceased
- 2007-03-30 JP JP2009503075A patent/JP2009532367A/ja active Pending
- 2007-03-30 AT AT07754701T patent/ATE479678T1/de not_active IP Right Cessation
- 2007-03-30 US US11/731,048 patent/US7589087B2/en active Active
- 2007-03-30 CN CN2007800202694A patent/CN101460168B/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP2004188A2 (de)	2008-12-24
CN101460168A (zh)	2009-06-17
EP2004188A4 (de)	2009-04-22
CN101460168B (zh)	2013-07-17
WO2007117400A2 (en)	2007-10-18
DE602007008859D1 (de)	2010-10-14
JP2009532367A (ja)	2009-09-10
EP2004188B1 (de)	2010-09-01
US20070232616A1 (en)	2007-10-04
US7589087B2 (en)	2009-09-15
ES2349237T3 (es)	2010-12-29
HK1124767A1 (en)	2009-07-24
WO2007117400A3 (en)	2008-02-21
AU2007235577B2 (en)	2011-09-15
AU2007235577A1 (en)	2007-10-18

Legal Events

Date	Code	Title	Description
2011-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE479678T1 (de)	2010-09-15	Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors
UA95949C2 (ru)	2011-09-26	Бензоимидазол-2-илпиримидины и пиразины как модуляторы рецептора гистамина h4
MY145349A (en)	2012-01-31	Benzofuro- and benzothienopyrimidine modulators of the histamine h4 receptor
MX2009008787A (es)	2010-02-15	Moduladores 2-aminopirimidina del receptor de histamina h4.
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