ATE481097T1 - Implantierbare vorrichtung enthaltend resorbierbares matrixmaterial und antiproliferative wirkstoffe zur vorbeugung oder behandlung von versagen vaskulärer hämodialysezugänge und anderer vaskulärer transplantate - Google Patents

Implantierbare vorrichtung enthaltend resorbierbares matrixmaterial und antiproliferative wirkstoffe zur vorbeugung oder behandlung von versagen vaskulärer hämodialysezugänge und anderer vaskulärer transplantate

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Publication number
ATE481097T1
ATE481097T1 AT02718844T AT02718844T ATE481097T1 AT E481097 T1 ATE481097 T1 AT E481097T1 AT 02718844 T AT02718844 T AT 02718844T AT 02718844 T AT02718844 T AT 02718844T AT E481097 T1 ATE481097 T1 AT E481097T1
Authority
AT
Austria
Prior art keywords
vascular
hemodialysis
antiproliferative
actives
approaches
Prior art date
Application number
AT02718844T
Other languages
English (en)
Inventor
Sriram Iyer
Nicholas Kipshidze
Victor Nikolaychik
Original Assignee
Vascular Therapies Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vascular Therapies Llc filed Critical Vascular Therapies Llc
Application granted granted Critical
Publication of ATE481097T1 publication Critical patent/ATE481097T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
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  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02718844T 2001-01-16 2002-01-16 Implantierbare vorrichtung enthaltend resorbierbares matrixmaterial und antiproliferative wirkstoffe zur vorbeugung oder behandlung von versagen vaskulärer hämodialysezugänge und anderer vaskulärer transplantate ATE481097T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26213201P 2001-01-16 2001-01-16
PCT/US2002/001375 WO2002062335A2 (en) 2001-01-16 2002-01-16 Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts

Publications (1)

Publication Number Publication Date
ATE481097T1 true ATE481097T1 (de) 2010-10-15

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ID=22996277

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02718844T ATE481097T1 (de) 2001-01-16 2002-01-16 Implantierbare vorrichtung enthaltend resorbierbares matrixmaterial und antiproliferative wirkstoffe zur vorbeugung oder behandlung von versagen vaskulärer hämodialysezugänge und anderer vaskulärer transplantate

Country Status (18)

Country Link
US (5) US6726923B2 (de)
EP (2) EP2314293B1 (de)
JP (2) JP4584537B2 (de)
CN (1) CN1492759A (de)
AP (1) AP2003002828A0 (de)
AT (1) ATE481097T1 (de)
AU (1) AU2002249958B2 (de)
BR (1) BR0206464A (de)
CA (1) CA2434972C (de)
CY (1) CY1119109T1 (de)
DE (1) DE60237671D1 (de)
DK (1) DK2314293T3 (de)
ES (1) ES2621652T3 (de)
MX (1) MXPA03006315A (de)
NZ (1) NZ527046A (de)
PT (1) PT2314293T (de)
RU (1) RU2345719C2 (de)
WO (1) WO2002062335A2 (de)

Families Citing this family (191)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8795242B2 (en) * 1994-05-13 2014-08-05 Kensey Nash Corporation Resorbable polymeric device for localized drug delivery
US7963997B2 (en) 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US8697108B2 (en) * 1994-05-13 2014-04-15 Kensey Nash Corporation Method for making a porous polymeric material
ES2248847T3 (es) * 1996-05-24 2006-03-16 Angiotech Pharmaceuticals, Inc. Composiciones y metodos para tratar o prevenir enfermedades de las vias de conduccion del cuerpo.
US7959664B2 (en) * 1996-12-26 2011-06-14 Medinol, Ltd. Flat process of drug coating for stents
US7399480B2 (en) * 1997-09-26 2008-07-15 Abbott Laboratories Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices
US20030129215A1 (en) * 1998-09-24 2003-07-10 T-Ram, Inc. Medical devices containing rapamycin analogs
US6890546B2 (en) 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
US8057816B2 (en) * 1997-09-26 2011-11-15 Abbott Laboratories Compositions and methods of administering paclitaxel with other drugs using medical devices
US8257726B2 (en) * 1997-09-26 2012-09-04 Abbott Laboratories Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices
US20030040790A1 (en) * 1998-04-15 2003-02-27 Furst Joseph G. Stent coating
US20020099438A1 (en) 1998-04-15 2002-07-25 Furst Joseph G. Irradiated stent coating
US8070796B2 (en) 1998-07-27 2011-12-06 Icon Interventional Systems, Inc. Thrombosis inhibiting graft
US7967855B2 (en) * 1998-07-27 2011-06-28 Icon Interventional Systems, Inc. Coated medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
AU9486901A (en) † 2000-09-29 2002-04-08 Cordis Corp Coated medical devices
US20050084514A1 (en) * 2000-11-06 2005-04-21 Afmedica, Inc. Combination drug therapy for reducing scar tissue formation
US6534693B2 (en) * 2000-11-06 2003-03-18 Afmedica, Inc. Surgically implanted devices having reduced scar tissue formation
US20040241211A9 (en) * 2000-11-06 2004-12-02 Fischell Robert E. Devices and methods for reducing scar tissue formation
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US6808518B2 (en) 2001-09-28 2004-10-26 Ethicon, Inc. Methods and devices for treating diseased blood vessels
US8740973B2 (en) * 2001-10-26 2014-06-03 Icon Medical Corp. Polymer biodegradable medical device
US20030163144A1 (en) * 2002-02-28 2003-08-28 Weadock Kevin S. Sponge for creating an anastomosis between vessels
JP4265888B2 (ja) * 2002-06-12 2009-05-20 株式会社リコー 画像形成装置
US7361368B2 (en) * 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
AU2003251787A1 (en) * 2002-07-02 2004-01-23 Polycord, Inc. Polymerized and modified rapamycins and their use in coating medical prostheses
AU2003248847A1 (en) * 2002-07-09 2004-01-23 Eva Corporation Delivery apparatus for use during a surgical procedure and method of using the same
US8016881B2 (en) * 2002-07-31 2011-09-13 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
US7438925B2 (en) 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
NZ538568A (en) * 2002-09-06 2010-09-30 Abbott Lab Medical device having hydration inhibitor
ES2428354T3 (es) 2002-09-18 2013-11-07 Trustees Of The University Of Pennsylvania Rapamicina para usar en la inhibición o prevención de la neovascularización coroidea
JP2006515186A (ja) * 2002-09-26 2006-05-25 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 血管周囲ラップ
AU2002953440A0 (en) * 2002-12-19 2003-01-09 Unisearch Limited A method of treating a stiffened vessel
US20050233030A1 (en) 2004-03-10 2005-10-20 Broin And Associates, Inc. Methods and systems for producing ethanol using raw starch and fractionation
MXPA05009553A (es) * 2003-03-10 2006-03-17 Broin And Associates Inc Metodo para producir etanol utilizando almidon como materia prima.
EP1460088A1 (de) 2003-03-21 2004-09-22 Biotest AG Humanisierter Antikörper gegen CD4 mit immunsuppressiven Merkmalen
US8383158B2 (en) 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
WO2004112864A2 (en) * 2003-06-19 2004-12-29 Vascular Therapies Llc Medical devices and methods for regulating the tissue response to vascular closure devices
JP2007505932A (ja) 2003-09-18 2007-03-15 マクサイト, インコーポレイテッド 経強膜送達
AU2004291062A1 (en) * 2003-11-10 2005-06-02 Angiotech International Ag Medical implants and anti-scarring agents
US7553326B2 (en) 2003-11-24 2009-06-30 Sweet Richard M Method and apparatus for preventing dialysis graft intimal hyperplasia
US7211108B2 (en) * 2004-01-23 2007-05-01 Icon Medical Corp. Vascular grafts with amphiphilic block copolymer coatings
US20050239181A1 (en) * 2004-03-10 2005-10-27 Broin And Associates, Inc. Continuous process for producing ethanol using raw starch
US20100030183A1 (en) * 2004-03-19 2010-02-04 Toner John L Method of treating vascular disease at a bifurcated vessel using a coated balloon
US8431145B2 (en) 2004-03-19 2013-04-30 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
US20070027523A1 (en) * 2004-03-19 2007-02-01 Toner John L Method of treating vascular disease at a bifurcated vessel using coated balloon
AU2005222719B2 (en) * 2004-03-19 2011-03-24 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
US7857767B2 (en) * 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
KR100596218B1 (ko) * 2004-06-10 2006-07-03 (주)액세스 플러스 약물이 표면처리된 혈액투석환자의 동정맥 연결용 튜브
US20060009839A1 (en) * 2004-07-12 2006-01-12 Scimed Life Systems, Inc. Composite vascular graft including bioactive agent coating and biodegradable sheath
WO2006017275A1 (en) 2004-07-13 2006-02-16 The University Of Tennessee Research Foundation Adhesive composition for carrying therapeutic agents as delivery vehicle on coatings applied to vascular grafts
US11207457B2 (en) 2004-08-27 2021-12-28 Edwards Lifesciences Corporation Device and method for establishing an artificial arterio-venous fistula
EP1791496B1 (de) 2004-08-31 2019-07-31 C.R. Bard, Inc. Selbstschliessendes ptfe-implantat mit knickbeständigkeit
US20060069426A1 (en) * 2004-09-27 2006-03-30 Weinberger Judah Z Methods and devices for extravascular intervention
US20060106406A1 (en) * 2004-09-27 2006-05-18 Judah Weinberger Methods and devices for extravascular intervention
US7452325B2 (en) 2004-11-15 2008-11-18 Benvenue Medical Inc. Catheter-based tissue remodeling devices and methods
US7993738B2 (en) * 2004-11-30 2011-08-09 The Regents Of The University Of Michigan Modified porous materials and method of forming the same
WO2006062909A2 (en) * 2004-12-08 2006-06-15 Pervasis Therapeutics, Inc. Methods and compositions for enhancing vascular access
CN103055350B (zh) * 2004-12-08 2014-12-10 夏尔再生医学公司 含细胞的可流动组合物的最小侵入性给药的材料和方法
WO2006086750A1 (en) 2005-02-09 2006-08-17 Macusight, Inc. Liquid formulations for treatment of diseases or conditions
WO2006110197A2 (en) * 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
US20060201601A1 (en) * 2005-03-03 2006-09-14 Icon Interventional Systems, Inc. Flexible markers
US8323333B2 (en) * 2005-03-03 2012-12-04 Icon Medical Corp. Fragile structure protective coating
US9107899B2 (en) 2005-03-03 2015-08-18 Icon Medical Corporation Metal alloys for medical devices
US7540995B2 (en) 2005-03-03 2009-06-02 Icon Medical Corp. Process for forming an improved metal alloy stent
AU2006221046B2 (en) * 2005-03-03 2012-02-02 Icon Medical Corp. Improved metal alloys for medical device
US20060264914A1 (en) * 2005-03-03 2006-11-23 Icon Medical Corp. Metal alloys for medical devices
WO2007032777A2 (en) * 2005-03-23 2007-03-22 Abbott Laboratories Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8828433B2 (en) * 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US20090087414A1 (en) * 2005-04-21 2009-04-02 Pervasis Therapeutics, Inc. Materials and methods for altering an immune response to exogenous and endogenous immunogens, including syngeneic and non-syngeneic cells, tissues or organs
US8333777B2 (en) 2005-04-22 2012-12-18 Benvenue Medical, Inc. Catheter-based tissue remodeling devices and methods
US20070037267A1 (en) * 2005-05-02 2007-02-15 Broin And Associates, Inc. Methods and systems for producing ethanol using raw starch and fractionation
US8002738B2 (en) * 2005-05-17 2011-08-23 Boston Scientific Scimed, Inc. Self-adhering lesion formation apparatus and methods
JP2008543376A (ja) * 2005-06-08 2008-12-04 シー・アール・バード・インコーポレーテッド 無機生体適合性カルシウム塩を有するグラフト及びステント
WO2007001472A2 (en) 2005-06-17 2007-01-04 C. R. Bard, Inc. Vascular graft with kink resistance after clamping
CN101257861B (zh) * 2005-06-21 2012-12-05 渗透治疗有限公司 用于增强血管通路的方法和组合物
JP5118042B2 (ja) * 2005-09-06 2013-01-16 シー・アール・バード・インコーポレーテッド 薬物結晶を含有する移植用インプラント
US7219021B2 (en) * 2005-09-13 2007-05-15 Honeywell International Inc. Multiple wireless sensors for dialysis application
US7919289B2 (en) 2005-10-10 2011-04-05 Poet Research, Inc. Methods and systems for producing ethanol using raw starch and selecting plant material
JP5285426B2 (ja) * 2005-10-14 2013-09-11 アボット ラボラトリーズ 医療デバイスを用いて、パクリタキセルとともにラパマイシン類似体を投与することについての組成物、システム、キット及び方法
US8636794B2 (en) 2005-11-09 2014-01-28 C. R. Bard, Inc. Grafts and stent grafts having a radiopaque marker
US20080317814A1 (en) * 2005-11-17 2008-12-25 Access Plus Co., Ltd. Tube for Connecting Marteriovenous and Interposition for Medical Operation
US20100204783A1 (en) * 2005-12-06 2010-08-12 Helen Marie Nugent Methods and compositions for enhancing vascular access
BRPI0600275A (pt) * 2006-01-03 2007-10-02 Brz Biotecnologia Ltda prótese coronária liberadora de composição medicamentosa para prevenção e tratamento da reestenose e processo de fabricação
US8492400B2 (en) 2006-02-09 2013-07-23 Santen Pharmaceutical Co., Ltd. Stable formulations, and methods of their preparation and use
US8828077B2 (en) * 2006-03-15 2014-09-09 Medinol Ltd. Flat process of preparing drug eluting stents
CN101443004B (zh) 2006-03-23 2013-03-06 参天制药株式会社 用于与血管通透性有关的疾病或病症的制剂
US8550344B2 (en) * 2006-06-16 2013-10-08 The Invention Science Fund I, Llc Specialty stents with flow control features or the like
US8095382B2 (en) * 2006-06-16 2012-01-10 The Invention Science Fund I, Llc Methods and systems for specifying a blood vessel sleeve
US8478437B2 (en) 2006-06-16 2013-07-02 The Invention Science Fund I, Llc Methods and systems for making a blood vessel sleeve
US20090024152A1 (en) * 2007-07-17 2009-01-22 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Custom-fitted blood vessel sleeve
US20080133040A1 (en) * 2006-06-16 2008-06-05 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for specifying a blood vessel sleeve
US8147537B2 (en) * 2006-06-16 2012-04-03 The Invention Science Fund I, Llc Rapid-prototyped custom-fitted blood vessel sleeve
US20080172073A1 (en) * 2006-06-16 2008-07-17 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Active blood vessel sleeve
US8163003B2 (en) * 2006-06-16 2012-04-24 The Invention Science Fund I, Llc Active blood vessel sleeve methods and systems
US7818084B2 (en) * 2006-06-16 2010-10-19 The Invention Science Fund, I, LLC Methods and systems for making a blood vessel sleeve
US8551155B2 (en) * 2006-06-16 2013-10-08 The Invention Science Fund I, Llc Stent customization system and method
US7722665B2 (en) * 2006-07-07 2010-05-25 Graft Technologies, Inc. System and method for providing a graft in a vascular environment
WO2008008291A2 (en) * 2006-07-13 2008-01-17 Icon Medical Corp. Stent
US20080039362A1 (en) * 2006-08-09 2008-02-14 Afmedica, Inc. Combination drug therapy for reducing scar tissue formation
US20080077070A1 (en) * 2006-08-10 2008-03-27 Kopia Gregory A Arteriovenous shunt
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US20080085293A1 (en) * 2006-08-22 2008-04-10 Jenchen Yang Drug eluting stent and therapeutic methods using c-Jun N-terminal kinase inhibitor
WO2008026644A1 (en) * 2006-08-29 2008-03-06 Fujifilm Corporation Hydrophilic matrix having poorly water-soluble compound sealed therein, and method for producing the same
EP2079575B1 (de) 2006-10-12 2021-06-02 C.R. Bard, Inc. Herstellungsverfahren für gefässtransplantate mit mehreren kanälen
JP5372764B2 (ja) * 2006-11-07 2013-12-18 シャイア リジェネラティブ メディシン, インコーポレイテッド 血管形成関連疾患の治療および管理のための材料および方法
US8741326B2 (en) * 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US8177798B2 (en) 2006-12-05 2012-05-15 Tyco Healthcare Group Lp Adhesive coated stent and insertion instrument
EP2155294B1 (de) * 2007-06-13 2012-02-15 Pervasis Therapeutics, Inc. Verfahren und vorrichtungen zur minimal invasiven abgabe von zellhaltigen fliessfähigen zusammensetzungen
US8361092B1 (en) 2007-06-18 2013-01-29 Wilson T. Asfora Vascular anastomosis device and method
US10004507B2 (en) 2007-06-18 2018-06-26 Asfora Ip, Llc Vascular anastomosis device and method
US9504469B2 (en) 2007-06-18 2016-11-29 Asfora Ip, Llc Vascular anastomosis device and method
US8721711B2 (en) * 2007-06-20 2014-05-13 Oregon Health & Science University Graft having microporous membrane for uniform fluid infusion
WO2009073782A2 (en) * 2007-12-04 2009-06-11 Ams Research Corporation Apparatus and methods for treatment of pathologic proliferative conditions of uterine tissue
US8808255B2 (en) * 2007-12-14 2014-08-19 Oregon Health & Science University Drug delivery cuff
AU2009214629A1 (en) 2008-02-13 2009-08-20 Eric T. Choi BMP-7 for use in treating vascular sclerosis
CN102105185A (zh) * 2008-02-26 2011-06-22 大卫·张 用于血管通路的方法和装置
CN102027017A (zh) 2008-03-13 2011-04-20 生物测试股份公司 一种治疗疾病的试剂
PL2262838T3 (pl) 2008-03-13 2016-10-31 Środek do leczenia choroby
AU2009224690B2 (en) 2008-03-13 2014-10-09 Biotest Ag Agent for treating disease
US20090264906A1 (en) * 2008-04-22 2009-10-22 Medtronic Vascular, Inc. Cuff Device
BRPI0919489A2 (pt) * 2008-09-29 2015-12-01 Biotest Ag composição, kit, métodos de tratamento de uma doença reumática, e de artrite reumatóide em um paciente, agente capaz de ativar células t reguladoras cd4+cd25+ e metotrexato, e, uso de um agente capaz de ativar células t reguladoras cd4+cd25+ e metotrexato
KR101034654B1 (ko) * 2009-01-15 2011-05-16 성균관대학교산학협력단 바이오액티브 물질 코팅방법
HUE025623T2 (en) 2009-03-03 2016-04-28 Poet Res Inc A method of fermenting biomass for ethanol production
US9068206B1 (en) 2009-03-03 2015-06-30 Poet Research, Inc. System for treatment of biomass to facilitate the production of ethanol
US8450094B1 (en) 2009-03-03 2013-05-28 Poet Research, Inc. System for management of yeast to facilitate the production of ethanol
WO2010102060A2 (en) * 2009-03-03 2010-09-10 Poet Research, Inc. System for pre-treatment of biomass for the production of ethanol
US20100233266A1 (en) * 2009-03-13 2010-09-16 Cleek Robert L Articles and methods of treating vascular conditions
EP3138517B1 (de) * 2009-04-20 2019-06-12 Rox Medical, Inc. Vorrichtung zur erstellung einer künstlichen venen-arterien-fistel
US8597262B2 (en) * 2009-07-09 2013-12-03 Ams Research Corporation Apparatus and methods of treatment of pathologic proliferative conditions uterine tissue
WO2011040652A1 (ko) * 2009-09-29 2011-04-07 주식회사 엠아이텍 이식용 튜브 및 그의 코팅 방법
US10016460B2 (en) 2009-11-27 2018-07-10 Stephen Anthony Livesey Method of inducing cellular growth and materials for use therewith
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease
US8480620B2 (en) * 2009-12-11 2013-07-09 Abbott Cardiovascular Systems Inc. Coatings with tunable solubility profile for drug-coated balloon
US20110144577A1 (en) * 2009-12-11 2011-06-16 John Stankus Hydrophilic coatings with tunable composition for drug coated balloon
US8951595B2 (en) * 2009-12-11 2015-02-10 Abbott Cardiovascular Systems Inc. Coatings with tunable molecular architecture for drug-coated balloon
JP2013514278A (ja) 2009-12-18 2013-04-25 インターフェース バイオロジクス,インコーポレーテッド 自己集合コーティングからの薬物の局所送達
JP2011130989A (ja) * 2009-12-25 2011-07-07 Japan Health Science Foundation 抗血栓性修飾剤、医療用具、及び、多孔質コラーゲン
ES2845398T3 (es) 2009-12-30 2021-07-26 Caliber Therapeutics Llc Sistemas de catéter de balón para administración de vesículas de administración de fármacos secos a un vaso en el cuerpo
US8399044B2 (en) * 2010-01-21 2013-03-19 Snu R And Db Foundation Method for coating medication on medical article
WO2011094459A1 (en) * 2010-01-27 2011-08-04 Iyer Sriram S Device and method for preventing stenosis at an anastomosis site
US8974519B2 (en) 2010-02-19 2015-03-10 Cardiovascular Systems, Inc. Therapeutic agent delivery system, device and method for localized application of therapeutic substances to a biological conduit
US8398916B2 (en) 2010-03-04 2013-03-19 Icon Medical Corp. Method for forming a tubular medical device
ES2656939T3 (es) * 2010-03-09 2018-03-01 Solinas Medical Inc. Dispositivos de cierre automático
IT1400232B1 (it) * 2010-05-07 2013-05-24 Advance Holdings Ltd Composizione farmaceutica topica comprendente eparina
BR112013027674A2 (pt) * 2011-04-28 2016-09-06 Abraxis Bioscience Llc "usos de composições de nanopartículas, composições compreendendo as referidas nanopartículas e cateter com uma agulha".
US10350431B2 (en) * 2011-04-28 2019-07-16 Gt Medical Technologies, Inc. Customizable radioactive carriers and loading system
WO2012159169A1 (en) * 2011-05-26 2012-11-29 Kathy Traianedes A method of ex vivo cellular growth
US8577693B2 (en) 2011-07-13 2013-11-05 The Invention Science Fund I, Llc Specialty stents with flow control features or the like
US9433722B2 (en) * 2011-08-09 2016-09-06 Abbott Cardiovascular Systems Inc. Vascular shield and delivery system
SMT202100257T1 (it) * 2012-01-09 2021-07-12 Innocoll Pharm Ltd Un collagene modificato
US20130303983A1 (en) * 2012-05-09 2013-11-14 Cook Medical Technologies Llc Coated medical devices including a water-insoluble therapeutic agent
WO2014070792A1 (en) 2012-10-29 2014-05-08 Ariste Medical, Inc. Polymer coating compositions and coated products
WO2014127278A2 (en) * 2013-02-18 2014-08-21 Elutin, Inc. Site specific drug delivery wraps, systems and methods of use thereof
US9492683B2 (en) 2013-03-15 2016-11-15 Gammatile Llc Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors
US20150119908A1 (en) * 2013-10-25 2015-04-30 Abbott Cardiovascular Systems Inc. Extravascular devices supporting an arteriovenous fistula
US20150119976A1 (en) * 2013-10-29 2015-04-30 Abbott Cardiovascular Systems Inc. Extravascular device for limiting blood flow adjacent an arteriovenous fistula
US9687239B2 (en) 2014-04-15 2017-06-27 Abbott Cardiovascular Systems Inc. Intravascular devices supporting an arteriovenous fistula
GB2537770B (en) 2014-04-22 2017-09-13 Ariste Medical Llc Methods and processes for application of drug delivery polymeric coatings
BR112016030273A2 (pt) 2014-06-24 2017-08-22 Icon Medical Corp Dispositivo médico e método para formar o referido dispositivo
US20160193390A1 (en) * 2015-01-05 2016-07-07 Wisconsin Alumni Research Foundation Perivascular Delivery System And Method
EP3250277B1 (de) * 2015-01-26 2022-09-21 Mercator Medsystems, Inc. Verfahren und systeme zur verhinderung von gefässentzündungen
US9821174B1 (en) 2015-02-06 2017-11-21 Gammatile Llc Radioactive implant planning system and placement guide system
JP6713795B2 (ja) * 2015-03-06 2020-06-24 国立大学法人東北大学 沿面放電装置
US9907680B2 (en) * 2015-04-10 2018-03-06 Cook Medical Technologies Llc Sliding fenestration
WO2017151548A1 (en) 2016-03-04 2017-09-08 Mirus Llc Stent device for spinal fusion
US10888710B1 (en) 2016-11-29 2021-01-12 Gt Medical Technologies, Inc. Transparent loading apparatus
JP2021531061A (ja) 2018-05-22 2021-11-18 インターフェース バイオロジクス,インコーポレーテッド 薬物を脈管壁に送達するための組成物及び方法
DE102018127200B3 (de) * 2018-10-31 2019-07-25 Andreas Haas Implantat zum subkutanen implantieren
IL263679A (en) * 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and compositions for preventing tissue adhesion
WO2021034537A1 (en) 2019-08-22 2021-02-25 Edwards Lifesciences Corporation Puncture needles
CN114727836B (zh) 2019-11-14 2026-01-09 爱德华兹生命科学公司 经导管的医疗植入物递送
CN111012409A (zh) * 2019-12-03 2020-04-17 王超 颞浅动脉额支与脑动脉皮层血运重建辅助三通及使用方法
US12527942B2 (en) 2021-02-01 2026-01-20 Edwards Lifesciences Corporation Pulmonary vein shunting
CN114259607B (zh) * 2021-12-28 2023-01-24 宇航 一种支架制备方法
US12053644B2 (en) 2021-12-30 2024-08-06 Gt Medical Technologies, Inc. Radiation shielding apparatus for implantable radioactive seeds
CA3245926A1 (en) * 2022-03-16 2023-09-21 W. L. Gore & Associates, Inc. ACCESS GRAFTING SYSTEMS AND METHODS
US20230355542A1 (en) * 2022-05-04 2023-11-09 Yasin Oduk Drug-eluting device with genetic and chemical therapeutics for treating or preventing vascular access dysfunctions
US20240074758A1 (en) * 2022-09-07 2024-03-07 Scott T. Kelley Device and method to prevent leakage
EP4594329A1 (de) 2022-09-30 2025-08-06 Biotronik Ag Synthese und charakterisierung von cyclischen kohlenwasserstoffestern von everolimus
CN119907670A (zh) 2022-09-30 2025-04-29 百多力股份公司 用于血管通路瘘、移植物和其它血管疾病的血管周围医学治疗的大环三烯免疫抑制化合物
WO2024119179A1 (en) * 2022-12-03 2024-06-06 Vascular Therapies, Inc. Unitary product for addressing arteriovenous fistula stenosis
WO2025250493A1 (en) * 2024-05-31 2025-12-04 Vascular Therapies, Inc. Product to treat or prevent stenosis in a blood vessel

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1937629C3 (de) 1969-07-19 1979-07-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen Nitrofuryl-aminoalkoxy-pyriinidine
US3797485A (en) 1971-03-26 1974-03-19 Alza Corp Novel drug delivery device for administering drug into blood circulation in blood vessel
US4391797A (en) 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
SU904693A1 (ru) * 1980-05-12 1982-02-15 Первый Московский Ордена Ленина И Ордена Трудового Красного Знамени Медицинский Институт Им. И.М.Сеченова Протез сосуда
US4409332A (en) 1982-01-12 1983-10-11 Jefferies Steven R Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same
US4677120A (en) 1985-07-31 1987-06-30 Molecular Design International Topical prodrugs for treatment of acne and skin diseases
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4889842A (en) 1987-03-03 1989-12-26 Morris Randall E Concanavalin A dimers as therapeutic agents
US5124356A (en) 1987-06-29 1992-06-23 Molecular Design International, Inc. Dermal uses of trans-retinoids for the treatment of photoaging
US4885311A (en) 1987-06-29 1989-12-05 Molecular Design International Topical transretinoids for treatment of acne and skin diseases
US4994491A (en) 1988-12-14 1991-02-19 Molecular Design International Dermal uses of trans-retinoids for the treatment of cancer
US4840940A (en) 1987-10-21 1989-06-20 Sottiurai Vikrom S Method for reducing the occurrence of distal anastomotic intimal hyperplasia using fractionated heparin
US5157049A (en) 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US5100668A (en) 1988-06-14 1992-03-31 Massachusetts Institute Of Technology Controlled release systems containing heparin and growth factors
US5074869A (en) * 1988-09-26 1991-12-24 Daicoff George R Vascular occlusion device
US5049584A (en) 1988-12-14 1991-09-17 Molecular Design International Dermal uses of cis-retinoids for the treatment of cancer
US5223269A (en) 1989-08-31 1993-06-29 Andrejs Liepins Methods and composition for the treatment of hypertension
US6326017B1 (en) 1989-10-02 2001-12-04 University Of Washington Methods for the localized delivery of agents to blood vessels
US5527532A (en) * 1989-11-13 1996-06-18 President And Fellows Of Harvard College Extraluminal regulation of the growth and repair of tubular structures in vivo
AU6747790A (en) 1989-11-13 1991-06-13 President And Fellows Of Harvard College Extraluminal regulation of the growth and repair of tubular structures in vivo
US5540928A (en) 1991-02-27 1996-07-30 President And Fellows Of Harvard College Extraluminal regulation of the growth and repair of tubular structures in vivo
US5138051A (en) 1991-08-07 1992-08-11 American Home Products Corporation Rapamycin analogs as immunosuppressants and antifungals
CA2082411A1 (en) 1991-06-28 1992-12-29 Robert D. Rosenberg Localized oligonucleotide therapy
US5202332A (en) 1991-08-07 1993-04-13 American Home Products Corporation Rapamycin analog as immunosuppressant
US5169851A (en) 1991-08-07 1992-12-08 American Home Products Corporation Rapamycin analog as immunosuppressants and antifungals
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2081424C (en) 1991-10-25 2008-12-30 Timothy A. Chuter Expandable transluminal graft prosthesis for repair of aneurysm
US5516781A (en) 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
US5288711A (en) 1992-04-28 1994-02-22 American Home Products Corporation Method of treating hyperproliferative vascular disease
AU4382593A (en) * 1992-05-20 1993-12-13 New England Deaconess Hospital Extravascular system for infusion of soluble substances
US5283257A (en) 1992-07-10 1994-02-01 The Board Of Trustees Of The Leland Stanford Junior University Method of treating hyperproliferative vascular disease
CA2086874E (en) 1992-08-03 2000-01-04 Renzo Mauro Canetta Methods for administration of taxol
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5480988A (en) 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2092271C (en) 1993-03-09 2009-10-13 Eddie Reed Use of g-csf for treating taxol side-effects
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5571800A (en) 1993-05-17 1996-11-05 Azura, Inc. Method for inhibiting allograft rejection by the administration of 6-azauridine or its triacetate derivative
EP0982302B1 (de) 1993-06-11 2004-04-14 PHARMACIA & UPJOHN COMPANY Delta 6,7-Taxol Derivate antineoplastische Verwendung und diese enthaltende pharmazeutische Zusammenstellungen
US5716981A (en) 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
ES2255477T5 (es) 1993-07-29 2010-04-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Uso de paclitaxel y sus derivados en la fabricacion de un medicamento para el tratamiento de reestenosis.
US6323184B1 (en) 1993-10-15 2001-11-27 Thomas Jefferson University Arteriovenous and venous graft treatments: methods and compositions
US5519042A (en) 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
IL127599A (en) 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs
UA10911C2 (uk) * 1994-08-10 1996-12-25 Мале Впроваджувальне Підприємство "Іhтерфалл" Біосумісhий гідрогель
EP0698396B1 (de) 1994-08-12 2001-12-12 Meadox Medicals, Inc. Mit einen Heparin enhaltendes Kollagendichtmittel imprägniertes Gefässtransplantat
US5660873A (en) 1994-09-09 1997-08-26 Bioseal, Limited Liability Corporaton Coating intraluminal stents
US5616680A (en) * 1994-10-04 1997-04-01 Hoechst Celanese Corporation Process for producing liquid crystal polymer
US5837728A (en) 1995-01-27 1998-11-17 Molecular Design International 9-cis retinoic acid esters and amides and uses thereof
US5766584A (en) 1995-06-02 1998-06-16 Massachusetts Institute Of Technology Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells
CA2178541C (en) 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
AU7360396A (en) 1995-09-11 1997-04-01 Enzymed, Inc. Biocatalytic methods for synthesizing and identifying biologically active compounds
US5795286A (en) * 1996-08-15 1998-08-18 Cathco, Inc. Radioisotope impregnated sheet of biocompatible material for preventing scar tissue formation
JP5053470B2 (ja) 1996-08-23 2012-10-17 クック バイオテク インコーポレイティド グラフト・プロテーゼとその材料及び方法
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US6090996A (en) 1997-08-04 2000-07-18 Collagen Matrix, Inc. Implant matrix
US6015815A (en) 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
US6117166A (en) 1997-10-27 2000-09-12 Winston; Thomas R. Apparatus and methods for grafting blood vessel tissue
US6224794B1 (en) 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
US6179858B1 (en) 1998-05-12 2001-01-30 Massachusetts Institute Of Technology Stent expansion and apposition sensing
US6091980A (en) 1998-05-12 2000-07-18 Massachusetts Institute Of Technology Stent slip sensing system and method
ES2229788T3 (es) * 1998-10-26 2005-04-16 Ludwig Institute For Cancer Research Uso del gen o proteina vegf-c o vegf-d para prevenir la restenosis.
DE19849589C1 (de) 1998-10-27 2000-06-15 Glatt Process Technology Gmbh Fibrin-Gewebekleber-Formulierung und Verfahren zu dessen Herstellung
US6333347B1 (en) 1999-01-29 2001-12-25 Angiotech Pharmaceuticals & Advanced Research Tech Intrapericardial delivery of anti-microtubule agents
US6391333B1 (en) 1999-04-14 2002-05-21 Collagen Matrix, Inc. Oriented biopolymeric membrane
US6328762B1 (en) * 1999-04-27 2001-12-11 Sulzer Biologics, Inc. Prosthetic grafts
US6730313B2 (en) 2000-01-25 2004-05-04 Edwards Lifesciences Corporation Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia
US6746773B2 (en) 2000-09-29 2004-06-08 Ethicon, Inc. Coatings for medical devices
US6534693B2 (en) 2000-11-06 2003-03-18 Afmedica, Inc. Surgically implanted devices having reduced scar tissue formation
PE20091074A1 (es) 2007-12-13 2009-07-26 Bayer Healthcare Ag Triazolotriazinas y triazolopirazinas y su uso

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US10272073B2 (en) 2019-04-30
EP1351681A2 (de) 2003-10-15
US7807191B2 (en) 2010-10-05
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RU2345719C2 (ru) 2009-02-10
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US8858982B2 (en) 2014-10-14
CY1119109T1 (el) 2018-02-14
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US20040197409A1 (en) 2004-10-07
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EP1351681B1 (de) 2010-09-15
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US20150209334A1 (en) 2015-07-30
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US20080091263A1 (en) 2008-04-17
AU2002249958B2 (en) 2007-11-08
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