ATE481377T1 - Hydroxyphenol-derivate, herstellungsverfahren dafür, pharmazeutische zusammensetzungen damit und therapeutische verwendung - Google Patents

Hydroxyphenol-derivate, herstellungsverfahren dafür, pharmazeutische zusammensetzungen damit und therapeutische verwendung

Info

Publication number
ATE481377T1
ATE481377T1 AT05823908T AT05823908T ATE481377T1 AT E481377 T1 ATE481377 T1 AT E481377T1 AT 05823908 T AT05823908 T AT 05823908T AT 05823908 T AT05823908 T AT 05823908T AT E481377 T1 ATE481377 T1 AT E481377T1
Authority
AT
Austria
Prior art keywords
pharmaceutical compositions
production process
therapeutic use
hydroxyphenol derivatives
hydroxyphenol
Prior art date
Application number
AT05823908T
Other languages
English (en)
Inventor
Nathalie Adje
Catherine Vidal
Jean-Jacques Zeiller
Stephane Yvon
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE481377T1 publication Critical patent/ATE481377T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT05823908T 2005-01-14 2005-12-22 Hydroxyphenol-derivate, herstellungsverfahren dafür, pharmazeutische zusammensetzungen damit und therapeutische verwendung ATE481377T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0500420A FR2880887B1 (fr) 2005-01-14 2005-01-14 Derives d'hydroxyphenols, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
PCT/EP2005/013858 WO2006074798A1 (en) 2005-01-14 2005-12-22 Hydroxyphenol derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
ATE481377T1 true ATE481377T1 (de) 2010-10-15

Family

ID=35033619

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05823908T ATE481377T1 (de) 2005-01-14 2005-12-22 Hydroxyphenol-derivate, herstellungsverfahren dafür, pharmazeutische zusammensetzungen damit und therapeutische verwendung

Country Status (16)

Country Link
US (1) US8653134B2 (de)
EP (1) EP1836150B1 (de)
JP (1) JP2008526904A (de)
KR (1) KR20070092278A (de)
CN (1) CN101098846A (de)
AR (1) AR053115A1 (de)
AT (1) ATE481377T1 (de)
AU (1) AU2005324904B2 (de)
BR (1) BRPI0519855A2 (de)
CA (1) CA2594707C (de)
DE (1) DE602005023659D1 (de)
ES (1) ES2353149T3 (de)
FR (1) FR2880887B1 (de)
MX (1) MX2007008351A (de)
WO (1) WO2006074798A1 (de)
ZA (1) ZA200706706B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100877200B1 (ko) 2007-09-11 2009-01-07 주식회사 동희산업 가속페달 장치의 킥 다운 스위치
JP5960839B2 (ja) * 2012-11-15 2016-08-02 帝人株式会社 ６，６’−（エチレンジオキシ）ジ−２−ナフトエ酸ジエステルの製造方法
EP3943771B1 (de) 2020-07-21 2023-11-15 Siemens Aktiengesellschaft Verfahren und vorrichtung zur montage einer oder mehrerer lager

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GB860303A (en) * 1958-06-20 1961-02-01 Ici Ltd Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª
BE654557A (de) * 1963-07-13
US3378582A (en) * 1964-03-20 1968-04-16 Merck & Co Inc (alpha-phenoxy)-and (alpha-phenylthio)-omegaphenyl-alkanoic acids
FR1498459A (de) * 1965-07-30 1968-01-08
BE759013R (fr) * 1969-11-17 1971-05-17 Ici Ltd Derives de la
DE2208893A1 (de) * 1972-02-25 1973-08-30 Boehringer Mannheim Gmbh Tricyclische alpha-oxy-carbonsaeurederivate und verfahren zur herstellung derselben
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JPS5732288A (en) * 1980-07-14 1982-02-20 Clin Midy Tarampicillin 2-methoxyphenoxyacetate and manufacture
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CA2074537A1 (en) * 1991-07-29 1993-01-30 Bruce E. Witzel Catechol type non-steroidal drugs as 5-alpha reductase inhibitors
DE4142514A1 (de) * 1991-12-21 1993-06-24 Basf Ag Verfahren zur bekaempfung von pilzen
JPH07173143A (ja) * 1993-12-17 1995-07-11 Wakamoto Pharmaceut Co Ltd 新規２−チオキソ−４−チアゾリジノン誘導体及び医薬
WO1995022323A1 (en) * 1994-02-16 1995-08-24 Idun Pharmaceuticals Methods for controlling free radical generation by inflammatory cells
EP0942903A1 (de) * 1996-09-26 1999-09-22 Novartis AG Arylsubstituierte acrylamine mit leukotriene b4-(ltb-4)-rezeptor antagonistischer aktivität
AU8750298A (en) * 1997-08-28 1999-03-22 Ono Pharmaceutical Co. Ltd. Peroxisome proliferator-activated receptor controllers
AU2622301A (en) * 1999-11-05 2001-05-14 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
JP2004500389A (ja) * 2000-03-09 2004-01-08 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｐｐａｒメディエーターの治療での使用
CA2415742A1 (en) * 2000-07-25 2002-01-31 Merck & Co., Inc. N-substituted indoles useful in the treatment of diabetes
BR0211810A (pt) * 2001-08-09 2004-08-24 Ono Pharmaceutical Co Derivados ácido carboxìlico e agente farmacêutico compreendendo os mesmos como ingrediente ativo
DE10142665B4 (de) * 2001-08-31 2004-05-06 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-one und ihre Derivate
EP1618090A1 (de) * 2003-04-11 2006-01-25 Novo Nordisk A/S 11 beta-hydroxysteroiddehydrogenase-typ-1-aktive verbindungen
WO2004089416A2 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent
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Also Published As

Publication number Publication date
JP2008526904A (ja) 2008-07-24
MX2007008351A (es) 2007-07-25
CA2594707A1 (en) 2006-07-20
KR20070092278A (ko) 2007-09-12
CA2594707C (en) 2013-10-22
ZA200706706B (en) 2008-09-25
BRPI0519855A2 (pt) 2009-03-24
AU2005324904A1 (en) 2006-07-20
AR053115A1 (es) 2007-04-25
US8653134B2 (en) 2014-02-18
FR2880887B1 (fr) 2009-01-30
EP1836150B1 (de) 2010-09-15
AU2005324904B2 (en) 2011-10-13
WO2006074798A1 (en) 2006-07-20
ES2353149T3 (es) 2011-02-25
EP1836150A1 (de) 2007-09-26
CN101098846A (zh) 2008-01-02
FR2880887A1 (fr) 2006-07-21
US20080161308A1 (en) 2008-07-03
DE602005023659D1 (de) 2010-10-28

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties