ATE482955T1 - Azabicyclooctan-3-onderivate und deren verwendung - Google Patents
Azabicyclooctan-3-onderivate und deren verwendungInfo
- Publication number
- ATE482955T1 ATE482955T1 AT05722253T AT05722253T ATE482955T1 AT E482955 T1 ATE482955 T1 AT E482955T1 AT 05722253 T AT05722253 T AT 05722253T AT 05722253 T AT05722253 T AT 05722253T AT E482955 T1 ATE482955 T1 AT E482955T1
- Authority
- AT
- Austria
- Prior art keywords
- azabicyclooctan
- derivatives
- compounds
- formula
- cancer
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400708A SE0400708D0 (sv) | 2004-03-22 | 2004-03-22 | New compounds and use thereof |
| PCT/SE2005/000412 WO2005090341A1 (en) | 2004-03-22 | 2005-03-22 | Azabicyclooctan-3-one derivatives and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482955T1 true ATE482955T1 (de) | 2010-10-15 |
Family
ID=32067464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05722253T ATE482955T1 (de) | 2004-03-22 | 2005-03-22 | Azabicyclooctan-3-onderivate und deren verwendung |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7759361B2 (de) |
| EP (1) | EP1727817B1 (de) |
| JP (1) | JP4904561B2 (de) |
| AT (1) | ATE482955T1 (de) |
| AU (1) | AU2005223728B2 (de) |
| CA (1) | CA2552855C (de) |
| CY (1) | CY1111256T1 (de) |
| DE (1) | DE602005023840D1 (de) |
| DK (1) | DK1727817T3 (de) |
| ES (1) | ES2349471T3 (de) |
| PL (1) | PL1727817T3 (de) |
| PT (1) | PT1727817E (de) |
| SE (1) | SE0400708D0 (de) |
| SI (1) | SI1727817T1 (de) |
| WO (1) | WO2005090341A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007062030A2 (en) * | 2005-11-21 | 2007-05-31 | Ohio University | Quinuclidinone derivatives as anticancer agents |
| PH12012501402A1 (en) * | 2010-01-21 | 2016-07-27 | Aprea Therapeutics Ab | Aqueous solution comprising 3-quinuclidinones for the treatment hyperproliferative, autoimmune and heart disease |
| CN104860994A (zh) * | 2014-02-20 | 2015-08-26 | 中国药科大学 | 3-奎宁环酮类含磷化合物的制备及其医药用途 |
| WO2017159877A1 (en) * | 2016-03-18 | 2017-09-21 | Eisai R&D Management Co., Ltd. | Use of eribulin and 3-quinuclidinone derivatives in the treatment of cancer |
| CN109280054A (zh) * | 2017-07-21 | 2019-01-29 | 上海时莱生物技术有限公司 | 氘代3-奎宁环酮类化合物、制备方法及用途 |
| CN109280056A (zh) * | 2017-07-21 | 2019-01-29 | 上海时莱生物技术有限公司 | 手性3-奎宁环酮类化合物、制备方法及用途 |
| CN112771041A (zh) * | 2018-09-20 | 2021-05-07 | 阿普里治疗公司 | 奎宁环-3-酮衍生物及其在癌症治疗中的用途 |
| EP4031136A1 (de) | 2019-09-18 | 2022-07-27 | Aprea Therapeutics AB | Kombinationstherapie mit einem p53-reaktivator und einem inhibitor eines antiapoptotischen proteins der bcl-2-familie |
| WO2021170772A1 (en) | 2020-02-26 | 2021-09-02 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of cd47 mediated signaling |
| WO2021180338A1 (en) | 2020-03-09 | 2021-09-16 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of dna methyltransferase post stem cell transplant |
| WO2022175402A1 (en) | 2021-02-18 | 2022-08-25 | Aprea Therapeutics Ab | Quinuclidine-3-one derivatives |
| US20240217964A1 (en) * | 2021-03-22 | 2024-07-04 | Newave Pharmaceutical Inc. | Quinuclidinone analogues as anticancer agents |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3384641A (en) * | 1967-09-19 | 1968-05-21 | Aldrich Chem Co Inc | 2-methylene-3-quinuclidones |
| US3726877A (en) * | 1970-10-28 | 1973-04-10 | Univ Temple | Amine substituted methylene quinuclidone anti-bacterial agents |
| US4599344A (en) * | 1984-10-31 | 1986-07-08 | Schering A.G. | Quinuclidines and quinuclidinium salts as antiarrhythmic agents |
| AU648317B2 (en) * | 1990-06-01 | 1994-04-21 | Pfizer Inc. | 3-amino-2-aryl quinuclidines, process for their preparation and pharmaceutical compositions containing them |
| US6432975B1 (en) * | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6953855B2 (en) * | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| US6500840B2 (en) * | 2000-08-21 | 2002-12-31 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| DE60136473D1 (de) * | 2000-09-20 | 2008-12-18 | Aprea Ab | Verwendung von 1-azabicyclo(2.2.2)octan-3-on-derivaten zur behandlung von krebstumoren |
| ES2269975T3 (es) | 2002-02-21 | 2007-04-01 | Aprea Ab | Uso de compuestos de bajo peso molecular para preparar un medicamento util para tratar enfermedades mediadas por p53 mutante. |
| EP1605939B1 (de) | 2003-03-24 | 2008-10-15 | Aprea Ab | Pharmazeutische verwendung von 1-azabicyclo¬ 2.2.2 octanen und verfahren zum testen von verbindungen auf die fähigkeit zur aktivierung von inaktivem wt p53 |
| SE0300812D0 (sv) | 2003-03-24 | 2003-03-24 | Karolinska Innovations Ab | Use of chemical compounds for preparing pharmaceutical compositions, and method of testing substances for medical effect |
-
2004
- 2004-03-22 SE SE0400708A patent/SE0400708D0/xx unknown
-
2005
- 2005-03-22 AT AT05722253T patent/ATE482955T1/de active
- 2005-03-22 JP JP2007504913A patent/JP4904561B2/ja not_active Expired - Lifetime
- 2005-03-22 PT PT05722253T patent/PT1727817E/pt unknown
- 2005-03-22 WO PCT/SE2005/000412 patent/WO2005090341A1/en not_active Ceased
- 2005-03-22 ES ES05722253T patent/ES2349471T3/es not_active Expired - Lifetime
- 2005-03-22 EP EP05722253A patent/EP1727817B1/de not_active Expired - Lifetime
- 2005-03-22 DE DE602005023840T patent/DE602005023840D1/de not_active Expired - Lifetime
- 2005-03-22 SI SI200531186T patent/SI1727817T1/sl unknown
- 2005-03-22 DK DK05722253.1T patent/DK1727817T3/da active
- 2005-03-22 AU AU2005223728A patent/AU2005223728B2/en not_active Expired
- 2005-03-22 US US10/590,054 patent/US7759361B2/en not_active Expired - Lifetime
- 2005-03-22 CA CA2552855A patent/CA2552855C/en not_active Expired - Lifetime
- 2005-03-22 PL PL05722253T patent/PL1727817T3/pl unknown
-
2010
- 2010-12-23 CY CY20101101187T patent/CY1111256T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005090341A1 (en) | 2005-09-29 |
| AU2005223728B2 (en) | 2011-02-10 |
| AU2005223728A1 (en) | 2005-09-29 |
| SE0400708D0 (sv) | 2004-03-22 |
| US7759361B2 (en) | 2010-07-20 |
| PL1727817T3 (pl) | 2011-03-31 |
| EP1727817B1 (de) | 2010-09-29 |
| JP4904561B2 (ja) | 2012-03-28 |
| CY1111256T1 (el) | 2015-08-05 |
| DE602005023840D1 (de) | 2010-11-11 |
| CA2552855A1 (en) | 2005-09-29 |
| JP2007530534A (ja) | 2007-11-01 |
| CA2552855C (en) | 2012-08-14 |
| DK1727817T3 (da) | 2011-01-10 |
| EP1727817A1 (de) | 2006-12-06 |
| SI1727817T1 (sl) | 2011-01-31 |
| US20070142370A1 (en) | 2007-06-21 |
| ES2349471T3 (es) | 2011-01-03 |
| PT1727817E (pt) | 2010-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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