ATE482966T1 - Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide - Google Patents
Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroideInfo
- Publication number
- ATE482966T1 ATE482966T1 AT05776411T AT05776411T ATE482966T1 AT E482966 T1 ATE482966 T1 AT E482966T1 AT 05776411 T AT05776411 T AT 05776411T AT 05776411 T AT05776411 T AT 05776411T AT E482966 T1 ATE482966 T1 AT E482966T1
- Authority
- AT
- Austria
- Prior art keywords
- norsteroids
- alkylated
- alpha
- producing
- fulvestrant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59168904P | 2004-07-27 | 2004-07-27 | |
| US60029204P | 2004-08-09 | 2004-08-09 | |
| US63392704P | 2004-12-06 | 2004-12-06 | |
| PCT/US2005/026715 WO2006015081A2 (en) | 2004-07-27 | 2005-07-27 | A PROCESS FOR THE PREPARATION OF 7α-ALKYLATED 19-NORSTEROIDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482966T1 true ATE482966T1 (de) | 2010-10-15 |
Family
ID=35385883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05776411T ATE482966T1 (de) | 2004-07-27 | 2005-07-27 | Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7790910B2 (de) |
| EP (1) | EP1771462B1 (de) |
| JP (1) | JP2007506805A (de) |
| KR (1) | KR20070061526A (de) |
| AT (1) | ATE482966T1 (de) |
| CA (1) | CA2574967A1 (de) |
| DE (1) | DE602005023877D1 (de) |
| TW (1) | TW200617019A (de) |
| WO (1) | WO2006015081A2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20071479A1 (it) * | 2007-07-23 | 2009-01-24 | Ind Chimica Srl | Processo per la preparazione di 7alfa-[9-(4,4,5,5,5-pentafluortiopentil)nonil]estra-1,3,5(10)-trien-3,17beta-diolo |
| US20100174101A1 (en) * | 2007-09-24 | 2010-07-08 | Xi'an Liband Pharmaceutical Co., Ltd. | Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol |
| CN101525364B (zh) * | 2008-03-07 | 2012-12-12 | 杭州九源基因工程有限公司 | 一种氟维司群的晶型及其制备方法 |
| NZ609420A (en) | 2010-09-16 | 2015-06-26 | Shimoda Biotech Pty Ltd | Fulvestrant compositions and methods of use |
| CN102600064A (zh) * | 2012-03-31 | 2012-07-25 | 西安力邦制药有限公司 | 氟维司群或其衍生物缓释制剂及其制备方法 |
| CA2873672A1 (en) | 2012-05-21 | 2013-11-28 | Novartis Ag | Novel ring-substituted n-pyridinyl amides as kinase inhibitors |
| EP2909224B1 (de) | 2012-10-22 | 2020-03-18 | Intas Pharmaceuticals Limited | Verbessertes verfahren zur herstellung von fulvestrant |
| CA2909418A1 (en) * | 2013-04-18 | 2014-10-23 | Xi'an Libang Pharmaceutical Technology Co., Ltd. | Ester derivative of 7-.alpha.-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)n onyl]-estra-1,3,5(10)-triene-3,17.beta.-diol having anticancer activity and preparation method thereof |
| CN103965280B (zh) * | 2014-05-21 | 2016-04-20 | 天津孚音生物科技发展有限公司 | 一种氟维司群中间体的制备方法 |
| CN103980336B (zh) * | 2014-05-21 | 2016-10-05 | 天津孚音生物科技发展有限公司 | 一种新的氟维司群的合成方法 |
| WO2015181116A1 (en) | 2014-05-26 | 2015-12-03 | Crystal Pharma, S.A.U. | Process and intermediades for the preparation of 7-alkylated steroids |
| CN104387435B (zh) * | 2014-12-10 | 2017-05-10 | 天津孚音生物科技发展有限公司 | 一种化合物及其制备方法与应用 |
| CN107033210B (zh) * | 2016-02-03 | 2019-08-16 | 正大天晴药业集团股份有限公司 | 一种氟维司群及其中间体的制备方法 |
| CN107286213A (zh) * | 2016-03-31 | 2017-10-24 | 杭州共泽医药科技有限公司 | 一种氟维司群中间体的制备方法 |
| CN107325143B (zh) * | 2017-08-07 | 2019-09-10 | 连云港恒运药业有限公司 | 氟维司群中间体合成方法 |
| CN110128497A (zh) * | 2018-02-09 | 2019-08-16 | 鲁南制药集团股份有限公司 | 一种氟维司群制备方法 |
| CN110818764A (zh) * | 2018-08-07 | 2020-02-21 | 重庆圣华曦药业股份有限公司 | 一种应用加料监测系统制备氟维斯群中间体的方法 |
| CN111662356A (zh) * | 2019-03-06 | 2020-09-15 | 正大天晴药业集团股份有限公司 | 一种氟维司群的杂质控制方法 |
| CN112094308B (zh) * | 2020-09-28 | 2022-05-17 | 湖南新合新生物医药有限公司 | 氟维司群中间体的制备方法 |
| CN114671922A (zh) * | 2020-12-24 | 2022-06-28 | 鲁南制药集团股份有限公司 | 一种氟维司群有关物质 |
| CN114685593B (zh) * | 2020-12-31 | 2024-01-23 | 鲁南制药集团股份有限公司 | 一种氟维司群制备方法及其中间体 |
| CN115448971B (zh) * | 2021-06-09 | 2026-02-17 | 上海弼领生物技术有限公司 | 一种用于制备氟维司群的中间体及其制备方法 |
| CN116003500A (zh) * | 2021-10-21 | 2023-04-25 | 杭州九源基因工程有限公司 | 一种氟维司群中间体的晶型及其制备方法与用途 |
| WO2025195993A1 (en) * | 2024-03-18 | 2025-09-25 | Minakem | Process for the preparation of fulvestrant |
| CN119431482B (zh) * | 2024-09-26 | 2025-10-24 | 江西君业生物制药有限公司 | 一锅法制备氟维司群中间体n-3的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2235949B1 (de) | 1973-06-18 | 1978-03-17 | Roussel Uclaf | |
| GB8327256D0 (en) * | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
| US5395842A (en) | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| US6500669B1 (en) * | 1994-05-04 | 2002-12-31 | Massachusetts Institute Of Technology | Programmable genotoxic agents and uses therefor |
| DE19622457A1 (de) * | 1996-05-24 | 1997-11-27 | Schering Ag | 7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln |
| US5866560A (en) * | 1996-08-20 | 1999-02-02 | Schering Ag | 7α-(ξ-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7α-(ξ-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents |
| DE19635525A1 (de) * | 1996-08-20 | 1998-02-26 | Schering Ag | 7alpha-(xi-Aminoalkyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha(xi-Aminoalkyl-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln |
| AR015500A1 (es) * | 1997-12-23 | 2001-05-02 | Schering Ag | 11 BETA-HALoGENO-ESTRATRIENOS SUSTITUIDOS EN 7 ALFA, PROCEDIMIENTO PARA ELABORAR PREPARADOS FARMACEUTICOS QUE CONTIENEN TALES 11 BETA-HALOGENO-ESTRATRIENOSSUSTITUIDOS EN 7 ALFA, ASI COMO SU UTILIZACION EN LA ELABORACION DE MEDICAMENTOS. |
| DE19807791A1 (de) | 1998-02-19 | 1999-08-26 | Schering Ag | Kombinationspräparat aus Östrogen und Antiöstrogen |
| GB0025221D0 (en) | 2000-10-14 | 2000-11-29 | Astrazeneca Ab | New process |
| GB0123961D0 (en) * | 2001-10-05 | 2001-11-28 | Astrazeneca Ab | Process and intermediates |
| DE10159217A1 (de) | 2001-11-27 | 2003-06-05 | Schering Ag | 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate |
-
2005
- 2005-07-27 JP JP2006534484A patent/JP2007506805A/ja active Pending
- 2005-07-27 WO PCT/US2005/026715 patent/WO2006015081A2/en not_active Ceased
- 2005-07-27 EP EP05776411A patent/EP1771462B1/de not_active Expired - Lifetime
- 2005-07-27 AT AT05776411T patent/ATE482966T1/de not_active IP Right Cessation
- 2005-07-27 KR KR1020077004141A patent/KR20070061526A/ko not_active Ceased
- 2005-07-27 US US11/192,071 patent/US7790910B2/en not_active Expired - Fee Related
- 2005-07-27 DE DE602005023877T patent/DE602005023877D1/de not_active Expired - Lifetime
- 2005-07-27 TW TW094125420A patent/TW200617019A/zh unknown
- 2005-07-27 CA CA002574967A patent/CA2574967A1/en not_active Abandoned
-
2009
- 2009-08-12 US US12/583,075 patent/US20090306417A1/en not_active Abandoned
- 2009-08-12 US US12/583,045 patent/US20090318721A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006015081A3 (en) | 2006-05-04 |
| US20090318721A1 (en) | 2009-12-24 |
| KR20070061526A (ko) | 2007-06-13 |
| TW200617019A (en) | 2006-06-01 |
| JP2007506805A (ja) | 2007-03-22 |
| EP1771462A2 (de) | 2007-04-11 |
| US20090306417A1 (en) | 2009-12-10 |
| CA2574967A1 (en) | 2006-02-09 |
| EP1771462B1 (de) | 2010-09-29 |
| DE602005023877D1 (de) | 2010-11-11 |
| US7790910B2 (en) | 2010-09-07 |
| WO2006015081A2 (en) | 2006-02-09 |
| US20060030552A1 (en) | 2006-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE482966T1 (de) | Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide | |
| DE602005009866D1 (de) | Verfahren zur herstellung von n-phenylpyrazol-1-carboxamiden | |
| DE602005018601D1 (de) | Verfahren zur herstellung von 2-aminothiazol-5-aro | |
| DE602005016292D1 (de) | Verfahren zur herstellung von glatiramer | |
| DE502005002059D1 (de) | Verfahren zur herstellung von polyetheralkoholen | |
| DE60323192D1 (de) | Verfahren zur Herstellung von Hydroxyalkylstärkederivaten | |
| DE60302682D1 (de) | Verfahren zur Herstellung von Nanopartikeln | |
| DE602004005137D1 (de) | Verfahren zur Herstellung von Nanopartikeln | |
| ATA8002004A (de) | Verfahren zur herstellung von 2-butanol | |
| DE502005007762D1 (de) | Verfahren zur herstellung von zahnrädern | |
| DE602006010302D1 (de) | Verfahren zur Herstellung von 5-methyl-2-furfural | |
| DE50311721D1 (de) | Verfahren zur Herstellung von Aryl-aminopropanolen | |
| DE60330775D1 (de) | Verfahren zur Herstellung von Hydroperoxiden | |
| DE602006009562D1 (de) | Verfahren zur herstellung von ferrisuccinylcasein | |
| DE502006004187D1 (de) | Verfahren zur herstellung von diorganopolysiloxanen | |
| DE602005024566D1 (de) | Verfahren zur herstellung von 2-amino-5-iodobenzoesäure | |
| DE60322356D1 (de) | Verfahren zur herstellung von 2-aminoindanderivaten | |
| DE50211253D1 (de) | Verfahren zur Herstellung von Makrokapseln | |
| DE60335766D1 (de) | Verfahren zur Herstellung von m-Xylylendiamin | |
| DE602004027840D1 (de) | Verfahren zur herstellung von thiazolopyrimidinen | |
| DE602004005239D1 (de) | Verfahren zur herstellung von tubulininhibitoren | |
| DE602005000377D1 (de) | Verfahren zur herstellung von n-alkyl-pyrrolidonen | |
| DE602005014035D1 (de) | Verfahren zur Herstellung von Aminen | |
| DE502005000184D1 (de) | Verfahren zur Herstellung von linearen Si-H-Gruppen aufweisenden Organopolysiloxanen | |
| DE602004012912D1 (de) | Verfahren zur Herstellung von Fluorhalogenethern |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |