ATE483714T1 - Podophyllotoxine als antiproliferative mittel - Google Patents

Podophyllotoxine als antiproliferative mittel

Info

Publication number
ATE483714T1
ATE483714T1 AT02791768T AT02791768T ATE483714T1 AT E483714 T1 ATE483714 T1 AT E483714T1 AT 02791768 T AT02791768 T AT 02791768T AT 02791768 T AT02791768 T AT 02791768T AT E483714 T1 ATE483714 T1 AT E483714T1
Authority
AT
Austria
Prior art keywords
podophyllotoxins
antiproliferative agents
antiproliferative
agents
production
Prior art date
Application number
AT02791768T
Other languages
English (en)
Inventor
Gerhard Gaedicke
Holger Lode
Wolfgang Wrasidlo
Original Assignee
Universitaetsklinikum Charite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7708614&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE483714(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Universitaetsklinikum Charite filed Critical Universitaetsklinikum Charite
Application granted granted Critical
Publication of ATE483714T1 publication Critical patent/ATE483714T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02791768T 2001-12-03 2002-12-03 Podophyllotoxine als antiproliferative mittel ATE483714T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10160515 2001-12-03
PCT/EP2002/013669 WO2003048166A1 (en) 2001-12-03 2002-12-03 Podophyllotoxins as antiproliferative agents

Publications (1)

Publication Number Publication Date
ATE483714T1 true ATE483714T1 (de) 2010-10-15

Family

ID=7708614

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02791768T ATE483714T1 (de) 2001-12-03 2002-12-03 Podophyllotoxine als antiproliferative mittel

Country Status (10)

Country Link
US (1) US7582778B2 (de)
EP (2) EP1451193B1 (de)
JP (2) JP4527978B2 (de)
AT (1) ATE483714T1 (de)
AU (1) AU2002358086B2 (de)
CA (1) CA2468479C (de)
DE (1) DE60237915D1 (de)
DK (1) DK2327705T3 (de)
ES (2) ES2354065T3 (de)
WO (1) WO2003048166A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10115740A1 (de) 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
ES2354065T3 (es) * 2001-12-03 2011-03-09 Universitätsklinikum Charité Der Humboldt- Universität Zu Berlin Podofilotoxinas en calidad de agentes antiproliferativos.
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
JP2011522515A (ja) 2008-04-10 2011-08-04 マサチューセッツ インスティテュート オブ テクノロジー 癌幹細胞を標的とする薬剤を同定する方法およびその使用
WO2010114997A1 (en) * 2009-04-02 2010-10-07 Allergan, Inc. Prostaglandin e receptor antagonists
US9889147B2 (en) * 2010-04-16 2018-02-13 Cellact Pharma Gmbh Analogues of etoposide for the treatment of tumours
CN102070645B (zh) * 2011-01-07 2015-04-22 兰州大学 一种脱氧鬼臼毒素类化合物及其制备与应用
US10106778B2 (en) 2012-11-08 2018-10-23 Whitehead Institute For Biomedical Research Selective targeting of cancer stem cells
GB2513299A (en) * 2013-03-12 2014-10-29 Cellact Pharma Gmbh Biomedizinzentrum Compounds for targeting cancer stem cells
US10398672B2 (en) 2014-04-29 2019-09-03 Whitehead Institute For Biomedical Research Methods and compositions for targeting cancer stem cells
EP3211091A1 (de) * 2016-02-24 2017-08-30 CellAct Pharma GmbH Verfahren zur diagnose von mit etoposid-prodrug behandelbarem krebs
KR20230131815A (ko) * 2020-08-19 2023-09-14 셀액트 파마 게엠베하 에토포시드 토니리베이트 제제
CN116178469A (zh) * 2023-02-08 2023-05-30 汤亚杰 寡核苷酸修饰鬼臼毒素类衍生物及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ225599A (en) * 1987-08-04 1991-09-25 Bristol Myers Co Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
ZA886810B (en) 1987-12-18 1989-08-30 Bristol Myers Co Epipodophyllotoxin glucoside 4'-acyl derivatives
US5411947A (en) 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
DE3935016A1 (de) 1989-10-20 1991-04-25 Behringwerke Ag Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
US6610841B1 (en) 1997-12-18 2003-08-26 Gilead Sciences, Inc. Nucleotide-based prodrugs
JP4115514B2 (ja) 1991-10-23 2008-07-09 キャンサー・リサーチ・キヤンペーン・テクノロジー・リミテツド Ｃｂ １９５４およびその類似体を細胞障害性の形態に還元するための細菌のニトロリダクターゼ
DE4236237A1 (de) * 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
AU739028B2 (en) 1996-09-27 2001-10-04 Bristol-Myers Squibb Company Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
ES2354065T3 (es) * 2001-12-03 2011-03-09 Universitätsklinikum Charité Der Humboldt- Universität Zu Berlin Podofilotoxinas en calidad de agentes antiproliferativos.

Also Published As

Publication number Publication date
CA2468479A1 (en) 2003-06-12
JP2005517645A (ja) 2005-06-16
JP2010120943A (ja) 2010-06-03
US20060293254A1 (en) 2006-12-28
DE60237915D1 (en) 2010-11-18
JP4527978B2 (ja) 2010-08-18
DK2327705T3 (en) 2015-08-24
AU2002358086B2 (en) 2009-06-04
JP5302862B2 (ja) 2013-10-02
EP1451193A1 (de) 2004-09-01
WO2003048166A1 (en) 2003-06-12
AU2002358086A1 (en) 2003-06-17
EP2327705B1 (de) 2015-05-27
ES2545393T3 (es) 2015-09-10
ES2354065T3 (es) 2011-03-09
EP1451193B1 (de) 2010-10-06
US7582778B2 (en) 2009-09-01
CA2468479C (en) 2010-04-27
EP2327705A1 (de) 2011-06-01

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties