ATE483716T1 - Lösungsmittelfreies amorphes rapamycin - Google Patents

Lösungsmittelfreies amorphes rapamycin

Info

Publication number
ATE483716T1
ATE483716T1 AT05792296T AT05792296T ATE483716T1 AT E483716 T1 ATE483716 T1 AT E483716T1 AT 05792296 T AT05792296 T AT 05792296T AT 05792296 T AT05792296 T AT 05792296T AT E483716 T1 ATE483716 T1 AT E483716T1
Authority
AT
Austria
Prior art keywords
free
solvent
amorphic
rapamycin
therapeutic agents
Prior art date
Application number
AT05792296T
Other languages
English (en)
Inventor
Cynthia A Maryanoff
Karel Six
Roger Vandecruys
Original Assignee
Cordis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cordis Corp filed Critical Cordis Corp
Application granted granted Critical
Publication of ATE483716T1 publication Critical patent/ATE483716T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT05792296T 2004-08-27 2005-08-24 Lösungsmittelfreies amorphes rapamycin ATE483716T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60532404P 2004-08-27 2004-08-27
PCT/US2005/030606 WO2006026531A1 (en) 2004-08-27 2005-08-24 Solvent free amorphous rapamycin

Publications (1)

Publication Number Publication Date
ATE483716T1 true ATE483716T1 (de) 2010-10-15

Family

ID=35539393

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05792296T ATE483716T1 (de) 2004-08-27 2005-08-24 Lösungsmittelfreies amorphes rapamycin

Country Status (7)

Country Link
US (2) US7393952B2 (de)
EP (1) EP1781672B1 (de)
JP (1) JP5117190B2 (de)
AT (1) ATE483716T1 (de)
CA (1) CA2578245C (de)
DE (1) DE602005024012D1 (de)
WO (1) WO2006026531A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7255891B1 (en) * 2003-02-26 2007-08-14 Advanced Cardiovascular Systems, Inc. Method for coating implantable medical devices
US8715771B2 (en) * 2003-02-26 2014-05-06 Abbott Cardiovascular Systems Inc. Coated stent and method of making the same
KR20060085246A (ko) 2003-09-18 2006-07-26 마커사이트, 인코포레이티드 경공막 전달
DK1848431T3 (en) 2005-02-09 2016-04-18 Santen Pharmaceutical Co Ltd LIQUID FORMULATIONS FOR TREATMENT OF DISEASES OR CONDITIONS
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
KR20140093764A (ko) * 2006-02-09 2014-07-28 산텐 세이야꾸 가부시키가이샤 안정한 제제와 그 제조 및 사용 방법
ES2563288T3 (es) 2006-03-23 2016-03-14 Santen Pharmaceutical Co., Ltd Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular
US20090011117A1 (en) * 2007-07-03 2009-01-08 Endotronix, Inc. Methods for texturing a surface of an endovascular implant
US9533078B2 (en) 2008-06-25 2017-01-03 Boston Scientific Scimed, Inc. Medical devices containing therapeutic agents
IT1400977B1 (it) 2010-07-01 2013-07-05 Euticals Spa Nuovi complessi di inclusione farmaceutici, solidi, solubili in acqua e le loro soluzioni acquose per uso orale, oftalmico, topico o parenterale, contenenti un macrolide ed alcune ciclodestrine.
AU2014209141B2 (en) 2013-01-24 2018-05-10 Palvella Therapeutics, Inc. Compositions for transdermal delivery of mTOR inhibitors
JP6472155B2 (ja) * 2013-04-01 2019-02-20 テルモ株式会社 ステントおよびステントデリバリーシステム
WO2015181826A1 (en) 2014-05-27 2015-12-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Crystalline coating and release of bioactive agents
CN113384390B (zh) 2015-09-15 2023-08-22 萨维奇医疗股份有限公司 用于在组织腔中锚定护套的装置和方法
EP3565520B1 (de) 2017-01-06 2026-02-25 Palvella Therapeutics, Inc. Wasserfreie zusammensetzungen von mtor-hemmern und verfahren zur verwendung
CN108129490B (zh) * 2017-12-11 2020-12-01 成都海创药业有限公司 一种制备依维莫司无定形固体的方法
US11000513B2 (en) 2018-07-02 2021-05-11 Palvella Therapeutics, Inc. Anhydrous compositions of mTOR inhibitors and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
FR2736550B1 (fr) * 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
US6384213B1 (en) * 1998-10-23 2002-05-07 Ranbaxy Laboratories Limited Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
WO2002057228A1 (en) 2001-01-17 2002-07-25 Biocon India Limited Atorvastatin calcium
AU2003227454B2 (en) * 2002-04-22 2009-07-30 Research Foundation Itsuu Laboratory Medicament for therapeutic treatment of vascular disease
DE10244847A1 (de) * 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
EP1539043B1 (de) * 2002-09-20 2013-12-18 Innovational Holdings, LLC Expandierbare medizinische vorrichtung mit öffnungen zur abgabe multipler heilmittel
US20040093064A1 (en) * 2002-11-12 2004-05-13 Gjalt Bosma Drug eluting stent graft combination
KR20060052880A (ko) * 2003-07-25 2006-05-19 와이어쓰 동결건조된 ｃｃｉ- 779 제형
UA84881C2 (ru) * 2003-09-03 2008-12-10 Уайт Аморфный 42-эфир рапамицина и 3-гидрокси-2-(гидроксиметил)-2-метилпропионовой кислоты и фармацевтическая композиция, содержащая его

Also Published As

Publication number Publication date
US20080227982A1 (en) 2008-09-18
JP2008511642A (ja) 2008-04-17
CA2578245C (en) 2013-10-29
US7393952B2 (en) 2008-07-01
JP5117190B2 (ja) 2013-01-09
CA2578245A1 (en) 2006-03-09
DE602005024012D1 (de) 2010-11-18
EP1781672B1 (de) 2010-10-06
US20060128739A1 (en) 2006-06-15
EP1781672A1 (de) 2007-05-09
WO2006026531A1 (en) 2006-03-09

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