ATE483716T1 - Lösungsmittelfreies amorphes rapamycin - Google Patents

Lösungsmittelfreies amorphes rapamycin

Info

Publication number: ATE483716T1
Authority: AT; Austria
Prior art keywords: free; solvent; amorphic; rapamycin; therapeutic agents
Prior art date: 2004-08-27

Application number

AT05792296T

Other languages

English (en)

Inventor

Cynthia A Maryanoff

Karel Six

Roger Vandecruys

Original Assignee

Cordis Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-08-27

Filing date

2005-08-24

Publication date

2010-10-15

2005-08-24 Application filed by Cordis Corp filed Critical Cordis Corp

2010-10-15 Application granted granted Critical

2010-10-15 Publication of ATE483716T1 publication Critical patent/ATE483716T1/de

Links

ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
229960002930 sirolimus Drugs 0.000 title 1
239000003814 drug Substances 0.000 abstract 3
229940124597 therapeutic agent Drugs 0.000 abstract 3
239000011248 coating agent Substances 0.000 abstract 2
238000000576 coating method Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT05792296T 2004-08-27 2005-08-24 Lösungsmittelfreies amorphes rapamycin ATE483716T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US60532404P	2004-08-27	2004-08-27
PCT/US2005/030606 WO2006026531A1 (en)	2004-08-27	2005-08-24	Solvent free amorphous rapamycin

Publications (1)

Publication Number	Publication Date
ATE483716T1 true ATE483716T1 (de)	2010-10-15

Family

ID=35539393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05792296T ATE483716T1 (de)	2004-08-27	2005-08-24	Lösungsmittelfreies amorphes rapamycin

Country Status (7)

Country	Link
US (2)	US7393952B2 (de)
EP (1)	EP1781672B1 (de)
JP (1)	JP5117190B2 (de)
AT (1)	ATE483716T1 (de)
CA (1)	CA2578245C (de)
DE (1)	DE602005024012D1 (de)
WO (1)	WO2006026531A1 (de)

Families Citing this family (17)

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Publication number	Priority date	Publication date	Assignee	Title
US7255891B1 (en) *	2003-02-26	2007-08-14	Advanced Cardiovascular Systems, Inc.	Method for coating implantable medical devices
US8715771B2 (en) *	2003-02-26	2014-05-06	Abbott Cardiovascular Systems Inc.	Coated stent and method of making the same
JP2007505932A (ja)	2003-09-18	2007-03-15	マクサイト，インコーポレイテッド	経強膜送達
WO2006086750A1 (en)	2005-02-09	2006-08-17	Macusight, Inc.	Liquid formulations for treatment of diseases or conditions
US8663639B2 (en)	2005-02-09	2014-03-04	Santen Pharmaceutical Co., Ltd.	Formulations for treating ocular diseases and conditions
US8492400B2 (en)	2006-02-09	2013-07-23	Santen Pharmaceutical Co., Ltd.	Stable formulations, and methods of their preparation and use
CN101443004B (zh)	2006-03-23	2013-03-06	参天制药株式会社	用于与血管通透性有关的疾病或病症的制剂
US20090011117A1 (en) *	2007-07-03	2009-01-08	Endotronix, Inc.	Methods for texturing a surface of an endovascular implant
WO2009158276A2 (en)	2008-06-25	2009-12-30	Boston Scientific Scimed, Inc.	Medical devices containing therapeutic agents
IT1400977B1 (it)	2010-07-01	2013-07-05	Euticals Spa	Nuovi complessi di inclusione farmaceutici, solidi, solubili in acqua e le loro soluzioni acquose per uso orale, oftalmico, topico o parenterale, contenenti un macrolide ed alcune ciclodestrine.
WO2014117035A1 (en)	2013-01-24	2014-07-31	Transderm, Inc.	COMPOSITIONS FOR TRANSDERMAL DELIVERY OF mTOR INHIBITORS
JP6472155B2 (ja) *	2013-04-01	2019-02-20	テルモ株式会社	ステントおよびステントデリバリーシステム
WO2015181826A1 (en)	2014-05-27	2015-12-03	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.	Crystalline coating and release of bioactive agents
CN113384390B (zh)	2015-09-15	2023-08-22	萨维奇医疗股份有限公司	用于在组织腔中锚定护套的装置和方法
AU2018205253B2 (en)	2017-01-06	2022-01-13	Palvella Therapeutics, Inc.	Anhydrous compositions of mTOR inhibitors and methods of use
CN108129490B (zh) *	2017-12-11	2020-12-01	成都海创药业有限公司	一种制备依维莫司无定形固体的方法
EP3817743A4 (de)	2018-07-02	2022-07-06	Palvella Therapeutics, Inc.	Wasserfreie zusammensetzungen von mtor-hemmern und verfahren zur verwendung

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA737247B (en) *	1972-09-29	1975-04-30	Ayerst Mckenna & Harrison	Rapamycin and process of preparation
GB9221220D0 (en) *	1992-10-09	1992-11-25	Sandoz Ag	Organic componds
FR2736550B1 (fr)	1995-07-14	1998-07-24	Sandoz Sa	Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
US6384213B1 (en)	1998-10-23	2002-05-07	Ranbaxy Laboratories Limited	Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
WO2002057228A1 (en) *	2001-01-17	2002-07-25	Biocon India Limited	Atorvastatin calcium
NZ536493A (en) *	2002-04-22	2007-03-30	Res Found Itsuu Lab	Medicament comprising a retinoid for therapeutic treatment of vascular disease
WO2004026174A2 (en) *	2002-09-20	2004-04-01	Conor Medsystems, Inc.	Expandable medical device with openings for delivery of multiple beneficial agents
DE10244847A1 (de)	2002-09-20	2004-04-01	Ulrich Prof. Dr. Speck	Medizinische Vorrichtung zur Arzneimittelabgabe
US20040093064A1 (en) *	2002-11-12	2004-05-13	Gjalt Bosma	Drug eluting stent graft combination
MXPA05013865A (es)	2003-07-25	2006-02-28	Wyeth Corp	Formulaciones liofilizadas de cci-779.
AU2004270154A1 (en)	2003-09-03	2005-03-17	Wyeth	Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same

2005
- 2005-08-24 AT AT05792296T patent/ATE483716T1/de not_active IP Right Cessation
- 2005-08-24 WO PCT/US2005/030606 patent/WO2006026531A1/en not_active Ceased
- 2005-08-24 JP JP2007530211A patent/JP5117190B2/ja not_active Expired - Fee Related
- 2005-08-24 US US11/210,393 patent/US7393952B2/en not_active Expired - Lifetime
- 2005-08-24 EP EP05792296A patent/EP1781672B1/de not_active Expired - Lifetime
- 2005-08-24 CA CA2578245A patent/CA2578245C/en not_active Expired - Fee Related
- 2005-08-24 DE DE602005024012T patent/DE602005024012D1/de not_active Expired - Lifetime
2008
- 2008-05-27 US US12/127,467 patent/US20080227982A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2578245A1 (en)	2006-03-09
JP5117190B2 (ja)	2013-01-09
US20060128739A1 (en)	2006-06-15
DE602005024012D1 (de)	2010-11-18
JP2008511642A (ja)	2008-04-17
US20080227982A1 (en)	2008-09-18
CA2578245C (en)	2013-10-29
WO2006026531A1 (en)	2006-03-09
EP1781672A1 (de)	2007-05-09
EP1781672B1 (de)	2010-10-06
US7393952B2 (en)	2008-07-01

Legal Events

Date	Code	Title	Description
2011-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602005024012D1 (de)	2010-11-18	Lösungsmittelfreies amorphes rapamycin
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