ATE483797T1 - Harnsäureoxidase - Google Patents

Harnsäureoxidase

Info

Publication number
ATE483797T1
ATE483797T1 AT99938996T AT99938996T ATE483797T1 AT E483797 T1 ATE483797 T1 AT E483797T1 AT 99938996 T AT99938996 T AT 99938996T AT 99938996 T AT99938996 T AT 99938996T AT E483797 T1 ATE483797 T1 AT E483797T1
Authority
AT
Austria
Prior art keywords
proteins
uric acid
uricase
acid oxidase
relates
Prior art date
Application number
AT99938996T
Other languages
English (en)
Inventor
Michael Hershfield
Susan Kelly
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Application granted granted Critical
Publication of ATE483797T1 publication Critical patent/ATE483797T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
    • C12N9/0048—Uricase (1.7.3.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
    • C12Y107/03—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with oxygen as acceptor (1.7.3)
    • C12Y107/03003—Factor-independent urate hydroxylase (1.7.3.3), i.e. uricase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99938996T 1998-08-06 1999-08-05 Harnsäureoxidase ATE483797T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9548998P 1998-08-06 1998-08-06
PCT/US1999/017678 WO2000008196A2 (en) 1998-08-06 1999-08-05 Urate oxidase

Publications (1)

Publication Number Publication Date
ATE483797T1 true ATE483797T1 (de) 2010-10-15

Family

ID=22252247

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99938996T ATE483797T1 (de) 1998-08-06 1999-08-05 Harnsäureoxidase

Country Status (22)

Country Link
US (1) US7056713B1 (de)
EP (2) EP2277998B1 (de)
JP (3) JP2002524053A (de)
KR (1) KR100841634B1 (de)
CN (2) CN1322243A (de)
AT (1) ATE483797T1 (de)
AU (1) AU766421B2 (de)
BR (1) BRPI9913360B8 (de)
CA (1) CA2337967C (de)
CY (1) CY1111001T1 (de)
CZ (1) CZ304223B6 (de)
DE (1) DE69942834D1 (de)
DK (1) DK1100880T3 (de)
ES (1) ES2352451T3 (de)
HU (1) HU229774B1 (de)
IL (3) IL141221A0 (de)
NZ (1) NZ509633A (de)
PL (1) PL207369B1 (de)
PT (1) PT1100880E (de)
RU (1) RU2290439C2 (de)
WO (1) WO2000008196A2 (de)
ZA (1) ZA200100974B (de)

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EP2277998B1 (de) * 1998-08-06 2016-04-20 Duke University Uratoxidase
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
CA2338665C (en) 1998-08-06 2011-01-18 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US20060188971A1 (en) * 1998-08-06 2006-08-24 Duke University Urate oxidase
HU226294B1 (en) * 1998-08-06 2008-08-28 Mountain View Pharmaceuticals Peg-urate oxidase conjugates and use thereof
CN100371439C (zh) * 2003-04-07 2008-02-27 北京双鹭药业股份有限公司 一种重组假丝酵母尿酸氧化酶的制备方法
CN100334207C (zh) * 2004-04-27 2007-08-29 杭州北斗生物技术有限公司 一种黄曲霉尿酸氧化酶的制备方法
US8188224B2 (en) 2005-04-11 2012-05-29 Savient Pharmaceuticals, Inc. Variant forms of urate oxidase and use thereof
WO2008051178A2 (en) * 2006-04-12 2008-05-02 Savient Pharmaceuticals, Inc. Purification of proteins with cationic surfactant
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
US7811800B2 (en) 2005-04-11 2010-10-12 Savient Pharmaceuticals, Inc. Variant form of urate oxidase and use thereof
AU2011257764B2 (en) * 2005-04-11 2012-04-05 Horizon Therapeutics Usa, Inc. A variant form of urate oxidase and use thereof
CN101402688B (zh) * 2008-11-18 2011-04-20 中国人民解放军军事医学科学院生物工程研究所 一种融合蛋白及其编码基因与应用
CN102361975A (zh) 2009-03-24 2012-02-22 名糖产业株式会社 来自微生物的改进型凝乳蛋白酶
EP4635567A3 (de) 2009-06-25 2025-12-03 Horizon Therapeutics USA, Inc. Verfahren und kits zur prävention des infusionsreaktionsrisikos und antikörpervermittelter reaktionsverlust durch überwachung von serumharnsäure während der pegylierten harnasetherapie
CN102051348B (zh) 2009-10-27 2012-10-03 重庆富进生物医药有限公司 人源化重组尿酸酶及其突变体
RU2460793C2 (ru) * 2010-01-15 2012-09-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae
US8940861B2 (en) 2010-04-08 2015-01-27 Georgia Tech Research Corporation Variants of ancestral uricases and uses thereof
CN102634492B (zh) 2011-02-14 2015-06-10 重庆富进生物医药有限公司 聚乙二醇化犬源尿酸氧化酶类似物及其制备方法和应用
CN102757945B (zh) * 2011-04-28 2015-03-18 杭州俊丰生物工程有限公司 人尿酸氧化酶蛋白及其制备方法和其聚乙二醇结合物
CN102260653B (zh) * 2011-06-30 2013-04-03 荣俊 一种peg化重组猪-人尿酸氧化酶融合蛋白的制备及应用方法
EP2986720B1 (de) * 2013-04-17 2017-09-06 Council of Scientific & Industrial Research Uricase mutanten
CN103834623B (zh) * 2014-02-11 2017-11-07 中国药科大学 具有催化活性的人源尿酸氧化酶
CN104388467A (zh) * 2014-10-27 2015-03-04 李长贵 一种构建自发性高尿酸血症小鼠模型的方法及其用途
AU2016265677B2 (en) 2015-05-15 2021-12-09 Medimmune, Llc Improved uricase sequences and methods of treatment
CN106554948B (zh) * 2015-09-29 2019-06-25 上海生物制品研究所有限责任公司 突变型尿酸酶、peg修饰的突变型尿酸酶及其应用
US20200237881A1 (en) 2019-01-30 2020-07-30 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
CN110234340A (zh) 2016-11-11 2019-09-13 好利恩风湿病制药有限责任公司 泼尼松和尿酸酶分子的组合疗法及其用途
CN108103079B (zh) * 2017-06-20 2021-07-13 北京锦篮基因科技有限公司 一种高尿酸血症的基因治疗药物
CN109554376B (zh) * 2018-11-13 2022-03-22 广西大学 一种碱性尿酸氧化酶及其在检测试剂盒和降低食品中尿酸的应用
US12121566B2 (en) 2019-01-30 2024-10-22 Horizon Therapeutics Usa, Inc. Methods for treating gout
CN111088268B (zh) * 2019-03-05 2022-08-02 北京锦篮基因科技有限公司 一种高尿酸血症的基因治疗药物
KR20250041198A (ko) 2019-05-10 2025-03-25 피이지-바이오 바이오팜 컴퍼니 리미티드 (총칭) 폴리에틸렌 글리콜로 변형된 요산 산화효소
CN112646790A (zh) * 2019-10-11 2021-04-13 上海君实生物医药科技股份有限公司 改进的尿酸酶及其用于治疗高尿酸血症的方法
CA3189100A1 (en) * 2020-08-10 2022-02-17 Paul PELOSO Methods of treating gout
CN111920942A (zh) * 2020-08-24 2020-11-13 深圳前海鹰岗生物科技有限公司 一种用于快速溶解痛风石的聚合物微针及制备方法和应用
KR20230110281A (ko) * 2020-11-03 2023-07-21 프로탈릭스 리미티드 변형된 유리카제(uricase) 및 이의 용도
CN114438047B (zh) 2020-11-05 2024-11-22 重庆派金生物科技有限公司 制备聚乙二醇修饰的尿酸氧化酶的方法
CN114438048B (zh) 2020-11-05 2024-10-22 重庆派金生物科技有限公司 尿酸氧化酶制剂及其应用
CN112852772A (zh) * 2021-01-19 2021-05-28 中国科学院过程工程研究所 一种基于分子内交联和聚乙二醇修饰的尿酸氧化酶及其制备方法
CN112662640A (zh) * 2021-01-28 2021-04-16 中国药科大学 一种具有催化活性的尿酸氧化酶
CN113244412B (zh) * 2021-06-25 2021-10-26 深圳市瑞吉生物科技有限公司 一种基于mRNA剂型的治疗高尿酸血症或痛风的药物及其制备方法
WO2023034904A1 (en) * 2021-09-01 2023-03-09 Synlogic Operating Company, Inc. Recombinant cells for treating diseases associated with uric acid and methods of use thereof
US20260007600A1 (en) * 2022-12-27 2026-01-08 Rigerna Therapeutics (Beijing) Co., Ltd. Nucleic acid drug for treating hyperuricemia-related diseases, preparation method therefor, and use thereof
CN118360300A (zh) * 2023-01-10 2024-07-19 优环(苏州)生物医药科技有限公司 一种表达尿酸氧化酶的环状rna、制备方法及应用
CN119215150A (zh) 2023-06-28 2024-12-31 杭州远大生物制药有限公司 尿酸氧化酶及其聚乙二醇化缀合物的稳定剂及其药物用途
WO2025030053A1 (en) 2023-08-01 2025-02-06 Insmed Incorporated Novel igg proteases and methods of use thereof
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers
CN119876069B (zh) * 2025-03-12 2025-10-21 开平牵牛生化制药有限公司 具有高活性且免疫原性弱化的人源尿酸氧化酶突变体
CN120005844B (zh) * 2025-04-22 2025-09-23 天津科技大学 人源尿酸氧化酶突变体及其制备方法与应用

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Also Published As

Publication number Publication date
HK1153508A1 (en) 2012-03-30
EP1100880B1 (de) 2010-10-06
DE69942834D1 (de) 2010-11-18
ZA200100974B (en) 2002-06-26
EP2277998B1 (de) 2016-04-20
BR9913360A (pt) 2001-07-03
CN1322243A (zh) 2001-11-14
CZ304223B6 (cs) 2014-01-15
WO2000008196A2 (en) 2000-02-17
CA2337967A1 (en) 2000-02-17
JP2013215199A (ja) 2013-10-24
HU229774B1 (en) 2014-07-28
CZ2001466A3 (cs) 2001-07-11
HUP0103205A2 (hu) 2001-12-28
AU766421B2 (en) 2003-10-16
EP1100880A4 (de) 2002-04-17
NZ509633A (en) 2003-04-29
HK1125402A1 (en) 2009-08-07
JP5721954B2 (ja) 2015-05-20
JP2002524053A (ja) 2002-08-06
KR100841634B1 (ko) 2008-06-26
ES2352451T3 (es) 2011-02-18
KR20010053633A (ko) 2001-06-25
AU5336599A (en) 2000-02-28
HK1037214A1 (en) 2002-02-01
DK1100880T3 (da) 2011-01-24
EP1100880A2 (de) 2001-05-23
PL346222A1 (en) 2002-01-28
PL207369B1 (pl) 2010-12-31
RU2290439C2 (ru) 2006-12-27
PT1100880E (pt) 2011-01-13
BR9913360B1 (pt) 2013-09-24
JP2010158244A (ja) 2010-07-22
IL141221A0 (en) 2002-03-10
WO2000008196A3 (en) 2000-03-30
IL197339A0 (en) 2011-07-31
EP2277998A1 (de) 2011-01-26
CN101280293B (zh) 2013-09-11
WO2000008196A9 (en) 2000-07-13
CY1111001T1 (el) 2015-06-11
IL197339A (en) 2015-02-26
US7056713B1 (en) 2006-06-06
CA2337967C (en) 2011-11-01
IL141221A (en) 2010-06-16
CN101280293A (zh) 2008-10-08
HUP0103205A3 (en) 2006-01-30
BRPI9913360B8 (pt) 2021-05-25

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