ATE484500T1 - Synthese von ccr5 rezeptor antagonisten - Google Patents

Synthese von ccr5 rezeptor antagonisten

Info

Publication number
ATE484500T1
ATE484500T1 AT06717461T AT06717461T ATE484500T1 AT E484500 T1 ATE484500 T1 AT E484500T1 AT 06717461 T AT06717461 T AT 06717461T AT 06717461 T AT06717461 T AT 06717461T AT E484500 T1 ATE484500 T1 AT E484500T1
Authority
AT
Austria
Prior art keywords
synthesis
receptor antagonists
ccr5 receptor
ccr5
antagonists
Prior art date
Application number
AT06717461T
Other languages
English (en)
Inventor
Wenxue Wu
Sa Bosco D
Feng Liang
Loc Tran
William Leong
Vilas Dahanukar
Ilia Zavialov
Cecilia Proietti
Shannon Zhao
Hong-Chang Lee
Yi Liu
Hoa Nguyen
Xiongwei Shih
Man Zhu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE484500T1 publication Critical patent/ATE484500T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT06717461T 2005-01-06 2006-01-05 Synthese von ccr5 rezeptor antagonisten ATE484500T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64190005P 2005-01-06 2005-01-06
PCT/US2006/000262 WO2006074270A2 (en) 2005-01-06 2006-01-05 Synthesis of ccr5 receptor antagonists

Publications (1)

Publication Number Publication Date
ATE484500T1 true ATE484500T1 (de) 2010-10-15

Family

ID=36571985

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06717461T ATE484500T1 (de) 2005-01-06 2006-01-05 Synthese von ccr5 rezeptor antagonisten

Country Status (12)

Country Link
US (2) US7728135B2 (de)
EP (1) EP1833817B1 (de)
JP (1) JP2008526863A (de)
CN (1) CN101137646A (de)
AR (1) AR054422A1 (de)
AT (1) ATE484500T1 (de)
CA (1) CA2594114A1 (de)
DE (1) DE602006017507D1 (de)
MX (1) MX2007008280A (de)
SG (1) SG158861A1 (de)
WO (1) WO2006074270A2 (de)
ZA (1) ZA200705524B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005101838A2 (en) 2004-04-13 2005-10-27 Incyte Corporation Piperazinylpiperidine derivatives as chemokine receptor antagonists
MX2009006881A (es) * 2006-12-22 2009-07-03 Schering Corp Procesos para la preparacion de antagonistas del receptor ccr-5 utilizando compuestos de 1-ciclopropan-sulfonil-piperidinilo 4-sustituido.
KR20140071318A (ko) 2011-06-19 2014-06-11 뉴욕 유니버시티 새로운 항-염증제 및 살균제로서의 류코톡신 e/d
CN103804445B (zh) * 2013-12-30 2016-01-13 广州自远生物科技有限公司 一种改进的乙酰异戊酰泰乐菌素的制备方法
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
ATE299139T1 (de) 2001-03-29 2005-07-15 Schering Corp Ccr5 antagonisten verwendbar für die behandlung von aids

Also Published As

Publication number Publication date
US20100036125A1 (en) 2010-02-11
MX2007008280A (es) 2007-09-07
WO2006074270A3 (en) 2007-10-04
US7728135B2 (en) 2010-06-01
SG158861A1 (en) 2010-02-26
HK1102303A1 (en) 2007-11-16
JP2008526863A (ja) 2008-07-24
EP1833817A2 (de) 2007-09-19
DE602006017507D1 (de) 2010-11-25
AR054422A1 (es) 2007-06-27
ZA200705524B (en) 2008-09-25
WO2006074270A2 (en) 2006-07-13
EP1833817B1 (de) 2010-10-13
CN101137646A (zh) 2008-03-05
US20060258863A1 (en) 2006-11-16
CA2594114A1 (en) 2006-07-13

Similar Documents

Publication Publication Date Title
ATE486853T1 (de) Synthese von acylaminoalkenylenamiden als substanz-p-antagonisten
CY2017008I2 (el) Νεες ενωσεις ως διαμορφωτες υποδοχεα οπιοειδων
DE602005021258D1 (de) Biphenylverbindungen geeignet für die Synthese von Muscarinrezeptorantagonisten
ATE496051T1 (de) Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten
ATE452886T1 (de) Chemokinrezeptorantagonisten
ATE458726T1 (de) Exo- und diastereoselektive synthese von himbacin-analoga
EP1943338A4 (de) Zellfreie synthese membrangebundener polypeptide
DE602007009305D1 (de) Thiazolpyrazolopyrimidine als antagonisten des crf1-rezeptors
NL1028624A1 (nl) Alfa-aryl- of -heteroarylmethyl-bèta-piperidinopropaan-zuurverbindingen als ORL1-receptorantagonisten.
DE602007010010D1 (de) 2-phenylindole als antagonisten des prostaglandin-d2-rezeptors
EP1765805A4 (de) Cgrp-rezeptorantagonisten
DE602005004011D1 (de) Hydroisoindolin-tachykininrezeptorantagonisten
DK1973886T3 (da) Prokineticin-1-receptor-antagonister
ATE421511T1 (de) Indol-3-carbonyl-spiro-piperidinderivate als antagonisten des v1a-rezeptors
ATE429428T1 (de) Indanderivate als antagonisten des mch-rezeptors
DE602005009355D1 (de) Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
NL2000241A1 (nl) Carboxamidederivaten als muscarine-receptorantagonisten.
EP1957474A4 (de) Synthese von ftsz-hemmern
ATE500249T1 (de) Synthese von himbacinanaloga
ZA200705524B (en) Synthesis of CCR5 receptor antagonists
ATE462688T1 (de) Diarylsulfone als 5-ht2a-antagonisten
ATE469900T1 (de) Spiropiperidinderivate als antagonisten des via- rezeptors
EP1898905A4 (de) Hydroisoindolin-tachykinin-rezeptor-antagonisten
ATE488519T1 (de) Indol-3-ylcarbonylazaspiroderivate als vasopressinrezeptorantagonisten
ATE402145T1 (de) Synthese von pyrrol-2-carbonsäurenitrilen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties