ATE485052T1 - Kovalenter faktor vii-gewebefaktor-komplex - Google Patents

Kovalenter faktor vii-gewebefaktor-komplex

Info

Publication number
ATE485052T1
ATE485052T1 AT07727577T AT07727577T ATE485052T1 AT E485052 T1 ATE485052 T1 AT E485052T1 AT 07727577 T AT07727577 T AT 07727577T AT 07727577 T AT07727577 T AT 07727577T AT E485052 T1 ATE485052 T1 AT E485052T1
Authority
AT
Austria
Prior art keywords
factor
covalent
complex
factor vii
tissue
Prior art date
Application number
AT07727577T
Other languages
English (en)
Inventor
Henrik Ystergaard
Ole Olsen
Anders Klarskov Petersen
Henning Ralf Stennicke
Original Assignee
Novo Nordisk Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag filed Critical Novo Nordisk Healthcare Ag
Application granted granted Critical
Publication of ATE485052T1 publication Critical patent/ATE485052T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT07727577T 2006-04-07 2007-03-30 Kovalenter faktor vii-gewebefaktor-komplex ATE485052T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112358 2006-04-07
PCT/EP2007/053105 WO2007115953A1 (en) 2006-04-07 2007-03-30 Covalent factor vii-tissue factor complex

Publications (1)

Publication Number Publication Date
ATE485052T1 true ATE485052T1 (de) 2010-11-15

Family

ID=36781437

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07727577T ATE485052T1 (de) 2006-04-07 2007-03-30 Kovalenter faktor vii-gewebefaktor-komplex

Country Status (8)

Country Link
US (1) US20110040073A1 (de)
EP (1) EP2007417B1 (de)
JP (1) JP5759102B2 (de)
CN (1) CN101466400B (de)
AT (1) ATE485052T1 (de)
DE (1) DE602007009956D1 (de)
ES (1) ES2353084T3 (de)
WO (1) WO2007115953A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2127640A1 (de) 2008-05-27 2009-12-02 Koninklijke Philips Electronics N.V. Modifizierte azid-enthaltende Proteine
RU2531639C2 (ru) 2009-06-24 2014-10-27 Конинклейке Филипс Электроникс Н.В. Способ и устройство для программирования микроконтроллера
CN102753575A (zh) * 2010-01-28 2012-10-24 诺沃—诺迪斯克保健股份有限公司 因子vii融合多肽
EP2831228A1 (de) * 2012-03-30 2015-02-04 Novo Nordisk Health Care AG Fviia-stf-komplexe mit exosite-vermittelter superaktivität
JP2015525222A (ja) 2012-06-08 2015-09-03 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． キメラ性凝固因子
EP2858659B1 (de) 2012-06-08 2019-12-25 Bioverativ Therapeutics Inc. Prokoagulationsverbindungen
CN104704118A (zh) 2012-10-15 2015-06-10 诺和诺德保健Ag（股份有限公司） 凝血因子vii多肽
CN107921103A (zh) 2015-08-12 2018-04-17 细胞机械股份有限公司 涉及长半衰期凝血复合物的方法和组合物
BR112021019959A2 (pt) 2019-04-17 2022-02-08 Novo Nordisk As Anticorpo biespecífico, e, formulação farmacêutica
CN114836503B (zh) * 2022-04-29 2023-08-25 江苏祈瑞医药科技有限公司 一组具有肝损伤保护作用的乳清蛋白肽、高f值寡肽及其制备方法和应用
CN116041537B (zh) * 2022-09-26 2025-09-19 山西博鑫生物科技有限公司 一种重组组织因子rhTF突变体及其应用
WO2025168826A1 (en) 2024-02-08 2025-08-14 Hemab Aps Methods of treating coagulopathy
CN117860874B (zh) * 2024-03-12 2024-07-02 正大天晴药业集团南京顺欣制药有限公司 重组人凝血因子VIIa的药物组合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5788965A (en) * 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
EP0866870B1 (de) * 1995-12-01 2003-03-12 Genentech, Inc. Fusionsproteine bestehend aus gewebefaktor-kunitzdomäne als inhibitoren des faktors viia
JP4213224B2 (ja) * 1997-05-02 2009-01-21 ジェネンテック，インコーポレーテッド ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法
DE60138364D1 (de) * 2000-02-11 2009-05-28 Bayer Healthcare Llc Gerinnungsfaktor vii oder viia konjugate
WO2002077199A2 (en) * 2001-03-27 2002-10-03 Massachusetts Institute Of Technology Methods and products related to fgf dimerization
BR0212818A (pt) * 2001-09-27 2004-10-05 Novo Nordisk Healthcare Ag Polipeptìdeo de fator vii, construção de polionucletìdeo, célula hospedeira, animal transgênico, planta transgênica, método para produzir o polipeptìdeo de fator vii composição farmacêutica, uso de um polipeptìdeo de fator vii, e, método para o tratamento de distúrbios do sangramento em um sujeito ou para o aprimoramento do sistema hemostático normal
IL161051A0 (en) * 2001-10-02 2004-08-31 Genentech Inc Apo-2 ligand variants and uses thereof
JP4567437B2 (ja) * 2002-05-01 2010-10-20 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 抗凝固剤としての新規組織因子標的化されたトロンボモジュリン融合タンパク質
EP1523504A2 (de) * 2002-07-12 2005-04-20 Novo Nordisk A/S Gewebe faktorbindende immunokonjugate die faktor viia enthalten
JP2007509843A (ja) * 2003-10-07 2007-04-19 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ＶＩＩ／ＶＩＩａ因子活性を有するハイブリッド分子

Also Published As

Publication number Publication date
EP2007417B1 (de) 2010-10-20
DE602007009956D1 (de) 2010-12-02
CN101466400A (zh) 2009-06-24
ES2353084T3 (es) 2011-02-25
EP2007417A1 (de) 2008-12-31
JP5759102B2 (ja) 2015-08-05
JP2009532048A (ja) 2009-09-10
US20110040073A1 (en) 2011-02-17
CN101466400B (zh) 2014-06-25
WO2007115953A1 (en) 2007-10-18

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