ATE485303T1 - Isoformen von gehirn-natriuretischem peptid - Google Patents
Isoformen von gehirn-natriuretischem peptidInfo
- Publication number
- ATE485303T1 ATE485303T1 AT04754213T AT04754213T ATE485303T1 AT E485303 T1 ATE485303 T1 AT E485303T1 AT 04754213 T AT04754213 T AT 04754213T AT 04754213 T AT04754213 T AT 04754213T AT E485303 T1 ATE485303 T1 AT E485303T1
- Authority
- AT
- Austria
- Prior art keywords
- isoforms
- natriuretic peptide
- brain natriuretic
- conditions
- kidney
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48046003P | 2003-06-20 | 2003-06-20 | |
| PCT/US2004/017554 WO2005000095A2 (en) | 2003-06-20 | 2004-06-02 | Isoforms of brain natriuretic peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE485303T1 true ATE485303T1 (de) | 2010-11-15 |
Family
ID=33551922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04754213T ATE485303T1 (de) | 2003-06-20 | 2004-06-02 | Isoformen von gehirn-natriuretischem peptid |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8354496B2 (de) |
| EP (2) | EP2308889B1 (de) |
| JP (1) | JP4881156B2 (de) |
| CN (1) | CN101208353B (de) |
| AT (1) | ATE485303T1 (de) |
| DE (1) | DE602004029680D1 (de) |
| DK (1) | DK1638443T3 (de) |
| ES (1) | ES2354881T3 (de) |
| IL (1) | IL172674A (de) |
| PL (1) | PL1638443T3 (de) |
| PT (1) | PT1638443E (de) |
| WO (1) | WO2005000095A2 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101208353B (zh) | 2003-06-20 | 2011-12-14 | 梅约医学教育与研究基金会 | 脑利尿钠肽的同种型 |
| GB0329288D0 (en) | 2003-12-18 | 2004-01-21 | Inverness Medical Switzerland | Monitoring method and apparatus |
| JP2007534363A (ja) * | 2003-12-18 | 2007-11-29 | インバーネス メディカル スウィッツァーランド ゲーエムベーハー | モニタリング方法およびモニタリング装置 |
| PL1759001T3 (pl) | 2004-04-21 | 2011-09-30 | Alexion Pharma Inc | Koniugaty dostarczane do kości i sposób ich zastosowania do nakierowywania białek do kości |
| US20070042957A1 (en) * | 2005-08-19 | 2007-02-22 | Mayo Foundation For Medical Education And Research | Type v phosphodiesterase inhibitors and natriuretic polypeptides |
| KR100702415B1 (ko) * | 2006-03-03 | 2007-04-09 | 안웅식 | 올리고 핵산 탐침 비드 어레이를 이용한 인유두종바이러스검출 키트 및 방법 |
| KR100736442B1 (ko) * | 2006-03-10 | 2007-07-09 | 주식회사 나노텍세라믹스 | 라텍스 바인딩된 저비산 실리카 조성물과 이의 제조방법 |
| US8324162B2 (en) | 2006-08-08 | 2012-12-04 | Mayo Foundation For Medical Education And Research | Diuretic and natriuretic polypeptides lacking the blood pressure lowering property |
| JP2010502231A (ja) | 2006-09-08 | 2010-01-28 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 血管拡張作用を欠く水利尿およびナトリウム利尿ポリペプチド |
| WO2009036448A2 (en) * | 2007-09-15 | 2009-03-19 | Mayo Foundation For Medical Education And Research | Natriuretic peptide receptor-c agonists |
| JP2012502290A (ja) * | 2008-09-11 | 2012-01-26 | エフ.ホフマン−ラ ロシュ アーゲー | メタボリックシンドロームを有する患者におけるナトリウム利尿ペプチドおよびアディポネクチン |
| EP2457581B1 (de) | 2009-07-23 | 2014-01-08 | Igisu Co., Ltd. | Zusammensetzung enthaltend cnp oder bnp für ein externes hautpräparat zur behandlung von dermatitis |
| WO2011024973A1 (ja) | 2009-08-27 | 2011-03-03 | 株式会社 イギス | 鼻炎治療剤 |
| JP6055779B2 (ja) | 2010-12-27 | 2016-12-27 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | ナトリウム利尿ペプチドを含む組成物およびその使用方法 |
| CN102174636B (zh) * | 2011-01-11 | 2013-10-30 | 中国食品药品检定研究院 | 应用gca稳定转染细胞系测定bnp活性 |
| BR112013018679B1 (pt) | 2011-01-21 | 2022-04-12 | Igisu Co. Ltd. | Agente para o tratamento da alopecia e uso de um peptídeo natriurético do tipo c |
| CN103906761B (zh) | 2011-08-30 | 2016-12-21 | 梅约医学教育与研究基金会 | 利钠多肽 |
| WO2013070741A1 (en) * | 2011-11-11 | 2013-05-16 | Mayo Foundation For Medical Education And Research | Methods and materials for regulating natriuretic polypeptide function |
| WO2013103896A1 (en) | 2012-01-06 | 2013-07-11 | Mayo Foundation For Medical Education And Research | Treating cardiovascular or renal diseases |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| WO2015011592A2 (en) * | 2013-07-26 | 2015-01-29 | Koninklijke Philips N.V. | Computerization and visualization of clinical rules and definitions for patient monitoring systems. |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| JP6787894B2 (ja) | 2014-12-05 | 2020-11-18 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 組換えアルカリホスファターゼを用いた発作の処置 |
| CA2973883A1 (en) | 2015-01-28 | 2016-08-04 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| JP6993961B2 (ja) | 2015-08-17 | 2022-01-14 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | アルカリホスファターゼの製造 |
| EP3355904A4 (de) | 2015-09-28 | 2019-06-12 | Alexion Pharmaceuticals, Inc. | Identifizierung wirksamer dosierungsschemata für gewebeunspezifische alkalische phosphatase-enzymersatztherapie von hypophosphatasie |
| EP3368062A4 (de) | 2015-10-30 | 2019-07-03 | Alexion Pharmaceuticals, Inc. | Verfahren zur behandlung von craniosynostose bei einem patienten |
| US11065306B2 (en) | 2016-03-08 | 2021-07-20 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| US10898549B2 (en) | 2016-04-01 | 2021-01-26 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| KR20180125979A (ko) | 2016-04-01 | 2018-11-26 | 알렉시온 파마슈티칼스, 인코포레이티드 | 알칼리성 포스파타아제로 근육 약화의 치료 |
| WO2017214130A1 (en) | 2016-06-06 | 2017-12-14 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
| JP7018933B2 (ja) | 2016-08-18 | 2022-02-14 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 気管気管支軟化症の治療方法 |
| KR20190129058A (ko) | 2017-03-31 | 2019-11-19 | 알렉시온 파마슈티칼스, 인코포레이티드 | 성인 및 청소년에서 저포스파타제증 (hpp)을 치료하는 방법 |
| WO2019190752A1 (en) | 2018-03-30 | 2019-10-03 | Alexion Pharmaceuticals, Inc. | Manufacturing of glycoproteins |
| WO2020033867A2 (en) | 2018-08-10 | 2020-02-13 | Alexion Pharmaceuticals, Inc. | Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase |
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| CA3161266A1 (en) | 2019-12-09 | 2021-06-17 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| US12611447B2 (en) | 2020-09-04 | 2026-04-28 | Alexion Pharmaceuticals, Inc. | Methods for treating bone mineralization disorders |
| AU2022218782B2 (en) | 2021-02-12 | 2026-06-25 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| KR102866559B1 (ko) | 2022-11-02 | 2025-10-02 | 노보 노르디스크 에이/에스 | Cnp 화합물 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| AU596068B2 (en) | 1983-02-22 | 1990-04-26 | Syngene, Inc. | Defined sequence single strand oligonucleotides incorporating reporter groups, process for the chemical synthesis thereof, and nucleosides useful in such synthesis |
| US4506671A (en) | 1983-03-30 | 1985-03-26 | United States Surgical Corporation | Apparatus for applying two-part surgical fasteners |
| US4496544A (en) * | 1983-11-10 | 1985-01-29 | Washington University | Atrial Peptides |
| US5212286A (en) * | 1984-04-19 | 1993-05-18 | Scios Nova Inc. | Atrial natriuretic/vasodilator peptide compounds |
| US4996143A (en) | 1985-12-23 | 1991-02-26 | Syngene, Inc. | Fluorescent stokes shift probes for polynucleotide hybridization |
| CA1339210C (en) * | 1988-05-31 | 1997-08-05 | John Lewicki | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
| US5114923A (en) * | 1988-05-31 | 1992-05-19 | California Biotechnology Inc. | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| JP2809533B2 (ja) * | 1991-01-31 | 1998-10-08 | 壽之 松尾 | Cnp類似体ペプチド |
| US5296347A (en) | 1991-02-08 | 1994-03-22 | Ciba Corning Diagnostics Corp. | Bridge immunoassay |
| EP1067134B1 (de) | 1991-11-07 | 2004-07-28 | Nanotronics, Inc. | Hybridisierung von mit Chromophoren und Fluorophoren konjugierten Polynukleotiden zur Erzeugung eines Donor-Donor Energietransfersystems |
| AU6360394A (en) * | 1993-03-03 | 1994-09-26 | Mayo Foundation For Medical Education And Research | Vasonatrin peptide and analogs thereof |
| US5846932A (en) * | 1993-11-12 | 1998-12-08 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| US5665704A (en) * | 1993-11-12 | 1997-09-09 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| WO1995024419A1 (en) | 1994-03-11 | 1995-09-14 | Ariad Pharmaceuticals, Inc. | Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domains |
| PT914344E (pt) * | 1996-03-04 | 2005-10-31 | Scios Inc | Ensaio e reagentes para a quantificacao de hbnp |
| AU731858B2 (en) * | 1997-09-11 | 2001-04-05 | Shionogi & Co., Ltd. | Immunoassay for BNP |
| US6551795B1 (en) * | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
| US6887481B1 (en) * | 1998-12-16 | 2005-05-03 | Agency For Science, Technology And Research | Bacterial-derived molecules and therapeutic and diagnostic uses therefor |
| US6849714B1 (en) * | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US6887470B1 (en) * | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| WO2000071576A2 (en) * | 1999-05-24 | 2000-11-30 | Mayo Foundation For Medical Education And Research | Adenovirus vectors encoding brain natriuretic peptide |
| US6407211B1 (en) * | 1999-12-17 | 2002-06-18 | Mayo Foundation For Medical Education And Research | Chimeric natriuretic peptides |
| US20110131679A2 (en) * | 2000-04-19 | 2011-06-02 | Thomas La Rosa | Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
| US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| AU2002224331A1 (en) | 2000-09-22 | 2002-04-02 | Incyte Genomics, Inc. | Transcription factors and zinc finger proteins |
| US7214786B2 (en) * | 2000-12-14 | 2007-05-08 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| CN101208353B (zh) | 2003-06-20 | 2011-12-14 | 梅约医学教育与研究基金会 | 脑利尿钠肽的同种型 |
| AU2005207886A1 (en) | 2004-01-27 | 2005-08-11 | Compugen Usa, Inc. | Novel brain natriuretic peptide variants and methods of use thereof |
| US7332569B2 (en) * | 2004-01-27 | 2008-02-19 | Compugen Ltd. | Brain natriuretic peptide spliced variant |
| US8324162B2 (en) | 2006-08-08 | 2012-12-04 | Mayo Foundation For Medical Education And Research | Diuretic and natriuretic polypeptides lacking the blood pressure lowering property |
| WO2009036448A2 (en) | 2007-09-15 | 2009-03-19 | Mayo Foundation For Medical Education And Research | Natriuretic peptide receptor-c agonists |
-
2004
- 2004-06-02 CN CN2004800209647A patent/CN101208353B/zh not_active Expired - Fee Related
- 2004-06-02 EP EP10187879.1A patent/EP2308889B1/de not_active Expired - Lifetime
- 2004-06-02 EP EP04754213A patent/EP1638443B1/de not_active Expired - Lifetime
- 2004-06-02 PT PT04754213T patent/PT1638443E/pt unknown
- 2004-06-02 DE DE602004029680T patent/DE602004029680D1/de not_active Expired - Lifetime
- 2004-06-02 AT AT04754213T patent/ATE485303T1/de active
- 2004-06-02 ES ES04754213T patent/ES2354881T3/es not_active Expired - Lifetime
- 2004-06-02 JP JP2006517173A patent/JP4881156B2/ja not_active Expired - Fee Related
- 2004-06-02 PL PL04754213T patent/PL1638443T3/pl unknown
- 2004-06-02 US US10/561,014 patent/US8354496B2/en not_active Expired - Fee Related
- 2004-06-02 WO PCT/US2004/017554 patent/WO2005000095A2/en not_active Ceased
- 2004-06-02 DK DK04754213.9T patent/DK1638443T3/da active
-
2005
- 2005-12-19 IL IL172674A patent/IL172674A/en active IP Right Grant
-
2012
- 2012-09-14 US US13/616,244 patent/US8912137B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8354496B2 (en) | 2013-01-15 |
| IL172674A (en) | 2011-08-31 |
| ES2354881T3 (es) | 2011-03-18 |
| PT1638443E (pt) | 2011-01-25 |
| PL1638443T3 (pl) | 2011-04-29 |
| EP2308889B1 (de) | 2018-05-23 |
| EP1638443A4 (de) | 2008-10-08 |
| US8912137B2 (en) | 2014-12-16 |
| EP2308889A1 (de) | 2011-04-13 |
| US20070281887A1 (en) | 2007-12-06 |
| US20130143816A1 (en) | 2013-06-06 |
| DK1638443T3 (da) | 2011-02-07 |
| JP2007525957A (ja) | 2007-09-13 |
| CN101208353B (zh) | 2011-12-14 |
| WO2005000095A3 (en) | 2008-01-24 |
| EP1638443B1 (de) | 2010-10-20 |
| DE602004029680D1 (de) | 2010-12-02 |
| EP1638443A2 (de) | 2006-03-29 |
| CN101208353A (zh) | 2008-06-25 |
| IL172674A0 (en) | 2006-04-10 |
| JP4881156B2 (ja) | 2012-02-22 |
| WO2005000095A2 (en) | 2005-01-06 |
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