ATE488235T1 - Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit - Google Patents

Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit

Info

Publication number: ATE488235T1
Authority: AT; Austria
Prior art keywords: modulators; amino; calcium; new; benzimidazole derivatives
Prior art date: 2005-01-11

Application number

AT06701206T

Other languages

English (en)

Inventor

Ulrik Syrensen

Lene Teuber

Dan Peters

Dorte Strybfk

Tina Johansen

Karin Nielsen

Palle Christophersen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-11

Filing date

2006-01-10

Publication date

2010-12-15

2006-01-10 Application filed by Neurosearch As filed Critical Neurosearch As

2010-12-15 Application granted granted Critical

2010-12-15 Publication of ATE488235T1 publication Critical patent/ATE488235T1/de

Links

JWYUFVNJZUSCSM-UHFFFAOYSA-N 2-aminobenzimidazole Chemical class C1=CC=C2NC(N)=NC2=C1 JWYUFVNJZUSCSM-UHFFFAOYSA-N 0.000 title abstract 2
102000005702 Calcium-Activated Potassium Channels Human genes 0.000 title 1
108010045489 Calcium-Activated Potassium Channels Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
108091006146 Channels Proteins 0.000 abstract 1
102000002582 Small-Conductance Calcium-Activated Potassium Channels Human genes 0.000 abstract 1
108010093479 Small-Conductance Calcium-Activated Potassium Channels Proteins 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Hospice & Palliative Care (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Psychology (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)

AT06701206T 2005-01-11 2006-01-10 Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit ATE488235T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US64253805P	2005-01-11	2005-01-11
DKPA200500049		2005-01-11
DKPA200500240		2005-02-16
US65351305P	2005-02-17	2005-02-17
PCT/EP2006/050108 WO2006074991A1 (en)	2005-01-11	2006-01-10	Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels

Publications (1)

Publication Number	Publication Date
ATE488235T1 true ATE488235T1 (de)	2010-12-15

Family

ID=36010294

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06701206T ATE488235T1 (de)	2005-01-11	2006-01-10	Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit

Country Status (6)

Country	Link
US (3)	US7842817B2 (de)
EP (2)	EP2319512A1 (de)
JP (1)	JP2008526815A (de)
AT (1)	ATE488235T1 (de)
DE (1)	DE602006018255D1 (de)
WO (1)	WO2006074991A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009511548A (ja) *	2005-10-14	2009-03-19	ノイロサーチアクティーゼルスカブ	新規ピリミジン−２，４−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用
CA2637674A1 (en) *	2006-01-19	2007-07-26	Abbott Laboratories	2-imino-benzimidazoles
EP2041096A1 (de) *	2006-07-07	2009-04-01	NeuroSearch AS	2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit
JP2010509249A (ja) *	2006-11-13	2010-03-25	ノイロサーチアクティーゼルスカブ	新規な４−アミノ−ピリジン誘導体及びカリウムチャネルモジュレーターとしてのその使用
US8039632B2 (en) *	2006-11-13	2011-10-18	Neurosearch A/S	2-aminio-pyridine derivatives and their use as potassium channel modulators
CN102307862A (zh)	2008-12-08	2012-01-04	贝林格尔.英格海姆国际有限公司	用于治疗癌症的化合物
CN102947274A (zh) *	2010-06-17	2013-02-27	诺瓦提斯公司	联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物
JP2013532149A (ja)	2010-06-17	2013-08-15	ノバルティスアーゲー	ピペリジニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体
EP2810773A1 (de)	2013-06-05	2014-12-10	Basell Poliolefine Italia S.r.l.	Buten-1-Copolymer Haftvermittler in Mehrschichtfolienstrukturen mit einer niedrigen Dichtungstemperatur und verbesserte Hot-Tack.
EP3055297A1 (de)	2013-10-10	2016-08-17	Basf Se	Substituierte n-(tetrazol-5-yl)- und n-(triazol-5-yl)arylcarboxamid-verbindungen und deren verwendung als herbizide
WO2016077541A1 (en) *	2014-11-12	2016-05-19	The Trustees Of The University Of Pennsylvania	Novel anti-infective compounds and methods using same
CN104744375B (zh) *	2015-02-10	2017-09-19	南开大学	一种胍类ntr1小分子拮抗剂
WO2019028308A1 (en) *	2017-08-04	2019-02-07	Goldfinch Bio, Inc.	BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES AND METHODS OF USE
EP3668841B1 (de) *	2017-08-14	2026-07-08	Acesion Pharma Aps	Substituierte benzimidazole als kaliumkanalinhibitoren
EP3672953B1 (de) *	2017-08-23	2021-07-28	Acesion Pharma ApS	Benzimidazolderivate als kaliumkanalinhibitoren
WO2019191327A1 (en) *	2018-03-27	2019-10-03	Board Of Regents, The University Of Texas System	Ox2r compounds
AU2021227966A1 (en) *	2020-02-26	2022-09-22	The Scripps Research Institute	Small molecule inhibitors of SLC15A4 with anti-inflammatory activity
EP4313973A1 (de) *	2021-03-22	2024-02-07	Acesion Pharma ApS	Neue kaliumkanalhemmer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3981886A (en)	1975-01-20	1976-09-21	E. R. Squibb & Sons, Inc.	Amino-benzimidazole derivatives
US4004016A (en) *	1975-08-11	1977-01-18	E. R. Squibb & Sons, Inc.	Amino-benzimidazole derivatives
DE69924493T2 (de)	1998-07-02	2005-09-15	Neurosearch A/S	Kaliumkanal-blockierende mittel
US6194447B1 (en) *	1998-07-02	2001-02-27	Neurosearch A/S	Bis (benzimidazole) derivatives serving as potassium blocking agents
MA26659A1 (fr)	1998-08-06	2004-12-20	Pfizer	Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
AU4537500A (en) *	1999-05-12	2000-12-05	Neurosearch A/S	Ion channel modulating agents
HRP20030081A2 (en)	2000-08-08	2005-02-28	Sanofi-Aventis	Benzimidazole derivatives, preparation and therapeutic use thereof
HUP0400063A2 (hu) *	2001-02-20	2004-04-28	Bristol-Myers Squibb Company	Fluor-oxo-indolszármazékok mint KCNQ káliumcsatorna modulátorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
DE10135050A1 (de)	2001-07-09	2003-02-06	Schering Ag	1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate
EP1511744A4 (de)	2002-05-13	2009-10-21	Icagen Inc	Bis-benzimidazole und verwandte verbindungen als kaliumkanalmodulatoren

2006
- 2006-01-10 EP EP10182012A patent/EP2319512A1/de not_active Withdrawn
- 2006-01-10 WO PCT/EP2006/050108 patent/WO2006074991A1/en not_active Ceased
- 2006-01-10 AT AT06701206T patent/ATE488235T1/de not_active IP Right Cessation
- 2006-01-10 JP JP2007549905A patent/JP2008526815A/ja not_active Abandoned
- 2006-01-10 US US11/795,018 patent/US7842817B2/en not_active Expired - Fee Related
- 2006-01-10 EP EP06701206A patent/EP1838306B1/de not_active Expired - Lifetime
- 2006-01-10 DE DE602006018255T patent/DE602006018255D1/de not_active Expired - Lifetime
2010
- 2010-07-08 US US12/832,343 patent/US20100280087A1/en not_active Abandoned
- 2010-10-21 US US12/909,362 patent/US20110034527A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2006074991A1 (en)	2006-07-20
EP1838306A1 (de)	2007-10-03
EP1838306B1 (de)	2010-11-17
DE602006018255D1 (de)	2010-12-30
US20100280087A1 (en)	2010-11-04
EP2319512A1 (de)	2011-05-11
JP2008526815A (ja)	2008-07-24
US7842817B2 (en)	2010-11-30
US20110034527A1 (en)	2011-02-10
US20080200529A1 (en)	2008-08-21

Legal Events

Date	Code	Title	Description
2011-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602006018255D1 (de)	2010-12-30	Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit
CL2011000846A1 (es)	2011-09-30	Compuestos heterociclicos sustituidos; composicion farmaceutica; y su uso para el tratamiento de la hepatitis c.
BR122013025375B8 (pt)	2021-05-25	compostos orgânicos, seus métodos de preparo e uso, bem como composições farmacêuticas
UY30610A1 (es)	2008-05-02	Moduladores de mglur5
CY1113102T1 (el)	2016-04-13	Ενωσεις φαινυλπροπιοναμιδιου και η χρηση αυτων
ECSP109953A (es)	2010-03-31	Derivados de piridazinona
CY1109911T1 (el)	2014-09-10	Πυρρολοβενζοδιαζεπινες
CY1109722T1 (el)	2014-04-09	Ενδιαμεσες ενωσεις για την παρασκευη της trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,73oxepino[4,5-c]pyrrole
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