ATE488235T1 - Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit - Google Patents

Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit

Info

Publication number: ATE488235T1
Authority: AT; Austria
Prior art keywords: modulators; amino; calcium; new; benzimidazole derivatives
Prior art date: 2005-01-11

Application number

AT06701206T

Other languages

English (en)

Inventor

Ulrik Syrensen

Lene Teuber

Dan Peters

Dorte Strybfk

Tina Johansen

Karin Nielsen

Palle Christophersen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-11

Filing date

2006-01-10

Publication date

2010-12-15

2006-01-10 Application filed by Neurosearch As filed Critical Neurosearch As

2010-12-15 Application granted granted Critical

2010-12-15 Publication of ATE488235T1 publication Critical patent/ATE488235T1/de

Links

JWYUFVNJZUSCSM-UHFFFAOYSA-N 2-aminobenzimidazole Chemical class C1=CC=C2NC(N)=NC2=C1 JWYUFVNJZUSCSM-UHFFFAOYSA-N 0.000 title abstract 2
102000005702 Calcium-Activated Potassium Channels Human genes 0.000 title 1
108010045489 Calcium-Activated Potassium Channels Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
108091006146 Channels Proteins 0.000 abstract 1
102000002582 Small-Conductance Calcium-Activated Potassium Channels Human genes 0.000 abstract 1
108010093479 Small-Conductance Calcium-Activated Potassium Channels Proteins 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)

AT06701206T 2005-01-11 2006-01-10 Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit ATE488235T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US64253805P	2005-01-11	2005-01-11
DKPA200500049		2005-01-11
DKPA200500240		2005-02-16
US65351305P	2005-02-17	2005-02-17
PCT/EP2006/050108 WO2006074991A1 (en)	2005-01-11	2006-01-10	Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels

Publications (1)

Publication Number	Publication Date
ATE488235T1 true ATE488235T1 (de)	2010-12-15

Family

ID=36010294

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06701206T ATE488235T1 (de)	2005-01-11	2006-01-10	Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit

Country Status (6)

Country	Link
US (3)	US7842817B2 (de)
EP (2)	EP1838306B1 (de)
JP (1)	JP2008526815A (de)
AT (1)	ATE488235T1 (de)
DE (1)	DE602006018255D1 (de)
WO (1)	WO2006074991A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090124645A1 (en) *	2005-10-14	2009-05-14	Neurosearch A/S	Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels
CA2637674A1 (en) *	2006-01-19	2007-07-26	Abbott Laboratories	2-imino-benzimidazoles
EP2041096A1 (de) *	2006-07-07	2009-04-01	NeuroSearch AS	2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit
US8039632B2 (en) *	2006-11-13	2011-10-18	Neurosearch A/S	2-aminio-pyridine derivatives and their use as potassium channel modulators
EP2083821A1 (de) *	2006-11-13	2009-08-05	Neurosearch A/S	Neue 4-aminopyridin-derivate und ihre verwendung als kaliumkanal-modulatoren
MX2011006000A (es)	2008-12-08	2011-07-20	Boehringer Ingelheim Int	Compuestos para tratar cancer.
EP2582680A1 (de)	2010-06-17	2013-04-24	Novartis AG	Biphenyl-substituierte 1,3-dihydro-benzoimidazol-2-ylidenamidderivate
EP2582681A1 (de)	2010-06-17	2013-04-24	Novartis AG	Piperidinylsubstituierte 1,3-dihydro-benzoimidazol-2-ylidenaminderivate
EP2810773A1 (de)	2013-06-05	2014-12-10	Basell Poliolefine Italia S.r.l.	Buten-1-Copolymer Haftvermittler in Mehrschichtfolienstrukturen mit einer niedrigen Dichtungstemperatur und verbesserte Hot-Tack.
CN105636950A (zh)	2013-10-10	2016-06-01	巴斯夫欧洲公司	取代的n-(四唑-5-基)-和n-(三唑-5-基)芳基羧酰胺化合物及其作为除草剂的用途
WO2016077541A1 (en) *	2014-11-12	2016-05-19	The Trustees Of The University Of Pennsylvania	Novel anti-infective compounds and methods using same
CN104744375B (zh) *	2015-02-10	2017-09-19	南开大学	一种胍类ntr1小分子拮抗剂
US20200377505A1 (en) *	2017-08-04	2020-12-03	Goldfinch Bio., Inc.	Benzimidazoles and aza-benzimidazoles, and methods of use thereof
WO2019034603A1 (en) *	2017-08-14	2019-02-21	Acesion Pharma Aps	SUBSTITUTED BENZIMIDAZOLES USEFUL AS INHIBITORS OF THE POTASSIUM CHANNEL
CN111372928B (zh) *	2017-08-23	2023-05-16	阿塞西翁制药公司	用作钾通道抑制剂的苯并咪唑衍生物
AU2019243141A1 (en) *	2018-03-27	2020-10-15	Board Of Regents, The University Of Texas System	OX2R compounds
KR20220147114A (ko) *	2020-02-26	2022-11-02	더 스크립스 리서치 인스티튜트	항-염증 활성을 갖는 scl15a4의 소분자 억제제들
WO2022200162A1 (en) *	2021-03-22	2022-09-29	Acecion Pharma Aps	Novel potassium channel inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3981886A (en) *	1975-01-20	1976-09-21	E. R. Squibb & Sons, Inc.	Amino-benzimidazole derivatives
US4004016A (en) *	1975-08-11	1977-01-18	E. R. Squibb & Sons, Inc.	Amino-benzimidazole derivatives
US6194447B1 (en) *	1998-07-02	2001-02-27	Neurosearch A/S	Bis (benzimidazole) derivatives serving as potassium blocking agents
ATE292120T1 (de)	1998-07-02	2005-04-15	Neurosearch As	Kaliumkanal-blockierende mittel
MA26659A1 (fr)	1998-08-06	2004-12-20	Pfizer	Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
JP2002544268A (ja)	1999-05-12	2002-12-24	ニューロサーチ、アクティーゼルスカブ	イオンチャネル調節剤
AR030121A1 (es)	2000-08-08	2003-08-13	Sanofi Aventis	Derivados de benzimidazol, su preparacion y su aplicacion en terapeutica
CA2438805A1 (en)	2001-02-20	2002-08-29	Bristol-Myers Squibb Company	Fluoro oxindole derivatives as modulators of kcnq potassium channels
DE10135050A1 (de)	2001-07-09	2003-02-06	Schering Ag	1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate
AU2003230401A1 (en)	2002-05-13	2003-11-11	Icagen, Inc.	Bis-benzimidazoles and related compounds as potassium channel modulators

2006
- 2006-01-10 WO PCT/EP2006/050108 patent/WO2006074991A1/en not_active Ceased
- 2006-01-10 JP JP2007549905A patent/JP2008526815A/ja not_active Abandoned
- 2006-01-10 EP EP06701206A patent/EP1838306B1/de not_active Expired - Lifetime
- 2006-01-10 EP EP10182012A patent/EP2319512A1/de not_active Withdrawn
- 2006-01-10 US US11/795,018 patent/US7842817B2/en not_active Expired - Fee Related
- 2006-01-10 DE DE602006018255T patent/DE602006018255D1/de not_active Expired - Lifetime
- 2006-01-10 AT AT06701206T patent/ATE488235T1/de not_active IP Right Cessation
2010
- 2010-07-08 US US12/832,343 patent/US20100280087A1/en not_active Abandoned
- 2010-10-21 US US12/909,362 patent/US20110034527A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1838306A1 (de)	2007-10-03
DE602006018255D1 (de)	2010-12-30
US7842817B2 (en)	2010-11-30
WO2006074991A1 (en)	2006-07-20
EP1838306B1 (de)	2010-11-17
JP2008526815A (ja)	2008-07-24
US20080200529A1 (en)	2008-08-21
US20100280087A1 (en)	2010-11-04
EP2319512A1 (de)	2011-05-11
US20110034527A1 (en)	2011-02-10

Legal Events

Date	Code	Title	Description
2011-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE488235T1 (de)	2010-12-15	Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit
CL2011000846A1 (es)	2011-09-30	Compuestos heterociclicos sustituidos; composicion farmaceutica; y su uso para el tratamiento de la hepatitis c.
BR122013025375B8 (pt)	2021-05-25	compostos orgânicos, seus métodos de preparo e uso, bem como composições farmacêuticas
UY30610A1 (es)	2008-05-02	Moduladores de mglur5
CY1113102T1 (el)	2016-04-13	Ενωσεις φαινυλπροπιοναμιδιου και η χρηση αυτων
ECSP109953A (es)	2010-03-31	Derivados de piridazinona
CY1109911T1 (el)	2014-09-10	Πυρρολοβενζοδιαζεπινες
CY1109722T1 (el)	2014-04-09	Ενδιαμεσες ενωσεις για την παρασκευη της trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,73oxepino[4,5-c]pyrrole
UY30748A1 (es)	2008-07-03	Compuesto0s novedosos
AR048069A1 (es)	2006-03-29	Derivados de pirazolo con heteroarilo fusionado
SV2010003502A (es)	2011-03-23	Fungicidas novedosos
ECSP10010722A (es)	2011-01-31	Compuestos orgánicos
UY29246A1 (es)	2006-08-31	Nuevos compuestos
ECSP099413A (es)	2009-07-31	COMPUESTOS A BASE DE 4 - fenil - 6 - (2,2,2 - trifluoro - 1 - feniletoxi)pirimidina Y MÉTODOS PARA SU EMPLEO
DK1951729T3 (da)	2014-10-06	Oxygenbundne pyrimidinderivater
CR10157A (es)	2008-10-29	Compuestos químicos
CY1111556T1 (el)	2015-10-07	Παραγωγα 2-βενζυλοπυριδαζινονης ως αναστολεις μετ-κινασης
CR10213A (es)	2008-10-03	Moduladores de la proteína quinasa aurora
EA200801428A1 (ru)	2008-10-30	Производные пиридиазинона для лечения опухолей
SV2010003475A (es)	2011-03-23	Nuevos herbicidas
WO2009046842A3 (de)	2009-06-25	Thialzolderivate zur behandlung von krebs
NO20075368L (no)	2007-12-11	Antiinflammatoriske modaliteter
CL2008003546A1 (es)	2010-02-05	Compuestos derivados de piridina; procedimiento de preparacion; composicion farmaceutica de dichos compuestos; y uso en el tratamiento y/o profilaxis de la diabetes mellitus tipo i y/o tipo ii.
ATE427927T1 (de)	2009-04-15	Phenylacetylenderivate mit affinitat zum mglur5- rezeptor
ATE478054T1 (de)	2010-09-15	Benzimidazolderivate