ATE488605T1 - Verfahren zur quantitativen bewertung einer umordnung oder einer gezielten genetischen rekombination bei einem individuum sowie verwendungen davon - Google Patents
Verfahren zur quantitativen bewertung einer umordnung oder einer gezielten genetischen rekombination bei einem individuum sowie verwendungen davonInfo
- Publication number
- ATE488605T1 ATE488605T1 AT04805634T AT04805634T ATE488605T1 AT E488605 T1 ATE488605 T1 AT E488605T1 AT 04805634 T AT04805634 T AT 04805634T AT 04805634 T AT04805634 T AT 04805634T AT E488605 T1 ATE488605 T1 AT E488605T1
- Authority
- AT
- Austria
- Prior art keywords
- quantitative evaluation
- elongation
- targeted genetic
- primer
- genetic rearrangement
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000011158 quantitative evaluation Methods 0.000 title abstract 3
- 230000006798 recombination Effects 0.000 title abstract 3
- 230000002068 genetic effect Effects 0.000 abstract 3
- 230000008707 rearrangement Effects 0.000 abstract 3
- 239000000523 sample Substances 0.000 abstract 3
- 230000003321 amplification Effects 0.000 abstract 2
- 238000004925 denaturation Methods 0.000 abstract 2
- 230000036425 denaturation Effects 0.000 abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000005215 recombination Methods 0.000 abstract 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 abstract 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 238000007403 mPCR Methods 0.000 abstract 1
- 238000011144 upstream manufacturing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0314289A FR2863274B1 (fr) | 2003-12-05 | 2003-12-05 | Procede d'evaluation quantitative d'un rearrangement ou d'une recombinaison genetique ciblee d'un individu et ses applications. |
| PCT/FR2004/003115 WO2005056828A1 (fr) | 2003-12-05 | 2004-12-03 | Procede d'evaluation quantitative d'un rearrangement ou d'une recombinaison genetique ciblee d'un individu et ses applications. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE488605T1 true ATE488605T1 (de) | 2010-12-15 |
Family
ID=34586330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04805634T ATE488605T1 (de) | 2003-12-05 | 2004-12-03 | Verfahren zur quantitativen bewertung einer umordnung oder einer gezielten genetischen rekombination bei einem individuum sowie verwendungen davon |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080166704A1 (de) |
| EP (1) | EP1704249B1 (de) |
| JP (1) | JP5709341B2 (de) |
| AT (1) | ATE488605T1 (de) |
| CA (1) | CA2548053C (de) |
| DE (1) | DE602004030156D1 (de) |
| FR (1) | FR2863274B1 (de) |
| WO (1) | WO2005056828A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1849877A1 (de) * | 2006-04-24 | 2007-10-31 | Erasmus University Medical Center Rotterdam | Replikationsgeschichte von Teilmengen von T- und B-Zellen |
| US20160068905A1 (en) | 2007-11-26 | 2016-03-10 | Immunid | Method for Studying V(D)J Combinatory Diversity |
| EP2062982A1 (de) | 2007-11-26 | 2009-05-27 | ImmunID | Verfahren zur Untersuchung der kombinatorischen Diversität von V(D)J. |
| WO2009137255A2 (en) | 2008-04-16 | 2009-11-12 | Hudsonalpha Institute For Biotechnology | Method for evaluating and comparing immunorepertoires |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| EP2364368B1 (de) | 2008-11-07 | 2014-01-15 | Sequenta, Inc. | Verfahren zur überwachung von krankheitszuständen mittels sequenzanalyse |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| DK3059337T3 (da) | 2009-01-15 | 2019-07-22 | Adaptive Biotechnologies Corp | Adaptive immunity profiling og metoder til frembringelse af monoklonale antibodier |
| US20120058902A1 (en) * | 2009-06-25 | 2012-03-08 | Livingston Robert J | Method of measuring adaptive immunity |
| RU2014144463A (ru) | 2009-06-25 | 2015-06-20 | Фред Хатчинсон Кансэр Рисёч Сентер | Способ измерения адаптивного иммунитета |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| GB0922006D0 (en) * | 2009-12-17 | 2010-02-03 | Genome Res Ltd | Diagnostic |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| US9279159B2 (en) * | 2011-10-21 | 2016-03-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| EP3388535B1 (de) | 2011-12-09 | 2021-03-24 | Adaptive Biotechnologies Corporation | Diagnose von lymphoid-malignomen und nachweis von minimaler resterkrankung |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| DK2823060T3 (en) | 2012-03-05 | 2018-05-28 | Adaptive Biotechnologies Corp | Determination of associated immune receptor chains from frequency-matched subunits |
| EP3091089B1 (de) | 2012-05-08 | 2019-01-23 | Adaptive Biotechnologies Corporation | Verfahren zum vermessen und kalibrieren eines amplifikationsbias in multiplexierten pcr-reaktionen |
| US20160002731A1 (en) | 2012-10-01 | 2016-01-07 | Adaptive Biotechnologies Corporation | Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization |
| US10150996B2 (en) | 2012-10-19 | 2018-12-11 | Adaptive Biotechnologies Corp. | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| WO2014144495A1 (en) | 2013-03-15 | 2014-09-18 | Abvitro, Inc. | Single cell bar-coding for antibody discovery |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| JP6164759B2 (ja) | 2013-11-21 | 2017-07-19 | Ｒｅｐｅｒｔｏｉｒｅ Ｇｅｎｅｓｉｓ株式会社 | Ｔ細胞受容体およびｂ細胞受容体レパトアの解析システムならびにその治療および診断への利用 |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| JP6565147B2 (ja) * | 2014-08-29 | 2019-08-28 | 東洋紡株式会社 | マルチプレックスｐｃｒ法 |
| KR102541849B1 (ko) | 2014-09-15 | 2023-06-09 | 에이비비트로, 엘엘씨 | 고-처리량 뉴클레오티드 라이브러리 서열결정 |
| CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| EP3224384A4 (de) | 2014-11-25 | 2018-04-18 | Adaptive Biotechnologies Corp. | Charakterisierung von adaptiver immunreaktion auf impfungen oder infektionen unter verwendung von immunrepertoiresequenzierung |
| US11047008B2 (en) | 2015-02-24 | 2021-06-29 | Adaptive Biotechnologies Corporation | Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing |
| WO2016161273A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| CN106156536B (zh) * | 2015-04-15 | 2018-11-13 | 深圳华大基因科技有限公司 | 对样本免疫组库测序数据进行处理的方法和系统 |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| CN113707220A (zh) * | 2021-08-27 | 2021-11-26 | 云测医学科技(深圳)有限公司 | 一种基于碱基序列匹配分组的免疫细胞受体转录组多样性检测多重引物智能选择方法 |
| CN117133351B (zh) * | 2023-10-24 | 2024-01-23 | 江西师范大学 | 一种优化的线粒体基因重排量化方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5296351A (en) * | 1988-10-20 | 1994-03-22 | Alexander A. Morley | Method for diagnosis of monoclonality in leukaemia and lymphoma |
| DE69018961T2 (de) * | 1989-08-11 | 1995-11-23 | Amoco Corp | Detektion von pneumocystis carinii durch die verwendung von nukleinsäuresonden. |
| FR2671356B1 (fr) * | 1991-01-09 | 1993-04-30 | Inst Nat Sante Rech Med | Procede de description des repertoires d'anticorps (ab) et des recepteurs des cellules t (tcr) du systeme immunitaire d'un individu. |
| EP0529033B1 (de) | 1991-02-08 | 2006-08-30 | Aventis Pharma S.A. | Nukleotidsequenzen, die für die veränderlichen bereiche der alpha-ketten menschlicher t-zell-rezeptoren kodieren sowie ihre verwendungen |
| US6087096A (en) | 1995-11-13 | 2000-07-11 | Dau; Peter C. | Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions |
| US5612473A (en) * | 1996-01-16 | 1997-03-18 | Gull Laboratories | Methods, kits and solutions for preparing sample material for nucleic acid amplification |
| CA2272845C (en) * | 1996-11-26 | 2010-01-12 | Bio Merieux | Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes |
| GB2368064B (en) * | 2000-09-30 | 2002-11-13 | Imp Cancer Res Tech | DNA Element and Associated Protein |
| US20030153044A1 (en) * | 2001-05-14 | 2003-08-14 | Monika Liljedahl | Tissues or organs for use in xenotransplantation |
| US6950755B2 (en) * | 2001-07-02 | 2005-09-27 | City Of Hope | Genotype pattern recognition and classification |
| EP1549764B1 (de) * | 2002-10-11 | 2010-10-06 | Erasmus Universiteit Rotterdam | Primer für nukleinsäureamplifikation in pcr-basierten klonalitätsstudien |
-
2003
- 2003-12-05 FR FR0314289A patent/FR2863274B1/fr not_active Expired - Fee Related
-
2004
- 2004-12-03 JP JP2006541986A patent/JP5709341B2/ja not_active Expired - Fee Related
- 2004-12-03 WO PCT/FR2004/003115 patent/WO2005056828A1/fr not_active Ceased
- 2004-12-03 AT AT04805634T patent/ATE488605T1/de not_active IP Right Cessation
- 2004-12-03 DE DE602004030156T patent/DE602004030156D1/de not_active Expired - Lifetime
- 2004-12-03 CA CA2548053A patent/CA2548053C/fr not_active Expired - Fee Related
- 2004-12-03 US US10/581,814 patent/US20080166704A1/en not_active Abandoned
- 2004-12-03 EP EP04805634A patent/EP1704249B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20080166704A1 (en) | 2008-07-10 |
| EP1704249A1 (de) | 2006-09-27 |
| EP1704249B1 (de) | 2010-11-17 |
| CA2548053C (fr) | 2014-07-08 |
| CA2548053A1 (fr) | 2005-06-23 |
| FR2863274B1 (fr) | 2012-11-16 |
| JP5709341B2 (ja) | 2015-04-30 |
| JP2007515955A (ja) | 2007-06-21 |
| DE602004030156D1 (de) | 2010-12-30 |
| WO2005056828A1 (fr) | 2005-06-23 |
| FR2863274A1 (fr) | 2005-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |