ATE489378T1 - Piperidinylverbindungen, die selektiv an integrine binden - Google Patents

Piperidinylverbindungen, die selektiv an integrine binden

Info

Publication number: ATE489378T1
Authority: AT; Austria
Prior art keywords: integrins; selectively bind; piperidinyl compounds; piperidinyl; compounds
Prior art date: 2002-08-16

Application number

AT03791686T

Other languages

English (en)

Inventor

Corte Bart De

William Kinney

Bruce Maryanoff

Shyamali Ghosh

Li Liu

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-16

Filing date

2003-08-15

Publication date

2010-12-15

2003-08-15 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2010-12-15 Application granted granted Critical

2010-12-15 Publication of ATE489378T1 publication Critical patent/ATE489378T1/de

Links

-1 PIPERIDINYL COMPOUNDS Chemical class 0.000 title 1
102000006495 integrins Human genes 0.000 title 1
108010044426 integrins Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Surgery (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Materials For Medical Uses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT03791686T 2002-08-16 2003-08-15 Piperidinylverbindungen, die selektiv an integrine binden ATE489378T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40423902P	2002-08-16	2002-08-16
PCT/US2003/025782 WO2004020435A1 (en)	2002-08-16	2003-08-15	Piperidinyl compounds that selectively bind integrins

Publications (1)

Publication Number	Publication Date
ATE489378T1 true ATE489378T1 (de)	2010-12-15

Family

ID=31978252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03791686T ATE489378T1 (de)	2002-08-16	2003-08-15	Piperidinylverbindungen, die selektiv an integrine binden

Country Status (24)

Country	Link
US (1)	US20040077684A1 (de)
EP (1)	EP1539739B1 (de)
JP (1)	JP4554364B2 (de)
KR (1)	KR20050031464A (de)
CN (1)	CN100506815C (de)
AR (1)	AR041010A1 (de)
AT (1)	ATE489378T1 (de)
AU (2)	AU2003259891A1 (de)
BR (1)	BR0313534A (de)
CA (1)	CA2496127C (de)
CR (1)	CR7692A (de)
CY (1)	CY1111194T1 (de)
DE (1)	DE60335118D1 (de)
DK (1)	DK1539739T3 (de)
ES (1)	ES2355139T3 (de)
IL (1)	IL166534A (de)
MX (1)	MXPA05001859A (de)
NO (1)	NO332036B1 (de)
PL (1)	PL219749B1 (de)
PT (1)	PT1539739E (de)
RU (1)	RU2333210C2 (de)
SI (1)	SI1539739T1 (de)
UA (1)	UA83467C2 (de)
WO (1)	WO2004020435A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040224986A1 (en) *	2002-08-16	2004-11-11	Bart De Corte	Piperidinyl targeting compounds that selectively bind integrins
US7351711B2 (en)	2003-07-31	2008-04-01	Janssen Pharmaceutical, N.V.	Tricyclic indanyls as integrin inhibitors
AU2005229015C1 (en) *	2004-04-02	2013-01-17	The Regents Of The University Of California	Methods and compositions for treating and preventing disease associated with alphaVbeta5 integrin
EP1830902A2 (de) *	2004-12-30	2007-09-12	Cinvention Ag	Kombination aus einem mittel, das ein signal abgibt, implantatmaterial und arzeimittel
EP1833512A1 (de) *	2005-01-06	2007-09-19	GE Healthcare AS	Optische bilddarstellung
US8372399B2 (en) *	2006-08-31	2013-02-12	Cardiac Pacemakers, Inc.	Bispecific antibodies and agents to enhance stem cell homing
US20080058922A1 (en) *	2006-08-31	2008-03-06	Cardiac Pacemakers, Inc.	Methods and devices employing vap-1 inhibitors
US8636995B2 (en) *	2006-08-31	2014-01-28	Cardiac Pacemakers, Inc.	Methods and devices to regulate stem cell homing
SI2178858T1 (sl) *	2007-08-02	2012-03-30	Recordati Ireland Ltd	Nove heterociklične spojine kot mGlu antagonisti
WO2009058314A1 (en)	2007-10-30	2009-05-07	Janssen Pharmaceutica, N.V.	Enantioselective process for preparing a substituted alkanoic acid
EP2730282A1 (de) *	2007-11-08	2014-05-14	The General Hospital Corporation	Verfahren und Zusammensetzung zur Behandlung von Proteinurie-Erkrankungen
EP2456460A4 (de)	2009-07-24	2013-02-20	Univ California	Verfahren und zusammensetzungen zur behandlung und prävention von mit avb5-integrin assoziierten krankheiten
SI3050878T1 (sl)	2013-09-24	2022-01-31	Fujifilm Corporation	Nova dušik-vsebujoča spojina ali njena sol ali kovinski kompleks le-te
EP3512839A4 (de)	2016-09-18	2020-03-25	H. Lee Moffitt Cancer Center And Research Institute, Inc.	Gegen interaktion von yap1 mit oct4 gerichtete yap1-inhibitoren
BR112019009245A2 (pt) *	2016-11-08	2019-07-16	Bristol-Myers Squibb Company	azol amidas e aminas como inibidores de alfav integrina
HRP20210228T1 (hr) *	2016-11-08	2021-03-19	Bristol-Myers Squibb Company	Amidi pirola kao inhibitori alfa v integrina
MA52117A (fr) *	2017-02-28	2022-04-06	Morphic Therapeutic Inc	Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
MX394210B (es)	2017-02-28	2025-03-04	Morphic Therapeutic Inc	INHIBIDORES DE INTEGRINA AVß6.
BR112020018642A2 (pt)	2018-03-14	2020-12-29	H. Lee Moffitt Cancer Center And Research Institute, Inc.	Composto da fórmula i, composição farmacêutica, método de tratamento de câncer em um sujeito em necessidade, método de eliminação de uma célula tumoral em um sujeito
WO2020047208A1 (en)	2018-08-29	2020-03-05	Morphic Therapeutic, Inc.	Inhibitors of (alpha-v)(beta-6) integrin
WO2020047239A1 (en)	2018-08-29	2020-03-05	Morphic Therapeutic, Inc.	INHIBITING αV β6 INTEGRIN
SI3844162T1 (sl)	2018-08-29	2025-06-30	Morphic Therapeutic, Inc.	Zaviralci integrina alfa v beta6
WO2025067433A1 (zh) *	2023-09-28	2025-04-03	云合智药（苏州）生物科技有限公司	靶向整合素的化合物及其在RNAi剂中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN148482B (de) *	1977-06-03	1981-03-07	Pfizer
PT627940E (pt) *	1992-03-05	2003-07-31	Univ Texas	Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados
US5474765A (en) *	1992-03-23	1995-12-12	Ut Sw Medical Ctr At Dallas	Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
US5902795A (en) *	1992-06-16	1999-05-11	Trustees Of Tufts College	Oligosaccharides reactive with hyaluronan-binding protein and their methods of use
US5340798A (en) *	1992-10-14	1994-08-23	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5753659A (en) *	1993-03-29	1998-05-19	Zeneca Limited	Heterocyclic compouds
US5700801A (en) *	1994-12-23	1997-12-23	Karl Thomae, Gmbh	Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
DE19516483A1 (de) *	1995-05-05	1996-11-07	Merck Patent Gmbh	Adhäsionsrezeptor-Antagonisten
DE19613933A1 (de) *	1996-04-06	1997-10-09	Merck Patent Gmbh	Cyclische Adhäsionsinhibitoren
US5919792A (en) *	1996-10-30	1999-07-06	Merck & Co., Inc.	Integrin antagonists
US6211191B1 (en) *	1997-12-17	2001-04-03	Merck & Co., Inc.	Integrin receptor antagonists
CA2315232A1 (en) *	1997-12-17	1999-06-24	Merck & Co., Inc.	Integrin receptor antagonists
AU4584199A (en) *	1998-06-29	2000-01-17	Du Pont Pharmaceuticals Company	Cyclic carbamates and isoxazolidines as iib/iiia antagonists
US6342219B1 (en) *	1999-04-28	2002-01-29	Board Of Regents, The University Of Texas System	Antibody compositions for selectively inhibiting VEGF
US6776796B2 (en) *	2000-05-12	2004-08-17	Cordis Corportation	Antiinflammatory drug and delivery device

2003
- 2003-08-15 AU AU2003259891A patent/AU2003259891A1/en not_active Abandoned
- 2003-08-15 JP JP2004532905A patent/JP4554364B2/ja not_active Expired - Fee Related
- 2003-08-15 AT AT03791686T patent/ATE489378T1/de active
- 2003-08-15 AR ARP030102976A patent/AR041010A1/es unknown
- 2003-08-15 KR KR1020057001657A patent/KR20050031464A/ko not_active Ceased
- 2003-08-15 RU RU2005104115/04A patent/RU2333210C2/ru not_active IP Right Cessation
- 2003-08-15 WO PCT/US2003/025782 patent/WO2004020435A1/en not_active Ceased
- 2003-08-15 CA CA2496127A patent/CA2496127C/en not_active Expired - Fee Related
- 2003-08-15 DK DK03791686.3T patent/DK1539739T3/da active
- 2003-08-15 BR BR0313534-9A patent/BR0313534A/pt not_active IP Right Cessation
- 2003-08-15 UA UAA200502396A patent/UA83467C2/uk unknown
- 2003-08-15 PT PT03791686T patent/PT1539739E/pt unknown
- 2003-08-15 CN CNB038240904A patent/CN100506815C/zh not_active Expired - Fee Related
- 2003-08-15 US US10/641,964 patent/US20040077684A1/en not_active Abandoned
- 2003-08-15 ES ES03791686T patent/ES2355139T3/es not_active Expired - Lifetime
- 2003-08-15 MX MXPA05001859A patent/MXPA05001859A/es active IP Right Grant
- 2003-08-15 SI SI200331951T patent/SI1539739T1/sl unknown
- 2003-08-15 EP EP03791686A patent/EP1539739B1/de not_active Expired - Lifetime
- 2003-08-15 DE DE60335118T patent/DE60335118D1/de not_active Expired - Lifetime
- 2003-08-15 PL PL375562A patent/PL219749B1/pl unknown
2005
- 2005-01-27 IL IL166534A patent/IL166534A/en not_active IP Right Cessation
- 2005-02-15 CR CR7692A patent/CR7692A/es unknown
- 2005-03-11 NO NO20051273A patent/NO332036B1/no not_active IP Right Cessation
2010
- 2010-10-25 AU AU2010236002A patent/AU2010236002B2/en not_active Ceased
2011
- 2011-02-09 CY CY20111100158T patent/CY1111194T1/el unknown

Also Published As

Publication number	Publication date
PL375562A1 (en)	2005-11-28
EP1539739B1 (de)	2010-11-24
AR041010A1 (es)	2005-04-27
EP1539739A1 (de)	2005-06-15
KR20050031464A (ko)	2005-04-06
BR0313534A (pt)	2005-07-12
JP2005539049A (ja)	2005-12-22
CA2496127C (en)	2012-05-29
AU2010236002B2 (en)	2012-05-03
PT1539739E (pt)	2011-01-05
AU2010236002A1 (en)	2010-11-11
NO332036B1 (no)	2012-06-04
RU2333210C2 (ru)	2008-09-10
AU2003259891A1 (en)	2004-03-19
CN1688572A (zh)	2005-10-26
UA83467C2 (uk)	2008-07-25
RU2005104115A (ru)	2005-08-27
ES2355139T3 (es)	2011-03-23
WO2004020435A1 (en)	2004-03-11
IL166534A (en)	2012-05-31
IL166534A0 (en)	2006-01-15
CN100506815C (zh)	2009-07-01
SI1539739T1 (sl)	2011-04-29
PL219749B1 (pl)	2015-07-31
MXPA05001859A (es)	2005-06-03
CY1111194T1 (el)	2015-06-11
NO20051273L (no)	2005-05-10
DK1539739T3 (da)	2011-03-07
CR7692A (es)	2009-01-14
DE60335118D1 (de)	2011-01-05
US20040077684A1 (en)	2004-04-22
JP4554364B2 (ja)	2010-09-29
CA2496127A1 (en)	2005-02-16

Legal Events

Date

Code

Title

Description

2011-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1539739

Country of ref document: EP

Publication	Publication Date	Title
ATE489378T1 (de)	2010-12-15	Piperidinylverbindungen, die selektiv an integrine binden
NL1027009A1 (nl)	2005-03-14	Antilichamen tegen M-CSF.
DE602004024737D1 (de)	2010-02-04	Fixierelemente, die Fluoreleastomere enthalten
SE0302991L (sv)	2005-05-14	Spånskiva
EP1489307A4 (de)	2011-03-23	Hydraulische maschine vom spiraltyp
NL1025902A1 (nl)	2004-10-13	Verpakking.
DE602004002300D1 (de)	2006-10-19	Selektive bankauffrischung
DE602004031170D1 (de)	2011-03-10	Druckmaschine
EP1695761A4 (de)	2012-04-04	Katalysatorzusammensetzung
ITBO20030403A1 (it)	2005-01-01	Macchina ginnica.
DE60305332D1 (de)	2006-06-22	IMIDAZOi1,2-AöPYRIDINE
DE602004009120D1 (de)	2007-11-08	Stanzpresse
AU2003240822A8 (en)	2003-12-19	Antibodies that specifically bind to neurokinin b
DE602004012181D1 (de)	2008-04-17	Thermo-elektrochemische Umsetzungsanordnung
ITRA20030024A1 (it)	2005-02-12	Macchina ginnica.
BR8301726Y1 (pt)	2012-09-04	disposição aplicada em embalagem.
ITMO20030004A0 (it)	2003-01-13	Macchina utensile.
ITTO20040422A1 (it)	2004-09-23	Punzonatrice per oggetti piani
ITPD20030246A1 (it)	2005-04-16	Macchina per il lavaggio di cani.
DE10209216B4 (de)	2005-04-28	Druckmaschine
ES1055446Y (es)	2004-03-01	Envase armable.
DE50303367D1 (de)	2006-06-22	Druckmaschine
FI20050487L (fi)	2005-05-06	Telavaipallinen puristinlaite
ITRM20020328A1 (it)	2003-12-10	Matrici per dnaser.
DE602005000531D1 (de)	2007-03-22	Formgesenk