ATE490314T1 - Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers - Google Patents

Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers

Info

Publication number
ATE490314T1
ATE490314T1 AT03771393T AT03771393T ATE490314T1 AT E490314 T1 ATE490314 T1 AT E490314T1 AT 03771393 T AT03771393 T AT 03771393T AT 03771393 T AT03771393 T AT 03771393T AT E490314 T1 ATE490314 T1 AT E490314T1
Authority
AT
Austria
Prior art keywords
homologous recombination
antibody
constructing
promoting
specific antibody
Prior art date
Application number
AT03771393T
Other languages
English (en)
Inventor
Kunihiro Ohta
Hidetaka Seo
Takehiko Shibata
Original Assignee
Riken
Japan Science & Tech Agency
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riken, Japan Science & Tech Agency filed Critical Riken
Application granted granted Critical
Publication of ATE490314T1 publication Critical patent/ATE490314T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03771393T 2002-07-30 2003-07-28 Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers ATE490314T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002221232 2002-07-30
PCT/JP2003/009563 WO2004011644A1 (ja) 2002-07-30 2003-07-28 体細胞相同組換えの促進方法及び特異的抗体の作製方法

Publications (1)

Publication Number Publication Date
ATE490314T1 true ATE490314T1 (de) 2010-12-15

Family

ID=31184846

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03771393T ATE490314T1 (de) 2002-07-30 2003-07-28 Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers

Country Status (7)

Country Link
US (2) US7776599B2 (de)
EP (1) EP1536004B1 (de)
JP (1) JP4214234B2 (de)
CN (1) CN100379862C (de)
AT (1) ATE490314T1 (de)
DE (1) DE60335191D1 (de)
WO (1) WO2004011644A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085644A2 (en) * 2003-03-26 2004-10-07 Basf Plant Science Gmbh Method for producing recombinant organisms
CN101052728A (zh) * 2004-11-08 2007-10-10 独立行政法人理化学研究所 高效选出特异性地结合于配体的蛋白质的方法
JP4482693B2 (ja) 2005-08-29 2010-06-16 国立大学法人 岡山大学 抗体産生細胞の特異的選択方法
WO2007049567A1 (ja) * 2005-10-24 2007-05-03 Kyowa Hakko Kogyo Co., Ltd. 物質の製造方法
JP2009291073A (ja) * 2006-09-22 2009-12-17 Chiome Bioscience Inc 抗体のクラスを変換する方法
JP2008099602A (ja) * 2006-10-19 2008-05-01 Institute Of Physical & Chemical Research 抗体遺伝子の可変領域における変異部位の分布状況の調節法
CA2685714C (en) 2007-05-31 2016-04-12 University Of Washington Inducible mutagenesis of target genes
JP5696316B2 (ja) * 2008-12-05 2015-04-08 株式会社カイオム・バイオサイエンス 細胞表面に発現したタンパク質に対する抗体作製法
US8901044B2 (en) * 2009-05-13 2014-12-02 Riken Method to prepare magnetic beads conjugated with small compounds
JP5158816B2 (ja) * 2009-10-19 2013-03-06 国立大学法人 東京大学 キメラ抗体の一段階作製方法
BR112014006405A2 (pt) 2011-09-21 2017-04-04 Fujirebio Kk anticorpo, conjunto, e, método para medir um complexo de afinidade
JP6262196B2 (ja) 2012-03-15 2018-01-17 オメロス コーポレーション 標的配列の多様化のための組成物および方法
US20160187325A1 (en) 2013-08-21 2016-06-30 Fujirebio Inc. Method and kit for measuring modified nucleobase using heterogeneous nucleic acid probe
EP3037535A4 (de) 2013-08-21 2017-04-05 Fujirebio Inc. Verfahren zur messung einer modifizierten nukleinsäurebase mit einem absorbierenden polynukleotid und kit dafür
US10107802B2 (en) 2013-08-21 2018-10-23 Fujirebio Inc. Method for measuring modified nucleobase using solid phase probe, and kit for same
WO2015108177A1 (ja) 2014-01-20 2015-07-23 富士レビオ株式会社 ガイドプローブを用いた修飾核酸塩基の測定方法およびそのためのキット
CN112877292A (zh) 2014-05-02 2021-06-01 凯奥目生物科学株式会社 产生人抗体的细胞
ES2936121T3 (es) 2016-09-30 2023-03-14 Chiome Bioscience Inc Método de adquisición de anticuerpos
WO2018147432A1 (ja) 2017-02-10 2018-08-16 株式会社カイオム・バイオサイエンス 抗体可変領域の多様化を促進する方法
EP3734271B1 (de) 2017-12-25 2026-04-15 Fujirebio Inc. Bluttestverfahren für makrolid-immunsuppressivum
CN118440202A (zh) 2019-12-27 2024-08-06 凯奥目生物科学株式会社 抗cdcp1抗体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122339B2 (en) * 1998-10-09 2006-10-17 Medical Research Council Method for generating diversity
JP4302894B2 (ja) 1998-10-09 2009-07-29 メディカル リサーチ カウンシル 多様性を生み出す方法
CN1345935A (zh) * 2000-09-26 2002-04-24 上海博德基因开发有限公司 一种新的多肽——人组蛋白去乙酰基酶12.98和编码这种多肽的多核苷酸
EP1506288B1 (de) 2002-05-10 2013-04-17 Medical Research Council Aktivierungsinduzierte deaminase (aid)

Also Published As

Publication number Publication date
US20110070650A1 (en) 2011-03-24
EP1536004B1 (de) 2010-12-01
CN100379862C (zh) 2008-04-09
US20060183225A1 (en) 2006-08-17
WO2004011644A1 (ja) 2004-02-05
DE60335191D1 (de) 2011-01-13
US7776599B2 (en) 2010-08-17
US8187884B2 (en) 2012-05-29
JPWO2004011644A1 (ja) 2005-11-24
CN1671842A (zh) 2005-09-21
EP1536004A1 (de) 2005-06-01
JP4214234B2 (ja) 2009-01-28
EP1536004A4 (de) 2006-06-14

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