ATE491028T1 - Transformierender wachstumsfaktor alpha hii - Google Patents

Transformierender wachstumsfaktor alpha hii

Info

Publication number: ATE491028T1
Authority: AT; Austria
Prior art keywords: polypeptides; growth factor; present; transforming growth; factor alpha
Prior art date: 1995-05-19

Application number

AT95921317T

Other languages

English (en)

Inventor

Ying-Fei Wei

Paul Meissner

Jian Ni

Original Assignee

Human Genome Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-19

Filing date

1995-05-19

Publication date

2010-12-15

1995-05-19 Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc

2010-12-15 Application granted granted Critical

2010-12-15 Publication of ATE491028T1 publication Critical patent/ATE491028T1/de

Links

NMWKYTGJWUAZPZ-WWHBDHEGSA-N (4S)-4-[[(4R,7S,10S,16S,19S,25S,28S,31R)-31-[[(2S)-2-[[(1R,6R,9S,12S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,53S,56S,59S,62S,65S,68S,71S,76S,79S,85S)-47-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-18-(4-aminobutyl)-27,68-bis(3-amino-3-oxopropyl)-36,71,76-tribenzyl-39-(3-carbamimidamidopropyl)-24-(2-carboxyethyl)-21,56-bis(carboxymethyl)-65,85-bis[(1R)-1-hydroxyethyl]-59-(hydroxymethyl)-62,79-bis(1H-imidazol-4-ylmethyl)-9-methyl-33-(2-methylpropyl)-8,11,17,20,23,26,29,32,35,38,41,48,54,57,60,63,66,69,72,74,77,80,83,86-tetracosaoxo-30-propan-2-yl-3,4,44,45-tetrathia-7,10,16,19,22,25,28,31,34,37,40,49,55,58,61,64,67,70,73,75,78,81,84,87-tetracosazatetracyclo[40.31.14.012,16.049,53]heptaoctacontane-6-carbonyl]amino]-3-methylbutanoyl]amino]-7-(3-carbamimidamidopropyl)-25-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-28-(1H-imidazol-4-ylmethyl)-10-methyl-6,9,12,15,18,21,24,27,30-nonaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacontane-4-carbonyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](Cc4ccccc4)NC3=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(=O)N[C@@H](C)C(O)=O NMWKYTGJWUAZPZ-WWHBDHEGSA-N 0.000 title abstract 2
102000006747 Transforming Growth Factor alpha Human genes 0.000 title abstract 2
101800004564 Transforming growth factor alpha Proteins 0.000 title abstract 2
229920001184 polypeptide Polymers 0.000 abstract 7
102000004196 processed proteins & peptides Human genes 0.000 abstract 7
108090000765 processed proteins & peptides Proteins 0.000 abstract 7
230000004936 stimulating effect Effects 0.000 abstract 2
230000001225 therapeutic effect Effects 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
208000022873 Ocular disease Diseases 0.000 abstract 1
230000033115 angiogenesis Effects 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
230000013020 embryo development Effects 0.000 abstract 1
210000003734 kidney Anatomy 0.000 abstract 1
208000017169 kidney disease Diseases 0.000 abstract 1
201000006370 kidney failure Diseases 0.000 abstract 1
208000019423 liver disease Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000035772 mutation Effects 0.000 abstract 1
230000009826 neoplastic cell growth Effects 0.000 abstract 1
150000007523 nucleic acids Chemical group 0.000 abstract 1
102000040430 polynucleotide Human genes 0.000 abstract 1
108091033319 polynucleotide Proteins 0.000 abstract 1
239000002157 polynucleotide Substances 0.000 abstract 1
238000010188 recombinant method Methods 0.000 abstract 1
230000029663 wound healing Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Toxicology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Neurology (AREA)
Physics & Mathematics (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT95921317T 1995-05-19 1995-05-19 Transformierender wachstumsfaktor alpha hii ATE491028T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1995/006386 WO1996036709A1 (en)	1995-05-19	1995-05-19	Transforming growth factor alpha hii

Publications (1)

Publication Number	Publication Date
ATE491028T1 true ATE491028T1 (de)	2010-12-15

Family

ID=22249142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95921317T ATE491028T1 (de)	1995-05-19	1995-05-19	Transformierender wachstumsfaktor alpha hii

Country Status (9)

Country	Link
EP (1)	EP0826041B1 (de)
JP (1)	JPH11506908A (de)
KR (1)	KR19990007806A (de)
AT (1)	ATE491028T1 (de)
AU (1)	AU713364B2 (de)
CA (1)	CA2215350C (de)
DE (1)	DE69536127D1 (de)
ES (1)	ES2357798T3 (de)
WO (1)	WO1996036709A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6074839A (en) *	1994-03-08	2000-06-13	Human Genome Sciences, Inc.	Transforming growth factor αHI
CA2242633A1 (en) *	1996-01-04	1997-07-17	Human Genome Sciences, Inc.	Transforming growth factor alpha hiii
JP3646191B2 (ja)	1996-03-19	2005-05-11	大塚製薬株式会社	ヒト遺伝子
US6005088A (en)	1996-03-19	1999-12-21	Otsuka Pharmaceutical Co., Ltd.	Human NPIK gene
US20220177533A1 (en)	2018-08-08	2022-06-09	Sree Chitra Tirunal Institute For Medical Sciences And Technology	Recombinant TGF a for wound healing purposes, and the process thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5240912A (en) *	1983-05-09	1993-08-31	Todaro George J	Transforming growth factor (TGF) peptides
EP0154434B1 (de) *	1984-02-17	1993-01-27	Genentech, Inc.	Menschlicher Transformationswachstumsfaktor und Vorläufer oder Fragment hiervon, Zellen, DNA, Vektoren und Verfahren zu ihrer Herstellung, Zusammensetzungen und Produkte, die diese enthalten, sowie davon abgeleitete Antikörper und Diagnostizierverfahren
US5182261A (en) *	1989-07-13	1993-01-26	The Rockefeller University	Modified transforming growth factor alpha oligopeptides and pharmaceutical compositions thereof
JP2004520806A (ja) *	2000-08-24	2004-07-15	ジェネンテック・インコーポレーテッド	腫瘍の診断と治療のための組成物と方法
DE60321041D1 (de) *	2002-03-08	2008-06-26	Pdl Biopharma Inc	Antikörper gegen krebsantigen tmeff2 und seine anwendungen

1995
- 1995-05-19 AT AT95921317T patent/ATE491028T1/de active
- 1995-05-19 DE DE69536127T patent/DE69536127D1/de not_active Expired - Lifetime
- 1995-05-19 EP EP95921317A patent/EP0826041B1/de not_active Expired - Lifetime
- 1995-05-19 AU AU26427/95A patent/AU713364B2/en not_active Expired
- 1995-05-19 CA CA2215350A patent/CA2215350C/en not_active Expired - Lifetime
- 1995-05-19 ES ES95921317T patent/ES2357798T3/es not_active Expired - Lifetime
- 1995-05-19 KR KR1019970707329A patent/KR19990007806A/ko not_active Withdrawn
- 1995-05-19 WO PCT/US1995/006386 patent/WO1996036709A1/en not_active Ceased
- 1995-05-19 JP JP8534782A patent/JPH11506908A/ja active Pending

Also Published As

Publication number	Publication date
KR19990007806A (ko)	1999-01-25
AU713364B2 (en)	1999-12-02
EP0826041A1 (de)	1998-03-04
EP0826041A4 (de)	2000-04-26
JPH11506908A (ja)	1999-06-22
CA2215350C (en)	2011-07-26
DE69536127D1 (de)	2011-01-20
WO1996036709A1 (en)	1996-11-21
AU2642795A (en)	1996-11-29
CA2215350A1 (en)	1996-11-21
ES2357798T3 (es)	2011-04-29
EP0826041B1 (de)	2010-12-08

Legal Events

Date

Code

Title

Description

2011-06-15

UEP

Publication of translation of european patent specification

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