ATE492630T1 - Primäre kultivierte adipozyten zur gentherapie - Google Patents

Primäre kultivierte adipozyten zur gentherapie

Info

Publication number
ATE492630T1
ATE492630T1 AT03736235T AT03736235T ATE492630T1 AT E492630 T1 ATE492630 T1 AT E492630T1 AT 03736235 T AT03736235 T AT 03736235T AT 03736235 T AT03736235 T AT 03736235T AT E492630 T1 ATE492630 T1 AT E492630T1
Authority
AT
Austria
Prior art keywords
gene therapy
adipocytes
cells
present
primary cultured
Prior art date
Application number
AT03736235T
Other languages
English (en)
Inventor
Masashi Ito
Yasushi Saito
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Application granted granted Critical
Publication of ATE492630T1 publication Critical patent/ATE492630T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03736235T 2002-06-18 2003-06-18 Primäre kultivierte adipozyten zur gentherapie ATE492630T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002177648 2002-06-18
JP2002237974 2002-08-19
PCT/JP2003/007721 WO2003106663A1 (ja) 2002-06-18 2003-06-18 遺伝子治療用初代培養脂肪細胞

Publications (1)

Publication Number Publication Date
ATE492630T1 true ATE492630T1 (de) 2011-01-15

Family

ID=29738440

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03736235T ATE492630T1 (de) 2002-06-18 2003-06-18 Primäre kultivierte adipozyten zur gentherapie

Country Status (20)

Country Link
US (2) US7820438B2 (de)
EP (2) EP1541674B9 (de)
JP (1) JPWO2003106663A1 (de)
KR (1) KR101004086B1 (de)
CN (1) CN1671836B (de)
AT (1) ATE492630T1 (de)
AU (1) AU2003242459B2 (de)
BR (1) BRPI0312441B8 (de)
CA (1) CA2488414C (de)
DE (1) DE60335473D1 (de)
DK (2) DK1541674T3 (de)
ES (1) ES2559430T3 (de)
HU (1) HUE025872T2 (de)
MA (1) MA27324A1 (de)
MX (1) MXPA04012859A (de)
NZ (1) NZ537072A (de)
PT (2) PT2213730E (de)
SI (1) SI1541674T1 (de)
WO (1) WO2003106663A1 (de)
ZA (1) ZA200500464B (de)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
JP4879867B2 (ja) * 2002-06-18 2012-02-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 遺伝子治療用初代培養脂肪細胞
WO2006134871A1 (ja) * 2005-06-15 2006-12-21 Takara Bio Inc. 脂肪細胞あるいは前駆脂肪細胞への遺伝子導入方法
WO2008108344A1 (ja) * 2007-03-02 2008-09-12 Cellgentech, Inc. Ｌｃａｔ欠損症の遺伝子治療用細胞並びにこれを産生するのに用いられる複製欠損性レトロウイルスベクター及びプラスミド
TW200927074A (en) * 2007-12-25 2009-07-01 Univ Nat Taiwan Colloidal frame used in tissue engineering
JP2009165403A (ja) * 2008-01-16 2009-07-30 Hokkaido Univ ハニカム状多孔質体を用いた脂肪細胞の長期培養方法
AU2009308152B2 (en) * 2008-10-21 2015-05-21 The General Hospital Corporation Cell transplantation
JP5806791B2 (ja) * 2010-01-21 2015-11-10 セルジェンテック株式会社 遺伝子治療用脂肪細胞の調製のための外来遺伝子の導入に適した細胞集団かどうかを判定する方法
JP6072684B2 (ja) 2010-08-06 2017-02-01 ザ ジェネラル ホスピタル コーポレーション ディー／ビー／エイ マサチューセッツ ジェネラル ホスピタル 細胞処置システムおよび細胞処置装置
KR20140009459A (ko) * 2011-03-16 2014-01-22 가부시키가이샤 구라레 배양 방법, 성숙 지방 세포군 및 약물 스크리닝 방법
JP2023002772A (ja) * 2011-09-23 2023-01-10 レジニアス リミテッド 脂肪細胞および細胞分泌物を使用する治療
KR102560970B1 (ko) 2016-03-31 2023-07-31 엘지전자 주식회사 청소기
WO2021241659A1 (ja) 2020-05-29 2021-12-02 株式会社 Numt Ｆｆａｒ４を高発現させた脂肪細胞及びその使用
EP4213863A4 (de) * 2020-09-15 2025-02-26 The Brigham and Women's Hospital, Inc. In-vivo-fettbioreaktor und kits zur herstellung und abgabe von biologischen mitteln
WO2023249904A1 (en) * 2022-06-20 2023-12-28 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating diabetes
CN117138053B (zh) * 2023-08-10 2025-02-14 吉林化工学院 一种脂肪细胞载体药物及其应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956455A (en) 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
EP0248819B2 (de) 1985-09-12 2000-08-30 Scios Inc. Rekombinanter fibroblast-wachstumsfaktor
IL80944A (en) 1985-12-17 1994-10-07 Synergen Inc Boulder Colo U S Human placenta angiogenic factor capable of stimulating capillary endothelial cell protease synthesis, dna synthesis and migration
DK122687A (da) 1986-03-14 1987-09-15 Takeda Chemical Industries Ltd Polypeptid, dna og anvendelse deraf
JP2526965B2 (ja) 1987-02-24 1996-08-21 武田薬品工業株式会社 ムテイン，ｄｎａおよびその用途
JPH02504468A (ja) 1987-11-24 1990-12-20 アムジエン・インコーポレーテツド 繊維芽細胞成長因子のアナログ
EP0326907A1 (de) 1988-01-26 1989-08-09 Takeda Chemical Industries, Ltd. Polypeptide, DNA und ihre Verwendung
EP0394951A1 (de) 1989-04-26 1990-10-31 Takeda Chemical Industries, Ltd. Glykosyliertes bFGF und dessen Herstellung
JP3135138B2 (ja) 1990-12-19 2001-02-13 科研製薬株式会社 骨疾患治療剤
ES2178654T3 (es) * 1993-08-12 2003-01-01 Neurotech Sa Capsulas biocompatibles inmonoaisladoras que contienen celulas geneticamente alteradas para el suministro de moleculas biologicamente activas.
FR2731014B1 (fr) * 1995-02-23 1997-03-28 Rhone Poulenc Rorer Sa Molecules d'adn, preparation et utilisation en therapie genique
FR2731710B1 (fr) * 1995-03-14 1997-04-30 Rhone Poulenc Rorer Sa Virus recombinants exprimant la lecithine cholesterol acyltransferase et utilisations en therapie genique
US5869037A (en) 1996-06-26 1999-02-09 Cornell Research Foundation, Inc. Adenoviral-mediated gene transfer to adipocytes
GB2327224A (en) 1997-07-09 1999-01-20 Mayo Foundation Gene transfer to adipocytes
WO1999011786A1 (fr) 1997-09-01 1999-03-11 Otsuka Pharmaceutical Co., Ltd. GENE pancpin ET COMPOSITION DE THERAPIE GENIQUE
BR9813917A (pt) 1997-11-03 2001-10-30 Univ Arizona Vetores de expressão induzìveis hipertérmicospara terapia de genetica e métodos de uso dos mesmos
US6797505B2 (en) 1998-05-27 2004-09-28 Cell Genesys, Inc. Recombinant AAV vectors for gene therapy of hemophilia A
WO2000031267A1 (en) * 1998-11-20 2000-06-02 The Autonomous University Of Barcelona Insulin production by engineered muscle cells
US6153432A (en) * 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
EP1226233B1 (de) 1999-08-05 2011-06-29 ABT Holding Company Multipotente erwachsene stammzellen und verfahren zu deren isolierung
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US20020177551A1 (en) * 2000-05-31 2002-11-28 Terman David S. Compositions and methods for treatment of neoplastic disease
WO2002006450A1 (en) * 2000-07-18 2002-01-24 Societe Des Produits Nestle S.A. Pre-adipose cell lines
WO2003031640A2 (en) * 2001-10-06 2003-04-17 Boston Medical Center Corporation Preadipocyte cell strains and uses therefore
KR20040094910A (ko) * 2002-04-03 2004-11-10 아르테셀 사이언스, 인크. 개선된 지방세포 분화된 지방 유래 성체 줄기세포 및 이의용도
WO2008108344A1 (ja) 2007-03-02 2008-09-12 Cellgentech, Inc. Ｌｃａｔ欠損症の遺伝子治療用細胞並びにこれを産生するのに用いられる複製欠損性レトロウイルスベクター及びプラスミド

Also Published As

Publication number Publication date
JPWO2003106663A1 (ja) 2005-10-13
DK2213730T3 (en) 2016-01-25
MA27324A1 (fr) 2005-05-02
ES2559430T3 (es) 2016-02-12
EP1541674B9 (de) 2011-09-14
EP1541674A1 (de) 2005-06-15
CN1671836B (zh) 2012-02-08
PT2213730E (pt) 2016-02-26
AU2003242459A1 (en) 2003-12-31
KR101004086B1 (ko) 2010-12-27
DE60335473D1 (de) 2011-02-03
EP1541674B1 (de) 2010-12-22
EP2213730A8 (de) 2010-11-10
EP1541674A4 (de) 2007-01-10
KR20070087062A (ko) 2007-08-27
DK1541674T3 (da) 2011-03-14
BR0312441A (pt) 2005-04-19
SI1541674T1 (sl) 2011-04-29
US7820438B2 (en) 2010-10-26
BRPI0312441B8 (pt) 2021-05-25
WO2003106663A1 (ja) 2003-12-24
CN1671836A (zh) 2005-09-21
HUE025872T2 (en) 2016-05-30
BRPI0312441B1 (pt) 2018-03-20
AU2003242459B2 (en) 2007-05-17
US20090010901A1 (en) 2009-01-08
CA2488414C (en) 2011-04-26
MXPA04012859A (es) 2005-03-31
ZA200500464B (en) 2005-12-28
EP2213730A1 (de) 2010-08-04
US20060121008A1 (en) 2006-06-08
PT1541674E (pt) 2011-03-21
CA2488414A1 (en) 2003-12-24
NZ537072A (en) 2006-12-22
US8071085B2 (en) 2011-12-06
EP2213730B1 (de) 2015-12-02

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