ATE494885T1 - Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe - Google Patents

Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe

Info

Publication number
ATE494885T1
ATE494885T1 AT04750642T AT04750642T ATE494885T1 AT E494885 T1 ATE494885 T1 AT E494885T1 AT 04750642 T AT04750642 T AT 04750642T AT 04750642 T AT04750642 T AT 04750642T AT E494885 T1 ATE494885 T1 AT E494885T1
Authority
AT
Austria
Prior art keywords
storage
drug
reservoirs
controlled delivery
solid matrix
Prior art date
Application number
AT04750642T
Other languages
English (en)
Inventor
James Prescott
Scott Uhland
Mark Staples
John Santini
Original Assignee
Boston Scient Scimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scient Scimed Inc filed Critical Boston Scient Scimed Inc
Application granted granted Critical
Publication of ATE494885T1 publication Critical patent/ATE494885T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
AT04750642T 2003-04-25 2004-04-26 Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe ATE494885T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46546603P 2003-04-25 2003-04-25
PCT/US2004/012757 WO2004096176A2 (en) 2003-04-25 2004-04-26 Solid drug formulation and device for storage and controlled delivery thereof

Publications (1)

Publication Number Publication Date
ATE494885T1 true ATE494885T1 (de) 2011-01-15

Family

ID=33418242

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04750642T ATE494885T1 (de) 2003-04-25 2004-04-26 Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe

Country Status (9)

Country Link
US (2) US20040247671A1 (de)
EP (1) EP1638522B1 (de)
JP (1) JP4734236B2 (de)
AT (1) ATE494885T1 (de)
AU (1) AU2004233869B2 (de)
CA (1) CA2523432C (de)
DE (1) DE602004031011D1 (de)
ES (1) ES2359243T3 (de)
WO (1) WO2004096176A2 (de)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179289B2 (en) 1998-03-30 2007-02-20 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
ES2420279T3 (es) 2000-03-02 2013-08-23 Microchips, Inc. Dispositivos microfabricados y métodos para almacenamiento y exposición selectiva de productos químicos
CA2432438C (en) 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US20040073294A1 (en) 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
CA2451953A1 (en) 2001-06-28 2003-04-24 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
JP4436258B2 (ja) * 2002-08-16 2010-03-24 マイクロチップス・インコーポレーテッド 制御された放出デバイスおよび方法
AU2004226327A1 (en) 2003-03-28 2004-10-14 Innovational Holdings, Llc Implantable medical device with beneficial agent concentration gradient
AU2004233869B2 (en) * 2003-04-25 2010-08-12 Boston Scientific Scimed, Inc. Solid drug formulation and device for storage and controlled delivery thereof
JP2007512859A (ja) 2003-11-03 2007-05-24 マイクロチップス・インコーポレーテッド グルコースを感知するための医療デバイス
WO2005048834A1 (en) 2003-11-13 2005-06-02 Medtronic Minimed, Inc. Long term analyte sensor array
US8414489B2 (en) * 2003-11-13 2013-04-09 Medtronic Minimed, Inc. Fabrication of multi-sensor arrays
JP2008501037A (ja) * 2004-06-01 2008-01-17 マイクロチップス・インコーポレーテッド 医療移植片への／医療移植片からの薬物または分析物の輸送の測定および輸送の増強のためのデバイスおよび方法
US20060067972A1 (en) * 2004-06-23 2006-03-30 Flowmedica, Inc. Devices for renal-based heart failure treatment
WO2006015299A2 (en) 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
JP5107041B2 (ja) 2004-09-01 2012-12-26 マイクロチップス・インコーポレーテッド レザバ内容物の制御された放出または曝露のための、マルチキャップレザバデバイス
JP5049787B2 (ja) 2004-11-04 2012-10-17 マイクロチップス・インコーポレーテッド 冷間圧接封止法および装置
US7413846B2 (en) 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
CA2595457A1 (en) * 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
US20070112421A1 (en) * 2005-11-14 2007-05-17 O'brien Barry Medical device with a grooved surface
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
EP2032091A2 (de) 2006-06-29 2009-03-11 Boston Scientific Limited Medizinprodukte mit selektiver beschichtung
JP2009545407A (ja) 2006-08-02 2009-12-24 ボストン サイエンティフィック サイムド，インコーポレイテッド 三次元分解制御を備えたエンドプロテーゼ
JP2010503469A (ja) 2006-09-14 2010-02-04 ボストン サイエンティフィック リミテッド 薬物溶出性皮膜を有する医療デバイス
US8052744B2 (en) 2006-09-15 2011-11-08 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
EP2210625B8 (de) 2006-09-15 2012-02-29 Boston Scientific Scimed, Inc. Biologisch erodierbare Endoprothese mit biostabilen anorganischen Schichten
WO2008034031A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
JP2010503494A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 生分解性内部人工器官およびその製造方法
JP2010503482A (ja) 2006-09-18 2010-02-04 ボストン サイエンティフィック リミテッド 内部人工器官
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
DE602007011822D1 (de) * 2006-11-16 2011-02-17 Boston Scient Ltd Stent mit funktion zur zu unterschiedlichen zeiten erfolgenden abluminalen und luminalen freisetzung eines behandlungsmittels
EP2125065B1 (de) 2006-12-28 2010-11-17 Boston Scientific Limited Bioerodierbare endoprothesen und herstellungsverfahren dafür
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
WO2009018340A2 (en) 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
JP2010535541A (ja) 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド 広い表面積を有する医療器具用のコーティング
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US20090076591A1 (en) * 2007-09-19 2009-03-19 Boston Scientific Scimed, Inc. Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface
JP5524851B2 (ja) * 2007-10-17 2014-06-18 エフ． オボカイティス，トッド 室温で安定な非結晶アスピリン
JP2011500688A (ja) * 2007-10-18 2011-01-06 デュレクト コーポレーション 制御された嵩密度を有する生分解性インプラント
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
WO2009094270A1 (en) * 2008-01-24 2009-07-30 Boston Scientific Scimed, Inc. Stent for delivering a therapeutic agent from a side surface of a stent strut
WO2009097468A2 (en) 2008-01-29 2009-08-06 Kliman Gilbert H Drug delivery devices, kits and methods therefor
JP5581311B2 (ja) 2008-04-22 2014-08-27 ボストン サイエンティフィック サイムド，インコーポレイテッド 無機材料のコーティングを有する医療デバイス及びその製造方法
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
CN107049928A (zh) 2008-07-07 2017-08-18 皇家飞利浦电子股份有限公司 包括储药器的电子药丸
US7951193B2 (en) 2008-07-23 2011-05-31 Boston Scientific Scimed, Inc. Drug-eluting stent
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8236238B2 (en) 2009-01-21 2012-08-07 Palo Alto Research Center Incorporated Drug deactivation system
US9480795B2 (en) * 2009-01-21 2016-11-01 Palo Alto Research Center Incorporated Sensor system for drug delivery device, drug delivery device having the same and method of using the same
US7838715B2 (en) * 2009-01-21 2010-11-23 Palo Alto Research Center Incorporated Drug deactivation system and method of deactivating a drug using the same
WO2010101901A2 (en) 2009-03-02 2010-09-10 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
EP2425209A4 (de) 2009-04-29 2013-01-09 Abbott Diabetes Care Inc Verfahren und system für die echtzeit-kalibrierung eines analytsensors mit rückwirkender füllung
EP2533737B1 (de) 2010-02-08 2014-01-08 On Demand Therapeutics, Inc. Laseraktivierte wirkstofffreisetzungsvorrichtung mit geringer permeabilität
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US10427153B2 (en) 2011-08-25 2019-10-01 Microchips Biotech, Inc. Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid
PT2747642T (pt) * 2011-08-25 2021-07-27 Microchips Biotech Inc Dispositivos de contenção eficientes em termos de espaço e método de criação dos mesmos
US20150005595A1 (en) 2011-12-30 2015-01-01 Kibur Medical, Inc. Implantable devices and methods for evaluation of active agents
CN104869888B (zh) * 2012-12-21 2017-12-19 微芯片生物技术公司 用于微创插入的可植入医疗装置
SG11201506675PA (en) * 2013-02-28 2015-09-29 Microchips Biotech Inc Implantable medical device for minimally-invasive insertion
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
WO2015187974A1 (en) 2014-06-06 2015-12-10 Ovokaitys Todd Frank Methods and compositions for increasing the bioactivity of nutrients
WO2017015571A1 (en) 2015-07-23 2017-01-26 Novaflux, Inc. Implants and constructs including hollow fibers
US10508755B2 (en) * 2017-07-21 2019-12-17 International Business Machines Corporation Fluid delivery device with hydrophobic surface
US20220161233A1 (en) * 2019-04-05 2022-05-26 Qidni Labs Inc. Sorbent for use in renal therapy
BR102020019674A2 (pt) * 2020-09-27 2022-04-12 Christiane Dias Maués Dispositivo protético tubular cilíndrico; e dispositivo protético com matriz biológica não-polimérica de suporte para liberação de fármacos, induzida por microchip e nanossensores de operabilidade e monitoramento remotos
AU2021397627A1 (en) 2020-12-08 2023-07-20 Todd Frank OVOKAITYS Methods and systems for increased production of stem cells

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992518A (en) * 1974-10-24 1976-11-16 G. D. Searle & Co. Method for making a microsealed delivery device
US4186184A (en) * 1977-12-27 1980-01-29 Alza Corporation Selective administration of drug with ocular therapeutic system
GB8422876D0 (en) * 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4917685A (en) * 1986-05-16 1990-04-17 International Minerals & Chem. Corp. Delivery device for the administration of stabilized growth promoting hormones
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
WO1990002546A1 (en) * 1988-09-09 1990-03-22 The Ronald T. Dodge Company Pharmaceuticals microencapsulated by vapor deposited polymers and method
US5391164A (en) * 1991-05-03 1995-02-21 Giampapa; Vincent C. Subcutaneous implantable multiple-agent delivery system
US5366454A (en) * 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US5510138A (en) * 1994-05-24 1996-04-23 Delco Electronics Corporation Hot melt conformal coating materials
US5891108A (en) * 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
US5609629A (en) * 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US6261584B1 (en) * 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
DE19610293C1 (de) * 1996-03-15 1997-07-31 Fraunhofer Ges Forschung Vorrichtung zur gekapselten Aufnahme eines Materials
US6783543B2 (en) * 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
CZ433898A3 (cs) * 1996-07-03 1999-04-14 Alza Corporation Nevodné protické peptidové formulace
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
US5981489A (en) * 1996-07-18 1999-11-09 Alza Corporation Non-aqueous protic peptide formulations
IN184589B (de) * 1996-10-16 2000-09-09 Alza Corp
ZA9710342B (en) * 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
IT1289815B1 (it) * 1996-12-30 1998-10-16 Sorin Biomedica Cardio Spa Stent per angioplastica e relativo procedimento di produzione
US6273913B1 (en) * 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US6273908B1 (en) * 1997-10-24 2001-08-14 Robert Ndondo-Lay Stents
US6241762B1 (en) * 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US20020038146A1 (en) * 1998-07-29 2002-03-28 Ulf Harry Expandable stent with relief cuts for carrying medicines and other materials
DE19855421C2 (de) * 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implantat
US6558422B1 (en) * 1999-03-26 2003-05-06 University Of Washington Structures having coated indentations
US6334859B1 (en) * 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
ATE290364T1 (de) * 1999-08-18 2005-03-15 Microchips Inc Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien
US6287628B1 (en) * 1999-09-03 2001-09-11 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
WO2001035928A1 (en) * 1999-11-17 2001-05-25 Microchips, Inc. Microfabricated devices for the delivery of molecules into a carrier fluid
DE60027458T2 (de) * 1999-12-10 2007-07-05 Massachusetts Institute Of Technology, Cambridge Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
ES2420279T3 (es) * 2000-03-02 2013-08-23 Microchips, Inc. Dispositivos microfabricados y métodos para almacenamiento y exposición selectiva de productos químicos
WO2001091902A2 (en) * 2000-05-30 2001-12-06 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
US6395326B1 (en) * 2000-05-31 2002-05-28 Advanced Cardiovascular Systems, Inc. Apparatus and method for depositing a coating onto a surface of a prosthesis
AU2002211629A1 (en) * 2000-10-10 2002-04-22 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
US6773429B2 (en) * 2000-10-11 2004-08-10 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
CA2432438C (en) * 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US6571125B2 (en) * 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
WO2002089767A1 (en) * 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US6973718B2 (en) * 2001-05-30 2005-12-13 Microchips, Inc. Methods for conformal coating and sealing microchip reservoir devices
WO2002099457A1 (en) * 2001-05-31 2002-12-12 Massachusetts Inst Technology Microchip devices with improved reservoir opening
CA2451953A1 (en) * 2001-06-28 2003-04-24 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
US6663615B1 (en) * 2001-09-04 2003-12-16 The Ohio State University Dual stage microvalve and method of use
AU2002353013A1 (en) * 2001-12-03 2003-06-17 Massachusetts Institute Of Technology Microscale lyophilization and drying methods for the stabilization of molecules
AU2003278766A1 (en) * 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
US7534241B2 (en) * 2002-09-23 2009-05-19 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
EP1551505B1 (de) * 2002-10-04 2010-02-24 Microchips, Inc. Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
AU2004233869B2 (en) * 2003-04-25 2010-08-12 Boston Scientific Scimed, Inc. Solid drug formulation and device for storage and controlled delivery thereof
CA2595457A1 (en) * 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments

Also Published As

Publication number Publication date
AU2004233869A1 (en) 2004-11-11
CA2523432C (en) 2014-10-28
WO2004096176A3 (en) 2005-03-24
WO2004096176A2 (en) 2004-11-11
ES2359243T3 (es) 2011-05-19
CA2523432A1 (en) 2004-11-11
EP1638522A2 (de) 2006-03-29
US20040247671A1 (en) 2004-12-09
US20100119604A1 (en) 2010-05-13
AU2004233869B2 (en) 2010-08-12
DE602004031011D1 (de) 2011-02-24
JP2006524705A (ja) 2006-11-02
JP4734236B2 (ja) 2011-07-27
EP1638522B1 (de) 2011-01-12

Similar Documents

Publication Publication Date Title
DE602004031011D1 (de) Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe
HU228269B1 (en) Hydrophilic/lipophilic polymeric matrix dosage formulation
ES2669585T3 (es) Micropartículas porosas de silicio para la entrega de fármaco para el ojo
WO2007130786A3 (en) Medical device having coating with zeolite drug reservoirs
WO2005120393A3 (en) Implantable device for drug delivery and improved visibility
ATE470438T1 (de) Pharmazeutische zusammensetzung mit gasgefüllten mikrokapseln für ultraschall-vermittelte abgabe
DE602004024228D1 (de) Transdermales arzneimittelabgabesystem
WO2005016558A3 (en) Methods for accelerated release of material from a reservoir device
CY1118182T1 (el) Σκευασματα ελεγχομενης αποδεσμευσης
PT1183014E (pt) Composicoes farmaceuticas orais de libertacao controlada e de dissimulacao de sabor
WO2006015299A3 (en) Multi-reservoir device for transdermal drug delivery and sensing
ATE269709T1 (de) Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
DE60216078D1 (de) Opioid enthaltende arzneiform gegen missbrauch
AR047112A1 (es) Composiciones de adn estabilizado para recubrir microproyecciones
EP2277568A3 (de) Medizinische Geräte, die Rapamycinanaloga enthalten
SMP200900075B (it) Dispositivi terapeutici ibridi impiantabli.
WO2009022101A8 (en) Dispenser and support for dispensing doses of a deliverable substance
WO2010041015A3 (en) Chewable gelled emulsions
ATE476176T1 (de) Wachsähnliches material enthaltende tabletten mit verzögerter freisetzung
MXPA05005527A (es) Forma de dosis de alergeno.
TW200640498A (en) Suspending vehicles and pharmaceutical suspensions for drug dosage forms
BR0210631A (pt) Composição farmacêutica de liberação prolongada
WO2005023337A3 (en) Application and method to disperse substance contained in a replaceable cartridge
WO2006081279A3 (en) Control of drug release by transient modification of local microenvironments
JP6297495B2 (ja) 浸透圧活性膣送達システム

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties