ATE495169T1 - Toluol-solvat von darifenacin - Google Patents

Toluol-solvat von darifenacin

Info

Publication number: ATE495169T1
Authority: AT; Austria
Prior art keywords: darifenacin; toluene solvate; solvate; toluene
Prior art date: 2002-03-26

Application number

AT03744716T

Other languages

English (en)

Inventor

Peter Dunn

John Matthews

Trevor NEWBURY

Garry O'oconnor

Original Assignee

Novartis Int Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-26

Filing date

2003-03-17

Publication date

2011-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9933731&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE495169(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-03-17 Application filed by Novartis Int Pharm Ltd filed Critical Novartis Int Pharm Ltd

2011-01-15 Application granted granted Critical

2011-01-15 Publication of ATE495169T1 publication Critical patent/ATE495169T1/de

Links

YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 title 3
HXGBXQDTNZMWGS-RUZDIDTESA-N darifenacin Chemical compound C=1C=CC=CC=1C([C@H]1CN(CCC=2C=C3CCOC3=CC=2)CC1)(C(=O)N)C1=CC=CC=C1 HXGBXQDTNZMWGS-RUZDIDTESA-N 0.000 title 1
229960002677 darifenacin Drugs 0.000 title 1
239000012453 solvate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT03744716T 2002-03-26 2003-03-17 Toluol-solvat von darifenacin ATE495169T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0207104.1A GB0207104D0 (en)	2002-03-26	2002-03-26	Stable hydrate of a muscarinic receptor antagonist
PCT/IB2003/001043 WO2003080599A1 (en)	2002-03-26	2003-03-17	Stable hydrate of a muscarinic receptor antagonist

Publications (1)

Publication Number	Publication Date
ATE495169T1 true ATE495169T1 (de)	2011-01-15

Family

ID=9933731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03744716T ATE495169T1 (de)	2002-03-26	2003-03-17	Toluol-solvat von darifenacin

Country Status (22)

Country	Link
US (3)	US6930188B2 (de)
EP (2)	EP1490357B1 (de)
JP (2)	JP2005524678A (de)
KR (4)	KR20120098888A (de)
CN (1)	CN100345840C (de)
AR (1)	AR042608A1 (de)
AT (1)	ATE495169T1 (de)
AU (1)	AU2003209921A1 (de)
BR (2)	BR122018000397B8 (de)
CA (1)	CA2480287C (de)
CY (2)	CY1111200T1 (de)
DE (1)	DE60335711D1 (de)
DK (2)	DK2336124T3 (de)
ES (2)	ES2394067T3 (de)
GB (1)	GB0207104D0 (de)
PA (1)	PA8569701A1 (de)
PT (2)	PT2336124E (de)
SI (2)	SI1490357T1 (de)
SV (1)	SV2003001515A (de)
TW (1)	TW200306816A (de)
UY (1)	UY27735A1 (de)
WO (1)	WO2003080599A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0207104D0 (en) *	2002-03-26	2002-05-08	Pfizer Ltd	Stable hydrate of a muscarinic receptor antagonist
US7244765B2 (en) *	2004-06-25	2007-07-17	Cytokine Pharmasciences, Inc	Guanylhydrazone salts, compositions, processes of making and methods of using
US20060258712A1 (en) *	2005-04-24	2006-11-16	Wyeth	Methods for modulating bladder function
US20070203221A1 (en)	2005-12-27	2007-08-30	Valeriano Merli	Processes for preparing darifenacin hydrobromide
EP2109601A2 (de) *	2007-01-05	2009-10-21	Dr. Reddy's Laboratories Ltd.	Zubereitung von darifenacin und seinen salzen
CA2675942C (en) *	2007-02-23	2016-04-12	Theravance, Inc.	Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2008144602A1 (en) *	2007-05-18	2008-11-27	Auspex Pharmaceuticals, Inc.	Deuterated zamifenacin derivatives
US20100204296A1 (en) *	2007-06-08	2010-08-12	Actavis Group Ptc Ehf	Novel Polymorphs of Darifenacin Free Base and its Hydrobromide Salt
WO2009006413A1 (en) *	2007-06-30	2009-01-08	Auspex Pharmaceuticals, Inc.	Substituted pyrrolidines
WO2009010846A2 (en) *	2007-07-13	2009-01-22	Medichem, S.A.	Amorphous form of darifenacin hydrobromide and processes for the preparation thereof
CZ300895B6 (cs)	2008-01-28	2009-09-02	Zentiva, A. S.	Zpusob prípravy Darifenacinu
WO2009125426A2 (en) *	2008-02-08	2009-10-15	Neuland Laboratories Ltd	NOVEL PROCESS FOR THE PREPARATION OF (3SM-[2-(2 J-DIHYDRO-5- BENZOFURANYLϊETHYL]-α.α -DIPHENYL-3-PYRROLIDINEACETAMIDE HYDROBROMIDE
WO2009122997A1 (ja)	2008-04-02	2009-10-08	株式会社カネカ	（ｓ）－３－（１－シアノ－１，１－ジフェニルメチル）－ピロリジンの製造法
WO2010032225A2 (en) *	2008-09-22	2010-03-25	Watson Pharma Private Limited	Process for preparation of darifenacin and intermediates used in the process
EP2236509A1 (de)	2009-04-01	2010-10-06	Ragactives, S.L.	Methode zur Herstellung von 1,3-difunktionalisierten Pyrrolidin-Derivaten
WO2011070419A1 (en)	2009-12-10	2011-06-16	Aurobindo Pharma Limited	An improved process for the preparation of darifenacin hydrobromide
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
US20180344735A1 (en) *	2015-12-14	2018-12-06	Ironwood Pharmaceuticals, Inc.	USE OF sGC STIMULATORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DYSFUNCTION
CN109641822B (zh) *	2016-08-12	2022-03-11	拜耳作物科学股份公司	制备取代苯乙烯衍生物的方法
JP7285259B2 (ja) *	2017-09-12	2023-06-01	エルテーエスローマンテラピー－ジステーメアーゲー	イオントフォレーシス用マイクロニードルデバイス

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8906166D0 (en) *	1989-03-17	1989-05-04	Pfizer Ltd	Therapeutic agents
US5233053A (en) *	1989-03-17	1993-08-03	Pfizer Inc.	Pyrrolidine derivatives
KR0166088B1 (ko)	1990-01-23	1999-01-15	.	수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en)	1990-01-23	1994-12-27	University Of Kansas	Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9400600D0 (en) *	1994-01-14	1994-03-09	Pfizer Ltd	Treatment of motion seckness
GB9518953D0 (en) *	1995-09-15	1995-11-15	Pfizer Ltd	Pharmaceutical formulations
GB9612710D0 (en) *	1996-06-18	1996-08-21	Pfizer Ltd	Method of treatment
WO1998011888A1 (en) *	1996-09-19	1998-03-26	American Home Products Corporation	Method of treating urinary incontinence
GB9711643D0 (en)	1997-06-05	1997-07-30	Janssen Pharmaceutica Nv	Glass thermoplastic systems
GB0207104D0 (en) *	2002-03-26	2002-05-08	Pfizer Ltd	Stable hydrate of a muscarinic receptor antagonist

2002
- 2002-03-26 GB GBGB0207104.1A patent/GB0207104D0/en not_active Ceased
2003
- 2003-03-17 KR KR1020127018787A patent/KR20120098888A/ko not_active Ceased
- 2003-03-17 JP JP2003578353A patent/JP2005524678A/ja not_active Withdrawn
- 2003-03-17 KR KR1020107018853A patent/KR20100101182A/ko not_active Ceased
- 2003-03-17 WO PCT/IB2003/001043 patent/WO2003080599A1/en not_active Ceased
- 2003-03-17 BR BR122018000397A patent/BR122018000397B8/pt not_active IP Right Cessation
- 2003-03-17 EP EP03744716A patent/EP1490357B1/de not_active Expired - Lifetime
- 2003-03-17 DE DE60335711T patent/DE60335711D1/de not_active Expired - Lifetime
- 2003-03-17 PT PT101777167T patent/PT2336124E/pt unknown
- 2003-03-17 DK DK10177716.7T patent/DK2336124T3/da active
- 2003-03-17 BR BRPI0308706A patent/BRPI0308706B8/pt not_active IP Right Cessation
- 2003-03-17 SI SI200331973T patent/SI1490357T1/sl unknown
- 2003-03-17 ES ES10177716T patent/ES2394067T3/es not_active Expired - Lifetime
- 2003-03-17 AU AU2003209921A patent/AU2003209921A1/en not_active Abandoned
- 2003-03-17 KR KR1020047015243A patent/KR101026283B1/ko not_active Expired - Lifetime
- 2003-03-17 AT AT03744716T patent/ATE495169T1/de active
- 2003-03-17 KR KR1020117027931A patent/KR101212908B1/ko not_active Expired - Lifetime
- 2003-03-17 DK DK03744716.6T patent/DK1490357T3/da active
- 2003-03-17 PT PT03744716T patent/PT1490357E/pt unknown
- 2003-03-17 CN CNB038070847A patent/CN100345840C/zh not_active Expired - Lifetime
- 2003-03-17 SI SI200332215T patent/SI2336124T1/sl unknown
- 2003-03-17 ES ES03744716T patent/ES2358644T3/es not_active Expired - Lifetime
- 2003-03-17 CA CA2480287A patent/CA2480287C/en not_active Expired - Lifetime
- 2003-03-17 EP EP10177716A patent/EP2336124B1/de not_active Expired - Lifetime
- 2003-03-20 PA PA20038569701A patent/PA8569701A1/es unknown
- 2003-03-24 AR ARP030101017A patent/AR042608A1/es unknown
- 2003-03-25 UY UY27735A patent/UY27735A1/es not_active Application Discontinuation
- 2003-03-25 SV SV2003001515A patent/SV2003001515A/es not_active Application Discontinuation
- 2003-03-25 US US10/396,887 patent/US6930188B2/en not_active Expired - Lifetime
- 2003-03-25 TW TW092106635A patent/TW200306816A/zh unknown
2005
- 2005-07-13 US US11/180,433 patent/US20050245597A1/en not_active Abandoned
2008
- 2008-03-17 US US12/049,660 patent/US7696357B2/en not_active Expired - Lifetime
2010
- 2010-06-02 JP JP2010126865A patent/JP2010195828A/ja active Pending
2011
- 2011-02-22 CY CY20111100213T patent/CY1111200T1/el unknown
2012
- 2012-11-29 CY CY20121101165T patent/CY1113433T1/el unknown

Also Published As

Publication number	Publication date
CY1111200T1 (el)	2015-06-11
EP1490357A1 (de)	2004-12-29
BRPI0308706B1 (pt)	2018-07-10
BR122018000397B8 (pt)	2021-07-27
DK2336124T3 (da)	2012-12-17
EP2336124A1 (de)	2011-06-22
KR101212908B1 (ko)	2012-12-14
SI2336124T1 (sl)	2012-12-31
JP2005524678A (ja)	2005-08-18
TW200306816A (en)	2003-12-01
UY27735A1 (es)	2003-10-31
KR20040093477A (ko)	2004-11-05
CN100345840C (zh)	2007-10-31
US20030191176A1 (en)	2003-10-09
AU2003209921A1 (en)	2003-10-08
DK1490357T3 (da)	2011-04-04
US20080167367A1 (en)	2008-07-10
EP1490357B1 (de)	2011-01-12
JP2010195828A (ja)	2010-09-09
ES2358644T3 (es)	2011-05-12
HK1156626A1 (en)	2012-06-15
CN1642945A (zh)	2005-07-20
PA8569701A1 (es)	2003-12-10
KR20120098888A (ko)	2012-09-05
KR20100101182A (ko)	2010-09-16
HK1080847A1 (zh)	2006-05-04
GB0207104D0 (en)	2002-05-08
CA2480287A1 (en)	2003-10-02
KR101026283B1 (ko)	2011-03-31
WO2003080599A1 (en)	2003-10-02
ES2394067T3 (es)	2013-01-16
US6930188B2 (en)	2005-08-16
PT1490357E (pt)	2011-03-01
SI1490357T1 (sl)	2011-05-31
BR122018000397B1 (pt)	2019-07-02
US20050245597A1 (en)	2005-11-03
US7696357B2 (en)	2010-04-13
KR20110130539A (ko)	2011-12-05
EP2336124B1 (de)	2012-08-29
DE60335711D1 (de)	2011-02-24
SV2003001515A (es)	2003-12-15
CY1113433T1 (el)	2016-06-22
BR0308706A (pt)	2005-01-04
AR042608A1 (es)	2005-06-29
BRPI0308706B8 (pt)	2021-05-25
CA2480287C (en)	2011-05-31
PT2336124E (pt)	2012-12-12

Legal Events

Date

Code

Title

Description

2011-10-15

UEP

Publication of translation of european patent specification

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Publication	Publication Date	Title
DE60335711D1 (de)	2011-02-24	Toluol-Solvat von Darifenacin
FI113616B (fi)	2004-05-31	Instrumentti
EP1294378A4 (de)	2004-01-28	Thrombopoietin-mimetika
IS7016A (is)	2003-11-05	Ný 4-anilínókínólín-3-karboxamíð
NO20043696L (no)	2004-11-05	Gamma-sekretaseinhibitorer
EP1412378A4 (de)	2006-09-20	Aptamere und antiaptamere
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NO20014597D0 (no)	2001-09-21	Fremgangsmåte
EP1560914A4 (de)	2007-05-30	Grasendophyten
FR2841960B1 (fr)	2008-04-04	Bague de traversee de cloison
DE60328306D1 (de)	2009-08-20	Drucktuch
NO20043664L (no)	2004-09-01	Ny fremgangsmate
NO20025163D0 (no)	2002-10-25	Penetrator
ITMI20021327A1 (it)	2003-12-15	Nuove ossialchilpiperazine
DE60331820D1 (de)	2010-05-06	Beseitigung von verstopfungen von rohrleitungen
EP1498386A4 (de)	2007-12-12	Mikrofeine selbstaggregierte einheit
FI20021294A7 (fi)	2003-12-29	Eristin
FI6126U1 (fi)	2004-02-16	Avoimen rakentamisen tehokas toteuttaminen
NO20043433L (no)	2004-08-17	Fremgangsmate
ATA14982002A (de)	2005-11-15	Ziegel
DE50300654D1 (de)	2005-07-21	Flachdichtung
DE50200691D1 (de)	2004-09-02	Spannungskomparator
NO20022407D0 (no)	2002-05-22	Sparkkoffert
FIU20020171U0 (fi)	2002-04-16	Puupalkki