ATE495253T1 - Die replikation des hepatitis-c-virus-replikons hemmendes nukleaseresistentes rna-aptamer - Google Patents
Die replikation des hepatitis-c-virus-replikons hemmendes nukleaseresistentes rna-aptamerInfo
- Publication number
- ATE495253T1 ATE495253T1 AT07793124T AT07793124T ATE495253T1 AT E495253 T1 ATE495253 T1 AT E495253T1 AT 07793124 T AT07793124 T AT 07793124T AT 07793124 T AT07793124 T AT 07793124T AT E495253 T1 ATE495253 T1 AT E495253T1
- Authority
- AT
- Austria
- Prior art keywords
- replication
- rna aptamer
- inhibiting
- nucleease
- hepatitis
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 3
- 108091023037 Aptamer Proteins 0.000 title abstract 2
- 230000010076 replication Effects 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 4
- 108091008103 RNA aptamers Proteins 0.000 abstract 2
- 229940104302 cytosine Drugs 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 229940035893 uracil Drugs 0.000 abstract 2
- 101710163270 Nuclease Proteins 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 108700008776 hepatitis C virus NS-5 Proteins 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/205—Aptamer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Analytical Chemistry (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20060118062 | 2006-11-28 | ||
| KR1020070054744A KR100861108B1 (ko) | 2006-11-28 | 2007-06-05 | 씨형 간염 바이러스 레플리콘 증식을 억제하는 알엔에이분해효소 저항성 알엔에이 압타머 |
| PCT/KR2007/002769 WO2008066231A1 (en) | 2006-11-28 | 2007-06-08 | Nuclease-resistant rna aptamer inhibiting replication of hepatitis c virus replicon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE495253T1 true ATE495253T1 (de) | 2011-01-15 |
Family
ID=39804607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07793124T ATE495253T1 (de) | 2006-11-28 | 2007-06-08 | Die replikation des hepatitis-c-virus-replikons hemmendes nukleaseresistentes rna-aptamer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8008272B2 (de) |
| EP (1) | EP2092078B1 (de) |
| JP (1) | JP2010510805A (de) |
| KR (1) | KR100861108B1 (de) |
| CN (1) | CN101605908A (de) |
| AT (1) | ATE495253T1 (de) |
| AU (1) | AU2007326284B2 (de) |
| CA (1) | CA2670447C (de) |
| DE (1) | DE602007011972D1 (de) |
| WO (2) | WO2008066230A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010115177A (ja) * | 2008-11-14 | 2010-05-27 | Nec Soft Ltd | 分解耐性を有するｒｎａアプタマー分子の修飾ヌクレオチド配列の選択方法 |
| US9382544B2 (en) | 2009-05-15 | 2016-07-05 | Nec Solution Innovators, Ltd. | Aptamer that recognizes peptide |
| JP5967687B2 (ja) * | 2009-07-17 | 2016-08-10 | Ｎｅｃソリューションイノベータ株式会社 | スフィンゴシルホスホリルコリンに結合するアプタマー分子 |
| KR20120068231A (ko) * | 2010-12-17 | 2012-06-27 | 한국식품연구원 | 살모넬라 티피뮤리움 균주의 ｏｍｐＣ단백질에 대해 결합하는 ＲＮＡ 앱타머 |
| RU2501862C1 (ru) * | 2012-04-16 | 2013-12-20 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ НАУКИ Лимнологический институт Сибирского отделения Российской академии наук | Способ получения терапевтического агента для лечения клещевого энцефалита |
| DK2872147T3 (da) | 2012-07-13 | 2023-02-20 | Wave Life Sciences Ltd | Fremgangsmåde til fremstilling af kirale oligonukleotider |
| KR101480495B1 (ko) * | 2013-04-30 | 2015-01-12 | 주식회사 포스코 | C형 간염바이러스의 표면 단백질 e2에 대한 압타머 및 이의 용도 |
| WO2016057920A1 (en) * | 2014-10-09 | 2016-04-14 | The Research Foundation For The State University Of New York | Rna hydrogel |
| CN107873056A (zh) * | 2015-04-01 | 2018-04-03 | 维也纳大学 | 新型表达调节性rna分子及其用途 |
| US10731165B2 (en) | 2016-10-06 | 2020-08-04 | The Research Foundation For The State University Of New York | RNA hydrogels |
| CN108330131A (zh) * | 2018-01-30 | 2018-07-27 | 中国人民解放军军事科学院军事医学研究院 | 抑制丝状病毒感染的抗病毒包膜糖蛋白的rna适配体及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2666142B2 (ja) * | 1987-02-04 | 1997-10-22 | 旭光学工業株式会社 | カメラの自動焦点検出装置 |
| US20050209180A1 (en) | 2001-05-18 | 2005-09-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
| US7465537B2 (en) | 2005-05-01 | 2008-12-16 | The Board Of Trustees Of The University Of Arkansas | Compounds and methods for inhibiting hepatitis C virus replication |
-
2007
- 2007-06-05 KR KR1020070054744A patent/KR100861108B1/ko not_active Expired - Fee Related
- 2007-06-08 CN CNA2007800444015A patent/CN101605908A/zh active Pending
- 2007-06-08 AT AT07793124T patent/ATE495253T1/de not_active IP Right Cessation
- 2007-06-08 WO PCT/KR2007/002768 patent/WO2008066230A1/en not_active Ceased
- 2007-06-08 AU AU2007326284A patent/AU2007326284B2/en not_active Ceased
- 2007-06-08 US US12/516,311 patent/US8008272B2/en not_active Expired - Fee Related
- 2007-06-08 WO PCT/KR2007/002769 patent/WO2008066231A1/en not_active Ceased
- 2007-06-08 CA CA2670447A patent/CA2670447C/en not_active Expired - Fee Related
- 2007-06-08 EP EP07793124A patent/EP2092078B1/de not_active Not-in-force
- 2007-06-08 DE DE602007011972T patent/DE602007011972D1/de active Active
- 2007-06-08 JP JP2009539170A patent/JP2010510805A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2092078A4 (de) | 2010-04-07 |
| AU2007326284B2 (en) | 2012-01-19 |
| EP2092078A1 (de) | 2009-08-26 |
| WO2008066230A1 (en) | 2008-06-05 |
| CA2670447A1 (en) | 2008-06-05 |
| CN101605908A (zh) | 2009-12-16 |
| US8008272B2 (en) | 2011-08-30 |
| JP2010510805A (ja) | 2010-04-08 |
| CA2670447C (en) | 2013-02-12 |
| KR20080048382A (ko) | 2008-06-02 |
| DE602007011972D1 (de) | 2011-02-24 |
| WO2008066231A1 (en) | 2008-06-05 |
| KR100861108B1 (ko) | 2008-09-30 |
| US20100160617A1 (en) | 2010-06-24 |
| AU2007326284A1 (en) | 2008-06-05 |
| EP2092078B1 (de) | 2011-01-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602007011972D1 (de) | Mmendes nukleaseresistentes rna-aptamer | |
| Lau et al. | Complete genome analysis of three novel picornaviruses from diverse bat species | |
| ATE491791T1 (de) | Oligonukleotidanalog und verfahren zur behandlung von flavivirusinfektionen | |
| EA201200217A1 (ru) | Рнк с комбинацией из немодифицированных и модифицированных нуклеотидов для экспрессии белков | |
| DK1747023T3 (da) | Fremgangsmåder og sammensætninger til formindskelse af HCV-virusgenommængder i en målcelle | |
| DK2230304T3 (da) | IRNA-modulering af RSV og terapeutiske anvendelser deraf | |
| EP2399575A3 (de) | Verfahren, Verwendungen und Zusammensetzungen zur Behandlung einer Infektion durch einen Virus aus der Familie der Flaviviridae durch Hemmung des Farnesoid X-Rezeptors (FXR) | |
| DE602007006457D1 (de) | Antivirale antisense-verbindung und verfahren zur behandlung von arenavirus-infektion | |
| WO2005014806A3 (en) | Conserved hbv and hcv sequences useful for gene silencing | |
| ATE505475T1 (de) | Nukleosidderivate als inhibitoren viraler polymerasen | |
| EA200900297A1 (ru) | Ингибиторы вируса гепатита с | |
| WO2010021681A3 (en) | Compositions and methods for treatment of viral diseases | |
| JP2011519414A5 (de) | ||
| WO2007030691A3 (en) | Antisense antiviral compound and method for treating picornavirus infection | |
| ATE507293T1 (de) | Zum gen-silencing geeignete konservierte hbv- und hcv-sequenzen | |
| EA200401362A1 (ru) | Антивирусная терапия, основанная на противодействии рнк | |
| DK1689886T3 (da) | Molekylær markör associeret med CMV-resistens og anvendelse deraf | |
| ATE505541T1 (de) | Targeting von zwischenprodukten zur gegenstrangreplikation von einzelstrangigen viren durch rnai | |
| DK1587828T3 (da) | Defensivproteiner | |
| ATE408013T1 (de) | Infektiöses cdna klon des gb-virus b und dessen verwendungen | |
| DK1749097T3 (da) | Replikationskompetente vira, der er i stand til silencing af ekspression af virushæmmende faktor | |
| EP2468297A3 (de) | Methoden zur identifizierung von Angenzien, die das AGG-Motif binden | |
| Arzumanov et al. | Inhibition of the HIV-1 Tat protein-TAR RNA interaction by 2'-O-methyl oligoribonucleotides | |
| Prostova et al. | Independent evolution of tetraloop in enterovirus oriL replicative element and its putative binding partners in virus protein 3C | |
| DE602006017727D1 (de) | Oligonukleotide, verwendung davon, erkennungsverfahren und kit zur feststellung der anwesenheit von h5- und n1-genen des influenza-virus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |