ATE495742T1 - Tetrahydro pyridinyl pyrazole cannabinoid modulatoren - Google Patents

Tetrahydro pyridinyl pyrazole cannabinoid modulatoren

Info

Publication number: ATE495742T1
Authority: AT; Austria
Prior art keywords: pyrazoles; tetrahydro; cannabinoid modulators; cannabinoid; pyridinyl
Prior art date: 2004-10-27

Application number

AT05810125T

Other languages

English (en)

Inventor

Mingde Xia

Meng Pan

Michael Wachter

Fina Liotta

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-27

Filing date

2005-10-18

Publication date

2011-02-15

2005-10-18 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE495742T1 publication Critical patent/ATE495742T1/de

Links

229930003827 cannabinoid Natural products 0.000 title abstract 2
239000003557 cannabinoid Substances 0.000 title abstract 2
-1 TETRAHYDRO PYRIDINYL PYRAZOLES Chemical class 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
JTMREYIZVRSBKK-UHFFFAOYSA-N 1-(1h-pyrazol-5-yl)-3,4-dihydro-2h-pyridine Chemical compound C1CCC=CN1C1=CC=NN1 JTMREYIZVRSBKK-UHFFFAOYSA-N 0.000 abstract 1
102000018208 Cannabinoid Receptor Human genes 0.000 abstract 1
108050007331 Cannabinoid receptor Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Psychology (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Child & Adolescent Psychology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

AT05810125T 2004-10-27 2005-10-18 Tetrahydro pyridinyl pyrazole cannabinoid modulatoren ATE495742T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US62264104P	2004-10-27	2004-10-27
PCT/US2005/037635 WO2006049880A1 (en)	2004-10-27	2005-10-18	Tetrahydro pyridinyl pyrazole cannabinoid modulators

Publications (1)

Publication Number	Publication Date
ATE495742T1 true ATE495742T1 (de)	2011-02-15

Family

ID=35789180

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05810125T ATE495742T1 (de)	2004-10-27	2005-10-18	Tetrahydro pyridinyl pyrazole cannabinoid modulatoren

Country Status (13)

Country	Link
US (1)	US20060089378A1 (de)
EP (1)	EP1804791B1 (de)
JP (1)	JP4942660B2 (de)
KR (1)	KR20070074638A (de)
CN (1)	CN101500560A (de)
AT (1)	ATE495742T1 (de)
AU (1)	AU2005302697B2 (de)
BR (1)	BRPI0517378A (de)
CA (1)	CA2585925C (de)
DE (1)	DE602005026037D1 (de)
ES (1)	ES2357776T3 (de)
MX (1)	MX2007005071A (de)
WO (1)	WO2006049880A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0616401A2 (pt) *	2005-09-23	2011-06-21	Janssen Pharmaceutica Nv	moduladores de hexa-hidro-ciclo-otil pirazol canabinoide e uso dos mesmos
US7825151B2 (en) *	2005-09-23	2010-11-02	Janssen Pharmaceutica Nv	Hexahydro-cyclooctyl pyrazole cannabinoid modulators
AR057959A1 (es) *	2005-12-01	2007-12-26	Elan Pharm Inc	5-pirazolpiperidinas-(sustituidas)
CN101686989B (zh) *	2007-06-21	2016-10-19	卡拉治疗学股份有限公司	取代的咪唑并杂环
AU2008272437A1 (en) *	2007-06-29	2009-01-08	Torrent Pharmaceuticals Ltd.	Novel substituted piperidones as HSP inducers
WO2009073633A1 (en)	2007-11-30	2009-06-11	Alltranz Inc.	Prodrugs of tetrahydrocannabinol, compositions comprising prodrugs of tetrahydrocannabinol and methods of using the same
WO2010088050A2 (en) *	2009-01-28	2010-08-05	Cara Therapeutics, Inc.	Bicyclic pyrazolo-heterocycles
JP5951625B2 (ja)	2010-11-24	2016-07-13	ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨークＴｈｅＴｒｕｓｔｅｅｓＯｆＣｏｌｕｍｂｉａＵｎｉｖｅｒｓｉｔｙＩｎＴｈｅＣｉｔｙＯｆＮｅｗＹｏｒｋ	加齢性黄斑変性症およびシュタルガルト病の処置のための非レチノイドｒｂｐ４アンタゴニスト
CN102093366B (zh) *	2011-03-04	2012-11-28	中国医学科学院医药生物技术研究所	双环氨基吡唑类化合物及其在抗柯萨奇病毒中的应用
FR2984324B1 (fr) *	2011-12-16	2014-02-21	Oreal	Tetrahydropyrazolopyridines cationiques, composition tinctoriale comprenant de telles bases d'oxydation, procede de mise en oeuvre et utilisation
US9333202B2 (en)	2012-05-01	2016-05-10	The Trustees Of Columbia University In The City Of New York	Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
WO2014152018A1 (en)	2013-03-14	2014-09-25	The Trustees Of Columbia University In The City Of New York	Octahydrocyclopentapyrroles, their preparation and use
EP3495357B1 (de)	2013-03-14	2021-05-05	The Trustees of Columbia University in the City of New York	4-phenylpiperidine, deren herstellung und verwendung
US9944644B2 (en)	2013-03-14	2018-04-17	The Trustees Of Columbia University In The City Of New York	Octahydropyrrolopyrroles their preparation and use
US9938291B2 (en)	2013-03-14	2018-04-10	The Trustess Of Columbia University In The City Of New York	N-alkyl-2-phenoxyethanamines, their preparation and use
SG11201608943VA (en)	2014-04-30	2016-11-29	Univ Columbia	Substituted 4-phenylpiperidines, their preparaiton and use
EP2993174A1 (de) *	2014-09-08	2016-03-09	Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH	Pyrazolopyridinderivate und deren Verwendung in der Therapie
CR20190119A (es)	2016-09-09	2019-06-03	Novartis Ag	Compuestos y composiciones como inhibidores de los receptores endosomales tipo peaje

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1320531T3 (da) *	2000-08-10	2011-01-03	Pfizer Italia Srl	Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse
BR0213562A (pt) *	2001-10-26	2004-08-31	Aventis Pharma Inc	Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna
US7666867B2 (en) *	2001-10-26	2010-02-23	University Of Connecticut	Heteroindanes: a new class of potent cannabimimetic ligands
US20070037790A1 (en) *	2003-03-11	2007-02-15	Francesca Abrate	Bicyclo-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
US20040214856A1 (en) *	2003-04-23	2004-10-28	Pfizer Inc	Cannabinoid receptor ligands and uses thereof

2005
- 2005-10-18 KR KR1020077011850A patent/KR20070074638A/ko not_active Withdrawn
- 2005-10-18 CN CNA2005800446543A patent/CN101500560A/zh active Pending
- 2005-10-18 BR BRPI0517378-7A patent/BRPI0517378A/pt not_active IP Right Cessation
- 2005-10-18 US US11/253,127 patent/US20060089378A1/en not_active Abandoned
- 2005-10-18 CA CA2585925A patent/CA2585925C/en not_active Expired - Fee Related
- 2005-10-18 WO PCT/US2005/037635 patent/WO2006049880A1/en not_active Ceased
- 2005-10-18 AT AT05810125T patent/ATE495742T1/de not_active IP Right Cessation
- 2005-10-18 AU AU2005302697A patent/AU2005302697B2/en not_active Ceased
- 2005-10-18 JP JP2007538991A patent/JP4942660B2/ja not_active Expired - Fee Related
- 2005-10-18 EP EP05810125A patent/EP1804791B1/de not_active Expired - Lifetime
- 2005-10-18 ES ES05810125T patent/ES2357776T3/es not_active Expired - Lifetime
- 2005-10-18 DE DE602005026037T patent/DE602005026037D1/de not_active Expired - Lifetime
- 2005-10-18 MX MX2007005071A patent/MX2007005071A/es unknown

Also Published As

Publication number	Publication date
AU2005302697B2 (en)	2012-09-13
US20060089378A1 (en)	2006-04-27
MX2007005071A (es)	2007-10-03
DE602005026037D1 (de)	2011-03-03
BRPI0517378A (pt)	2008-10-07
CA2585925C (en)	2014-04-22
EP1804791B1 (de)	2011-01-19
WO2006049880A1 (en)	2006-05-11
JP2008518008A (ja)	2008-05-29
JP4942660B2 (ja)	2012-05-30
EP1804791A1 (de)	2007-07-11
ES2357776T3 (es)	2011-04-29
AU2005302697A1 (en)	2006-05-11
CN101500560A (zh)	2009-08-05
CA2585925A1 (en)	2006-05-11
KR20070074638A (ko)	2007-07-12

Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE495742T1 (de)	2011-02-15	Tetrahydro pyridinyl pyrazole cannabinoid modulatoren
IL190348A0 (en)	2009-09-22	Hexahydro cyclooctyl pyrazole cannabinoid modulators
TW200602324A (en)	2006-01-16	Tetrahydro-indazole cannabinoid modulators cross reference to related applications
IL193479A0 (en)	2009-05-04	Modulators of muscarinic receptors
MX2008012400A (es)	2008-10-10	Azolopirimidinas como inhibidores de actividad de cannabinoide 1.
ATE493397T1 (de)	2011-01-15	Neuartige tetrazolderivate als positive allosterische modulatoren von metabotropen glutamatrezeptoren
MX2010001714A (es)	2010-03-10	Moduladores de canabinoides 5-vinilfenil-1-fenil-pirazol sustituidos.
NO20064325L (no)	2006-11-22	Heteroarylaminopyrazolderivativer nyttige for behandling av diabetes
NO20082505L (no)	2008-08-12	Substtuert 5-heteroaryl-1-fenyl-pyrazol-cannabinoid-modulatorer
NO20075764L (no)	2008-01-14	Kombinert anvendelse av prostaglandinforbindelse og protonpumpeinhibitor til behandling av forstyrrelser i mage- og tarmkanalen
UA98487C2 (en)	2012-05-25	Hexahydro-cycloheptapyrazole cannabinoid modulators
ZA200803532B (en)	2009-09-30	Hexahydro-cycloheptapyrazole cannabinoid modulators
ATE544344T1 (de)	2012-02-15	Therapeutische pyrazolochinolinderivate
MY157425A (en)	2016-06-15	Substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
MX2009010159A (es)	2009-10-12	Moduladores de cannabinoides hexahidro-ciclooctil pirazol.
NO20045343L (no)	2004-12-06	Ny kombinasjon for behandling av luftveisforstyrrelser
ZA200709342B (en)	2009-09-30	Tertrahydrothiopyrano pyrazole cannabinoid modulators
IS8139A (is)	2005-11-22	Notkun týrósínkínasatálma til að meðhöndla sykursýki