ATE495742T1 - Tetrahydro pyridinyl pyrazole cannabinoid modulatoren - Google Patents

Tetrahydro pyridinyl pyrazole cannabinoid modulatoren

Info

Publication number: ATE495742T1
Authority: AT; Austria
Prior art keywords: pyrazoles; tetrahydro; cannabinoid modulators; cannabinoid; pyridinyl
Prior art date: 2004-10-27

Application number

AT05810125T

Other languages

English (en)

Inventor

Mingde Xia

Meng Pan

Michael Wachter

Fina Liotta

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-27

Filing date

2005-10-18

Publication date

2011-02-15

2005-10-18 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE495742T1 publication Critical patent/ATE495742T1/de

Links

229930003827 cannabinoid Natural products 0.000 title abstract 2
239000003557 cannabinoid Substances 0.000 title abstract 2
-1 TETRAHYDRO PYRIDINYL PYRAZOLES Chemical class 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
JTMREYIZVRSBKK-UHFFFAOYSA-N 1-(1h-pyrazol-5-yl)-3,4-dihydro-2h-pyridine Chemical compound C1CCC=CN1C1=CC=NN1 JTMREYIZVRSBKK-UHFFFAOYSA-N 0.000 abstract 1
102000018208 Cannabinoid Receptor Human genes 0.000 abstract 1
108050007331 Cannabinoid receptor Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Addiction (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Immunology (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Gynecology & Obstetrics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT05810125T 2004-10-27 2005-10-18 Tetrahydro pyridinyl pyrazole cannabinoid modulatoren ATE495742T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US62264104P	2004-10-27	2004-10-27
PCT/US2005/037635 WO2006049880A1 (en)	2004-10-27	2005-10-18	Tetrahydro pyridinyl pyrazole cannabinoid modulators

Publications (1)

Publication Number	Publication Date
ATE495742T1 true ATE495742T1 (de)	2011-02-15

Family

ID=35789180

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05810125T ATE495742T1 (de)	2004-10-27	2005-10-18	Tetrahydro pyridinyl pyrazole cannabinoid modulatoren

Country Status (13)

Country	Link
US (1)	US20060089378A1 (de)
EP (1)	EP1804791B1 (de)
JP (1)	JP4942660B2 (de)
KR (1)	KR20070074638A (de)
CN (1)	CN101500560A (de)
AT (1)	ATE495742T1 (de)
AU (1)	AU2005302697B2 (de)
BR (1)	BRPI0517378A (de)
CA (1)	CA2585925C (de)
DE (1)	DE602005026037D1 (de)
ES (1)	ES2357776T3 (de)
MX (1)	MX2007005071A (de)
WO (1)	WO2006049880A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7825151B2 (en) *	2005-09-23	2010-11-02	Janssen Pharmaceutica Nv	Hexahydro-cyclooctyl pyrazole cannabinoid modulators
UA93389C2 (en) *	2005-09-23	2011-02-10	Янссен Фармацевтика H.B.	Hexahydro cyclooctyl pyrazole cannabinoid modulators
EA014906B1 (ru) *	2005-12-01	2011-02-28	Элан Фармасьютикалз, Инк.	5-(арилсульфонил)пиразолопиперидины
EA201000046A1 (ru) *	2007-06-21	2011-02-28	Кара Терапеутикс, Инк.	Замещенные имидазогетероциклы
BRPI0812997A2 (pt) *	2007-06-29	2014-12-23	Torrent Pharmaceuticals Ltd	Novas piperidonas substituídas como indutores de hsp
PL2963031T3 (pl)	2007-11-30	2019-08-30	Zynerba Pharmaceuticals, Inc.	Proleki tetrahydrokannabinolu, kompozycje zawierające proleki tetrahydrokannabinolu i sposoby ich stosowania
CN102282147B (zh) *	2009-01-28	2015-09-30	卡拉治疗学股份有限公司	二环吡唑并-杂环
WO2012071369A2 (en)	2010-11-24	2012-05-31	The Trustees Of Columbia University In The City Of New York	A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease
CN102093366B (zh) *	2011-03-04	2012-11-28	中国医学科学院医药生物技术研究所	双环氨基吡唑类化合物及其在抗柯萨奇病毒中的应用
FR2984324B1 (fr) *	2011-12-16	2014-02-21	Oreal	Tetrahydropyrazolopyridines cationiques, composition tinctoriale comprenant de telles bases d'oxydation, procede de mise en oeuvre et utilisation
US9333202B2 (en)	2012-05-01	2016-05-10	The Trustees Of Columbia University In The City Of New York	Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
US9944644B2 (en)	2013-03-14	2018-04-17	The Trustees Of Columbia University In The City Of New York	Octahydropyrrolopyrroles their preparation and use
US9938291B2 (en)	2013-03-14	2018-04-10	The Trustess Of Columbia University In The City Of New York	N-alkyl-2-phenoxyethanamines, their preparation and use
US10273243B2 (en)	2013-03-14	2019-04-30	The Trustees Of Columbia University In The City Of New York	4-phenylpiperidines, their preparation and use
EP2968303B1 (de)	2013-03-14	2018-07-04	The Trustees of Columbia University in the City of New York	Octahydrocyclopentapyrrole und deren herstellung und verwendung
CN111393434B (zh)	2014-04-30	2022-11-04	哥伦比亚大学董事会	取代的4-苯基哌啶及其制备和用途
EP2993174A1 (de) *	2014-09-08	2016-03-09	Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH	Pyrazolopyridinderivate und deren Verwendung in der Therapie
EP4059934B1 (de)	2016-09-09	2026-07-29	Novartis AG	Verbindungen und zusammensetzungen als inhibitoren der endosomalen toll-like-rezeptoren

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2416527C (en) *	2000-08-10	2009-12-22	Pharmacia Italia S.P.A.	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2003035005A2 (en) *	2001-10-26	2003-05-01	University Of Connecticut	Heteroindanes: a new class of potent cannabimimetic ligands
IL161576A0 (en) *	2001-10-26	2004-09-27	Aventis Pharma Inc	Benzimidazoles and analogues and their use as protein kinases inhibitors
BRPI0408486A (pt) *	2003-03-11	2006-04-04	Pharmacia Italia Spa	derivados de biciclopirazol ativos como inibidores da cinase, processo para a sua preparação e composições farmacêuticas compreendendo-os
US20040214856A1 (en) *	2003-04-23	2004-10-28	Pfizer Inc	Cannabinoid receptor ligands and uses thereof

2005
- 2005-10-18 US US11/253,127 patent/US20060089378A1/en not_active Abandoned
- 2005-10-18 JP JP2007538991A patent/JP4942660B2/ja not_active Expired - Fee Related
- 2005-10-18 AU AU2005302697A patent/AU2005302697B2/en not_active Ceased
- 2005-10-18 AT AT05810125T patent/ATE495742T1/de not_active IP Right Cessation
- 2005-10-18 DE DE602005026037T patent/DE602005026037D1/de not_active Expired - Lifetime
- 2005-10-18 CA CA2585925A patent/CA2585925C/en not_active Expired - Fee Related
- 2005-10-18 KR KR1020077011850A patent/KR20070074638A/ko not_active Withdrawn
- 2005-10-18 EP EP05810125A patent/EP1804791B1/de not_active Expired - Lifetime
- 2005-10-18 CN CNA2005800446543A patent/CN101500560A/zh active Pending
- 2005-10-18 BR BRPI0517378-7A patent/BRPI0517378A/pt not_active IP Right Cessation
- 2005-10-18 WO PCT/US2005/037635 patent/WO2006049880A1/en not_active Ceased
- 2005-10-18 ES ES05810125T patent/ES2357776T3/es not_active Expired - Lifetime
- 2005-10-18 MX MX2007005071A patent/MX2007005071A/es unknown

Also Published As

Publication number	Publication date
CN101500560A (zh)	2009-08-05
CA2585925A1 (en)	2006-05-11
CA2585925C (en)	2014-04-22
DE602005026037D1 (de)	2011-03-03
WO2006049880A1 (en)	2006-05-11
US20060089378A1 (en)	2006-04-27
AU2005302697A1 (en)	2006-05-11
EP1804791B1 (de)	2011-01-19
JP4942660B2 (ja)	2012-05-30
EP1804791A1 (de)	2007-07-11
MX2007005071A (es)	2007-10-03
JP2008518008A (ja)	2008-05-29
KR20070074638A (ko)	2007-07-12
ES2357776T3 (es)	2011-04-29
BRPI0517378A (pt)	2008-10-07
AU2005302697B2 (en)	2012-09-13

Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602005026037D1 (de)	2011-03-03	Tetrahydro pyridinyl pyrazole cannabinoid modulatoren
ZA200803533B (en)	2009-10-28	Hexahydro cyclooctyl pyrazole cannabinoid modulators
TW200602324A (en)	2006-01-16	Tetrahydro-indazole cannabinoid modulators cross reference to related applications
IL193479A0 (en)	2009-05-04	Modulators of muscarinic receptors
MX2008012400A (es)	2008-10-10	Azolopirimidinas como inhibidores de actividad de cannabinoide 1.
MX2010008397A (es)	2010-08-23	Inhibidores del receptor de quimioquinas cxcr3.
UA98487C2 (en)	2012-05-25	Hexahydro-cycloheptapyrazole cannabinoid modulators
MX2010001714A (es)	2010-03-10	Moduladores de canabinoides 5-vinilfenil-1-fenil-pirazol sustituidos.
NO20064325L (no)	2006-11-22	Heteroarylaminopyrazolderivativer nyttige for behandling av diabetes
NO20082505L (no)	2008-08-12	Substtuert 5-heteroaryl-1-fenyl-pyrazol-cannabinoid-modulatorer
NO20075764L (no)	2008-01-14	Kombinert anvendelse av prostaglandinforbindelse og protonpumpeinhibitor til behandling av forstyrrelser i mage- og tarmkanalen
ZA200803532B (en)	2009-09-30	Hexahydro-cycloheptapyrazole cannabinoid modulators
NO20073369L (no)	2007-08-29	Modulatorer av muskarinreseptorer
MY141528A (en)	2010-05-14	Anilinopyrazole derivatives useful for the treatment of diabetes
ATE544344T1 (de)	2012-02-15	Therapeutische pyrazolochinolinderivate
MX2009010159A (es)	2009-10-12	Moduladores de cannabinoides hexahidro-ciclooctil pirazol.
ZA200709342B (en)	2009-09-30	Tertrahydrothiopyrano pyrazole cannabinoid modulators
IS2712B (is)	2011-01-15	Notkun týrósínkínasatálma til að meðhöndla sykursýki