ATE495749T1 - Zusammensetzung für selektive hemmung der serotoninwiederaufnahme und verfahren dafür - Google Patents

Zusammensetzung für selektive hemmung der serotoninwiederaufnahme und verfahren dafür

Info

Publication number: ATE495749T1
Authority: AT; Austria
Prior art keywords: composition; serotonin reuptake; extract; relates; reuptake inhibition
Prior art date: 2007-02-12

Application number

AT08720152T

Other languages

English (en)

Inventor

Sunil Bhaskaran

Mohan Vishwaraman

Original Assignee

Indus Biotech Private Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-02-12

Filing date

2008-02-11

Publication date

2011-02-15

2008-02-11 Application filed by Indus Biotech Private Ltd filed Critical Indus Biotech Private Ltd

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE495749T1 publication Critical patent/ATE495749T1/de

Links

230000005764 inhibitory process Effects 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 4
230000000697 serotonin reuptake Effects 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 abstract 4
239000002904 solvent Substances 0.000 abstract 3
WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 abstract 2
BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 abstract 2
BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 abstract 2
WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 abstract 2
229940022757 asiaticoside Drugs 0.000 abstract 2
229930182470 glycoside Natural products 0.000 abstract 2
229940090813 madecassoside Drugs 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
239000000546 pharmaceutical excipient Substances 0.000 abstract 2
-1 terpenoid glycosides Chemical class 0.000 abstract 2
244000146462 Centella asiatica Species 0.000 abstract 1
229930002875 chlorophyll Natural products 0.000 abstract 1
235000019804 chlorophyll Nutrition 0.000 abstract 1
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 abstract 1
239000003086 colorant Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000004128 high performance liquid chromatography Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Natural Medicines & Medicinal Plants (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Mycology (AREA)
Alternative & Traditional Medicine (AREA)
Biotechnology (AREA)
Botany (AREA)
Medical Informatics (AREA)
Microbiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Medicinal Preparation (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Steroid Compounds (AREA)

AT08720152T 2007-02-12 2008-02-11 Zusammensetzung für selektive hemmung der serotoninwiederaufnahme und verfahren dafür ATE495749T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN255MU2007		2007-02-12
PCT/IN2008/000132 WO2008099426A1 (en)	2007-02-12	2008-02-11	A composition for selective serotonin reuptake inhibition and process thereof

Publications (1)

Publication Number	Publication Date
ATE495749T1 true ATE495749T1 (de)	2011-02-15

Family

ID=39402592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08720152T ATE495749T1 (de)	2007-02-12	2008-02-11	Zusammensetzung für selektive hemmung der serotoninwiederaufnahme und verfahren dafür

Country Status (12)

Country	Link
US (1)	US9669043B2 (de)
EP (1)	EP2117560B1 (de)
JP (1)	JP5266254B2 (de)
KR (1)	KR101183045B1 (de)
CN (1)	CN101652143B (de)
AT (1)	ATE495749T1 (de)
AU (1)	AU2008215743B2 (de)
BR (1)	BRPI0806793B8 (de)
CA (1)	CA2677872C (de)
DE (1)	DE602008004625D1 (de)
ES (1)	ES2358306T3 (de)
WO (1)	WO2008099426A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2010354973B2 (en) *	2010-06-10	2015-01-22	Indus Biotech Private Limited	A method for preparation of highly pure asiaticoside composition from Centella asiatica and a method of use thereof
FR2964570A1 (fr) *	2010-09-09	2012-03-16	Burgundy	Procede de preparation d'un extrait de centella asiatica
CN101983966B (zh) *	2010-11-19	2012-08-15	浙江大学	低积雪草苷含量总苷出发同时制备积雪草苷和羟基积雪草苷的工艺
EP2714051B1 (de) *	2011-06-02	2016-09-07	Indus Biotech Private Limited	Verfahren zur behandlung von hypercortisolämie, kopfschmerzen, neuropathischen schmerzen und verwandten erkrankungen
TWI746597B (zh) *	2016-07-17	2021-11-21	合一生技股份有限公司	促進傷口癒合的局部配方
CN108002997B (zh) *	2017-12-15	2020-10-23	中国医学科学院药用植物研究所海南分所	一种具有止呕作用的沉香提取物及其应用
CN111329866B (zh) *	2020-04-12	2023-04-07	云南民族大学	一种五环三萜类化合物在制备抗偏头痛药物中的应用
EP4159725A4 (de)	2020-05-29	2023-12-20	Daegu-Gyeongbuk Medical Innovation Foundation	Carboxamidderivat und pharmazeutische zusammensetzung damit als wirkstoff zur vorbeugung oder behandlung von geisteskrankheiten
CN116157124A (zh)	2020-05-29	2023-05-23	大邱庆北尖端医疗产业振兴财团	磺胺衍生物和含其作为活性成分的用于预防或治疗精神疾病的药物组合物
WO2021241982A1 (ko)	2020-05-29	2021-12-02	재단법인 대구경북첨단의료산업진흥재단	N을 하나 이상 포함하는 5원자의 헤테로아릴 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0383171A3 (de)	1989-02-11	1991-07-24	Hoechst Aktiengesellschaft	2,3,23-Trihydroxy-urs-12-en Derivate zur Behandlung von Kognitiven Störungen
KR100228873B1 (ko) *	1997-03-24	1999-11-01	강재헌	센텔라아시아티카에서 분리한 아시아티코사이드와 마테카소 사이드의 수용성 추출물을 함유한 간세포 및 항간섬유화 치료제
JP4497566B2 (ja) *	1998-09-02	2010-07-07	株式会社日本薬用食品研究所	アルドース還元酵素阻害剤並びに新規サポニン及び新規サポゲノール
CN1211098C (zh) *	2001-05-29	2005-07-20	中国人民解放军第二军医大学	积雪草总甙抗抑郁症的用途
JP2004002335A (ja) *	2002-03-28	2004-01-08	Ortho Corporation	不定愁訴症状改善剤及び食品とその組成物
CN1121862C (zh) *	2002-04-16	2003-09-24	中国人民解放军第二军医大学	羟基积雪草甙用于制备治疗抑郁症药物的用途
FR2848117B1 (fr) *	2002-12-10	2006-08-04	Roche Consumer Health Ltd	Procede de preparation d'un extrait de centella asiatica riche en madecassoside et en terminoloside
CN100467025C (zh) *	2004-06-09	2009-03-11	北京苏里曼医药科技有限公司	积雪草总苷、积雪草苷或羟基积雪草苷在制备防治心、脑血管疾病药物中的用途
CN1583127A (zh)	2004-06-11	2005-02-23	张正生	一种治疗抑郁症和肿瘤的中药制剂及其制备方法
CN100441201C (zh)	2005-06-08	2008-12-10	浙江省医学科学院	含积雪草水溶性有效组分的中药缓释制剂及其制备方法

2008
- 2008-02-11 BR BRPI0806793A patent/BRPI0806793B8/pt active IP Right Grant
- 2008-02-11 ES ES08720152T patent/ES2358306T3/es active Active
- 2008-02-11 KR KR1020097016796A patent/KR101183045B1/ko active Active
- 2008-02-11 WO PCT/IN2008/000132 patent/WO2008099426A1/en not_active Ceased
- 2008-02-11 AU AU2008215743A patent/AU2008215743B2/en active Active
- 2008-02-11 CN CN2008800086984A patent/CN101652143B/zh active Active
- 2008-02-11 EP EP08720152A patent/EP2117560B1/de active Active
- 2008-02-11 JP JP2009548800A patent/JP5266254B2/ja active Active
- 2008-02-11 DE DE602008004625T patent/DE602008004625D1/de active Active
- 2008-02-11 AT AT08720152T patent/ATE495749T1/de not_active IP Right Cessation
- 2008-02-11 CA CA2677872A patent/CA2677872C/en active Active
- 2008-02-12 US US12/069,766 patent/US9669043B2/en active Active

Also Published As

Publication number	Publication date
DE602008004625D1 (de)	2011-03-03
AU2008215743A1 (en)	2008-08-21
BRPI0806793B8 (pt)	2021-05-25
ES2358306T3 (es)	2011-05-09
US20080194499A1 (en)	2008-08-14
BRPI0806793B1 (pt)	2021-03-09
AU2008215743B2 (en)	2010-10-07
EP2117560A1 (de)	2009-11-18
BRPI0806793A2 (pt)	2011-09-13
JP5266254B2 (ja)	2013-08-21
KR20090117736A (ko)	2009-11-12
CN101652143B (zh)	2013-11-06
JP2010530841A (ja)	2010-09-16
US9669043B2 (en)	2017-06-06
KR101183045B1 (ko)	2012-09-20
CA2677872A1 (en)	2008-08-21
WO2008099426A1 (en)	2008-08-21
EP2117560B1 (de)	2011-01-19
CA2677872C (en)	2012-04-03
CN101652143A (zh)	2010-02-17

Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE495749T1 (de)	2011-02-15	Zusammensetzung für selektive hemmung der serotoninwiederaufnahme und verfahren dafür
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CN108653368A (zh)	2018-10-16	一种珊瑚树萜类成分的制备方法
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WO2011065699A3 (ko)	2011-09-29	백미증법을 이용한 한방성분 추출방법
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