ATE496029T1 - Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren - Google Patents

Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren

Info

Publication number
ATE496029T1
ATE496029T1 AT07785908T AT07785908T ATE496029T1 AT E496029 T1 ATE496029 T1 AT E496029T1 AT 07785908 T AT07785908 T AT 07785908T AT 07785908 T AT07785908 T AT 07785908T AT E496029 T1 ATE496029 T1 AT E496029T1
Authority
AT
Austria
Prior art keywords
pyridinylalkylene
alcohols
phenyl
derivatives
phosphodiesterase inhibitors
Prior art date
Application number
AT07785908T
Other languages
English (en)
Inventor
Gabriele Amari
Elisabetta Armani
Eleonora Ghidini
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Application granted granted Critical
Publication of ATE496029T1 publication Critical patent/ATE496029T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
AT07785908T 2006-07-14 2007-07-06 Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren ATE496029T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06014672 2006-07-14
PCT/EP2007/005982 WO2008006509A1 (en) 2006-07-14 2007-07-06 Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
ATE496029T1 true ATE496029T1 (de) 2011-02-15

Family

ID=38691860

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07785908T ATE496029T1 (de) 2006-07-14 2007-07-06 Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren

Country Status (9)

Country Link
US (1) US7671066B2 (de)
EP (1) EP2044023B1 (de)
CN (1) CN101490004B (de)
AR (1) AR062074A1 (de)
AT (1) ATE496029T1 (de)
DE (1) DE602007012105D1 (de)
PE (1) PE20080552A1 (de)
TW (1) TW200813010A (de)
WO (1) WO2008006509A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2022783A1 (de) 2007-08-08 2009-02-11 CHIESI FARMACEUTICI S.p.A. 1-Phenyl-2-Pyridinylalkyl-Alkoholderivate als Phosphodiesterasehemmer
EP2070913A1 (de) * 2007-12-14 2009-06-17 CHIESI FARMACEUTICI S.p.A. Ester-Derivate als Phosphodiesterase-Hemmer
EP2110375A1 (de) 2008-04-14 2009-10-21 CHIESI FARMACEUTICI S.p.A. Phosphodiesterase-4-Hemmer der Tertiäraminklasse
EP2216327A1 (de) * 2009-02-06 2010-08-11 CHIESI FARMACEUTICI S.p.A. (1-Phenyl-2-Pyridin-4-yl)ethyl-benzoate als Phosphodiesterasehemmer
WO2011076725A1 (en) 2009-12-21 2011-06-30 Bayer Cropscience Ag Thienylpyri (mi) dinylazole and their use for controlling phytopathogenic fungi
RU2580312C2 (ru) 2010-04-21 2016-04-10 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Способ получения частиц с пониженным электростатическим зарядом
ES2628891T3 (es) 2010-08-03 2017-08-04 Chiesi Farmaceutici S.P.A. Formulación farmacéutica que comprende un inhibidor de fosfodiesterasa
CN102617457A (zh) * 2011-01-28 2012-08-01 天津药物研究院 一种制备罗氟司特的新方法
CN102060762B (zh) * 2011-01-28 2013-05-29 海南美大制药有限公司 孟鲁司特化合物及其新制法
PH12013502516A1 (en) * 2011-06-06 2017-08-23 Chiesi Farm Spa Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
JP5759305B2 (ja) * 2011-08-19 2015-08-05 キヤノン株式会社 アクセス管理システム、アクセス管理方法、アクセス管理サーバ、連携サーバ、およびプログラム
CN103827088B (zh) * 2011-09-26 2017-10-13 奇斯药制品公司 作为磷酸二酯酶抑制剂的1‑苯基‑2‑吡啶基烷基醇的衍生物
KR20140078719A (ko) * 2011-10-21 2014-06-25 키에시 파르마슈티시 엣스. 피. 에이. 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체
CN102603623A (zh) * 2011-12-26 2012-07-25 北京赛林泰医药技术有限公司 制备高纯度罗氟司特的方法
CN102417449A (zh) * 2012-01-09 2012-04-18 四川蜀中制药有限公司 一种3-环丙基甲氧基-4-二氟甲氧基苯甲酸的制备方法
WO2013131255A1 (en) 2012-03-07 2013-09-12 Scinopharm (Changshu) Pharmaceutical, Ltd. Preparation method of roflumilast
KR20150022789A (ko) * 2012-06-04 2015-03-04 키에시 파르마슈티시 엣스. 피. 에이. 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체
CA2893628C (en) * 2012-12-05 2021-11-30 Chiesi Farmaceutici S.P.A. 1-phenyl-2-pyridinyl alkyl alcohol derivatives as phosphodiesterase inhibitors
CA2893622A1 (en) * 2012-12-05 2014-06-12 Chiesi Farmaceutici S.P.A. Novel compounds
US10366264B2 (en) * 2013-08-09 2019-07-30 Korea Advanced Institute Of Science And Technology System and method for transferring content among devices
US9427376B2 (en) 2013-10-10 2016-08-30 Chiesi Farmaceutici S.P.A. Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient
AU2014339136C1 (en) * 2013-10-22 2019-10-31 Chiesi Farmaceutici S.P.A. Process for the preparation of a PDE4 inhibitor
CN103992220B (zh) * 2014-06-05 2015-11-18 山东省医学科学院药物研究所 一种罗氟司特中间体的制备方法
JP6785666B2 (ja) * 2014-06-23 2020-11-18 レオ ファーマ アクティーゼルスカブ １，３−ベンゾジオキソール複素環化合物の調製方法
CN104447244B (zh) * 2014-10-29 2017-06-06 成都森科制药有限公司 罗氟司特中间体及罗氟司特的制备方法
CN104447245B (zh) * 2014-10-29 2017-06-06 成都森科制药有限公司 罗氟司特中间体、中间体制备方法及罗氟司特的制备方法
CN105254559B (zh) * 2015-11-30 2017-07-11 山东罗欣药业集团股份有限公司 一种高纯度罗氟司特的制备方法
DK3390407T3 (da) 2015-12-18 2023-11-06 Union Therapeutics As Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser
AU2018286964B2 (en) 2017-06-20 2022-04-14 UNION therapeutics A/S Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
US20210038575A1 (en) 2017-12-28 2021-02-11 Chiesi Farmaceutici S.P.A. Use of 1-phenyl-2-pyridinyl alkyl alcohol derivatives for treating cystic fibrosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL106517A0 (en) * 1992-07-28 1994-08-26 Rhone Poulenc Rorer Ltd Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic or heteroatom containing linking group
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation

Also Published As

Publication number Publication date
CN101490004B (zh) 2012-01-11
WO2008006509A1 (en) 2008-01-17
US20080015226A1 (en) 2008-01-17
CN101490004A (zh) 2009-07-22
HK1135383A1 (en) 2010-06-04
EP2044023B1 (de) 2011-01-19
AR062074A1 (es) 2008-10-15
DE602007012105D1 (de) 2011-03-03
PE20080552A1 (es) 2008-06-24
EP2044023A1 (de) 2009-04-08
US7671066B2 (en) 2010-03-02
TW200813010A (en) 2008-03-16

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