ATE496121T1 - Lactobacillus fermentum n-desoxyribosyl- transferasen und deren verwendung zur enzymatischen synthese von 2',3'- didesoxynucleosiden und 2',3'-didehydro-2',3'- didesoxynucleosiden - Google Patents

Lactobacillus fermentum n-desoxyribosyl- transferasen und deren verwendung zur enzymatischen synthese von 2',3'- didesoxynucleosiden und 2',3'-didehydro-2',3'- didesoxynucleosiden

Info

Publication number
ATE496121T1
ATE496121T1 AT05744634T AT05744634T ATE496121T1 AT E496121 T1 ATE496121 T1 AT E496121T1 AT 05744634 T AT05744634 T AT 05744634T AT 05744634 T AT05744634 T AT 05744634T AT E496121 T1 ATE496121 T1 AT E496121T1
Authority
AT
Austria
Prior art keywords
transferases
seq
didehydro
lactobacillus fermentum
enzymatic synthesis
Prior art date
Application number
AT05744634T
Other languages
English (en)
Inventor
Pierre-Alexandre Kaminski
Original Assignee
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut filed Critical Pasteur Institut
Application granted granted Critical
Publication of ATE496121T1 publication Critical patent/ATE496121T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT05744634T 2004-03-30 2005-03-29 Lactobacillus fermentum n-desoxyribosyl- transferasen und deren verwendung zur enzymatischen synthese von 2',3'- didesoxynucleosiden und 2',3'-didehydro-2',3'- didesoxynucleosiden ATE496121T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0403319A FR2868432B1 (fr) 2004-03-30 2004-03-30 N-desoxyribosyltransferases de lactobacillus fermantum et application a la synthese enzymatique de 2',3'-didesoxynucleosides et de 2'3'-didehydro- 2'3'-didesoxynucleosides
PCT/FR2005/000743 WO2005095596A1 (fr) 2004-03-30 2005-03-29 N-desoxyribosyltransferases de lactobacillus fermentum et application a la synthese enzymatique de 2’, 3’ -didesoxynucleoside et de 2’,3’-didehydro-2’, 3’-didesoxynucleosides

Publications (1)

Publication Number Publication Date
ATE496121T1 true ATE496121T1 (de) 2011-02-15

Family

ID=34945835

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05744634T ATE496121T1 (de) 2004-03-30 2005-03-29 Lactobacillus fermentum n-desoxyribosyl- transferasen und deren verwendung zur enzymatischen synthese von 2',3'- didesoxynucleosiden und 2',3'-didehydro-2',3'- didesoxynucleosiden

Country Status (8)

Country Link
US (1) US7820795B2 (de)
EP (1) EP1730275B1 (de)
JP (1) JP4690390B2 (de)
AT (1) ATE496121T1 (de)
BR (1) BRPI0509293A (de)
DE (1) DE602005025989D1 (de)
FR (1) FR2868432B1 (de)
WO (1) WO2005095596A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102000927B1 (ko) * 2017-09-29 2019-07-17 에스티팜 주식회사 N-데옥시리보실 트랜스퍼라아제 변이체 및 이를 이용한 뉴클레오시드의 제조방법
CN109295026B (zh) * 2018-10-18 2021-08-24 清华大学 一种n-脱氧核糖转移酶ii定向进化改造和生物催化应用
CN110819604B (zh) * 2019-12-05 2021-07-27 上海兆维科技发展有限公司 脱氧核糖转移酶突变体及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823219B1 (fr) * 2001-04-10 2003-07-04 Pasteur Institut Mutants de la desoxycytidine kinase possedant une activite enzymatique elargie
US7381555B2 (en) * 2001-09-14 2008-06-03 Institut Pasteur Lactobacillus N-deoxyribosyl transferases, corresponding nucleotide sequences and their uses
FR2829774B1 (fr) * 2001-09-14 2004-09-03 Pasteur Institut N-desoxyribosyltransferases de lactobacilles, sequences nucleotidiques correspondantes et leurs applications
FR2852968B1 (fr) * 2003-03-28 2007-10-26 Pasteur Institut Procede de modification in vivo de l'activite de synthese d'un metabolite par modification d'un gene dont l'activite n'est pas l'activite originelle

Also Published As

Publication number Publication date
WO2005095596A1 (fr) 2005-10-13
US7820795B2 (en) 2010-10-26
EP1730275B1 (de) 2011-01-19
US20080064646A1 (en) 2008-03-13
DE602005025989D1 (de) 2011-03-03
FR2868432A1 (fr) 2005-10-07
JP4690390B2 (ja) 2011-06-01
FR2868432B1 (fr) 2007-11-02
EP1730275A1 (de) 2006-12-13
BRPI0509293A (pt) 2007-09-18
JP2007530067A (ja) 2007-11-01

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