ATE496622T1 - Verwendung von thienopyridonderivaten als ampk- aktivatoren und pharmazeutische zusammensetzungen,die diese enthalten - Google Patents
Verwendung von thienopyridonderivaten als ampk- aktivatoren und pharmazeutische zusammensetzungen,die diese enthaltenInfo
- Publication number
- ATE496622T1 ATE496622T1 AT06762350T AT06762350T ATE496622T1 AT E496622 T1 ATE496622 T1 AT E496622T1 AT 06762350 T AT06762350 T AT 06762350T AT 06762350 T AT06762350 T AT 06762350T AT E496622 T1 ATE496622 T1 AT E496622T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- containing same
- ampk activators
- thienopyridone derivatives
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 title 1
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05291753A EP1754483A1 (de) | 2005-08-18 | 2005-08-18 | Verwendung von Thienopyridonederivativen als AMPK Aktivatoren und pharmazeutische Zusammensetzungen, die diese enthalten |
| PCT/EP2006/006446 WO2007019914A1 (en) | 2005-08-18 | 2006-07-03 | Use of thienopyridone derivatives as ampk activators and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE496622T1 true ATE496622T1 (de) | 2011-02-15 |
Family
ID=35636709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06762350T ATE496622T1 (de) | 2005-08-18 | 2006-07-03 | Verwendung von thienopyridonderivaten als ampk- aktivatoren und pharmazeutische zusammensetzungen,die diese enthalten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20090105293A1 (de) |
| EP (2) | EP1754483A1 (de) |
| JP (1) | JP5161774B2 (de) |
| KR (1) | KR20080034491A (de) |
| CN (1) | CN101232883A (de) |
| AT (1) | ATE496622T1 (de) |
| AU (1) | AU2006281761B2 (de) |
| BR (1) | BRPI0614828A2 (de) |
| CA (1) | CA2619505C (de) |
| CY (1) | CY1111660T1 (de) |
| DE (1) | DE602006019880D1 (de) |
| DK (1) | DK1915150T3 (de) |
| ES (1) | ES2359860T3 (de) |
| MX (1) | MX2008002062A (de) |
| PL (1) | PL1915150T3 (de) |
| PT (1) | PT1915150E (de) |
| RU (1) | RU2416409C2 (de) |
| SI (1) | SI1915150T1 (de) |
| WO (1) | WO2007019914A1 (de) |
| ZA (1) | ZA200802454B (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005017152B4 (de) * | 2005-04-13 | 2007-02-08 | Lindauer Dornier Gmbh | Verfahren zum Trocknen von vorzugsweise plattenförmigen Produkten und Durchlauftrockner in Mehretagenbauweise |
| US8263641B2 (en) | 2007-09-10 | 2012-09-11 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| UA103321C2 (ru) * | 2008-04-11 | 2013-10-10 | Мерк Патент Гмбх | Производные тиенопиридона как активаторы amp-активированной протеинкиназы (амрк) |
| HRP20120549T1 (hr) * | 2008-05-05 | 2012-07-31 | Merck@Patent@GmbH | Derivati tienopiridona kao amp aktivirani aktivatori protein kinaze ampk |
| GB0813403D0 (en) * | 2008-07-22 | 2008-08-27 | Lectus Therapeutics Ltd | Potassium ion channel modulators & uses thereof |
| TWI392673B (zh) | 2008-08-27 | 2013-04-11 | Calcimedica Inc | 調控細胞內鈣離子濃度之化合物 |
| US8524763B2 (en) | 2008-09-22 | 2013-09-03 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| WO2010103040A1 (en) | 2009-03-10 | 2010-09-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | 5'-adenosine monophosphate-activated protein kinase (ampk) activators for treating pulmonary hypertension |
| KR101062670B1 (ko) * | 2009-06-01 | 2011-09-06 | (주)아모레퍼시픽 | 2,5-비스-아릴-3,4-디메틸테트라하이드로퓨란 리그난을 유효성분으로 포함하는 에이엠피케이의 활성화에 의해 매개되는 비만 관련 질환의 예방 또는 치료용 조성물 |
| EP2477982A4 (de) | 2009-09-16 | 2013-04-03 | Calcimedica Inc | Verbindungen als modulatoren von intrazellulärem calcium |
| CN102666485A (zh) * | 2009-09-21 | 2012-09-12 | 霍夫曼-拉罗奇有限公司 | 烯烃羟吲哚衍生物及其用于治疗肥胖症，糖尿病和高脂血症的应用 |
| EP2552435A1 (de) | 2010-04-02 | 2013-02-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren und zusammensetzungen mit einem ampk-aktivator (metformin/troglitazon) zur behandlung von myotoner dystrophie typ 1 (dm1) |
| EP2609095A4 (de) | 2010-08-27 | 2014-06-18 | Calcimedica Inc | Verbindungen als modulatoren von intrazellulärem calcium |
| JP5990170B2 (ja) * | 2010-09-01 | 2016-09-07 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 除草活性を有するケトスルタム類及びジケトピリジン類 |
| US9005909B2 (en) | 2011-01-06 | 2015-04-14 | Rigel Pharmaceuticals, Inc. | Whole blood assay for measuring AMPK activation |
| EP2683690A1 (de) * | 2011-03-07 | 2014-01-15 | GlaxoSmithKline LLC | Chinolinonderivate |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| EP2679591A1 (de) | 2012-06-29 | 2014-01-01 | Poxel | Thienopyridon-Derivate zur Verwendung als AMPK-Aktivatoren |
| US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| EP2970177A1 (de) | 2013-03-15 | 2016-01-20 | Pfizer Inc. | Indolverbindungen zur ampk-aktivierung |
| WO2015103480A1 (en) | 2014-01-02 | 2015-07-09 | Massachusetts Eye & Ear Infirmary | Treating ocular neovascularization |
| CN105315275B (zh) * | 2014-07-14 | 2019-10-01 | 中国科学院上海药物研究所 | 一类吡唑酮化合物及其用途 |
| US20190054096A1 (en) | 2015-09-30 | 2019-02-21 | Instituto De Medicina Molecular | Methods for attenuating parasite virulence |
| WO2018002215A1 (en) | 2016-06-30 | 2018-01-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cardiomyopathies |
| EP3522877B1 (de) | 2016-10-05 | 2023-12-06 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Kleinmolekülige ampk-aktivatoren |
| CA3053388C (en) | 2017-02-22 | 2024-02-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Compounds and methods for inhibiting emt pathways to treat cancer, organ fibrosis and metabolic disorders |
| MX2021005772A (es) * | 2018-11-16 | 2021-10-13 | Poxel | Sal de monohidrato potasico de un derivado de tienopiridona y su proceso de preparacion. |
| WO2020201263A1 (en) | 2019-04-01 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling |
| AU2020345766A1 (en) | 2019-09-10 | 2022-03-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for increasing level of phosphorylated AMPK protein |
| WO2022106892A1 (en) | 2020-11-17 | 2022-05-27 | Instituto De Medicina Molecular | Anti-malarial compounds |
| JP2024540522A (ja) | 2021-11-19 | 2024-10-31 | ザ・ブロード・インスティテュート・インコーポレイテッド | キナーゼを標的結合部分で標識するための二官能性キメラ分子及びその使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2358150A1 (fr) * | 1976-07-13 | 1978-02-10 | Parcor | Nouvelles thieno (2,3-c) et (3,2-c) pyridines, leur procede de preparation et leur application |
| GB8625941D0 (en) * | 1986-10-30 | 1986-12-03 | Sandoz Ltd | Substituted alpha-amino acids |
| DE4444815A1 (de) * | 1994-12-15 | 1996-06-20 | Merck Patent Gmbh | Thienopyridone |
| FR2846656B1 (fr) | 2002-11-05 | 2004-12-24 | Servier Lab | Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US7119205B2 (en) | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
| JP2005089384A (ja) | 2003-09-18 | 2005-04-07 | Kao Corp | 持久力向上剤 |
-
2005
- 2005-08-18 EP EP05291753A patent/EP1754483A1/de not_active Withdrawn
-
2006
- 2006-07-03 US US11/997,470 patent/US20090105293A1/en not_active Abandoned
- 2006-07-03 AT AT06762350T patent/ATE496622T1/de active
- 2006-07-03 PT PT06762350T patent/PT1915150E/pt unknown
- 2006-07-03 SI SI200630954T patent/SI1915150T1/sl unknown
- 2006-07-03 EP EP06762350A patent/EP1915150B1/de active Active
- 2006-07-03 RU RU2008109914/04A patent/RU2416409C2/ru active
- 2006-07-03 DK DK06762350.4T patent/DK1915150T3/da active
- 2006-07-03 KR KR1020087005115A patent/KR20080034491A/ko not_active Ceased
- 2006-07-03 MX MX2008002062A patent/MX2008002062A/es active IP Right Grant
- 2006-07-03 JP JP2008526387A patent/JP5161774B2/ja not_active Expired - Fee Related
- 2006-07-03 WO PCT/EP2006/006446 patent/WO2007019914A1/en not_active Ceased
- 2006-07-03 CN CNA2006800282800A patent/CN101232883A/zh active Pending
- 2006-07-03 AU AU2006281761A patent/AU2006281761B2/en not_active Ceased
- 2006-07-03 BR BRPI0614828-0A patent/BRPI0614828A2/pt not_active IP Right Cessation
- 2006-07-03 CA CA2619505A patent/CA2619505C/en active Active
- 2006-07-03 ES ES06762350T patent/ES2359860T3/es active Active
- 2006-07-03 DE DE602006019880T patent/DE602006019880D1/de active Active
- 2006-07-03 PL PL06762350T patent/PL1915150T3/pl unknown
-
2008
- 2008-03-17 ZA ZA200802454A patent/ZA200802454B/xx unknown
-
2011
- 2011-03-14 CY CY20111100285T patent/CY1111660T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1915150T3 (pl) | 2011-05-31 |
| AU2006281761A1 (en) | 2007-02-22 |
| EP1754483A1 (de) | 2007-02-21 |
| EP1915150B1 (de) | 2011-01-26 |
| MX2008002062A (es) | 2008-04-16 |
| ZA200802454B (en) | 2009-01-28 |
| CA2619505A1 (en) | 2007-02-22 |
| AU2006281761B2 (en) | 2012-01-19 |
| WO2007019914A1 (en) | 2007-02-22 |
| JP5161774B2 (ja) | 2013-03-13 |
| CA2619505C (en) | 2015-04-28 |
| BRPI0614828A2 (pt) | 2011-04-19 |
| SI1915150T1 (sl) | 2011-04-29 |
| CY1111660T1 (el) | 2015-10-07 |
| US20090105293A1 (en) | 2009-04-23 |
| PT1915150E (pt) | 2011-05-02 |
| DE602006019880D1 (de) | 2011-03-10 |
| DK1915150T3 (da) | 2011-02-21 |
| RU2008109914A (ru) | 2009-09-27 |
| KR20080034491A (ko) | 2008-04-21 |
| RU2416409C2 (ru) | 2011-04-20 |
| EP1915150A1 (de) | 2008-04-30 |
| CN101232883A (zh) | 2008-07-30 |
| ES2359860T3 (es) | 2011-05-27 |
| JP2009504693A (ja) | 2009-02-05 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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