ATE496991T1 - Kristallstruktur von tak1-tab1 - Google Patents

Kristallstruktur von tak1-tab1

Info

Publication number
ATE496991T1
ATE496991T1 AT06735797T AT06735797T ATE496991T1 AT E496991 T1 ATE496991 T1 AT E496991T1 AT 06735797 T AT06735797 T AT 06735797T AT 06735797 T AT06735797 T AT 06735797T AT E496991 T1 ATE496991 T1 AT E496991T1
Authority
AT
Austria
Prior art keywords
tak1
relates
molecules
molecular complexes
coordinates
Prior art date
Application number
AT06735797T
Other languages
English (en)
Inventor
Graham Cheetham
Kieron Brown
Sarah Vial
Neesha Dedi
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE496991T1 publication Critical patent/ATE496991T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Piezo-Electric Or Mechanical Vibrators, Or Delay Or Filter Circuits (AREA)
AT06735797T 2005-02-23 2006-02-23 Kristallstruktur von tak1-tab1 ATE496991T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65560605P 2005-02-23 2005-02-23
PCT/US2006/006286 WO2006091673A2 (en) 2005-02-23 2006-02-23 Crystal structure of tak1-tab1

Publications (1)

Publication Number Publication Date
ATE496991T1 true ATE496991T1 (de) 2011-02-15

Family

ID=36927986

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06735797T ATE496991T1 (de) 2005-02-23 2006-02-23 Kristallstruktur von tak1-tab1

Country Status (5)

Country Link
US (2) US20070178573A1 (de)
EP (1) EP1851310B1 (de)
AT (1) ATE496991T1 (de)
DE (1) DE602006019826D1 (de)
WO (1) WO2006091673A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2780922A1 (en) 2010-02-11 2011-08-18 OSI Pharmaceuticals, LLC 7-aminofuropyridine derivatives
WO2012166722A1 (en) * 2011-06-03 2012-12-06 The General Hospital Corporation Treating colorectal, pancreatic, and lung cancer
WO2016196256A2 (en) 2015-06-04 2016-12-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
SG10201508927SA (en) 2015-10-29 2017-05-30 Agency Science Tech & Res Protein crystal

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5147700A (en) * 1999-05-19 2000-12-05 Amgen, Inc. Crystal of a lymphocyte kinase-ligand complex and methods of use
JP2003135070A (ja) * 2001-11-01 2003-05-13 Tanabe Seiyaku Co Ltd Ｔａｋ１−ｔａｂ１融合蛋白質
US20050261836A1 (en) * 2001-12-05 2005-11-24 Wuyi Meng Crystal structure of mitogen-activated protein kinase-activated protein kinase 2 and binding pockets thereof
EP1549318B1 (de) * 2002-05-01 2010-02-17 Vertex Pharmaceuticals Incorporated Kristallstruktur des aurora-2 proteins und dessen bindungstaschen
WO2004087862A2 (en) * 2003-04-01 2004-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Tak1-mediated inhibition of osteogenesis

Also Published As

Publication number Publication date
DE602006019826D1 (de) 2011-03-10
WO2006091673A3 (en) 2007-04-19
EP1851310A2 (de) 2007-11-07
US20110171714A1 (en) 2011-07-14
EP1851310B1 (de) 2011-01-26
WO2006091673A2 (en) 2006-08-31
US20070178573A1 (en) 2007-08-02

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Legal Events

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