ATE497493T1 - Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungen - Google Patents
Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungenInfo
- Publication number
- ATE497493T1 ATE497493T1 AT06818694T AT06818694T ATE497493T1 AT E497493 T1 ATE497493 T1 AT E497493T1 AT 06818694 T AT06818694 T AT 06818694T AT 06818694 T AT06818694 T AT 06818694T AT E497493 T1 ATE497493 T1 AT E497493T1
- Authority
- AT
- Austria
- Prior art keywords
- intermediate product
- related compounds
- new intermediate
- producing montelukast
- montelukast
- Prior art date
Links
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 229960005127 montelukast Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/75—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73775205P | 2005-11-18 | 2005-11-18 | |
| US79442906P | 2006-04-24 | 2006-04-24 | |
| US82438206P | 2006-09-01 | 2006-09-01 | |
| PCT/EP2006/011134 WO2007057228A1 (en) | 2005-11-18 | 2006-11-20 | A new intermediate for making montelukast and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE497493T1 true ATE497493T1 (de) | 2011-02-15 |
Family
ID=37685804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06818694T ATE497493T1 (de) | 2005-11-18 | 2006-11-20 | Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungen |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US7476748B2 (de) |
| EP (3) | EP1960362A1 (de) |
| JP (1) | JP2009515922A (de) |
| AR (3) | AR057909A1 (de) |
| AT (1) | ATE497493T1 (de) |
| AU (3) | AU2006314729A1 (de) |
| CA (3) | CA2629840A1 (de) |
| DE (1) | DE602006019979D1 (de) |
| IL (1) | IL185129A0 (de) |
| NO (1) | NO20074188L (de) |
| PT (1) | PT1954679E (de) |
| WO (3) | WO2007057227A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080146809A1 (en) * | 2004-11-19 | 2008-06-19 | Matrix Laboratories Ltd | Process for the Preparation of Novel Amorphous Montelukast Sodium |
| US7812168B2 (en) | 2005-07-05 | 2010-10-12 | Teva Pharmaceutical Industries Ltd. | Purification of montelukast |
| AR057909A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. |
| EP2014650A1 (de) * | 2007-07-13 | 2009-01-14 | Lonza Ag | Verfahren und Zwischenprodukt zur Herstellung eines Zwischenprodukts bei der Herstellung von Montelukast |
| ES2320077B1 (es) | 2007-07-31 | 2010-02-26 | Moehs Iberica, S.L. | Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo. |
| WO2009130056A1 (en) * | 2008-04-25 | 2009-10-29 | Synthon B.V. | Process for making montelukast intermediates |
| EP2552892A1 (de) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Effiziente synthese zur herstellung von montelukast und neue kristalline form von zwischenprodukten darin |
| SG185389A1 (en) | 2010-05-03 | 2012-12-28 | Teikoku Pharma Usa Inc | Non-aqueous taxane pro-emulsion formulations and methods of making and using the same |
| TWI450275B (zh) * | 2010-05-19 | 2014-08-21 | Wistron Corp | 可提升寫入保護之記憶體系統及相關方法 |
| US8471030B2 (en) | 2010-12-06 | 2013-06-25 | Orochem Technologies Inc. | Purification of montelukast using simulated moving bed |
| EP2502910A1 (de) | 2011-03-15 | 2012-09-26 | Laboratorios Lesvi, S.L. | Camphersulfonsalz eines Montelukastschlüssels Zwischenprodukt |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR930011486B1 (ko) * | 1985-08-06 | 1993-12-08 | 베링거 만하임 이탈리아 에스.피.에이. | 제약상 유효한 2-티오메틸-치환-1,4-디히드로피리딘 |
| CA2038178A1 (en) | 1990-04-05 | 1991-10-06 | Carl C. Greco | Niobium alkoxyalkoxides and process for formation |
| US5565473A (en) | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5266568A (en) | 1990-10-12 | 1993-11-30 | Merck Frosst Canada, Inc. | Hydroxyalkylquinoline ether acids as leukotriene antagonists |
| US5856322A (en) | 1990-10-12 | 1999-01-05 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5428033A (en) * | 1990-10-12 | 1995-06-27 | Merck Frosst Canada, Inc. | Saturated hydroxyalkylquinoline acids as leukotriene antagonists |
| HU222344B1 (hu) | 1990-10-12 | 2003-06-28 | Merck Frosst Canada & Co. | Eljárás telítetlen hidroxi-alkil-kinolinsavak, és ezeket tartalmazó gyógyszerkészítmények előállítására |
| IE920499A1 (en) * | 1991-02-21 | 1992-08-26 | Merck Frosst Canada Inc | Quinoline-containing ketoacids as leukotriene antagonists |
| US5270324A (en) * | 1992-04-10 | 1993-12-14 | Merck Frosst Canada, Inc. | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
| TW416948B (en) | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
| GB9423511D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| US5585115A (en) | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
| US5523477A (en) | 1995-01-23 | 1996-06-04 | Merck & Co., Inc. | Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid |
| US5869673A (en) | 1997-02-28 | 1999-02-09 | Merck & Co., Inc. | Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde |
| CN1420113A (zh) * | 2001-11-16 | 2003-05-28 | 北京上地新世纪生物医药研究所 | 孟鲁司特钠的制备方法及其制备中间体 |
| CN1171873C (zh) * | 2001-12-26 | 2004-10-20 | 北京上地新世纪生物医药研究所 | 一种孟鲁司特钠的制备方法及其制备中间体 |
| US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
| US20040265375A1 (en) | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
| IL174758A (en) * | 2003-10-10 | 2012-09-24 | Synthon Bv | Crystalline form of montelukast, pharmaceutical composition comprising it, process for the preparation thereof and uses thereof as a medicament |
| EP1708708A1 (de) * | 2004-01-30 | 2006-10-11 | Teva Pharmaceutical Industries Ltd. | Montelukast-freie säure-polymorphen |
| US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
| US7829716B2 (en) | 2004-04-30 | 2010-11-09 | Synthon Pharmaceuticals, Inc. | Process for making montelukast and intermediates therefor |
| US7501517B2 (en) * | 2004-04-30 | 2009-03-10 | Synthon Ip, Inc. | Process for making montelukast and intermediates therefor |
| ATE500225T1 (de) * | 2004-07-19 | 2011-03-15 | Matrix Lab Ltd | Verfahren zur herstellung von montelukast und salzen davon |
| ITMI20050247A1 (it) * | 2005-02-18 | 2006-08-19 | Chemi Spa | Processo per la preparazione di montelukast |
| AR057909A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. |
-
2006
- 2006-11-17 AR ARP060105063A patent/AR057909A1/es not_active Application Discontinuation
- 2006-11-17 AR ARP060105061A patent/AR056815A1/es not_active Application Discontinuation
- 2006-11-17 AR ARP060105062A patent/AR057908A1/es not_active Application Discontinuation
- 2006-11-20 EP EP06818693A patent/EP1960362A1/de not_active Withdrawn
- 2006-11-20 JP JP2008540534A patent/JP2009515922A/ja not_active Withdrawn
- 2006-11-20 AU AU2006314729A patent/AU2006314729A1/en not_active Abandoned
- 2006-11-20 EP EP06818694A patent/EP1954679B1/de not_active Not-in-force
- 2006-11-20 AT AT06818694T patent/ATE497493T1/de not_active IP Right Cessation
- 2006-11-20 AU AU2006314726A patent/AU2006314726A1/en not_active Abandoned
- 2006-11-20 WO PCT/EP2006/011133 patent/WO2007057227A1/en not_active Ceased
- 2006-11-20 CA CA002629840A patent/CA2629840A1/en not_active Abandoned
- 2006-11-20 DE DE602006019979T patent/DE602006019979D1/de active Active
- 2006-11-20 US US11/561,689 patent/US7476748B2/en not_active Expired - Fee Related
- 2006-11-20 US US11/561,732 patent/US7786138B2/en not_active Expired - Fee Related
- 2006-11-20 CA CA002598093A patent/CA2598093A1/en not_active Abandoned
- 2006-11-20 US US11/561,724 patent/US7601741B2/en not_active Expired - Fee Related
- 2006-11-20 WO PCT/EP2006/011127 patent/WO2007057225A2/en not_active Ceased
- 2006-11-20 PT PT06818694T patent/PT1954679E/pt unknown
- 2006-11-20 WO PCT/EP2006/011134 patent/WO2007057228A1/en not_active Ceased
- 2006-11-20 EP EP06818691A patent/EP1948610A2/de not_active Withdrawn
- 2006-11-20 AU AU2006314728A patent/AU2006314728A1/en not_active Abandoned
- 2006-11-20 CA CA002629834A patent/CA2629834A1/en not_active Abandoned
-
2007
- 2007-08-08 IL IL185129A patent/IL185129A0/en unknown
- 2007-08-15 NO NO20074188A patent/NO20074188L/no not_active Application Discontinuation
-
2008
- 2008-12-12 US US12/334,124 patent/US20090093636A1/en not_active Abandoned
-
2009
- 2009-10-09 US US12/576,773 patent/US20100099879A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090093636A1 (en) | 2009-04-09 |
| PT1954679E (pt) | 2011-05-05 |
| IL185129A0 (en) | 2007-12-03 |
| CA2629840A1 (en) | 2007-05-24 |
| EP1948610A2 (de) | 2008-07-30 |
| WO2007057227A1 (en) | 2007-05-24 |
| EP1954679B1 (de) | 2011-02-02 |
| US20070135480A1 (en) | 2007-06-14 |
| US7476748B2 (en) | 2009-01-13 |
| AR057909A1 (es) | 2007-12-26 |
| AR057908A1 (es) | 2007-12-26 |
| EP1954679A1 (de) | 2008-08-13 |
| WO2007057225A3 (en) | 2007-07-26 |
| EP1960362A1 (de) | 2008-08-27 |
| AU2006314729A1 (en) | 2007-05-24 |
| AU2006314728A1 (en) | 2007-05-24 |
| CA2629834A1 (en) | 2007-05-24 |
| US20100099879A1 (en) | 2010-04-22 |
| WO2007057225A2 (en) | 2007-05-24 |
| US20070135643A1 (en) | 2007-06-14 |
| AU2006314726A1 (en) | 2007-05-24 |
| AR056815A1 (es) | 2007-10-24 |
| US7601741B2 (en) | 2009-10-13 |
| WO2007057228A1 (en) | 2007-05-24 |
| US7786138B2 (en) | 2010-08-31 |
| US20070135642A1 (en) | 2007-06-14 |
| JP2009515922A (ja) | 2009-04-16 |
| CA2598093A1 (en) | 2007-05-24 |
| DE602006019979D1 (de) | 2011-03-17 |
| NO20074188L (no) | 2008-08-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1934354A4 (de) | Verfahren zur herstellung von hybridsaat | |
| NO20070753L (no) | Fremgangsmåte for fremstilling av dihydropteridinoner | |
| DE602006019317D1 (de) | Prozess zur display-herstellung und laminationsverfahren | |
| DE602007013512D1 (de) | Verfahren zur kontinuierlichen Herstellung von Bauteilen | |
| DE502006001614D1 (de) | Verfahren zur herstellung von 1-alkyl-3-phenyluracilen | |
| DE502006008840D1 (de) | Verfahren zur Herstellung von Isocyanaten | |
| NO20076030L (no) | Fremgangsmåte for fremstilling av hydroklorsilaner | |
| DE602005026987D1 (de) | Verfahren zur herstellung von 1,2-dichlorethan | |
| DE602006018429D1 (de) | Verfahren zur herstellung von verschlüssen | |
| DE502006000138D1 (de) | Verfahren zur Herstellung von Triorganosiloxygruppen aufweisenden Organopolysiloxanen | |
| DE602006006237D1 (de) | Verfahren zur Herstellung von keramischen Heizern | |
| EP1916302A4 (de) | Verfahren zur herstellung von lymphozyten | |
| DE502006006498D1 (de) | Verfahren zur Herstellung von Organopolysiloxanen | |
| DE502006000036D1 (de) | Kontinuierliches Verfahren zur Herstellung SiOC-enthaltender Verbindungen | |
| ATE497493T1 (de) | Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungen | |
| DE602006010302D1 (de) | Verfahren zur Herstellung von 5-methyl-2-furfural | |
| DE602006018699D1 (de) | Verfahren zur Herstellung von Fluorhalogenethern | |
| ATE461919T1 (de) | Verfahren zur herstellung von montelukast und zwischenprodukte dafür | |
| EP2202361A4 (de) | Form zur herstellung von beton-cubipods | |
| DE602006001531D1 (de) | Verfahren zur Herstellung von Cyclohexanon-oxim | |
| DE602006009562D1 (de) | Verfahren zur herstellung von ferrisuccinylcasein | |
| EP1914220A4 (de) | Verfahren zur herstellung von 2-hydroxyestern | |
| DE112006000985A5 (de) | Verfahren zur Herstellung von Tetrahydropyranen aus Tetrahydropyran-3-onen | |
| DE502006004187D1 (de) | Verfahren zur herstellung von diorganopolysiloxanen | |
| DE602006018182D1 (de) | Verfahren zur herstellung von aralkyloxypyrrolidinderivaten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |