ATE497534T1 - Tier mit gen-hypoexpression - Google Patents
Tier mit gen-hypoexpressionInfo
- Publication number
- ATE497534T1 ATE497534T1 AT02780744T AT02780744T ATE497534T1 AT E497534 T1 ATE497534 T1 AT E497534T1 AT 02780744 T AT02780744 T AT 02780744T AT 02780744 T AT02780744 T AT 02780744T AT E497534 T1 ATE497534 T1 AT E497534T1
- Authority
- AT
- Austria
- Prior art keywords
- llpl
- screening
- gene
- animals
- prophylactics
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 101710127148 Phospholipase A2 group XV Proteins 0.000 abstract 9
- 102100040865 Phospholipase A2 group XV Human genes 0.000 abstract 6
- 201000010099 disease Diseases 0.000 abstract 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 6
- 238000012216 screening Methods 0.000 abstract 5
- 230000000069 prophylactic effect Effects 0.000 abstract 4
- 229940126585 therapeutic drug Drugs 0.000 abstract 4
- 230000002950 deficient Effects 0.000 abstract 3
- 230000004071 biological effect Effects 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 230000007812 deficiency Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- 102100031415 Hepatic triacylglycerol lipase Human genes 0.000 abstract 1
- 108020002496 Lysophospholipase Proteins 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 210000001671 embryonic stem cell Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001152520 | 2001-05-22 | ||
| JP2001311971 | 2001-10-09 | ||
| PCT/JP2002/004876 WO2002102998A1 (fr) | 2001-05-22 | 2002-05-21 | Animal avec hypoexpression genetique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE497534T1 true ATE497534T1 (de) | 2011-02-15 |
Family
ID=26615513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02780744T ATE497534T1 (de) | 2001-05-22 | 2002-05-21 | Tier mit gen-hypoexpression |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7462757B2 (de) |
| EP (1) | EP1391506B1 (de) |
| AT (1) | ATE497534T1 (de) |
| DE (1) | DE60239099D1 (de) |
| WO (1) | WO2002102998A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003221402A1 (en) * | 2002-03-18 | 2003-09-29 | Takeda Chemical Industries, Ltd. | Llpl gene and novel use of its gene product |
| US7715350B2 (en) | 2003-06-12 | 2010-05-11 | Broadcom Corporation | Classifier for communication device |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6498019B1 (en) | 1997-04-11 | 2002-12-24 | Takeda Chemical Industries, Ltd. | Lecithin-cholesterol acyltransferase protein |
| JP4344408B2 (ja) | 1997-04-11 | 2009-10-14 | 武田薬品工業株式会社 | 新規タンパク質およびそのdna |
| ES2235893T3 (es) | 1999-06-21 | 2005-07-16 | Forbes Medi-Tech Inc. | Derivados aromaticos y heterociclicos de fitosteroles y/o fitostanoles para su utilizacion en el tratamiento o la prevencion de enfermedades cardiovasculares. |
| AU2003221402A1 (en) * | 2002-03-18 | 2003-09-29 | Takeda Chemical Industries, Ltd. | Llpl gene and novel use of its gene product |
-
2002
- 2002-05-21 US US10/478,466 patent/US7462757B2/en not_active Expired - Fee Related
- 2002-05-21 DE DE60239099T patent/DE60239099D1/de not_active Expired - Lifetime
- 2002-05-21 AT AT02780744T patent/ATE497534T1/de not_active IP Right Cessation
- 2002-05-21 EP EP02780744A patent/EP1391506B1/de not_active Expired - Lifetime
- 2002-05-21 WO PCT/JP2002/004876 patent/WO2002102998A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1391506A4 (de) | 2005-03-09 |
| US20040143862A1 (en) | 2004-07-22 |
| EP1391506B1 (de) | 2011-02-02 |
| WO2002102998A1 (fr) | 2002-12-27 |
| DE60239099D1 (de) | 2011-03-17 |
| EP1391506A1 (de) | 2004-02-25 |
| US7462757B2 (en) | 2008-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |