ATE497603T1 - Drei-hybrid-assaysystem - Google Patents
Drei-hybrid-assaysystemInfo
- Publication number
- ATE497603T1 ATE497603T1 AT02723332T AT02723332T ATE497603T1 AT E497603 T1 ATE497603 T1 AT E497603T1 AT 02723332 T AT02723332 T AT 02723332T AT 02723332 T AT02723332 T AT 02723332T AT E497603 T1 ATE497603 T1 AT E497603T1
- Authority
- AT
- Austria
- Prior art keywords
- assay system
- hybrid assay
- ligand
- user
- isolating
- Prior art date
Links
- 238000003161 three-hybrid assay Methods 0.000 title 1
- 239000003446 ligand Substances 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27293201P | 2001-03-02 | 2001-03-02 | |
| US27823301P | 2001-03-23 | 2001-03-23 | |
| US32943701P | 2001-10-15 | 2001-10-15 | |
| PCT/US2002/006677 WO2002070662A2 (en) | 2001-03-02 | 2002-03-04 | Three hybrid assay system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE497603T1 true ATE497603T1 (de) | 2011-02-15 |
Family
ID=27402511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02723332T ATE497603T1 (de) | 2001-03-02 | 2002-03-04 | Drei-hybrid-assaysystem |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20030165873A1 (de) |
| EP (2) | EP1975620A3 (de) |
| JP (1) | JP4343534B2 (de) |
| AT (1) | ATE497603T1 (de) |
| CA (1) | CA2439263C (de) |
| DE (1) | DE60239097D1 (de) |
| ES (1) | ES2360205T3 (de) |
| WO (1) | WO2002070662A2 (de) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0101686D0 (en) * | 2001-01-23 | 2001-03-07 | Cancer Res Campaign Tech | Cyclin dependent kinase inhibitors |
| US7605175B2 (en) | 2001-03-02 | 2009-10-20 | Gpc Biotech Ag | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
| US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
| EP2363396A1 (de) * | 2001-06-11 | 2011-09-07 | Virochem Pharma Inc. | Thiophenderivate als antivirale Mittel gegen Flavivirus-Infektion |
| EP1404670A4 (de) * | 2001-07-06 | 2004-11-24 | Bristol Myers Squibb Pharma Co | Semicarbazide und deren verwendungen |
| US7446106B2 (en) * | 2001-09-05 | 2008-11-04 | Smithkline Beecham Plc | Pyridylfurans and pyrroles as Raf kinase inhibitors |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| IL166241A0 (en) * | 2002-07-29 | 2006-01-15 | Rigel Pharmaceuticals Inc | Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds |
| US7230101B1 (en) * | 2002-08-28 | 2007-06-12 | Gpc Biotech, Inc. | Synthesis of methotrexate-containing heterodimeric molecules |
| DE60332482D1 (de) | 2002-12-10 | 2010-06-17 | Virochem Pharma Inc | Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen |
| US7098332B2 (en) * | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) * | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| KR20050108383A (ko) * | 2003-03-11 | 2005-11-16 | 노파르티스 아게 | 이소퀴놀린 유도체의 암 및 ｍａｐ 키나제 관련 질병의치료를 위한 용도 |
| SG173222A1 (en) * | 2003-04-07 | 2011-08-29 | Agennix Usa Inc | Aminoindeno[1,2-c]pyrazol-4-ones as inhibitors of cyclin-dependent kinases, useful for the treatment of alopecia, viral infections and hyperproliferative disorders, a pharmaceutical composition and uses related thereto |
| CA2531327A1 (en) * | 2003-07-03 | 2005-01-13 | Myriad Genetics, Inc. | Compounds and therapeutical use thereof |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| CA2532067C (en) * | 2003-07-24 | 2010-12-21 | Stephen Douglas Barrett | N-methyle-substituted benzamidazoles |
| ES2421139T3 (es) * | 2003-07-30 | 2013-08-29 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias |
| WO2005030151A2 (en) * | 2003-10-02 | 2005-04-07 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| MXPA06007399A (es) | 2003-12-23 | 2007-01-26 | Gpc Biotech Inc | Inhibidores de quinasas dependientes de ciclina, composiciones y usos relacionados con ellos. |
| WO2005067644A2 (en) * | 2004-01-07 | 2005-07-28 | Ambit Biosciences Corporation | Conjugated small molecules |
| WO2005070891A2 (en) * | 2004-01-23 | 2005-08-04 | Amgen Inc | Compounds and methods of use |
| US7626030B2 (en) | 2004-01-23 | 2009-12-01 | Amgen Inc. | Compounds and methods of use |
| ES2364340T3 (es) | 2004-03-30 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | Azaindoles útiles como inhibidores de jak y otras proteína quinasas. |
| AU2005231440B9 (en) * | 2004-04-02 | 2012-02-23 | Dogwood Pharmaceuticals, Inc. | Selective antagonists of A2A adenosine receptors |
| EP1751136B1 (de) * | 2004-05-07 | 2014-07-02 | Amgen Inc. | Nitrogenierte heterozyklische derivate als proteinkinasemodulatoren und deren verwendung zur behandlung von angiogenese und krebs |
| WO2005118551A2 (en) * | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
| DE602005024599D1 (de) * | 2004-10-25 | 2010-12-16 | Ligand Pharm Inc | Verbindungen modulierende thrombopoietinaktivität und verfahren |
| ATE540035T1 (de) | 2004-11-24 | 2012-01-15 | Rigel Pharmaceuticals Inc | Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
| MX2007006230A (es) * | 2004-11-30 | 2007-07-25 | Amgen Inc | Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer. |
| CA2592118C (en) | 2004-12-23 | 2015-11-17 | Deciphera Pharmaceuticals, Llc | Urea derivatives as enzyme modulators |
| CA2592116A1 (en) * | 2004-12-23 | 2006-08-03 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| JP2008540436A (ja) * | 2005-05-03 | 2008-11-20 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｊａｋキナーゼインヒビターおよびそれらの使用 |
| CN102295636A (zh) * | 2005-07-29 | 2011-12-28 | 弗·哈夫曼-拉罗切有限公司 | 吲哚-3-基-羰基-哌啶和哌嗪衍生物 |
| WO2007042771A1 (en) * | 2005-10-10 | 2007-04-19 | Astrazeneca Ab | Three hybrid screening assay using reverse transfected mammalian cell arrays |
| JP2009001496A (ja) * | 2005-10-13 | 2009-01-08 | Taisho Pharmaceutical Co Ltd | ２−チエニルウレア誘導体 |
| US20070231906A1 (en) * | 2005-10-25 | 2007-10-04 | Invitrogen Corporation | Three Frame cDNA Expression Libraries for Functional Screening of Proteins |
| NZ592968A (en) | 2006-01-17 | 2012-08-31 | Vertex Pharma | Azaindoles substituted with either triazine or pyrimidine useful as inhibitors of janus kinases consisting of JAK1, JAK2, JAK3, and TYK2 |
| WO2007098130A2 (en) * | 2006-02-16 | 2007-08-30 | The Regents Of The University Of California | Novel pooling and deconvolution strategy for large scale screening |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| US20100273776A1 (en) * | 2006-03-29 | 2010-10-28 | FOLDRx PHARMACEUTICALS, INC | Inhibition of alpha-synuclein toxicity |
| US7709253B2 (en) * | 2006-08-04 | 2010-05-04 | The Board Of Trustees Of The Leland Stanford Junior University | Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists |
| US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| WO2008057280A1 (en) * | 2006-10-27 | 2008-05-15 | Amgen Inc. | Multi-cyclic compounds and methods of use |
| SG176488A1 (en) | 2006-11-15 | 2011-12-29 | Virochem Pharma Inc | Thiophene analogues for the treatment or prevention of flavivirus infections |
| US20100093061A1 (en) * | 2006-12-20 | 2010-04-15 | Bodie Elizabeth A | Assays for Improved Fungal Strains |
| WO2008079346A1 (en) | 2006-12-21 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| US20110189167A1 (en) * | 2007-04-20 | 2011-08-04 | Flynn Daniel L | Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases |
| WO2008140895A1 (en) * | 2007-04-20 | 2008-11-20 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| WO2009022171A1 (en) * | 2007-08-13 | 2009-02-19 | Astrazeneca Ab | Pyridinyiioxy pyridines as alk5 inhibitors |
| CA2736177A1 (en) | 2007-09-06 | 2009-03-12 | Boston Biomedical, Inc. | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
| TW200922566A (en) | 2007-09-14 | 2009-06-01 | Ortho Mcneil Janssen Pharm | 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
| EA017648B1 (ru) | 2007-09-14 | 2013-02-28 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | 1',3'-двузамещенные-4-фенил-3,4,5,6-тетрагидро-2н,1'н-[1,4']бипириди-нил-2'-оны |
| BRPI0816970A2 (pt) | 2007-09-14 | 2015-03-24 | Ortho Mcneil Janssen Pharm | 1,3-dissubstituídas-4-fenil-1h-piridin-2-onas |
| MX2010005033A (es) * | 2007-11-06 | 2010-05-27 | Du Pont | Aminas heterociclicas fungicidas. |
| CA2704436C (en) | 2007-11-14 | 2016-01-05 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体 |
| WO2010043396A1 (en) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| AU2009305669A1 (en) * | 2008-10-16 | 2010-04-22 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
| CA2742007C (en) * | 2008-10-29 | 2014-07-08 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| CN102264743B (zh) | 2008-11-25 | 2015-02-11 | 罗彻斯特大学 | Mlk抑制剂及其使用方法 |
| JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
| TW201036614A (en) * | 2008-12-30 | 2010-10-16 | Arqule Inc | Substituted 1H-pyrazolo[3,4-d]pyrimidine-6-amine compounds |
| CZ302122B6 (cs) * | 2009-01-28 | 2010-10-20 | Univerzita Palackého v Olomouci | Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující |
| EP2414361A1 (de) * | 2009-03-31 | 2012-02-08 | ArQule, Inc. | Substituierte heterocyclische verbindungen |
| CN102439015B (zh) | 2009-05-12 | 2015-05-13 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| HRP20131122T1 (hr) | 2009-05-12 | 2013-12-20 | Janssen Pharmaceuticals, Inc. | Derivati 1,2,4-triazolo[4,3-a] piridina i njihova uporaba u lijeäśenju ili prevenciji neuroloških i psihijatrijskih poremeä†aja |
| GEP20207129B (en) | 2009-06-17 | 2020-07-10 | Vertex Pharma | Inhibitors of influenza viruses replication |
| JP4879314B2 (ja) * | 2009-12-07 | 2012-02-22 | 独立行政法人農業生物資源研究所 | ユビキチン依存型タンパク質分解系を利用した生体内タンパク質分解システム，及びそのシステムを利用したタンパク質の機能解明方法 |
| EP2576549A4 (de) | 2010-05-24 | 2013-12-18 | Univ Rochester | Bizyklische heteroarylkinase-hemmer und verfahren zu ihrer verwendung |
| JP5852664B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| EP2661435B1 (de) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazol[4,3-a]pyridinderivate und ihre verwendung als positive allosterische mglur2-rezeptormodulatoren |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| CN103748270B (zh) * | 2011-03-24 | 2018-04-24 | 欧科制药有限责任公司 | 使用基于珠或颗粒的文库以及诊断试剂盒和治疗学在复杂生物液体中的生物标记发现 |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| WO2013077921A2 (en) | 2011-09-02 | 2013-05-30 | The Regents Of The University Of California | Substituted pyrazolo[3,4-d]pyrimidines and uses thereof |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| CA2886240A1 (en) | 2012-09-26 | 2014-04-03 | The Regents Of The University Of California | Modulation of ire1 |
| RU2529356C2 (ru) * | 2012-09-27 | 2014-09-27 | Федеральное государственное бюджетное учреждение науки Институт биологии гена Российской академии наук | Модифицированная дрожжевая двугибридная система для эффективного исследования взаимодействия между белками и их доменами. |
| PH12015501130B1 (en) | 2012-11-21 | 2023-01-27 | Ptc Therapeutics Inc | Substituted reverse pyrimidine bmi-1 inhibitors |
| US10485800B2 (en) | 2012-11-30 | 2019-11-26 | The University Of Rochester | Mixed lineage kinase inhibitors for HIV/AIDS therapies |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| MX370588B (es) | 2013-08-30 | 2019-12-16 | Ptc Therapeutics Inc | Inhibidores de la bmi-1 de pirimidina sustituida. |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| HUE038820T2 (hu) | 2013-11-13 | 2018-11-28 | Vertex Pharma | Eljárás influenzavírusok replikációjának inhibitorai elõállítására |
| PT3068776T (pt) | 2013-11-13 | 2019-08-26 | Vertex Pharma | Inibidores da replicação de vírus da gripe |
| US10584115B2 (en) | 2013-11-21 | 2020-03-10 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine BMI-1 inhibitors |
| PL3096790T3 (pl) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie |
| ME03518B (de) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinationen mit positiven allosterischen modulatoren von metabotropem glutamatergen rezeptor vom subtyp 2 und deren verwendung |
| EP3247692B1 (de) * | 2015-01-23 | 2022-09-07 | GVK Biosciences Private Limited | Inhibitoren der trka-kinase |
| EP3294717B1 (de) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Verfahren zur herstellung von inhibitoren der influenzavirenreplikation |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| JP6542375B2 (ja) * | 2015-09-10 | 2019-07-10 | 株式会社東芝 | 分子検出装置、分子検出方法、および有機物プローブ |
| WO2018085208A1 (en) | 2016-11-02 | 2018-05-11 | The Research Foundation For The State University Of New York | Methods of inhibiting viruses using compositions targeting tsg101-ubiquitin interaction |
| CN108191857B (zh) * | 2017-01-24 | 2020-10-23 | 晟科药业（江苏）有限公司 | 6-取代的吡啶并[2,3-d]嘧啶类化合物作为蛋白激酶抑制剂 |
| CN118903436A (zh) | 2018-01-31 | 2024-11-08 | 德西费拉制药有限责任公司 | 治疗肥大细胞增多症的组合疗法 |
| KR102708177B1 (ko) | 2018-01-31 | 2024-09-23 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양의 치료를 위한 병용 요법 |
| JP2021535198A (ja) | 2018-08-17 | 2021-12-16 | ピーティーシー セラピューティクス， インコーポレイテッド | 膵臓癌を治療する方法 |
| CN111285872B (zh) * | 2018-12-06 | 2022-05-17 | 北京志健金瑞生物医药科技有限公司 | 吲哚-2-酮衍生物及其制备方法与用途 |
| KR20210125476A (ko) * | 2018-12-07 | 2021-10-18 | 옥탄트, 인크. | 단백질-단백질 상호작용 스크리닝을 위한 시스템 |
| IL330104A (en) | 2019-03-11 | 2026-08-01 | Deciphera Pharmaceuticals Llc | Crystalline forms of rifatinib |
| EP3986389A4 (de) * | 2019-06-24 | 2023-10-11 | Diverse Biotech, Inc. | Cannabinoid-konjugatmoleküle |
| HRP20260411T1 (hr) | 2019-08-12 | 2026-05-08 | Deciphera Pharmaceuticals, Llc | Ripretinib za liječenje gastrointestinalnih stromalnih tumora |
| US12691108B2 (en) | 2019-08-12 | 2026-07-28 | Deciphera Pharmaceuticals, Llc | Methods for treating vascular malformations |
| CN112759589B (zh) * | 2019-11-01 | 2022-04-08 | 暨南大学 | 嘧啶并吡啶酮类化合物及其应用 |
| FI4084779T3 (fi) | 2019-12-30 | 2024-12-16 | Deciphera Pharmaceuticals Llc | 1-(4-bromi-5-(1-etyyli-7-(metyyliamino)-2-okso-1,2-dihydro-1,6-naftyridin-3-yyli)-2-fluorifenyyli)-3-fenyyliurean koostumuksia |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5525465A (en) * | 1987-10-28 | 1996-06-11 | Howard Florey Institute Of Experimental Physiology And Medicine | Oligonucleotide-polyamide conjugates and methods of production and applications of the same |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| EP0411060A4 (en) | 1988-09-06 | 1991-04-03 | Asarco Incorporated | Method and burner for melting copper |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| CA2040896C (en) * | 1990-04-20 | 2002-01-29 | Edwin F. Ullman | Double receptor polynucleotide assay method |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5677440A (en) * | 1990-07-16 | 1997-10-14 | Howard Florey Institute Of Experimental Physiology And Medicine | Oligonucleotide-polyamide conjugates |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| US5292646A (en) | 1991-02-06 | 1994-03-08 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
| US5270181A (en) | 1991-02-06 | 1993-12-14 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
| DE69233697T2 (de) | 1991-03-01 | 2008-01-24 | Dyax Corp., Cambridge | Verfahren zur Entwicklung von bindenden Mikroproteinen |
| PT100379B (pt) | 1991-04-10 | 1999-01-29 | Scripps Research Inst | Bibliotecas de receptores heterodimericos usando fagomideos |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US6172208B1 (en) * | 1992-07-06 | 2001-01-09 | Genzyme Corporation | Oligonucleotides modified with conjugate groups |
| US5691196A (en) * | 1992-12-31 | 1997-11-25 | American Cyanamid Company | Recombinant nucleic acid containing a response element |
| US5869337A (en) * | 1993-02-12 | 1999-02-09 | President And Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| US6140120A (en) * | 1993-02-12 | 2000-10-31 | Board Of Trustees Of Leland Stanford Jr. University | Regulated transcription of targeted genes and other biological events |
| US20020173474A1 (en) * | 1993-02-12 | 2002-11-21 | President And Fellows Of Harvard College | Methods & materials involving dimerization-mediated regulation of biological events |
| US6891021B2 (en) * | 1993-02-12 | 2005-05-10 | Board Of Trustees Of The Leland Stanford Junior University | Regulated apoptosis |
| US5834266A (en) * | 1993-02-12 | 1998-11-10 | President & Fellows Of Harvard College | Regulated apoptosis |
| HUT73101A (en) | 1993-02-12 | 1996-06-28 | Harvard College | Method for regulating transcription of targeted genes and other biological events |
| US5830462A (en) * | 1993-02-12 | 1998-11-03 | President & Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| CA2158274C (en) | 1993-03-31 | 2000-05-30 | Dana Merriman Fowlkes | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor |
| US5480971A (en) | 1993-06-17 | 1996-01-02 | Houghten Pharmaceuticals, Inc. | Peralkylated oligopeptide mixtures |
| US5440016A (en) | 1993-06-18 | 1995-08-08 | Torrey Pines Institute For Molecular Studies | Peptides of the formula (KFmoc) ZZZ and their uses |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5521066A (en) | 1993-09-13 | 1996-05-28 | Bristol-Myers Squibb Company | Periplasmic membrane-bound system for detecting protein-protein interactions |
| US5585245A (en) | 1994-04-22 | 1996-12-17 | California Institute Of Technology | Ubiquitin-based split protein sensor |
| US5503977A (en) | 1994-04-22 | 1996-04-02 | California Institute Of Technology | Split ubiquitin protein sensor |
| EP0758392A1 (de) | 1994-04-26 | 1997-02-19 | Cadus Pharmaceutical Corporation | Die expression von funktionaler, menschlicher adenylyl-cyclase in hefe |
| ES2210306T3 (es) | 1994-07-20 | 2004-07-01 | The General Hospital Corporation | Sistemas de trampa para interacciones, para detectar interacciones de proteinas. |
| US6133456A (en) * | 1994-08-18 | 2000-10-17 | Ariad Gene Therapeutics, Inc. | Synthetic multimerizing agents |
| US6150527A (en) * | 1994-08-18 | 2000-11-21 | Ariad Pharmaceuticals, Inc. | Synthetic multimerizing agents |
| ES2245781T3 (es) | 1994-08-18 | 2006-01-16 | Ariad Gene Therapeutics, Inc. | Nuevos agentes de multimerizacion. |
| EP0787207B1 (de) | 1994-11-01 | 2005-10-26 | Ariad Gene Therapeutics, Inc. | Neue methode zum auffindenund bewerten biologisch aktiver moleküle |
| US6326155B1 (en) * | 1995-03-20 | 2001-12-04 | Dyax Corp. | Engineering affinity ligands for macromolecules |
| EP0830459B1 (de) * | 1995-04-11 | 2007-01-24 | The General Hospital Corporation | Reverse "two-hybrid"-systeme |
| EP0937098B1 (de) | 1995-06-07 | 2002-08-14 | Invitrogen Corporation | Rekombinatorische klonierung in vitro unter verwendung genmanipulierter rekombinationsorte |
| SE9504046D0 (sv) * | 1995-11-14 | 1995-11-14 | Pharmacia Ab | Method of determining affinity and kinetic properties |
| US5672508A (en) * | 1996-01-23 | 1997-09-30 | Mitotix, Inc. | Inhibitors of cell-cycle progression, and uses related thereto |
| CA2252886C (en) * | 1996-04-26 | 2008-02-12 | Massachusetts Institute Of Technology | Three-hybrid screening assay |
| US5955275A (en) | 1997-02-14 | 1999-09-21 | Arcaris, Inc. | Methods for identifying nucleic acid sequences encoding agents that affect cellular phenotypes |
| AU4159697A (en) | 1996-08-23 | 1998-03-06 | President And Fellows Of Harvard College | Interaction trap assay, reagents and uses thereof |
| US5846722A (en) | 1996-10-16 | 1998-12-08 | Terrapin Technologies, Inc. | System to detect small molecule/peptide interaction |
| DE19642751A1 (de) | 1996-10-16 | 1998-04-23 | Deutsches Krebsforsch | Saccharid-Bibliothek |
| ATE289353T1 (de) | 1996-12-11 | 2005-03-15 | Bristol Myers Squibb Co | Prokaryotisches zwei-hybrid system |
| CA2196496A1 (en) * | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| JP2003524368A (ja) * | 1997-08-26 | 2003-08-19 | アリアド ジーン セラピューティクス インコーポレイテッド | ニ量化ドメイン、三量化ドメインまたは四量化ドメインおよび補足的非相同転写活性化ドメイン、転写抑制ドメイン、ｄｎａ結合ドメインまたはリガンド結合ドメインを含む融合蛋白 |
| US6479653B1 (en) * | 1997-08-26 | 2002-11-12 | Ariad Gene Therapeutics, Inc. | Compositions and method for regulation of transcription |
| US6015709A (en) * | 1997-08-26 | 2000-01-18 | Ariad Pharmaceuticals, Inc. | Transcriptional activators, and compositions and uses related thereto |
| GB2338711B (en) | 1997-11-27 | 2000-11-15 | Max Planck Gesellschaft | Identification and characterization of interacting molecules |
| JP2002503667A (ja) | 1998-02-13 | 2002-02-05 | プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | 新規な二量体化剤、その製造および使用 |
| GB9814527D0 (en) * | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| WO2000007018A2 (en) * | 1998-07-28 | 2000-02-10 | Curagen Corporation | Three-hybrid screening method for ligand-protein interactions |
| JP2002522031A (ja) | 1998-07-28 | 2002-07-23 | フラームス・インテルウニフェルシタイル・インスティチュート・フォール・ビオテヒノロヒー | 真核細胞ベースの遺伝子相互作用クローニング |
| EP1254179A4 (de) | 2000-01-24 | 2005-06-01 | Univ Columbia | In vivo screen unter verwendung von chemischen induktoren |
| DE60112282T2 (de) | 2000-05-22 | 2006-04-20 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Auf rezeptorgrundlage arbeitende screening-verfahren für protein wechselwirkungen |
| WO2002012902A2 (en) | 2000-08-04 | 2002-02-14 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Split-ubiquitin based reporter systems and methods of their use |
| US20020168737A1 (en) | 2001-01-24 | 2002-11-14 | Cornish Virginia W. | Binding and catalysis screen for high throughput determination of protein function using chemical inducers of dimerization |
| WO2003033499A2 (en) * | 2001-10-15 | 2003-04-24 | Gpc Biotech Inc. | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
-
2002
- 2002-03-04 AT AT02723332T patent/ATE497603T1/de active
- 2002-03-04 WO PCT/US2002/006677 patent/WO2002070662A2/en not_active Ceased
- 2002-03-04 JP JP2002570690A patent/JP4343534B2/ja not_active Expired - Fee Related
- 2002-03-04 DE DE60239097T patent/DE60239097D1/de not_active Expired - Lifetime
- 2002-03-04 US US10/091,177 patent/US20030165873A1/en not_active Abandoned
- 2002-03-04 ES ES02723332T patent/ES2360205T3/es not_active Expired - Lifetime
- 2002-03-04 EP EP08103127A patent/EP1975620A3/de not_active Withdrawn
- 2002-03-04 EP EP02723332A patent/EP1364212B1/de not_active Expired - Lifetime
- 2002-03-04 CA CA2439263A patent/CA2439263C/en not_active Expired - Lifetime
- 2002-09-03 US US10/234,985 patent/US7135550B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7135550B2 (en) | 2006-11-14 |
| US20030165873A1 (en) | 2003-09-04 |
| EP1364212A2 (de) | 2003-11-26 |
| WO2002070662A3 (en) | 2002-12-27 |
| JP2005516580A (ja) | 2005-06-09 |
| EP1364212A4 (de) | 2005-05-04 |
| EP1364212B1 (de) | 2011-02-02 |
| US20040043388A1 (en) | 2004-03-04 |
| JP4343534B2 (ja) | 2009-10-14 |
| DE60239097D1 (de) | 2011-03-17 |
| CA2439263C (en) | 2012-10-23 |
| EP1975620A2 (de) | 2008-10-01 |
| CA2439263A1 (en) | 2002-09-12 |
| EP1975620A3 (de) | 2008-12-24 |
| WO2002070662A2 (en) | 2002-09-12 |
| ES2360205T3 (es) | 2011-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60239097D1 (de) | Drei-hybrid-assaysystem | |
| CY1116863T1 (el) | Πρωτεϊνη δεσμευσης υποδοχεα nogo | |
| EA200700210A1 (ru) | ВАРИАНТЫ ОБЛАСТИ Fc | |
| DK1709081T3 (da) | Fusionspolypeptider, der kan aktivere receptorer | |
| WO2004081026A3 (en) | Polypeptides | |
| CY1114164T1 (el) | Μεθοδος ελεγχου της δραστικοτητας ανοσολογικα λειτουργικου μοριου | |
| PT1015586E (pt) | Homologos de ligandos do receptor tirosina-quinase tie | |
| PT2298347E (pt) | Proteínas quiméricas de fator de coagulação para o tratamento de um disturbio hemostático | |
| MX2007006830A (es) | Porciones de la familia del polipeptido pancreatico, polipeptidos y metodos que comprenden las mismas. | |
| WO2004009834A3 (en) | Novel nucleic acids and secreted polypeptides | |
| WO2003007689A3 (en) | Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids | |
| WO2004087874A3 (en) | Novel nucleic acids and polypeptides | |
| WO2002057792A3 (en) | Affinity selection-based screening of hydrophobic proteins | |
| DE502004004808D1 (de) | Proteinbindende derivate von platinkomplexen mit cyclobutan-1,1-dicarboxylatliganden | |
| WO2002056236A3 (en) | Classification of polypeptides by ligand geometry and related methods | |
| DK1368483T3 (da) | Fremgangsmåde til fremstilling af polypeptider | |
| SE9002213D0 (sv) | Albumin binding proteins | |
| WO2000073345A3 (en) | Antibodies specific for mycobacterial polypeptides and uses thereof | |
| WO2004066917A3 (en) | Tandem analyses of noncovalently driven effectors for modulatory mapping of activities of protein sites | |
| CY1117092T1 (el) | Μοτιβα της οικογενειας παγκρεατικων πολυπεπτιδιων, πολυπεπτιδια και μεθοδοι που τα περιλαμβανουν | |
| DE60238243D1 (de) | Polypeptide, abgeleitet von der amyloid vorläuferprotein (app), und ihre verwendungen | |
| ES1045245U (es) | Dispositivo de union de perfiles. | |
| WO2004054907A3 (en) | Ftsz-polypeptides as a target for herbicidal compounds | |
| ATE408816T1 (de) | Verfahren zur bestimmung sekundärer molekülmodifikationen unter verwendung von arrays |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification |
Ref document number: 1364212 Country of ref document: EP |