ATE499114T1 - Stabilisierte wässrige erythropoietinhaltige arzneizusammensetzungen - Google Patents

Stabilisierte wässrige erythropoietinhaltige arzneizusammensetzungen

Info

Publication number: ATE499114T1
Authority: AT; Austria
Prior art keywords: erythropoiety; compositions containing; medicinal compositions; stabilized aqueous; aqueous medicinal
Prior art date: 2002-07-17

Application number

AT03764286T

Other languages

English (en)

Inventor

Andreja Vukmirovic

Tanja Rozman

Jelka Svetek

Alenka Paris

Original Assignee

Lek Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-17

Filing date

2003-07-14

Publication date

2011-03-15

2003-07-14 Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals

2011-03-15 Application granted granted Critical

2011-03-15 Publication of ATE499114T1 publication Critical patent/ATE499114T1/de

Links

239000000203 mixture Substances 0.000 title 1
102000003951 Erythropoietin Human genes 0.000 abstract 2
108090000394 Erythropoietin Proteins 0.000 abstract 2
229940105423 erythropoietin Drugs 0.000 abstract 2
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical group [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229960000502 poloxamer Drugs 0.000 abstract 1
229920001983 poloxamer Polymers 0.000 abstract 1
-1 poloxamer polyol Chemical class 0.000 abstract 1
229920005862 polyol Polymers 0.000 abstract 1
150000005846 sugar alcohols Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Hematology (AREA)
Inorganic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT03764286T 2002-07-17 2003-07-14 Stabilisierte wässrige erythropoietinhaltige arzneizusammensetzungen ATE499114T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SI200200178A SI21258A (sl)	2002-07-17	2002-07-17	Stabilni farmacevtski pripravek, ki vsebuje eritropoietin in poloksamerni poliol
PCT/SI2003/000023 WO2004006958A1 (en)	2002-07-17	2003-07-14	Stable pharmaceutical composition comprising erythropoietin

Publications (1)

Publication Number	Publication Date
ATE499114T1 true ATE499114T1 (de)	2011-03-15

Family

ID=30113492

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03764286T ATE499114T1 (de)	2002-07-17	2003-07-14	Stabilisierte wässrige erythropoietinhaltige arzneizusammensetzungen

Country Status (11)

Country	Link
US (1)	US7534870B2 (de)
EP (1)	EP1524998B1 (de)
JP (1)	JP2005535673A (de)
CN (1)	CN1668333A (de)
AT (1)	ATE499114T1 (de)
AU (1)	AU2003251284B2 (de)
CA (1)	CA2492485A1 (de)
DE (1)	DE60336142D1 (de)
MX (1)	MXPA05000662A (de)
SI (1)	SI21258A (de)
WO (1)	WO2004006958A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1641486B1 (de) *	2003-06-10	2012-04-18	LG Life Sciences Ltd.	Stabile wässrige lösung von human-erythropoietin, die kein serumalbumin enthält
CN100342909C (zh) *	2005-05-11	2007-10-17	北京双鹭药业股份有限公司	一种胸腺素α1的水溶液制剂、其制备方法及应用
JP5553506B2 (ja) *	2006-03-22	2014-07-16	中外製薬株式会社	エリスロポエチン溶液製剤
JP2011116752A (ja) *	2009-10-29	2011-06-16	Jcr Pharmaceuticals Co Ltd	エリスロポエチン含有水性液剤
BR112012017982A2 (pt) *	2010-01-19	2016-05-03	Hanmi Science Co Ltd	formulações líquidas para conjugado de eritropoietina de longa ação
CN105431378A (zh) *	2014-06-25	2016-03-23	生物辐射实验室股份有限公司	纳米粒子-抗体偶联物的纯化

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6191131A (ja)	1984-10-09	1986-05-09	Chugai Pharmaceut Co Ltd	医薬品の吸着防止方法および組成物
GB8822857D0 (en)	1988-09-29	1988-11-02	Patralan Ltd	Pharmaceutical formulations
EP0803255A4 (de)	1994-06-03	1999-06-30	Tsumura & Co	Arzneimittel
US6284234B1 (en) *	1998-08-04	2001-09-04	Johnson & Johnson Consumer Companies, Inc.	Topical delivery systems for active agents
US7163671B2 (en) *	2000-02-29	2007-01-16	Chugai Seiyaku Kabushiki Kaisha	Long-term stabilized formulations
ME00673B (me) *	2000-05-15	2011-12-20	Hoffmann La Roche	Nova farmaceutska smjesa
BR0111948A (pt) *	2000-06-26	2004-08-24	Rxkinetix Inc	Composição para entrega de fator de crescimento hematopoiético

2002
- 2002-07-17 SI SI200200178A patent/SI21258A/sl not_active IP Right Cessation
2003
- 2003-07-14 WO PCT/SI2003/000023 patent/WO2004006958A1/en not_active Ceased
- 2003-07-14 CN CNA038170078A patent/CN1668333A/zh active Pending
- 2003-07-14 DE DE60336142T patent/DE60336142D1/de not_active Expired - Lifetime
- 2003-07-14 MX MXPA05000662A patent/MXPA05000662A/es active IP Right Grant
- 2003-07-14 AU AU2003251284A patent/AU2003251284B2/en not_active Ceased
- 2003-07-14 US US10/521,298 patent/US7534870B2/en not_active Expired - Fee Related
- 2003-07-14 EP EP03764286A patent/EP1524998B1/de not_active Expired - Lifetime
- 2003-07-14 JP JP2004521371A patent/JP2005535673A/ja active Pending
- 2003-07-14 CA CA002492485A patent/CA2492485A1/en not_active Abandoned
- 2003-07-14 AT AT03764286T patent/ATE499114T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
US7534870B2 (en)	2009-05-19
JP2005535673A (ja)	2005-11-24
AU2003251284B9 (en)	2004-02-02
WO2004006958A1 (en)	2004-01-22
CA2492485A1 (en)	2004-01-22
DE60336142D1 (de)	2011-04-07
EP1524998A1 (de)	2005-04-27
WO2004006958A8 (en)	2005-01-13
AU2003251284B2 (en)	2007-08-02
US20050202091A1 (en)	2005-09-15
EP1524998B1 (de)	2011-02-23
SI21258A (sl)	2004-02-29
MXPA05000662A (es)	2005-08-19
CN1668333A (zh)	2005-09-14
AU2003251284A1 (en)	2004-02-02

Legal Events

Date	Code	Title	Description
2011-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DK1086706T3 (da)	2004-03-08	Stabiliserede sammensætninger indeholdende nootropiske lægemidler
UY27320A1 (es)	2003-02-28	Nuevas composiciones farmacéuticas
CR8824A (es)	2007-08-28	Derivados de 2-carbamida-4-feniltiazol, su preparacion y su aplicacion en terapeutica
BR0307541A (pt)	2004-12-07	Composição para cuidado pessoal e composição cosmética
HN2002000300A (es)	2003-10-17	Nuevos derivados de piperazina
ID26033A (id)	2000-11-16	Metode penstabilan komposisi bahan farmasi dengan penggunaan khusus dari antioksidan
UY26716A1 (es)	2001-12-28	Emulsiones estables para productos cosméticos.
ATE486587T1 (de)	2010-11-15	Formulierungen zur oralen verabreichung von wirkstoffen
BR0109943A (pt)	2003-05-27	Composições farmacêuticas
DE60114171D1 (de)	2006-03-02	Minoxidil enthaltende zubereitung
BR0212386A (pt)	2004-07-27	Composto, formulação farmacêutica, e, uso de um composto
ATE331497T1 (de)	2006-07-15	Zweiphasen kosmetische zusammensetzung
BR0209283A (pt)	2004-07-13	Método para a fabricação de uma composição farmacêutica de baixa dosagem tendo distribuição e potência de droga uniforme
EE200300476A (et)	2003-12-15	4-tsüanotrifluoro-3-(4-fluorofenüülsulfonüül)-2-hüdroksü-2-metüülpropiono-m-toluidii di ja PVP-d sisaldav tahke farmatseutiline kompositsioon
BR0111678A (pt)	2003-06-03	Composições medicinais contendo derivados de propenona
ATE499114T1 (de)	2011-03-15	Stabilisierte wässrige erythropoietinhaltige arzneizusammensetzungen
CO5580729A2 (es)	2005-11-30	Composiciones nutricionales que comprenden cistationina
TW200517117A (en)	2005-06-01	Stabilized compositions containing an oxygen-labile active agent
ATE318575T1 (de)	2006-03-15	Orale zubereitung chlorhexidin und maltitol oder erythritol oder deren mischung enthaltend
HN2003000115A (es)	2004-04-20	Formulacion farmaceutica que comprende melatonina
DE602004015794D1 (de)	2008-09-25	Metalloxid-formulierungen
BR0206960A (pt)	2004-03-09	Composição farmacêutica oral, e, uso de um polìmero de ftalato de hidroxipropilmetilcelulose
MXPA05000661A (es)	2005-08-19	Composicion farmaceutica estable que comprende eritropoyetina.
BR0206922A (pt)	2004-02-03	Compostos orgânicos
PT1250125E (pt)	2004-04-30	Composicoes farmaceuticas contendo terbinafina