ATE499378T1 - Anthracyclinderivate - Google Patents

Anthracyclinderivate

Info

Publication number
ATE499378T1
ATE499378T1 AT05733719T AT05733719T ATE499378T1 AT E499378 T1 ATE499378 T1 AT E499378T1 AT 05733719 T AT05733719 T AT 05733719T AT 05733719 T AT05733719 T AT 05733719T AT E499378 T1 ATE499378 T1 AT E499378T1
Authority
AT
Austria
Prior art keywords
diagnosis
anthracycline derivatives
radiolabelled
derivatives
delivery system
Prior art date
Application number
AT05733719T
Other languages
English (en)
Inventor
Katarin Edwards
Stefan Sjoeberg
Joergen Carlsson
Lars Gedda
Original Assignee
Nuclisome Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuclisome Ab filed Critical Nuclisome Ab
Application granted granted Critical
Publication of ATE499378T1 publication Critical patent/ATE499378T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT05733719T 2004-04-22 2005-04-22 Anthracyclinderivate ATE499378T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0401066A SE0401066D0 (sv) 2004-04-22 2004-04-22 Chemical Derivatives
PCT/SE2005/000596 WO2005103065A1 (en) 2004-04-22 2005-04-22 Anthracycline derivatives

Publications (1)

Publication Number Publication Date
ATE499378T1 true ATE499378T1 (de) 2011-03-15

Family

ID=32322666

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05733719T ATE499378T1 (de) 2004-04-22 2005-04-22 Anthracyclinderivate

Country Status (10)

Country Link
US (2) US20070258890A1 (de)
EP (1) EP1740599B1 (de)
JP (1) JP5156372B2 (de)
CN (1) CN1956992A (de)
AT (1) ATE499378T1 (de)
BR (1) BRPI0510062A (de)
DE (1) DE602005026510D1 (de)
ES (1) ES2360708T3 (de)
SE (1) SE0401066D0 (de)
WO (1) WO2005103065A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2552443T3 (da) * 2010-04-01 2021-09-27 Oncorena Ab Forbedret behandling af nyrecellekarcinom
CN102086219A (zh) * 2010-11-24 2011-06-08 河南师范大学 具有抗癌活性的蒽环类抗生素简单结构类似物及制备方法
CN102146107B (zh) * 2011-01-14 2014-12-31 河南师范大学 (s)-2-羟烷基-1,4-二羟基-9,10-蒽醌与糖基缀合物的合成及抗肿瘤活性
JP6966428B2 (ja) * 2015-09-16 2021-11-17 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System 副溝結合テイルを有するｄｎａ結合物質
CN113750047A (zh) * 2020-05-28 2021-12-07 浙江大学 多功能纳米脂质体、制备方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS539756A (en) * 1976-07-14 1978-01-28 Microbial Chem Res Found Antitumers
US4250303A (en) * 1977-10-17 1981-02-10 Sri International N-Benzyl anthracyclines
GB2007645B (en) * 1977-10-17 1982-05-12 Stanford Res Inst Int Benzyl anthracyclines and pharmaceutical compositions containing them
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
CA1248944A (en) * 1982-09-28 1989-01-17 Gareth J. Thomas Anthracycline glycosides
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives
DE3641833A1 (de) * 1986-12-08 1988-06-09 Behringwerke Ag Zytostatisch wirksame anthracyclinderivate
US5003055A (en) * 1987-09-25 1991-03-26 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Anthracycline derivatives having inhibitory activity against reverse transcriptase of human immunodeficiency virus
US5874412A (en) * 1996-03-22 1999-02-23 Priebe; Waldemar Bis-anthracyclines with high activity against doxorubicin resistant tumors
ATE546457T1 (de) * 1999-03-19 2012-03-15 Waldemar Priebe Verfahren und zusammensetzungen zur herstellung von c-3' und c-4' -anthracyclin antibiotika
WO2003057687A1 (en) * 2001-12-27 2003-07-17 Albany Molecular Research, Inc. Methods for preparing doxorubicin derivatives

Also Published As

Publication number Publication date
EP1740599B1 (de) 2011-02-23
EP1740599A1 (de) 2007-01-10
JP2007533736A (ja) 2007-11-22
US20100092388A1 (en) 2010-04-15
US20070258890A1 (en) 2007-11-08
WO2005103065A1 (en) 2005-11-03
BRPI0510062A (pt) 2007-10-16
JP5156372B2 (ja) 2013-03-06
ES2360708T3 (es) 2011-06-08
DE602005026510D1 (en) 2011-04-07
US8609135B2 (en) 2013-12-17
SE0401066D0 (sv) 2004-04-22
CN1956992A (zh) 2007-05-02

Similar Documents

Publication Publication Date Title
IL273765A (en) Combinations and forms of administration of therapeutic agents and combined treatment
MX2009006779A (es) Antagonistas especificos para terapia con adyuvantes y neo-adyuvantes y el tratamiento de tumores en etapa temprana.
WO2004113571A3 (en) Prostate specific genes and the use thereof as targets for prostate cancer therapy and diagnosis
MX361467B (es) Compuestos de isoindolina para uso en el tratamiento de cancer.
DOP2009000208A (es) Métodos de tratamiento del cáncer mediante administración de combinaciones de il-18 humana
WO2005065361A3 (en) Compounds and compositions for treating dysproliferative diseases, and methods of use thereof
WO2008039994A3 (en) Targeted photodynamic therapy agent
WO2011056566A3 (en) Compounds and methods for treatment of cancer
ATE499378T1 (de) Anthracyclinderivate
TW200633700A (en) Methods of using temozolomide formulation intrathecally in the treatment of cancers
WO2006027693A8 (en) Tumor specific genes and variant rnas and uses thereof as targets for cancer therapy and diagnosis
MX2008001661A (es) Metodos para tratar afecciones malignas de celulas b que utilizan una molecula de fusion del activador de transmembrana o interactor del ligando de ciclofilina de modulacion de calcio-ig.
WO2005113720A3 (en) A strategy for designing patient-specific anti-cancer drugs
BRPI0810682A2 (pt) agente antitumoral em especial para o tratamento de tumores dérmicos, fármaco, kit compreendendo fármaco.
WO2007008490A3 (en) Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer
WO2006069217A3 (en) Small molecule cyclin d1 ablative agents
IL164356A (en) Use of alpha- bromo or alpha-chloro acryloyl distamycin derivatives in the preparation of medicaments for treating cancer
BRPI0409870A (pt) uso de irinotecano para tratamento de cáncer de mama resistente
MXPA05008879A (es) Una terapia combinada que comprende un derivado de indolopirrolocarbazol y otro agente antitumoral.
UA35392U (ru) Способ комплексной терапии злокачественных опухолей и метастазов
WO2009140572A3 (en) Combinatorial treatment with glucose regulated protein-170 and melanoma differentiation associated gene-7

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties