ATE500219T1 - Neue dipeptidylpeptidase-iv-inhibitoren und verfahren zur ihrer herstellung und pharmazeutische zusammensetzung, die diese enthalten - Google Patents
Neue dipeptidylpeptidase-iv-inhibitoren und verfahren zur ihrer herstellung und pharmazeutische zusammensetzung, die diese enthaltenInfo
- Publication number
- ATE500219T1 ATE500219T1 AT07734152T AT07734152T ATE500219T1 AT E500219 T1 ATE500219 T1 AT E500219T1 AT 07734152 T AT07734152 T AT 07734152T AT 07734152 T AT07734152 T AT 07734152T AT E500219 T1 ATE500219 T1 AT E500219T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- ring system
- denotes
- heterocyclic ring
- heteroatoms
- Prior art date
Links
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 title abstract 2
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- 125000005842 heteroatom Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 5
- 125000002950 monocyclic group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000524 functional group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- -1 hydroxy, amino Chemical group 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000005485 noradamantyl group Chemical group 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229910052760 oxygen Chemical group 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN610CH2006 | 2006-04-03 | ||
| US80143706P | 2006-05-18 | 2006-05-18 | |
| PCT/IB2007/000830 WO2007113634A1 (en) | 2006-04-03 | 2007-03-30 | Novel dipeptidyl peptidase iv inhibitors and processes for their preparation and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500219T1 true ATE500219T1 (de) | 2011-03-15 |
Family
ID=40743745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07734152T ATE500219T1 (de) | 2006-04-03 | 2007-03-30 | Neue dipeptidylpeptidase-iv-inhibitoren und verfahren zur ihrer herstellung und pharmazeutische zusammensetzung, die diese enthalten |
Country Status (8)
| Country | Link |
|---|---|
| CN (1) | CN101448785B (da) |
| AT (1) | ATE500219T1 (da) |
| BR (1) | BRPI0709894A2 (da) |
| DE (1) | DE602007012845D1 (da) |
| DK (1) | DK2004601T3 (da) |
| NZ (1) | NZ571319A (da) |
| RU (1) | RU2443687C2 (da) |
| ZA (1) | ZA200808188B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104530011B (zh) * | 2015-01-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一种腈基金刚烷四氮唑化合物、其制备方法和用途 |
| CN104530012B (zh) * | 2015-01-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 金刚烷胺四氮唑类衍生物、其制备方法和用途 |
| CN104496876A (zh) * | 2015-01-13 | 2015-04-08 | 佛山市赛维斯医药科技有限公司 | 一种羟基金刚烷酰胺衍生物、其制备方法和用途 |
| CN104530009B (zh) * | 2015-01-13 | 2016-08-24 | 佛山市赛维斯医药科技有限公司 | 金刚烷胺四氮唑类衍生物、其制备方法和用途 |
| CN104530010B (zh) * | 2015-01-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一种羟基金刚烷四氮唑化合物、其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW492957B (en) * | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| CO5150173A1 (es) * | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
| JP2002265497A (ja) * | 2001-03-12 | 2002-09-18 | Tadashi Hashimoto | 生理活性ペプチドニューロメジンｕの高活性誘導体 |
| CN1703399A (zh) * | 2002-09-19 | 2005-11-30 | 艾博特公司 | 作为二肽酰肽酶－iv(dpp－iv)抑制剂的药用组合物 |
| US7842707B2 (en) * | 2004-07-23 | 2010-11-30 | Nuada, Llc | Peptidase inhibitors |
-
2007
- 2007-03-30 CN CN2007800183871A patent/CN101448785B/zh not_active Expired - Fee Related
- 2007-03-30 DK DK07734152.7T patent/DK2004601T3/da active
- 2007-03-30 BR BRPI0709894-4A patent/BRPI0709894A2/pt not_active IP Right Cessation
- 2007-03-30 NZ NZ571319A patent/NZ571319A/en not_active IP Right Cessation
- 2007-03-30 DE DE602007012845T patent/DE602007012845D1/de active Active
- 2007-03-30 AT AT07734152T patent/ATE500219T1/de not_active IP Right Cessation
- 2007-03-30 RU RU2008143321/04A patent/RU2443687C2/ru not_active IP Right Cessation
-
2008
- 2008-09-25 ZA ZA200808188A patent/ZA200808188B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2004601T3 (da) | 2011-06-27 |
| BRPI0709894A2 (pt) | 2011-07-26 |
| NZ571319A (en) | 2011-05-27 |
| RU2008143321A (ru) | 2010-05-10 |
| CN101448785B (zh) | 2013-03-27 |
| ZA200808188B (en) | 2009-07-29 |
| RU2443687C2 (ru) | 2012-02-27 |
| DE602007012845D1 (de) | 2011-04-14 |
| CN101448785A (zh) | 2009-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY173930A (en) | Crystalline solvates and complexes of (is)-1,5-anhydro-1-c-(3-((phenyl)methyl)phenyl)-d-glucitol derivatives with amino acids as sglt2 inhibitors for the treatment of diabetes | |
| PE20080538A1 (es) | Derivado heterociclico fusionado y su uso | |
| PE20080843A1 (es) | Inhibidores de renina y metodo para su utilizacion | |
| EA200870461A1 (ru) | Производные лактама циклогексилимидазола в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы 1 | |
| PE20091842A1 (es) | Pirrolidinonas como activadores de glucoquinasa | |
| DOP2007000051A (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevención de diabetes | |
| PE20070218A1 (es) | COMPUESTOS DE CICLOALQUILO AMINO-HIDANTOINA Y USO DE ESTOS PARA LA MODULACION DE ß-SECRETASA | |
| EA201070442A1 (ru) | НОВЫЕ ИНГИБИТОРЫ sEH И ИХ ПРИМЕНЕНИЕ | |
| PE20090365A1 (es) | Imidazopirazinas como inhibidores de proteina quinasa | |
| EA200870471A1 (ru) | Замещенные пирролидиноны в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 типа | |
| ATE471311T1 (de) | Inhibitoren von11-beta- hydroxysteroiddehydrogenase 1 | |
| EA200601896A1 (ru) | Производные пролина и их применение в качестве ингибиторов дипептидилпептидазы iv | |
| PE20110150A1 (es) | Amidofenoxiindazoles como inhibidores de c-met | |
| TW200745067A (en) | Novel compounds | |
| DE602004010829D1 (de) | Adamantan- und azabicyclooctan- und -nonanderivate, verfahren zu deren herstellung und deren verwendung als dpp-iv-inhibitoren | |
| PE20121157A1 (es) | Compuestos heterociclicos como inhibidores de proteasas serinas | |
| WO2009025839A3 (en) | Phosphodiesterase 10 inhibitors | |
| TW200716531A (en) | Cyclohexanesulfonyl derivatives as GLYT1 inhibitors to treat schizophrenia | |
| ATE473221T1 (de) | 1-(1-benzylpiperidin-4-yl)benzimidazol-5- carbonsäurederivate zur behandlung von diabetes mellitus | |
| TN2010000173A1 (fr) | Antagonistes de cgrp | |
| ATE500219T1 (de) | Neue dipeptidylpeptidase-iv-inhibitoren und verfahren zur ihrer herstellung und pharmazeutische zusammensetzung, die diese enthalten | |
| PE20080608A1 (es) | Compuestos quimicos | |
| DE602006006850D1 (de) | Als modulatoren von dopamin-d3-rezeptoren geeignete azabicyclo-(3,1,0)-hexan-derivate | |
| PE20091426A1 (es) | Compuestos de piridina | |
| PE20081680A1 (es) | Piperidinas sustituidas que contienen un componente de heteroarilamida o de heteroarilfenil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |