ATE500345T1 - Kunitz-domäne-bibliothek - Google Patents
Kunitz-domäne-bibliothekInfo
- Publication number
- ATE500345T1 ATE500345T1 AT04700617T AT04700617T ATE500345T1 AT E500345 T1 ATE500345 T1 AT E500345T1 AT 04700617 T AT04700617 T AT 04700617T AT 04700617 T AT04700617 T AT 04700617T AT E500345 T1 ATE500345 T1 AT E500345T1
- Authority
- AT
- Austria
- Prior art keywords
- kunitz domain
- domain library
- libraries
- kunitz
- phage
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Optical Communication System (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Gyroscopes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43849103P | 2003-01-07 | 2003-01-07 | |
| PCT/US2004/000333 WO2004063337A2 (en) | 2003-01-07 | 2004-01-07 | Kunitz domain library |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500345T1 true ATE500345T1 (de) | 2011-03-15 |
Family
ID=32713336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04700617T ATE500345T1 (de) | 2003-01-07 | 2004-01-07 | Kunitz-domäne-bibliothek |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20040209243A1 (de) |
| EP (2) | EP2290107A1 (de) |
| JP (2) | JP2007524348A (de) |
| AT (1) | ATE500345T1 (de) |
| AU (1) | AU2004204095B2 (de) |
| CA (1) | CA2512590A1 (de) |
| DE (1) | DE602004031589D1 (de) |
| DK (1) | DK1587907T3 (de) |
| ES (1) | ES2362424T3 (de) |
| PT (1) | PT1587907E (de) |
| WO (1) | WO2004063337A2 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US6010880A (en) * | 1994-01-11 | 2000-01-04 | Dyax Corp. | Inhibitors of human plasmin derived from the kunitz domains |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| EP2311432B1 (de) | 2002-06-07 | 2014-12-24 | Dyax Corporation | Polypeptides mit modifizierten Kunitz Domains und deren Verwendung zur Verringerung der Ischämie oder des Beginns einer systemischen Entzündungsreaktion verbunden mit einer chirurgischen Prozedur |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| CA2587775A1 (en) * | 2004-11-22 | 2006-06-01 | Dyax Corp. | Plasmin-inhibitory therapies |
| CA2614186A1 (en) * | 2005-07-13 | 2007-01-18 | Amgen Mountain View Inc. | Il-6 binding proteins |
| WO2009026334A2 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| US8450275B2 (en) | 2010-03-19 | 2013-05-28 | Baxter International Inc. | TFPI inhibitors and methods of use |
| KR101792032B1 (ko) | 2008-12-19 | 2017-11-02 | 백스터 인터내셔널 인코포레이티드 | Ｔｆｐｉ 억제제 및 사용 방법 |
| JP2013516389A (ja) | 2009-01-06 | 2013-05-13 | ダイアックス コーポレーション | カリクレイン阻害剤による粘膜炎治療 |
| EP3459564B1 (de) | 2010-01-06 | 2021-10-27 | Takeda Pharmaceutical Company Limited | Plasmakallikreinbindende proteine |
| JP2014506257A (ja) | 2011-01-06 | 2014-03-13 | ダイアックス コーポレーション | 血漿カリクレイン結合タンパク質 |
| NZ749998A (en) | 2012-03-21 | 2023-06-30 | Takeda Pharmaceuticals Co | Tfpi inhibitors and methods of use |
| DK2883954T3 (da) | 2012-08-08 | 2020-09-28 | Daiichi Sankyo Co Ltd | Peptidbibliotek og anvendelse deraf |
| AU2015235967B2 (en) | 2014-03-27 | 2020-10-22 | Takeda Pharmaceutical Company Limited | Compositions and methods for treatment of diabetic macular edema |
| US9982052B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| US9982053B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| CN116869964B (zh) | 2014-12-24 | 2024-10-18 | 耐克西缪恩有限公司 | 用于免疫疗法的纳米颗粒组合物和方法 |
| US11702477B2 (en) | 2015-11-06 | 2023-07-18 | Orionis Biosciences BV | Bi-functional chimeric proteins and uses thereof |
| EP3377080B1 (de) | 2015-11-19 | 2024-02-14 | Asclepix Therapeutics, LLC | Peptide mit anti-angiogenen, anti-lymphangiogenen und anti-ödematösen eigenschaften und nanopartikelformulierungen |
| JP7003354B2 (ja) | 2015-12-11 | 2022-03-04 | 武田薬品工業株式会社 | 遺伝性血管性浮腫の発作を治療するための血漿カリクレイン阻害薬およびその用途 |
| US11214617B2 (en) | 2016-01-22 | 2022-01-04 | MabQuest SA | Immunological reagents |
| WO2017125815A2 (en) | 2016-01-22 | 2017-07-27 | MabQuest SA | Immunological reagents |
| CN108883180B (zh) | 2016-02-05 | 2023-07-07 | 奥里尼斯生物科学私人有限公司 | Clec9a结合剂及其用途 |
| US11248057B2 (en) | 2016-03-07 | 2022-02-15 | Vib Vzw | CD20 binding single domain antibodies |
| CA3023883A1 (en) | 2016-05-13 | 2017-11-16 | Orionis Biosciences Nv | Targeted mutant interferon-beta and uses thereof |
| EP3455245A2 (de) | 2016-05-13 | 2019-03-20 | Orionis Biosciences NV | Therapeutisches targeting von nichtzellulären strukturen |
| SG10202103032QA (en) | 2016-10-04 | 2021-05-28 | Asclepix Therapeutics Inc | Compounds and methods for activating tie2 signaling |
| ES2917000T3 (es) | 2016-10-24 | 2022-07-06 | Orionis Biosciences BV | Interferón-gamma mutante diana y usos del mismo |
| US10906985B2 (en) | 2017-02-06 | 2021-02-02 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
| MX2019009255A (es) | 2017-02-06 | 2019-11-05 | Orionis Biosciences Nv | Proteínas quiméricas dirigidas y sus usos. |
| WO2018146074A1 (en) | 2017-02-07 | 2018-08-16 | Vib Vzw | Immune-cell targeted bispecific chimeric proteins and uses thereof |
| US11674959B2 (en) | 2017-08-03 | 2023-06-13 | The Johns Hopkins University | Methods for identifying and preparing pharmaceutical agents for activating Tie1 and/or Tie2 receptors |
| US12059476B2 (en) | 2017-10-10 | 2024-08-13 | The Johns Hopkins University | Biodegradable biomimetic particles |
| US20190231690A1 (en) | 2017-11-08 | 2019-08-01 | L.E.A.F. Holdings Group Llc | Platinum complexes and uses thereof |
| KR102806145B1 (ko) | 2017-11-14 | 2025-05-15 | 아르셀엑스, 인크. | 다기능성 면역 세포 요법 |
| WO2019148089A1 (en) | 2018-01-26 | 2019-08-01 | Orionis Biosciences Inc. | Xcr1 binding agents and uses thereof |
| KR102877915B1 (ko) | 2018-02-05 | 2025-10-29 | 오리오니스 바이오사이언시즈 인코포레이티드 | 섬유아세포 결합제 및 이의 용도 |
| CA3118892A1 (en) | 2018-11-08 | 2020-05-14 | Orionis Biosciences, Inc. | Modulation of dendritic cell lineages |
| MA54955A (fr) | 2019-02-15 | 2021-12-22 | Integral Molecular Inc | Anticorps anti-claudine 6 et leurs utilisations |
| CA3129317A1 (en) | 2019-02-15 | 2020-08-20 | Integral Molecular, Inc. | Antibodies comprising a common light chain and uses thereof |
| WO2020198665A1 (en) | 2019-03-28 | 2020-10-01 | Orionis Biosciences, Inc. | Fibroblast activation protein binding agents and use thereof |
| WO2021026310A1 (en) | 2019-08-06 | 2021-02-11 | L.E.A.F. Holdings Group Llc | Processes of preparing polyglutamated antifolates and uses of their compositions |
| JP2023510854A (ja) | 2020-01-13 | 2023-03-15 | 武田薬品工業株式会社 | 小児遺伝性血管性浮腫発作を治療するための血漿カリクレイン阻害剤及びその使用 |
| GB202004514D0 (en) | 2020-03-27 | 2020-05-13 | Inst De Medicina Molecular Joaeo Lobo Antunes | Treatment of Immunosuppressive Cancer |
| WO2022081804A1 (en) | 2020-10-14 | 2022-04-21 | Viridian Therapeutics, Inc. | Compositions and methods for treatment of thyroid eye disease |
| GB202019817D0 (en) * | 2020-12-15 | 2021-01-27 | Univ Oxford Innovation Ltd | Ligand-binding polypeptides and uses thereof |
| CA3212948A1 (en) | 2021-03-26 | 2022-09-29 | David M. Hilbert | Multifunctional immune cell therapies |
| WO2023019171A1 (en) | 2021-08-10 | 2023-02-16 | Viridian Therapeutics, Inc. | Compositions, doses, and methods for treatment of thyroid eye disease |
| US20250304677A1 (en) | 2022-07-04 | 2025-10-02 | Vib Vzw | Blood-Cerebrospinal Fluid Barrier Crossing Antibodies |
| EP4598635A2 (de) | 2022-10-06 | 2025-08-13 | Bicara Therapeutics Inc. | Multispezifische proteine und zugehörige verfahren |
| EP4626933A1 (de) | 2022-11-30 | 2025-10-08 | Integral Molecular, Inc. | Gegen claudin 6 gerichtete antikörper mit bispezifischen formaten davon |
| CN121358771A (zh) | 2023-04-03 | 2026-01-16 | 非营利性组织佛兰芒综合大学生物技术研究所 | 血-脑屏障穿越抗体 |
| WO2025014773A1 (en) | 2023-07-07 | 2025-01-16 | Viridian Therapeutics, Inc. | Methods of treating chronic thyroid eye disease |
| AU2024299328A1 (en) | 2023-07-21 | 2026-01-22 | Marrow Therapeutics, Inc. | Hematopoietic cell targeting conjugates and related methods |
| WO2025093683A1 (en) | 2023-11-03 | 2025-05-08 | Neuvasq Biotechnologies Sa | Wnt7 signaling agonists |
| WO2025136985A1 (en) | 2023-12-17 | 2025-06-26 | Viridian Therapeutics, Inc. | Compositions, doses, and methods for treatment of thyroid eye disease |
| WO2025151492A1 (en) | 2024-01-09 | 2025-07-17 | Viridian Therapeutics, Inc. | Compositions and methods for treatment of thyroid eye disease |
| WO2025151502A1 (en) | 2024-01-09 | 2025-07-17 | Viridian Therapeutics, Inc. | Modified antibodies |
| WO2025151496A1 (en) | 2024-01-09 | 2025-07-17 | Viridian Therapeutics, Inc. | Compositions and methods for treatment of thyroid eye disease |
| WO2025160334A1 (en) | 2024-01-26 | 2025-07-31 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| US20250353881A1 (en) | 2024-05-16 | 2025-11-20 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| WO2025245111A1 (en) | 2024-05-22 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor targeting proteins and related methods |
| US20260015407A1 (en) | 2024-07-15 | 2026-01-15 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory fusion proteins and related methods |
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-
2004
- 2004-01-07 AT AT04700617T patent/ATE500345T1/de active
- 2004-01-07 CA CA002512590A patent/CA2512590A1/en not_active Abandoned
- 2004-01-07 EP EP10012620A patent/EP2290107A1/de not_active Withdrawn
- 2004-01-07 DK DK04700617.6T patent/DK1587907T3/da active
- 2004-01-07 JP JP2006500832A patent/JP2007524348A/ja active Pending
- 2004-01-07 ES ES04700617T patent/ES2362424T3/es not_active Expired - Lifetime
- 2004-01-07 AU AU2004204095A patent/AU2004204095B2/en not_active Ceased
- 2004-01-07 EP EP04700617A patent/EP1587907B1/de not_active Expired - Lifetime
- 2004-01-07 DE DE602004031589T patent/DE602004031589D1/de not_active Expired - Lifetime
- 2004-01-07 WO PCT/US2004/000333 patent/WO2004063337A2/en not_active Ceased
- 2004-01-07 US US10/753,544 patent/US20040209243A1/en not_active Abandoned
- 2004-01-07 PT PT04700617T patent/PT1587907E/pt unknown
-
2007
- 2007-07-09 US US11/774,964 patent/US20080020394A1/en not_active Abandoned
-
2010
- 2010-02-22 JP JP2010036225A patent/JP2010162030A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004063337A2 (en) | 2004-07-29 |
| EP2290107A1 (de) | 2011-03-02 |
| AU2004204095A1 (en) | 2004-07-29 |
| WO2004063337A3 (en) | 2007-01-25 |
| US20080020394A1 (en) | 2008-01-24 |
| EP1587907B1 (de) | 2011-03-02 |
| JP2007524348A (ja) | 2007-08-30 |
| DK1587907T3 (da) | 2011-04-04 |
| ES2362424T3 (es) | 2011-07-05 |
| JP2010162030A (ja) | 2010-07-29 |
| EP1587907A2 (de) | 2005-10-26 |
| CA2512590A1 (en) | 2004-07-29 |
| PT1587907E (pt) | 2011-04-08 |
| AU2004204095B2 (en) | 2009-07-30 |
| US20040209243A1 (en) | 2004-10-21 |
| DE602004031589D1 (de) | 2011-04-14 |
| EP1587907A4 (de) | 2007-11-14 |
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